Epidermal Growth Factor

"Epidermal Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.

Descriptor ID	D004815
MeSH Number(s)	D06.472.317.350 D12.644.276.382.500 D12.776.467.382.500 D23.529.382.500
Concept/Terms	Epidermal Growth Factor Epidermal Growth Factor Growth Factor, Epidermal Urogastrone Epidermal Growth Factor-Urogastrone Growth Factor-Urogastrone, Epidermal Human Urinary Gastric Inhibitor beta-Urogastrone beta Urogastrone EGF

Below are MeSH descriptors whose meaning is more general than "Epidermal Growth Factor".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Gastrointestinal Hormones [D06.472.317]
Epidermal Growth Factor [D06.472.317.350]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
EGF Family of Proteins [D12.644.276.382]
Epidermal Growth Factor [D12.644.276.382.500]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
EGF Family of Proteins [D12.776.467.382]
Epidermal Growth Factor [D12.776.467.382.500]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
EGF Family of Proteins [D23.529.382]
Epidermal Growth Factor [D23.529.382.500]

Below are MeSH descriptors whose meaning is related to "Epidermal Growth Factor".

Below are MeSH descriptors whose meaning is more specific than "Epidermal Growth Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epidermal Growth Factor" by people in this website by year, and whether "Epidermal Growth Factor" was a major or minor topic of these publications.

Bar chart showing 38 publications over 21 distinct years, with a maximum of 4 publications in 2004 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	2	3
1998	0	2	2
1999	0	2	2
2001	1	1	2
2002	2	0	2
2003	0	1	1
2004	2	2	4
2005	0	3	3
2007	2	0	2
2008	2	0	2
2010	2	2	4
2011	0	1	1
2012	0	1	1
2013	0	1	1
2014	0	1	1
2015	0	2	2
2016	1	0	1
2017	1	0	1
2018	0	1	1
2021	1	0	1
2022	1	0	1

Below are the most recent publications written about "Epidermal Growth Factor" by people in Profiles.

Yerramilli VS, Ross AH, Scarlata S, Gericke A. IQGAP1 scaffolding links phosphoinositide kinases to cytoskeletal reorganization. Biophys J. 2022 03 01; 121(5):793-807.

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Neculaes B, Frelinger AL, Gerrits AJ, Gremmel T, Forde EE, Klopman S, Carmichael SL, Michelson AD. Activation of platelet-rich plasma by pulse electric fields: Voltage, pulse width and calcium concentration can be used to control and tune the release of growth factors, serotonin and hemoglobin. PLoS One. 2021; 16(4):e0249209.

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Frelinger AL, Gerrits AJ, Neculaes VB, Gremmel T, Torres AS, Caiafa A, Carmichael SL, Michelson AD. Tunable activation of therapeutic platelet-rich plasma by pulse electric field: Differential effects on clot formation, growth factor release, and platelet morphology. PLoS One. 2018; 13(9):e0203557.

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Sundaram GM, Ismail HM, Bashir M, Muhuri M, Vaz C, Nama S, Ow GS, Vladimirovna IA, Ramalingam R, Burke B, Tanavde V, Kuznetsov V, Lane EB, Sampath P. EGF hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis. J Exp Med. 2017 Oct 02; 214(10):2889-2900.

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Ly S, Navaroli DM, Didiot MC, Cardia J, Pandarinathan L, Alterman JF, Fogarty K, Standley C, Lifshitz LM, Bellve KD, Prot M, Echeverria D, Corvera S, Khvorova A. Visualization of self-delivering hydrophobically modified siRNA cellular internalization. Nucleic Acids Res. 2017 01 09; 45(1):15-25.

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Ciccarese C, Brunelli M, Montironi R, Fiorentino M, Iacovelli R, Heng D, Tortora G, Massari F. The prospect of precision therapy for renal cell carcinoma. Cancer Treat Rev. 2016 Sep; 49:37-44.

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Nostro MC, Sarangi F, Yang C, Holland A, Elefanty AG, Stanley EG, Greiner DL, Keller G. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines. Stem Cell Reports. 2015 Apr 14; 4(4):591-604.

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Rohatgi RA, Janusis J, Leonard D, Bellv? KD, Fogarty KE, Baehrecke EH, Corvera S, Shaw LM. Beclin 1 regulates growth factor receptor signaling in breast cancer. Oncogene. 2015 Oct 16; 34(42):5352-62.

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Torres AS, Caiafa A, Garner AL, Klopman S, LaPlante N, Morton C, Conway K, Michelson AD, Frelinger AL, Neculaes VB. Platelet activation using electric pulse stimulation: growth factor profile and clinical implications. J Trauma Acute Care Surg. 2014 Sep; 77(3 Suppl 2):S94-S100.

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Kural MH, Billiar KL. Mechanoregulation of valvular interstitial cell phenotype in the third dimension. Biomaterials. 2014 Jan; 35(4):1128-37.

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