"Genistein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.
| Descriptor ID |
D019833
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| MeSH Number(s) |
D03.383.663.283.266.450.400.375 D03.633.100.150.266.450.400.375
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Genistein".
Below are MeSH descriptors whose meaning is more specific than "Genistein".
This graph shows the total number of publications written about "Genistein" by people in this website by year, and whether "Genistein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genistein" by people in Profiles.
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Kondratyuk TP, Adrian JA, Wright B, Park EJ, van Breemen RB, Morris KR, Pezzuto JM. Evidence supporting the conceptual framework of cancer chemoprevention in canines. Sci Rep. 2016 05 24; 6:26500.
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Carroll KJ, Esain V, Garnaas MK, Cortes M, Dovey MC, Nissim S, Frechette GM, Liu SY, Kwan W, Cutting CC, Harris JM, Gorelick DA, Halpern ME, Lawson ND, Goessling W, North TE. Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Dev Cell. 2014 May 27; 29(4):437-53.
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Figueiras-Fierro D, Acevedo JJ, Mart?nez-L?pez P, Escoffier J, Sep?lveda FV, Balderas E, Orta G, Visconti PE, Darszon A. Electrophysiological evidence for the presence of cystic fibrosis transmembrane conductance regulator (CFTR) in mouse sperm. J Cell Physiol. 2013 Mar; 228(3):590-601.
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Di X, Andrews DM, Tucker CJ, Yu L, Moore AB, Zheng X, Castro L, Hermon T, Xiao H, Dixon D. A high concentration of genistein down-regulates activin A, Smad3 and other TGF-? pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30; 44(4):281-92.
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Escoffier J, Krapf D, Navarrete F, Darszon A, Visconti PE. Flow cytometry analysis reveals a decrease in intracellular sodium during sperm capacitation. J Cell Sci. 2012 Jan 15; 125(Pt 2):473-85.
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Zhang S, Joseph G, Pollok K, Berthoux L, Sastry L, Luban J, Cornetta K. G2 cell cycle arrest and cyclophilin A in lentiviral gene transfer. Mol Ther. 2006 Oct; 14(4):546-54.
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Heim M, Frank O, Kampmann G, Sochocky N, Pennimpede T, Fuchs P, Hunziker W, Weber P, Martin I, Bendik I. The phytoestrogen genistein enhances osteogenesis and represses adipogenic differentiation of human primary bone marrow stromal cells. Endocrinology. 2004 Feb; 145(2):848-59.
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Madison JM, Ethier MF, Yamaguchi H. Refilling of caffeine-sensitive intracellular calcium stores in bovine airway smooth muscle cells. Am J Physiol. 1998 11; 275(5):L852-60.
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Weber C, Negrescu E, Erl W, Pietsch A, Frankenberger M, Ziegler-Heitbrock HW, Siess W, Weber PC. Inhibitors of protein tyrosine kinase suppress TNF-stimulated induction of endothelial cell adhesion molecules. J Immunol. 1995 Jul 01; 155(1):445-51.