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Junhao Mao PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
Phone508-856-4149
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program


    Collapse Biography 
    Collapse education and training
    Zhejiang University, Hangzhou, , ChinaB ABiochemistry
    University of Rochester, Rochester, NY, United StatesPHDPharmacology
    Harvard Univeristy, Cambridge, MA, United StatesPostdoc FellowshipDevelopmental Biology

    Collapse Overview 
    Collapse overview

    BIOGRAPHY

    JunhaoMao

    Junhao Mao received his Ph.D. degree from the University of Rochester in 2003. He did his postdoctoral research at Harvard University from 2003 to 2008, where he was supported by the fellowships from Damon Runyon Cancer Research Foundation and Charles A. King Trust. He joined the University of Massachusetts Medical School in fall 2008. Dr. Mao was also a recipient of the Charles H. Hood Foundation Child Health Research Award in 2009, American Cancer Society Research Scholar Award in 2011, Pancreatic Cancer Alliance Research Award in 2015, and Sanofi iAward in 2020. 

    RESEARCH

    My lab is interested in investigating the signaling mechanisms that underlie tissue homeostasis and tumorigenesis.  Our work is focused on several key developmental pathways including Hippo, Wnt and Hedgehog signaling.  We use a combination of molecular, cellular and mouse genetic approaches to dissect their roles in stem cell/progenitor function, and understand how dysregulation of these pathways contributes to tumor initiation and progression.

     

     

     

     


    Collapse Post Docs

    Postdoctoral positions are available for this lab. Please contact Junhao Mao directly, 508-856-4149 or via email, Junhao.Mao@umassmed.edu



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. B?rub? M, Gusscott S, Mao J, Zamberlam G, Boyer A, St-Jean G, Brind'Amour J, Boerboom D. Sustained YAP1 signaling alters the fates of lutein and M?llerian mesenchymal cells in mice. Reproduction. 2025 Aug 01; 170(2). PMID: 40658769.
      Citations:    
    2. Miao G, Fortier TM, Liu H, Schafer DP, Fitzgerald KA, Mao J, Baehrecke EH. Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration. Nat Struct Mol Biol. 2025 Oct; 32(10):2046-2059. PMID: 40563011.
      Citations:    
    3. Guo S, Hu X, Cotton JL, Ma L, Li Q, Cui J, Wang Y, Thakare RP, Tao Z, Ip YT, Wu X, Wang J, Mao J. VGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ-independent tumorigenesis by engaging EP300. Elife. 2025 May 08; 13. PMID: 40338073.
      Citations:    
    4. Abou Nader N, Jakuc N, Meinsohn MC, Charrier L, Banville L, Brind'Amour J, Paquet M, St-Jean G, Boerboom D, Mao J, P?pin D, Breault DT, Zamberlam G, Boyer A. Hippo Signaling Is Essential for the Maintenance of Zona Glomerulosa Cell Fate in the Murine Adrenal Cortex. Endocrinology. 2025 Apr 22; 166(6). PMID: 40233139.
      Citations:    
    5. Phillips CS, Morris SE, Rodriguez E, Woods H, Hebdon M, Choi E, Morris J, Morgan RB, Moorjani D, Lutrell J, Gruber C, Schroder A, Umberson D, Mao JJ. Storytelling Through Music With Parents Whose Children Have Died From Cancer: A Randomized Controlled Feasibility Trial. Psychooncology. 2025 Apr; 34(4):e70143. PMID: 40195024.
      Citations:    
    6. Guo S, Hu X, Cotton JL, Ma L, Li Q, Cui J, Wang Y, Thakare RP, Tao Z, Ip YT, Wu X, Wang J, Mao J. VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent tumorigenesis by engaging p300. bioRxiv. 2025 Feb 18. PMID: 38746415.
      Citations:    
    7. Dang K, Singh A, Chen X, Cotton JL, Guo S, Hu X, Tao Z, Liu H, Zhu LJ, Ip YT, Wu X, Mao J. Mesenchymal Hippo signaling regulates intestinal homeostasis in adult mice. iScience. 2025 Feb 21; 28(2):111847. PMID: 39981512.
      Citations:    
    8. Sigafoos AN, Tolosa EJ, Carr RM, Fernandez-Barrena MG, Almada LL, Pease DR, Hogenson TL, Raja Arul GL, Mousavi F, Sen S, Vera RE, Marks DL, Flores LF, LaRue-Nolan KC, Wu C, Bamlet WR, Vrabel AM, Sicotte H, Schenk EL, Smyrk TC, Zhang L, Rabe KG, Oberg AL, Zaphiropoulos PG, Chevet E, Graham RP, Hagen CE, di Magliano MP, Elsawa SF, Pin CL, Mao J, McWilliams RR, Fernandez-Zapico ME. KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis. Cancer Res Commun. 2024 07 01; 4(7):1677-1689. PMID: 38896052.
      Citations:    
    9. Hannan A, Wang Q, Wu Y, Makrides N, Qu X, Mao J, Que J, Cardoso W, Zhang X. Crk mediates Csk-Hippo signaling independently of Yap tyrosine phosphorylation to induce cell extrusion. bioRxiv. 2024 Jul 01. PMID: 39005335.
      Citations:    
    10. Qi S, Zhong Z, Zhu Y, Wang Y, Ma M, Wang Y, Liu X, Jin R, Jiao Z, Zhu R, Sha Z, Dang K, Liu Y, Lim DS, Mao J, Zhang L, Yu FX. Two Hippo signaling modules orchestrate liver size and tumorigenesis. EMBO J. 2023 Nov 15; 42(22):e115749. PMID: 37849424.
      Citations:    Fields:    
    11. Im EO, Chee W, Paul S, Choi MY, Kim SY, Deatrick JA, Inouye J, Ma G, Meghani S, Nguyen GT, Schapira MM, Ulrich CM, Yeo S, Bao T, Shin D, Mao JJ. A randomized controlled trial testing a virtual program for Asian American women breast cancer survivors. Nat Commun. 2023 10 14; 14(1):6475. PMID: 37838727.
      Citations:    Fields:    Translation:Humans
    12. Qi S, Zhong Z, Zhu Y, Wang Y, Ma M, Wang Y, Liu X, Jin R, Jiao Z, Zhu R, Sha Z, Dang K, Liu Y, Lim DS, Mao J, Zhang L, Yu FX. Two Hippo signaling modules orchestrate liver size and tumorigenesis. EMBO J. 2023 06 01; 42(11):e112126. PMID: 36919851.
      Citations: 4     Fields:    Translation:AnimalsCells
    13. Hu L, Sun Y, Liu S, Erb H, Singh A, Mao J, Luo X, Wu X. Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. Elife. 2022 11 18; 11. PMID: 36398861.
      Citations: 8     Fields:    Translation:HumansCells
    14. Sun Y, Hu L, Tao Z, Jarugumilli GK, Erb H, Singh A, Li Q, Cotton JL, Greninger P, Egan RK, Tony Ip Y, Benes CH, Che J, Mao J, Wu X. Pharmacological blockade of TEAD-YAP reveals its therapeutic limitation in cancer cells. Nat Commun. 2022 11 08; 13(1):6744. PMID: 36347861.
      Citations: 16     Fields:    Translation:HumansCells
    15. Ulrich CM, Ratcliffe SJ, Zhou Q, Huang L, Hochheimer C, Gordon T, Knafl K, Miller V, Naylor MD, Schapira MM, Richmond TS, Grady C, Mao JJ. Association of Perceived Benefit or Burden of Research Participation With Participants' Withdrawal From Cancer Clinical Trials. JAMA Netw Open. 2022 11 01; 5(11):e2244412. PMID: 36449287.
      Citations:    
    16. Mao JJ, Ismaila N, Bao T, Barton D, Ben-Arye E, Garland EL, Greenlee H, Leblanc T, Lee RT, Lopez AM, Loprinzi C, Lyman GH, MacLeod J, Master VA, Ramchandran K, Wagner LI, Walker EM, Bruner DW, Witt CM, Bruera E. Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology-ASCO Guideline. J Clin Oncol. 2022 12 01; 40(34):3998-4024. PMID: 36122322.
      Citations: 25     Fields:    Translation:Humans
    17. Cotton JL, Dang K, Hu L, Sun Y, Singh A, Rajurkar MS, Li Q, Wu X, Mao J. PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis. Cell Rep. 2022 07 19; 40(3):111125. PMID: 35858546.
      Citations:    Fields:    Translation:Humans
    18. Mia MM, Cibi DM, Ghani SABA, Singh A, Tee N, Sivakumar V, Bogireddi H, Cook SA, Mao J, Singh MK. Loss of Yap/Taz in cardiac fibroblasts attenuates adverse remodelling and improves cardiac function. Cardiovasc Res. 2022 06 22; 118(7):1785-1804. PMID: 34132780.
      Citations: 32     Fields:    Translation:AnimalsCells
    19. Zhang YQ, Jiao RM, Witt CM, Lao L, Liu JP, Thabane L, Sherman KJ, Cummings M, Richards DP, Kim EA, Kim TH, Lee MS, Wechsler ME, Brinkhaus B, Mao JJ, Smith CA, Gang WJ, Liu BY, Liu ZS, Liu Y, Zheng H, Wu JN, Carrasco-Labra A, Bhandari M, Devereaux PJ, Jing XH, Guyatt G. How to design high quality acupuncture trials-a consensus informed by evidence. BMJ. 2022 03 30; 376:e067476. PMID: 35354583.
      Citations: 11     Fields:    Translation:Humans
    20. Mao JJ, Pillai GG, Andrade CJ, Ligibel JA, Basu P, Cohen L, Khan IA, Mustian KM, Puthiyedath R, Dhiman KS, Lao L, Ghelman R, C?ceres Guido P, Lopez G, Gallego-Perez DF, Salicrup LA. Integrative oncology: Addressing the global challenges of cancer prevention and treatment. CA Cancer J Clin. 2022 03; 72(2):144-164. PMID: 34751943.
      Citations: 71     Fields:    Translation:Humans
    21. Nirala NK, Li Q, Ghule PN, Chen HJ, Li R, Zhu LJ, Wang R, Rice NP, Mao J, Stein JL, Stein GS, van Wijnen AJ, Ip YT. Hinfp is a guardian of the somatic genome by repressing transposable elements. Proc Natl Acad Sci U S A. 2021 10 12; 118(41). PMID: 34620709.
      Citations: 3     Fields:    Translation:AnimalsCells
    22. Zhu YJ, Wu XY, Wang W, Chang XS, Zhan DD, Diao DC, Xiao J, Li Y, Ma D, Hu M, Li JC, Wan J, Wu GN, Ke CF, Sun KY, Huang ZL, Cao TY, Zhai XH, Chen YD, Peng JJ, Mao JJ, Zhang HB. Acupuncture for Quality of Life in Gastric Cancer Patients Undergoing Adjuvant Chemotherapy. J Pain Symptom Manage. 2022 02; 63(2):210-220. PMID: 34563627.
      Citations: 11     Fields:    Translation:Humans
    23. Jung R, Janardhan HP, Dresser K, Cotton JL, Hutchinson L, Mao J, Trivedi CM. Response by Jung et al to Letter Regarding Article, "Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma". Arterioscler Thromb Vasc Biol. 2021 10; 41(10):e493-e495. PMID: 34550712.
      Citations:    Fields:    Translation:Humans
    24. Jung R, Janardhan HP, Dresser K, Cotton JL, Hutchinson L, Mao J, Trivedi CM. Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma. Arterioscler Thromb Vasc Biol. 2021 07; 41(7):2233-2235. PMID: 34078092.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    25. Carter P, Schnell U, Chaney C, Tong B, Pan X, Ye J, Mernaugh G, Cotton JL, Margulis V, Mao J, Zent R, Evers BM, Kapur P, Carroll TJ. Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma. J Clin Invest. 2021 06 01; 131(11). PMID: 34060480.
      Citations: 4     Fields:    Translation:HumansAnimals
    26. Genovese TJ, Gehrman P, Yang M, Li Y, Garland SN, Orlow I, Mao JJ. Genetic Predictors of Response to Acupuncture or Cognitive Behavioral Therapy for Insomnia in Cancer Survivors: An Exploratory Analysis. J Pain Symptom Manage. 2021 09; 62(3):e192-e199. PMID: 33716034.
      Citations:    
    27. Mia MM, Cibi DM, Abdul Ghani SAB, Song W, Tee N, Ghosh S, Mao J, Olson EN, Singh MK. YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction. PLoS Biol. 2020 12; 18(12):e3000941. PMID: 33264286.
      Citations: 46     Fields:    Translation:AnimalsCells
    28. Jia L, Lu W, Niemtzow RC, Crawford P, Greenlee H, Ma Q, Mao JJ, Lin Y, Olaku O. A Virtual Roundtable Discussion Highlighting the Latest Acupuncture Research and Practice. Med Acupunct. 2020 Dec 01; 32(6):336-344. PMID: 33381260.
      Citations:    
    29. Romero SAD, Li QS, Orlow I, Gonen M, Su HI, Mao JJ. Genetic predictors to acupuncture response for hot flashes: an exploratory study of breast cancer survivors. Menopause. 2020 08; 27(8):913-917. PMID: 32217888.
      Citations: 2     Fields:    Translation:Humans
    30. Cheung P, Xiol J, Dill MT, Yuan WC, Panero R, Roper J, Osorio FG, Maglic D, Li Q, Gurung B, Calogero RA, Yilmaz ?H, Mao J, Camargo FD. Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer. Cell Stem Cell. 2020 10 01; 27(4):590-604.e9. PMID: 32730753.
      Citations: 74     Fields:    Translation:Animals
    31. Charo LM, Homer MV, Natarajan L, Haunschild C, Chung K, Mao JJ, DeMichele AM, Su HI. Drug metabolising enzyme polymorphisms and chemotherapy-related ovarian failure in young breast cancer survivors. J Obstet Gynaecol. 2021 Apr; 41(3):447-452. PMID: 32496149.
      Citations:    
    32. Li Q, Sun Y, Jarugumilli GK, Liu S, Dang K, Cotton JL, Xiol J, Chan PY, DeRan M, Ma L, Li R, Zhu LJ, Li JH, Leiter AB, Ip YT, Camargo FD, Luo X, Johnson RL, Wu X, Mao J. Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription. Cell Stem Cell. 2020 05 07; 26(5):675-692.e8. PMID: 32259481.
      Citations: 55     Fields:    Translation:HumansCells
    33. Li H, Li Q, Dang K, Ma S, Cotton JL, Yang S, Zhu LJ, Deng AC, Ip YT, Johnson RL, Wu X, Punzo C, Mao J. YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression. Cell Rep. 2019 12 03; 29(10):3200-3211.e4. PMID: 31801083.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    34. Romero SAD, Su HI, Satagopan J, Li QS, Seluzicki CM, Dries A, DeMichele AM, Mao JJ. Clinical and genetic risk factors for aromatase inhibitor-associated arthralgia in breast cancer survivors. Breast. 2020 Feb; 49:48-54. PMID: 31678641.
      Citations: 7     Fields:    Translation:Humans
    35. Liu J, Mao JJ, Wang XS, Lin H. Evaluation of Traditional Chinese Medicine Herbs in Oncology Clinical Trials. Cancer J. 2019 Sep/Oct; 25(5):367-371. PMID: 31567465.
      Citations:    
    36. Irene Su H, Stark S, Kwan B, Boles S, Chingos D, Ehren J, Gorman JR, Krychman M, Romero SAD, Mao JJ, Pierce JP, Natarajan L. Efficacy of a web-based women's health survivorship care plan for young breast cancer survivors: a randomized controlled trial. Breast Cancer Res Treat. 2019 Aug; 176(3):579-589. PMID: 31054032.
      Citations:    
    37. Li Q, Nirala NK, Chen HJ, Nie Y, Wang W, Zhang B, Czech MP, Wang Q, Xu L, Mao J, Ip YT. The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium. J Cell Physiol. 2019 12; 234(12):21925-21936. PMID: 31042012.
      Citations: 2     Fields:    Translation:AnimalsCells
    38. Im EO, Ji X, Kim S, Chee E, Bao T, Mao JJ, Chee W. Challenges in a Technology-Based Cancer Pain Management Program Among Asian American Breast Cancer Survivors. Comput Inform Nurs. 2019 05; 37(5):243-249. PMID: 31094913.
      Citations: 4     Fields:    Translation:Humans
    39. Diamond EL, Reiner AS, Buthorn JJ, Shuk E, Applebaum AJ, Hyman DM, Abdel-Wahab O, Rampal R, Janku F, Brewer K, Campbell J, Mao JJ, Atkinson TM, Panageas KS. A scale for patient-reported symptom assessment for patients with Erdheim-Chester disease. Blood Adv. 2019 04 09; 3(7):934-938. PMID: 30917949.
      Citations:    
    40. Mao JJ, Davis RT, Coeytaux R, Hullender-Rubin L, Kong JT, MacPherson H, Napadow V, Schnyer R, Wayne PM, Witt C, Harris R. Acupuncture for Chronic Low Back Pain: Recommendations to Medicare/Medicaid from the Society for Acupuncture Research. J Altern Complement Med. 2019 04; 25(4):367-369. PMID: 30925124.
      Citations: 8     Fields:    Translation:Humans
    41. Stark SS, Natarajan L, Chingos D, Ehren J, Gorman JR, Krychman M, Kwan B, Mao JJ, Myers E, Walpole T, Pierce JP, Su HI. Design of a randomized controlled trial on the efficacy of a reproductive health survivorship care plan in young breast cancer survivors. Contemp Clin Trials. 2019 02; 77:27-36. PMID: 30553078.
      Citations:    
    42. Vincent-Mistiaen Z, Elbediwy A, Vanyai H, Cotton J, Stamp G, Nye E, Spencer-Dene B, Thomas GJ, Mao J, Thompson B. YAP drives cutaneous squamous cell carcinoma formation and progression. Elife. 2018 09 20; 7. PMID: 30231971.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    43. Mao H, Bao T, Shen X, Li Q, Seluzicki C, Im EO, Mao JJ. Prevalence and risk factors for fatigue among breast cancer survivors on aromatase inhibitors. Eur J Cancer. 2018 09; 101:47-54. PMID: 30014974.
      Citations: 18     Fields:    Translation:Humans
    44. Li Q, Nirala NK, Nie Y, Chen HJ, Ostroff G, Mao J, Wang Q, Xu L, Ip YT. Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth. Dev Cell. 2018 05 21; 45(4):433-449.e6. PMID: 29754801.
      Citations: 33     Fields:    Translation:AnimalsCells
    45. Zia FZ, Olaku O, Bao T, Berger A, Deng G, Fan AY, Garcia MK, Herman PM, Kaptchuk TJ, Ladas EJ, Langevin HM, Lao L, Lu W, Napadow V, Niemtzow RC, Vickers AJ, Shelley Wang X, Witt CM, Mao JJ. The National Cancer Institute's Conference on Acupuncture for Symptom Management in Oncology: State of the Science, Evidence, and Research Gaps. J Natl Cancer Inst Monogr. 2017 11 01; 2017(52). PMID: 29140486.
      Citations: 43     Fields:    Translation:Humans
    46. Xi D, Bao T, Chen Q, Chen S, Cheng YC, Cullen J, Frank DA, Friedberg JW, Kronish I, Lee JE, Levine M, Li P, Li S, Lu W, Mao JJ, O'Keefe S, Rubinstein L, Shah MA, Standish L, Paller CJ, Chu E. State of the Science: Cancer Complementary and Alternative Medicine Therapeutics Research-NCI Strategic Workshop Highlights of Discussion Report. J Natl Cancer Inst Monogr. 2017 11 01; 2017(52). PMID: 29140484.
      Citations: 2     Fields:    Translation:Humans
    47. Yun H, Sun L, Mao JJ. Growth of Integrative Medicine at Leading Cancer Centers Between 2009 and 2016: A Systematic Analysis of NCI-Designated Comprehensive Cancer Center Websites. J Natl Cancer Inst Monogr. 2017 11 01; 2017(52). PMID: 29140485.
      Citations: 54     Fields:    Translation:Humans
    48. Witt CM, Balneaves LG, Cardoso MJ, Cohen L, Greenlee H, Johnstone P, K?c?k ?, Mailman J, Mao JJ. A Comprehensive Definition for Integrative Oncology. J Natl Cancer Inst Monogr. 2017 11 01; 2017(52). PMID: 29140493.
      Citations: 78     Fields:    Translation:Humans
    49. Cotton JL, Li Q, Ma L, Park JS, Wang J, Ou J, Zhu LJ, Ip YT, Johnson RL, Mao J. YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme. Dev Cell. 2017 10 09; 43(1):35-47.e4. PMID: 28943241.
      Citations: 32     Fields:    Translation:AnimalsCells
    50. Deng G, Giralt S, Chung DJ, Landau H, Siman J, Search B, Coleton M, Vertosick E, Shapiro N, Chien C, Wang XS, Cassileth B, Mao JJ. Acupuncture for reduction of symptom burden in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation: a randomized sham-controlled trial. Support Care Cancer. 2018 02; 26(2):657-665. PMID: 28920142.
      Citations: 10     Fields:    Translation:Humans
    51. Lopez G, Mao JJ, Cohen L. Integrative Oncology. Med Clin North Am. 2017 Sep; 101(5):977-985. PMID: 28802474.
      Citations: 8     Fields:    Translation:Humans
    52. Homer MV, Charo LM, Natarajan L, Haunschild C, Chung K, Mao JJ, DeMichele AM, Su HI. Genetic variants of age at menopause are not related to timing of ovarian failure in breast cancer survivors. Menopause. 2017 06; 24(6):663-668. PMID: 28118297.
      Citations: 3     Fields:    Translation:Humans
    53. Rajurkar M, Dang K, Fernandez-Barrena MG, Liu X, Fernandez-Zapico ME, Lewis BC, Mao J. IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis. Cancer Res. 2017 01 15; 77(2):320-329. PMID: 28069799.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    54. Tang CM, Lee TE, Syed SA, Burgoyne AM, Leonard SY, Gao F, Chan JC, Shi E, Chmielecki J, Morosini D, Wang K, Ross JS, Kendrick ML, Bardsley MR, Siena M, Mao J, Harismendy O, Ordog T, Sicklick JK. Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. Oncotarget. 2016 Nov 29; 7(48):78226-78241. PMID: 27793025.
      Citations: 20     Fields:    Translation:HumansCells
    55. Sansone P, Ceccarelli C, Berishaj M, Chang Q, Rajasekhar VK, Perna F, Bowman RL, Vidone M, Daly L, Nnoli J, Santini D, Taffurelli M, Shih NN, Feldman M, Mao JJ, Colameco C, Chen J, DeMichele A, Fabbri N, Healey JH, Cricca M, Gasparre G, Lyden D, Bonaf? M, Bromberg J. Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer. Nat Commun. 2016 Feb 09; 7:10442. PMID: 26858125.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    56. Liu X, Li H, Rajurkar M, Li Q, Cotton JL, Ou J, Zhu LJ, Goel HL, Mercurio AM, Park JS, Davis RJ, Mao J. Tead and AP1 Coordinate Transcription and Motility. Cell Rep. 2016 Feb 09; 14(5):1169-1180. PMID: 26832411.
      Citations: 118     Fields:    Translation:HumansCells
    57. Hettmer S, Lin MM, Tchessalova D, Tortorici SJ, Castiglioni A, Desai T, Mao J, McMahon AP, Wagers AJ. Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity. Exp Cell Res. 2016 Jan 01; 340(1):43-52. PMID: 26460176.
      Citations: 2     Fields:    Translation:Animals
    58. Chang C, Goel HL, Gao H, Pursell B, Shultz LD, Greiner DL, Ingerpuu S, Patarroyo M, Cao S, Lim E, Mao J, McKee KK, Yurchenco PD, Mercurio AM. A laminin 511 matrix is regulated by TAZ and functions as the ligand for the a6B?1 integrin to sustain breast cancer stem cells. Genes Dev. 2015 Jan 01; 29(1):1-6. PMID: 25561492.
      Citations: 67     Fields:    Translation:HumansCells
    59. Junker JP, Peterson KA, Nishi Y, Mao J, McMahon AP, van Oudenaarden A. A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning. Dev Cell. 2014 Nov 24; 31(4):448-60. PMID: 25458012.
      Citations: 12     Fields:    Translation:AnimalsCells
    60. Li Q, Li S, Mana-Capelli S, Roth Flach RJ, Danai LV, Amcheslavsky A, Nie Y, Kaneko S, Yao X, Chen X, Cotton JL, Mao J, McCollum D, Jiang J, Czech MP, Xu L, Ip YT. The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila. Dev Cell. 2014 Nov 10; 31(3):291-304. PMID: 25453828.
      Citations: 89     Fields:    Translation:AnimalsCells
    61. Mao JJ, Cohen L. Advancing the science of integrative oncology to inform patient-centered care for cancer survivors. J Natl Cancer Inst Monogr. 2014 Nov; 2014(50):283-4. PMID: 25749588.
      Citations: 6     Fields:    Translation:Humans
    62. Rajurkar M, Huang H, Cotton JL, Brooks JK, Sicklick J, McMahon AP, Mao J. Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis. Oncogene. 2014 Nov 13; 33(46):5370-8. PMID: 24276242.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    63. Hettmer S, Teot LA, van Hummelen P, MacConaill L, Bronson RT, Dall'Osso C, Mao J, McMahon AP, Gruber PJ, Grier HE, Rodriguez-Galindo C, Fletcher CD, Wagers AJ. Mutations in Hedgehog pathway genes in fetal rhabdomyomas. J Pathol. 2013 Sep; 231(1):44-52. PMID: 23780909.
      Citations: 14     Fields:    Translation:HumansAnimals
    64. Wang J, Park JS, Wei Y, Rajurkar M, Cotton JL, Fan Q, Lewis BC, Ji H, Mao J. TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPa function. Mol Cell. 2013 Jul 25; 51(2):211-25. PMID: 23769673.
      Citations: 82     Fields:    Translation:Humans
    65. Huang H, Cotton JL, Wang Y, Rajurkar M, Zhu LJ, Lewis BC, Mao J. Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development. J Biol Chem. 2013 Jun 14; 288(24):17589-96. PMID: 23645682.
      Citations: 19     Fields:    Translation:AnimalsCells
    66. Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM. GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med. 2013 Apr; 5(4):488-508. PMID: 23436775.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    67. Kamberov YG, Wang S, Tan J, Gerbault P, Wark A, Tan L, Yang Y, Li S, Tang K, Chen H, Powell A, Itan Y, Fuller D, Lohmueller J, Mao J, Schachar A, Paymer M, Hostetter E, Byrne E, Burnett M, McMahon AP, Thomas MG, Lieberman DE, Jin L, Tabin CJ, Morgan BA, Sabeti PC. Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell. 2013 Feb 14; 152(4):691-702. PMID: 23415220.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    68. Rajurkar M, De Jesus-Monge WE, Driscoll DR, Appleman VA, Huang H, Cotton JL, Klimstra DS, Zhu LJ, Simin K, Xu L, McMahon AP, Lewis BC, Mao J. The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):E1038-47. PMID: 22493246.
      Citations: 62     Fields:    Translation:Animals
    69. Kim TH, Kim BM, Mao J, Rowan S, Shivdasani RA. Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme. Development. 2011 Aug; 138(15):3225-33. PMID: 21750033.
      Citations: 11     Fields:    Translation:AnimalsCells
    70. Kaneko S, Chen X, Lu P, Yao X, Wright TG, Rajurkar M, Kariya K, Mao J, Ip YT, Xu L. Smad inhibition by the Ste20 kinase Misshapen. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):11127-32. PMID: 21690388.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    71. Mao J, Kim BM, Rajurkar M, Shivdasani RA, McMahon AP. Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development. 2010 May; 137(10):1721-9. PMID: 20430747.
      Citations: 86     Fields:    Translation:AnimalsCells
    72. Su HI, Sammel MD, Springer E, Freeman EW, DeMichele A, Mao JJ. Weight gain is associated with increased risk of hot flashes in breast cancer survivors on aromatase inhibitors. Breast Cancer Res Treat. 2010 Nov; 124(1):205-11. PMID: 20182796.
      Citations:    
    73. Hofmann I, Stover EH, Cullen DE, Mao J, Morgan KJ, Lee BH, Kharas MG, Miller PG, Cornejo MG, Okabe R, Armstrong SA, Ghilardi N, Gould S, de Sauvage FJ, McMahon AP, Gilliland DG. Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell. 2009 Jun 05; 4(6):559-67. PMID: 19497284.
      Citations: 87     Fields:    Translation:AnimalsCells
    74. Mao J, McGlinn E, Huang P, Tabin CJ, McMahon AP. Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell. 2009 Apr; 16(4):600-6. PMID: 19386268.
      Citations: 74     Fields:    Translation:AnimalsCells
    75. Sch?ller U, Heine VM, Mao J, Kho AT, Dillon AK, Han YG, Huillard E, Sun T, Ligon AH, Qian Y, Ma Q, Alvarez-Buylla A, McMahon AP, Rowitch DH, Ligon KL. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell. 2008 Aug 12; 14(2):123-34. PMID: 18691547.
      Citations: 348     Fields:    Translation:HumansAnimalsCells
    76. Kim BM, Miletich I, Mao J, McMahon AP, Sharpe PA, Shivdasani RA. Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development. 2007 Oct; 134(20):3603-13. PMID: 17855428.
      Citations: 34     Fields:    Translation:AnimalsCells
    77. Kim BM, Mao J, Taketo MM, Shivdasani RA. Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology. 2007 Aug; 133(2):529-38. PMID: 17681174.
      Citations: 54     Fields:    Translation:AnimalsCells
    78. Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, McMahon AP. A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res. 2006 Oct 15; 66(20):10171-8. PMID: 17047082.
      Citations: 174     Fields:    Translation:Animals
    79. Mao J, Barrow J, McMahon J, Vaughan J, McMahon AP. An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo. Nucleic Acids Res. 2005 Oct 12; 33(18):e155. PMID: 16221970.
      Citations: 22     Fields:    Translation:AnimalsCells
    80. Zhang Y, Wang Y, Li X, Zhang J, Mao J, Li Z, Zheng J, Li L, Harris S, Wu D. The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol Cell Biol. 2004 Jun; 24(11):4677-84. PMID: 15143163.
      Citations: 67     Fields:    Translation:AnimalsCells
    81. Jeong J, Mao J, Tenzen T, Kottmann AH, McMahon AP. Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 2004 Apr 15; 18(8):937-51. PMID: 15107405.
      Citations: 316     Fields:    Translation:HumansAnimalsCells
    82. Weaver C, Farr GH, Pan W, Rowning BA, Wang J, Mao J, Wu D, Li L, Larabell CA, Kimelman D. GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs. Development. 2003 Nov; 130(22):5425-36. PMID: 14507779.
      Citations: 22     Fields:    Translation:AnimalsCells
    83. Mao J, Maye P, Kogerman P, Tejedor FJ, Toftgard R, Xie W, Wu G, Wu D. Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J Biol Chem. 2002 Sep 20; 277(38):35156-61. PMID: 12138125.
      Citations: 86     Fields:    Translation:AnimalsCells
    84. Boyden LM, Mao J, Belsky J, Mitzner L, Farhi A, Mitnick MA, Wu D, Insogna K, Lifton RP. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med. 2002 May 16; 346(20):1513-21. PMID: 12015390.
      Citations: 566     Fields:    Translation:HumansCells
    85. Mao J, Wu D. Functional interaction of G alpha 13 with p115RhoGEF determined with transcriptional reporter system. Methods Enzymol. 2002; 345:404-10. PMID: 11665624.
      Citations:    Fields:    Translation:AnimalsCells
    86. Li L, Mao J, Sun L, Liu W, Wu D. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem. 2002 Feb 22; 277(8):5977-81. PMID: 11742004.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    87. Mao J, Wang J, Liu B, Pan W, Farr GH, Flynn C, Yuan H, Takada S, Kimelman D, Li L, Wu D. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell. 2001 Apr; 7(4):801-9. PMID: 11336703.
      Citations: 318     Fields:    Translation:AnimalsCells
    88. Wong HC, Mao J, Nguyen JT, Srinivas S, Zhang W, Liu B, Li L, Wu D, Zheng J. Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat Struct Biol. 2000 Dec; 7(12):1178-84. PMID: 11101902.
      Citations: 77     Fields:    Translation:AnimalsCells
    89. Yuan H, Mao J, Li L, Wu D. Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation. J Biol Chem. 1999 Oct 22; 274(43):30419-23. PMID: 10521419.
      Citations: 35     Fields:    Translation:AnimalsCells
    90. Li L, Yuan H, Weaver CD, Mao J, Farr GH, Sussman DJ, Jonkers J, Kimelman D, Wu D. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J. 1999 Aug 02; 18(15):4233-40. PMID: 10428961.
      Citations: 114     Fields:    Translation:AnimalsCells
    91. Li L, Yuan H, Xie W, Mao J, Caruso AM, McMahon A, Sussman DJ, Wu D. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. J Biol Chem. 1999 Jan 01; 274(1):129-34. PMID: 9867820.
      Citations: 101     Fields:    Translation:AnimalsCells
    92. Mao J, Yuan H, Xie W, Wu D. Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):12973-6. PMID: 9789025.
      Citations: 31     Fields:    Translation:AnimalsCells
    93. Mao J, Yuan H, Xie W, Simon MI, Wu D. Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors. J Biol Chem. 1998 Oct 16; 273(42):27118-23. PMID: 9765229.
      Citations: 35     Fields:    Translation:AnimalsCells
    94. Mao J, Xie W, Yuan H, Simon MI, Mano H, Wu D. Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13. EMBO J. 1998 Oct 01; 17(19):5638-46. PMID: 9755164.
      Citations: 26     Fields:    Translation:AnimalsCells
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