Nod1 Signaling Adaptor Protein
"Nod1 Signaling Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A NOD-signaling adaptor protein that contains a C-terminal leucine-rich domain which recognizes bacterial PEPTIDOGLYCAN. It signals via an N-terminal caspase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. It plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM.
| Descriptor ID |
D053474
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| MeSH Number(s) |
D12.644.360.024.131.249 D12.644.360.024.313.249 D12.644.360.075.358.249 D12.644.360.539.500.249 D12.776.157.057.006.249 D12.776.157.057.078.249 D12.776.476.024.139.249 D12.776.476.024.391.249 D12.776.476.075.358.249
|
| Concept/Terms |
Nod1 Signaling Adaptor Protein- Nod1 Signaling Adaptor Protein
- Caspase Recruitment Domain Protein 4
- Nucleotide Oligomerization Domain 1 Protein
- CARD4 Protein
|
Below are MeSH descriptors whose meaning is more general than "Nod1 Signaling Adaptor Protein".
Below are MeSH descriptors whose meaning is more specific than "Nod1 Signaling Adaptor Protein".
This graph shows the total number of publications written about "Nod1 Signaling Adaptor Protein" by people in this website by year, and whether "Nod1 Signaling Adaptor Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2023 | 1 | 1 | 2 |
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Below are the most recent publications written about "Nod1 Signaling Adaptor Protein" by people in Profiles.
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Bharadwaj R, Anonick MV, Jaiswal S, Mashayekh S, Brown A, Wodzanowski KA, Okuda K, Silverman N, Grimes CL. Synthesis and validation of click-modified NOD1/2 agonists. Innate Immun. 2023 Nov; 29(8):186-200.
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Bharadwaj R, Lusi CF, Mashayekh S, Nagar A, Subbarao M, Kane GI, Wodzanowski KA, Brown AR, Okuda K, Monahan A, Paik D, Nandy A, Anonick MV, Goldman WE, Kanneganti TD, Orzalli MH, Grimes CL, Atukorale PU, Silverman N. Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity. Immunity. 2023 05 09; 56(5):998-1012.e8.
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D'Ambrosio EA, Drake WR, Mashayekh S, Ukaegbu OI, Brown AR, Grimes CL. Modulation of the NOD-like receptors NOD1 and NOD2: A chemist's perspective. Bioorg Med Chem Lett. 2019 05 15; 29(10):1153-1161.
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Mavrogiorgos N, Mekasha S, Yang Y, Kelliher MA, Ingalls RR. Activation of NOD receptors by Neisseria gonorrhoeae modulates the innate immune response. Innate Immun. 2014 May; 20(4):377-89.
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Okugawa T, Kaneko T, Yoshimura A, Silverman N, Hara Y. NOD1 and NOD2 mediate sensing of periodontal pathogens. J Dent Res. 2010 Feb; 89(2):186-91.
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Auerbuch V, Golenbock DT, Isberg RR. Innate immune recognition of Yersinia pseudotuberculosis type III secretion. PLoS Pathog. 2009 Dec; 5(12):e1000686.
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Fukazawa A, Alonso C, Kurachi K, Gupta S, Lesser CF, McCormick BA, Reinecker HC. GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors. PLoS Pathog. 2008 Nov; 4(11):e1000228.