Mast Cells

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"Mast Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.

Descriptor ID	D008407
MeSH Number(s)	A11.329.427 A15.382.652
Concept/Terms	Mast Cells Mast Cells Cell, Mast Cells, Mast Mast Cell Basophils, Tissue Basophil, Tissue Tissue Basophil Tissue Basophils

Below are MeSH descriptors whose meaning is more general than "Mast Cells".

Anatomy [A]
Cells [A11]
Connective Tissue Cells [A11.329]
Mast Cells [A11.329.427]
Hemic and Immune Systems [A15]
Immune System [A15.382]
Mast Cells [A15.382.652]

Below are MeSH descriptors whose meaning is related to "Mast Cells".

Below are MeSH descriptors whose meaning is more specific than "Mast Cells".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mast Cells" by people in this website by year, and whether "Mast Cells" was a major or minor topic of these publications.

Bar chart showing 33 publications over 19 distinct years, with a maximum of 7 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1997	1	0	1
1998	1	0	1
2000	0	1	1
2002	0	1	1
2005	1	1	2
2006	1	0	1
2009	0	1	1
2012	1	1	2
2013	1	2	3
2015	0	1	1
2016	3	4	7
2018	1	1	2
2019	2	0	2
2020	1	0	1
2021	1	0	1
2022	1	0	1
2024	3	0	3
2025	1	0	1

Below are the most recent publications written about "Mast Cells" by people in Profiles.

Krajewski D, Ranjitkar S, Jordan N, Schneider SS, Mathias CB. IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy. Front Immunol. 2025; 16:1526498.

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Ranjitkar S, Krajewski D, Tedeschi C, Perez NM, Jordan N, Gregory K, Schneider SS, Mathias CB. Mast cell responses in a mouse model of food allergy are regulated via a ST2/IL-4 axis. Allergy. 2024 Sep; 79(9):2561-2564.

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Krajewski D, Ranjitkar S, Tedeschi C, Perez NM, Jordan N, Mire M, Schneider SS, Mathias CB. IL-10 Neutralization Attenuates Mast Cell Responses in a Murine Model of Experimental Food Allergy. Immunohorizons. 2024 06 01; 8(6):431-441.

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Ranjitkar S, Krajewski D, Garcia C, Tedeschi C, Polukort SH, Rovatti J, Mire M, Blesso CN, Jellison E, Schneider SS, Ryan JJ, Mathias CB. IL-10 Differentially Promotes Mast Cell Responsiveness to IL-33, Resulting in Enhancement of Type 2 Inflammation and Suppression of Neutrophilia. J Immunol. 2024 May 01; 212(9):1407-1419.

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Schanin J, Korver W, Brock EC, Leung J, Benet Z, Luu T, Chang K, Xu A, De Freitas N, Luehrsen K, Brehm MA, Wong A, Youngblood BA. Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells. Commun Biol. 2022 11 11; 5(1):1226.

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Li Y, Qi X, Zhao D, Urban JF, Huang H. IL-3 Expands Pre-Basophil and Mast Cell Progenitors by Upregulating the IL-3 Receptor Expression. Cell Immunol. 2022 04; 374:104498.

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Harcha PA, Garc?s P, Arredondo C, Fern?ndez G, S?ez JC, van Zundert B. Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer's Disease, ALS, and Harmful Stress Conditions. Int J Mol Sci. 2021 Feb 15; 22(4).

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Krajewski D, Polukort SH, Gelzinis J, Rovatti J, Kaczenski E, Galinski C, Pantos M, Shah NN, Schneider SS, Kennedy DR, Mathias CB. Protein Disulfide Isomerases Regulate IgE-Mediated Mast Cell Responses and Their Inhibition Confers Protective Effects During Food Allergy. Front Immunol. 2020; 11:606837.

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Youngblood BA, Brock EC, Leung J, Falahati R, Bryce PJ, Bright J, Williams J, Shultz LD, Greiner DL, Brehm MA, Bebbington C, Tomasevic N. AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice. Int Arch Allergy Immunol. 2019; 180(2):91-102.

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Zhang Z, Xiao H, Zhang X, Zhou P. Insight into the effects of deglycosylation and glycation of shrimp tropomyosin on in vivo allergenicity and mast cell function. Food Funct. 2019 Jul 17; 10(7):3934-3941.

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