"Receptor, trkA" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.
Descriptor ID |
D020917
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MeSH Number(s) |
D08.811.913.696.620.682.725.400.660 D12.776.543.750.630.496 D12.776.543.750.750.400.550.550
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Concept/Terms |
Receptor, trkA- Receptor, trkA
- Proto-Oncogene Protein trk
- Proto Oncogene Protein trk
- trk, Proto-Oncogene Protein
- gp140(c-TRK)
- trk Proto-Oncogene Protein
- Proto-Oncogene Protein, trk
- trk Proto Oncogene Protein
- NTRK1 Receptor
- Receptor, NTRK1
- Proto-Oncogene Products c-trk
- Proto Oncogene Products c trk
- c-trk, Proto-Oncogene Products
- c-trk Protein
- c trk Protein
- gp140 c-trk
- c-trk, gp140
- gp140 c trk
- p140-trkA
- p140 trkA
- trk1 Transforming Tryrosine Kinase
- Neurotrophic Tyrosine Kinase Receptor Type 1
- trkA Receptor
- Receptor, Neurotrophic Tyrosine Kinase Type 1
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Below are MeSH descriptors whose meaning is more general than "Receptor, trkA".
Below are MeSH descriptors whose meaning is more specific than "Receptor, trkA".
This graph shows the total number of publications written about "Receptor, trkA" by people in this website by year, and whether "Receptor, trkA" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2003 | 1 | 0 | 1 |
2010 | 0 | 1 | 1 |
2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptor, trkA" by people in Profiles.
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Frank P, Barrientos G, Tirado-Gonz?lez I, Cohen M, Moschansky P, Peters EM, Klapp BF, Rose M, Tometten M, Blois SM. Balanced levels of nerve growth factor are required for normal pregnancy progression. Reproduction. 2014 Aug; 148(2):179-89.
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Weiss GJ, Hidalgo M, Borad MJ, Laheru D, Tibes R, Ramanathan RK, Blaydorn L, Jameson G, Jimeno A, Isaacs JD, Scaburri A, Pacciarini MA, Fiorentini F, Ciomei M, Von Hoff DD. Phase I study of the safety, tolerability and pharmacokinetics of PHA-848125AC, a dual tropomyosin receptor kinase A and cyclin-dependent kinase inhibitor, in patients with advanced solid malignancies. Invest New Drugs. 2012 Dec; 30(6):2334-43.
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Sirianni RW, Olausson P, Chiu AS, Taylor JR, Saltzman WM. The behavioral and biochemical effects of BDNF containing polymers implanted in the hippocampus of rats. Brain Res. 2010 Mar 19; 1321:40-50.
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Lachyankar MB, Condon PJ, Daou MC, De AK, Levine JB, Obermeier A, Ross AH. Novel functional interactions between Trk kinase and p75 neurotrophin receptor in neuroblastoma cells. J Neurosci Res. 2003 Jan 15; 71(2):157-72.