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Junhao Mao PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
Phone508-856-4149
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program


    Collapse Biography 
    Collapse education and training
    Zhejiang University, Hangzhou, , ChinaB ABiochemistry
    University of Rochester, Rochester, NY, United StatesPHDPharmacology
    Harvard Univeristy, Cambridge, MA, United StatesPostdoc FellowshipDevelopmental Biology

    Collapse Overview 
    Collapse overview

    BIOGRAPHY

    JunhaoMao

    Junhao Mao received his Ph.D. degree from the University of Rochester in 2003. He did his postdoctoral research at Harvard University from 2003 to 2008, where he was supported by the fellowships from Damon Runyon Cancer Research Foundation and Charles A. King Trust. He joined the University of Massachusetts Medical School in fall 2008. Dr. Mao was also a recipient of the Charles H. Hood Foundation Child Health Research Award in 2009, American Cancer Society Research Scholar Award in 2011, Pancreatic Cancer Alliance Research Award in 2015, and Sanofi iAward in 2020. 

    RESEARCH

    My lab is interested in investigating the signaling mechanisms that underlie tissue homeostasis and tumorigenesis.  Our work is focused on several key developmental pathways including Hippo, Wnt and Hedgehog signaling.  We use a combination of molecular, cellular and mouse genetic approaches to dissect their roles in stem cell/progenitor function, and understand how dysregulation of these pathways contributes to tumor initiation and progression.

     

     

     

     


    Collapse Post Docs

    Postdoctoral positions are available for this lab. Please contact Junhao Mao directly, 508-856-4149 or via email, Junhao.Mao@umassmed.edu



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mia MM, Cibi DM, Abdul Ghani SAB, Song W, Tee N, Ghosh S, Mao J, Olson EN, Singh MK. YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction. PLoS Biol. 2020 12; 18(12):e3000941. PMID: 33264286.
      Citations: 46     Fields:    Translation:AnimalsCells
    2. Cheung P, Xiol J, Dill MT, Yuan WC, Panero R, Roper J, Osorio FG, Maglic D, Li Q, Gurung B, Calogero RA, Yilmaz ?H, Mao J, Camargo FD. Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer. Cell Stem Cell. 2020 10 01; 27(4):590-604.e9. PMID: 32730753.
      Citations: 74     Fields:    Translation:Animals
    3. Li Q, Nirala NK, Chen HJ, Nie Y, Wang W, Zhang B, Czech MP, Wang Q, Xu L, Mao J, Ip YT. The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium. J Cell Physiol. 2019 12; 234(12):21925-21936. PMID: 31042012.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Rajurkar M, Huang H, Cotton JL, Brooks JK, Sicklick J, McMahon AP, Mao J. Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis. Oncogene. 2014 Nov 13; 33(46):5370-8. PMID: 24276242.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    5. Zhang Y, Wang Y, Li X, Zhang J, Mao J, Li Z, Zheng J, Li L, Harris S, Wu D. The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol Cell Biol. 2004 Jun; 24(11):4677-84. PMID: 15143163.
      Citations: 67     Fields:    Translation:AnimalsCells
    6. Weaver C, Farr GH, Pan W, Rowning BA, Wang J, Mao J, Wu D, Li L, Larabell CA, Kimelman D. GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs. Development. 2003 Nov; 130(22):5425-36. PMID: 14507779.
      Citations: 22     Fields:    Translation:AnimalsCells
    7. Mao J, Maye P, Kogerman P, Tejedor FJ, Toftgard R, Xie W, Wu G, Wu D. Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J Biol Chem. 2002 Sep 20; 277(38):35156-61. PMID: 12138125.
      Citations: 86     Fields:    Translation:AnimalsCells
    8. Boyden LM, Mao J, Belsky J, Mitzner L, Farhi A, Mitnick MA, Wu D, Insogna K, Lifton RP. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med. 2002 May 16; 346(20):1513-21. PMID: 12015390.
      Citations: 566     Fields:    Translation:HumansCells
    9. Mao J, Wu D. Functional interaction of G alpha 13 with p115RhoGEF determined with transcriptional reporter system. Methods Enzymol. 2002; 345:404-10. PMID: 11665624.
      Citations:    Fields:    Translation:AnimalsCells
    10. Li L, Mao J, Sun L, Liu W, Wu D. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem. 2002 Feb 22; 277(8):5977-81. PMID: 11742004.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    11. Mao J, Wang J, Liu B, Pan W, Farr GH, Flynn C, Yuan H, Takada S, Kimelman D, Li L, Wu D. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell. 2001 Apr; 7(4):801-9. PMID: 11336703.
      Citations: 318     Fields:    Translation:AnimalsCells
    12. Wong HC, Mao J, Nguyen JT, Srinivas S, Zhang W, Liu B, Li L, Wu D, Zheng J. Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat Struct Biol. 2000 Dec; 7(12):1178-84. PMID: 11101902.
      Citations: 77     Fields:    Translation:AnimalsCells
    13. Yuan H, Mao J, Li L, Wu D. Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation. J Biol Chem. 1999 Oct 22; 274(43):30419-23. PMID: 10521419.
      Citations: 35     Fields:    Translation:AnimalsCells
    14. Li L, Yuan H, Weaver CD, Mao J, Farr GH, Sussman DJ, Jonkers J, Kimelman D, Wu D. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J. 1999 Aug 02; 18(15):4233-40. PMID: 10428961.
      Citations: 114     Fields:    Translation:AnimalsCells
    15. Li L, Yuan H, Xie W, Mao J, Caruso AM, McMahon A, Sussman DJ, Wu D. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. J Biol Chem. 1999 Jan 01; 274(1):129-34. PMID: 9867820.
      Citations: 101     Fields:    Translation:AnimalsCells
    16. Mao J, Yuan H, Xie W, Wu D. Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):12973-6. PMID: 9789025.
      Citations: 31     Fields:    Translation:AnimalsCells
    17. Mao J, Yuan H, Xie W, Simon MI, Wu D. Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors. J Biol Chem. 1998 Oct 16; 273(42):27118-23. PMID: 9765229.
      Citations: 35     Fields:    Translation:AnimalsCells
    18. Mao J, Xie W, Yuan H, Simon MI, Mano H, Wu D. Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13. EMBO J. 1998 Oct 01; 17(19):5638-46. PMID: 9755164.
      Citations: 26     Fields:    Translation:AnimalsCells
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