Interleukin-4

"Interleukin-4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.

Descriptor ID	D015847
MeSH Number(s)	D12.644.276.374.465.186 D12.776.467.374.465.178 D23.529.374.465.186
Concept/Terms	Interleukin-4 Interleukin-4 Interleukin 4 B-Cell Growth Factor-1 B Cell Growth Factor 1 B-Cell Growth Factor-I B Cell Growth Factor I B-Cell Proliferating Factor B Cell Proliferating Factor B-Cell Stimulating Factor-1 B Cell Stimulating Factor 1 B-Cell Stimulatory Factor 1 B-Cell Stimulatory Factor-1 BCGF-1 Binetrakin BSF-1 IL-4 IL4 Mast Cell Growth Factor-2 Mast Cell Growth Factor 2 MCGF-2 B Cell Stimulatory Factor-1 B Cell Stimulatory Factor 1

Below are MeSH descriptors whose meaning is more general than "Interleukin-4".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-4 [D12.644.276.374.465.186]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-4 [D12.776.467.374.465.178]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-4 [D23.529.374.465.186]

Below are MeSH descriptors whose meaning is related to "Interleukin-4".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-4" by people in this website by year, and whether "Interleukin-4" was a major or minor topic of these publications.

Bar chart showing 88 publications over 26 distinct years, with a maximum of 10 publications in 2001

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	1	2
1997	1	1	2
1998	1	6	7
1999	0	3	3
2000	3	1	4
2001	3	7	10
2002	3	6	9
2003	1	2	3
2004	1	2	3
2005	5	2	7
2006	0	3	3
2007	1	2	3
2008	1	4	5
2009	1	1	2
2011	0	1	1
2012	0	4	4
2013	0	2	2
2014	1	4	5
2015	0	4	4
2016	1	0	1
2017	1	0	1
2020	1	0	1
2021	0	1	1
2022	0	1	1
2024	1	1	2
2026	1	1	2

Below are the most recent publications written about "Interleukin-4" by people in Profiles.

Lee D, Lu MP, Rajamanimuthu P, Das M, Ferraj E, Fisher C, Matatia P, Chen CW, Geha RS, Sokol CL, Gowthaman U. Interleukin-4-producing type 2 innate lymphoid cells in the lymph node promote proallergic Tfh13 cell differentiation. Immunity. 2026 Jul 14; 59(7):1860-1875.e7.

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Vargas-Robles D, Yap YR, Singha B, Tien J, Purandare M, Rojas-Correa M, Madziar C, Picker M, Dumont T, Leftwich HK, Frisard CF, Ward DV, Peter I, Olendzki B, Maldonado-Contreras A. Association of vaginal IL-4, IL-6, IL-8, IL-17, IFN-?, and dietary intake with IBD status and vaginal microbiota in pregnant individuals. PLoS One. 2026; 21(1):e0335178.

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Frisoli ML, Ko WC, Martinez N, Afshari K, Wang Y, Garber M, Harris JE. Single-Cell RNA Sequencing Reveals Molecular Signatures that Distinguish Allergic from Irritant Contact Dermatitis. J Invest Dermatol. 2025 May; 145(5):1117-1126.e14.

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Ranjitkar S, Krajewski D, Tedeschi C, Perez NM, Jordan N, Gregory K, Schneider SS, Mathias CB. Mast cell responses in a mouse model of food allergy are regulated via a ST2/IL-4 axis. Allergy. 2024 09; 79(9):2561-2564.

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D'Arcy Q, Gharaee-Kermani M, Zhilin-Roth A, Macoska JA. The IL-4/IL-13 signaling axis promotes prostatic fibrosis. PLoS One. 2022; 17(10):e0275064.

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de Freitas CL, Polonio CM, Brand?o WN, Rossato C, Zanluqui NG, de Oliveira LG, de Oliveira MG, Evangelista LP, Halpern S, Maluf M, Czresnia CE, Perin P, de Almeida DC, Peron JPS. Human Fallopian Tube - Derived Mesenchymal Stem Cells Inhibit Experimental Autoimmune Encephalomyelitis by Suppressing Th1/Th17 Activation and Migration to Central Nervous System. Stem Cell Rev Rep. 2022 02; 18(2):609-625.

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Xi R, Montague J, Lin X, Lu C, Lei W, Tanaka K, Zhang YV, Xu X, Zheng X, Zhou X, Urban JF, Iwatsuki K, Margolskee RF, Matsumoto I, Tizzano M, Li J, Jiang P. Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity. Proc Natl Acad Sci U S A. 2021 07 27; 118(30).

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?ebi M, Durmus H, Aysal F, ?zkan B, G?l GE, ?akar A, Hocaoglu M, Mercan M, Yent?r SP, T?t?nc? M, Yayla V, Akan O, Dogan ?, Parman Y, Saruhan-Direskeneli G. CD4+ T Cells of Myasthenia Gravis Patients Are Characterized by Increased IL-21, IL-4, and IL-17A Productions and Higher Presence of PD-1 and ICOS. Front Immunol. 2020; 11:809.

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Chen C, Smith AD, Cheung L, Pham Q, Urban JF, Dawson HD. Potentiation of IL-4 Signaling by Retinoic Acid in Intestinal Epithelial Cells and Macrophages-Mechanisms and Targets. Front Immunol. 2020; 11:605.

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Chen C, Perry TL, Chitko-McKown CG, Smith AD, Cheung L, Beshah E, Urban JF, Dawson HD. The regulatory actions of retinoic acid on M2 polarization of porcine macrophages. Dev Comp Immunol. 2019 09; 98:20-33.

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