 Gangliosides
"Gangliosides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subclass of ACIDIC GLYCOSPHINGOLIPIDS. They contain one or more sialic acid (N-ACETYLNEURAMINIC ACID) residues. Using the Svennerholm system of abbrevations, gangliosides are designated G for ganglioside, plus subscript M, D, or T for mono-, di-, or trisialo, respectively, the subscript letter being followed by a subscript arabic numeral to indicated sequence of migration in thin-layer chromatograms. (From Oxford Dictionary of Biochemistry and Molecular Biology, 1997)
| Descriptor ID |
D005732
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| MeSH Number(s) |
D09.400.410.420.025.475 D10.390.470.025.475 D10.570.877.360.025.475
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Gangliosides".
Below are MeSH descriptors whose meaning is more specific than "Gangliosides".
This graph shows the total number of publications written about "Gangliosides" by people in this website by year, and whether "Gangliosides" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 2 | 0 | 2 | | 2005 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 2 | 2 |
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Below are the most recent publications written about "Gangliosides" by people in Profiles.
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Weismann CM, Ferreira J, Keeler AM, Su Q, Qui L, Shaffer SA, Xu Z, Gao G, Sena-Esteves M. Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan. Hum Mol Genet. 2015 Aug 01; 24(15):4353-64.
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Rockwell HE, McCurdy VJ, Eaton SC, Wilson DU, Johnson AK, Randle AN, Bradbury AM, Gray-Edwards HL, Baker HJ, Hudson JA, Cox NR, Sena-Esteves M, Seyfried TN, Martin DR. AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system. ASN Neuro. 2015 Mar-Apr; 7(2).
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McCurdy VJ, Rockwell HE, Arthur JR, Bradbury AM, Johnson AK, Randle AN, Brunson BL, Hwang M, Gray-Edwards HL, Morrison NE, Johnson JA, Baker HJ, Cox NR, Seyfried TN, Sena-Esteves M, Martin DR. Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease. Gene Ther. 2015 Feb; 22(2):181-9.
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Susuki K, Yuki N, Schafer DP, Hirata K, Zhang G, Funakoshi K, Rasband MN. Dysfunction of nodes of Ranvier: a mechanism for anti-ganglioside antibody-mediated neuropathies. Exp Neurol. 2012 Jan; 233(1):534-42.
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Ciron C, Desmaris N, Colle MA, Raoul S, Joussemet B, Vérot L, Ausseil J, Froissart R, Roux F, Chérel Y, Ferry N, Lajat Y, Schwartz B, Vanier MT, Maire I, Tardieu M, Moullier P, Heard JM. Gene therapy of the brain in the dog model of Hurler's syndrome. Ann Neurol. 2006 Aug; 60(2):204-13.
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Tamboli IY, Prager K, Barth E, Heneka M, Sandhoff K, Walter J. Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. J Biol Chem. 2005 Jul 29; 280(30):28110-7.
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Yamamoto M, Schwarting GA, Crandall JE. Altered 9-O acetylation of disialogangliosides in cerebellar Purkinje cells of the nervous mutant mouse. Brain Res. 1994 Oct 31; 662(1-2):223-32.
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Cualing H, Siegel R, Schwarting GA, Suchy SF, McCluer RH, Bernal S. The expression of H-like blood group glycolipids in small cell carcinoma of the lung. Hybridoma. 1993 Jun; 12(3):239-47.
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Leclerc N, Schwarting GA, Herrup K, Hawkes R, Yamamoto M. Compartmentation in mammalian cerebellum: Zebrin II and P-path antibodies define three classes of sagittally organized bands of Purkinje cells. Proc Natl Acad Sci U S A. 1992 Jun 1; 89(11):5006-10.
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Suchy SF, Schwarting GA, Lethco BA, Ramirez JJ. The expression of a fucosyl-ganglioside in the molecular layer of the dentate gyrus following entorhinal cortical lesions. Neurosci Lett. 1991 Sep 30; 131(1):105-8.
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