GTPase-Activating Proteins
"GTPase-Activating Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins that activate the GTPase of specific GTP-BINDING PROTEINS.
| Descriptor ID |
D020690
|
| MeSH Number(s) |
D12.644.360.325.150 D12.776.476.325.150
|
| Concept/Terms |
GTPase-Activating Proteins- GTPase-Activating Proteins
- GTPase Activating Proteins
- GAP Proteins
- GAP Protein
- GTPase-Activating Protein
- GTPase Activating Protein
|
Below are MeSH descriptors whose meaning is more general than "GTPase-Activating Proteins".
Below are MeSH descriptors whose meaning is more specific than "GTPase-Activating Proteins".
This graph shows the total number of publications written about "GTPase-Activating Proteins" by people in this website by year, and whether "GTPase-Activating Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "GTPase-Activating Proteins" by people in Profiles.
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Egri SB, Ouch C, Chou HT, Yu Z, Song K, Xu C, Shen K. Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol Cell. 2022 05 19; 82(10):1836-1849.e5.
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Das S, Malaby AW, Nawrotek A, Zhang W, Zeghouf M, Maslen S, Skehel M, Chakravarthy S, Irving TC, Bilsel O, Cherfils J, Lambright DG. Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes. Structure. 2019 12 03; 27(12):1782-1797.e7.
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Shen K, Valenstein ML, Gu X, Sabatini DM. Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases. J Biol Chem. 2019 02 22; 294(8):2970-2975.
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Shen K, Huang RK, Brignole EJ, Condon KJ, Valenstein ML, Chantranupong L, Bomaliyamu A, Choe A, Hong C, Yu Z, Sabatini DM. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature. 2018 04 05; 556(7699):64-69.
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Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017 03 16; 543(7645):438-442.
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Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM. Sestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016 Jan 01; 351(6268):43-8.
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Mishra AK, Lambright DG. High-throughput assay for profiling the substrate specificity of Rab GTPase-activating proteins. Methods Mol Biol. 2015; 1298:47-60.
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Moquin DM, McQuade T, Chan FK. CYLD deubiquitinates RIP1 in the TNFa-induced necrosome to facilitate kinase activation and programmed necrosis. PLoS One. 2013; 8(10):e76841.
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Mishra AK, Del Campo CM, Collins RE, Roy CR, Lambright DG. The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism. J Biol Chem. 2013 Aug 16; 288(33):24000-11.
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Yasuda K, N?ndel K, Watkins AA, Dhawan T, Bonegio RG, Ubellacker JM, Marshak-Rothstein A, Rifkin IR. Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2. Int Immunol. 2013 May; 25(5):295-306.