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Junhao Mao PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-4149
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program


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    Collapse Biography 
    Collapse education and training
    Zhejiang University, Hangzhou, , ChinaB ABiochemistry
    University of Rochester, Rochester, NY, United StatesPHDPharmacology
    Harvard Univeristy, Cambridge, MA, United StatesPostdoc FellowshipDevelopmental Biology

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    BIOGRAPHY

    JunhaoMao

    Junhao Mao received his Ph.D. degree from the University of Rochester in 2003. He did his postdoctoral research at Harvard University from 2003 to 2008, where he was supported by the fellowships from Damon Runyon Cancer Research Foundation and Charles A. King Trust. He joined the University of Massachusetts Medical School in fall 2008. Dr. Mao was also a recipient of the Charles H. Hood Foundation Child Health Research Award in 2009, American Cancer Society Research Scholar Award in 2011, Pancreatic Cancer Alliance Research Award in 2015, and Sanofi iAward in 2020. 

    RESEARCH

    My lab is interested in investigating the signaling mechanisms that underlie tissue homeostasis and tumorigenesis.  Our work is focused on several key developmental pathways including Hippo, Wnt and Hedgehog signaling.  We use a combination of molecular, cellular and mouse genetic approaches to dissect their roles in stem cell/progenitor function, and understand how dysregulation of these pathways contributes to tumor initiation and progression.

     

     

     

     



    Collapse Post Docs

    Postdoctoral positions are available for this lab. Please contact Junhao Mao directly, 508-856-4149 or via email, Junhao.Mao@umassmed.edu




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Nirala NK, Li Q, Ghule PN, Chen HJ, Li R, Zhu LJ, Wang R, Rice NP, Mao J, Stein JL, Stein GS, van Wijnen AJ, Ip YT. Hinfp is a guardian of the somatic genome by repressing transposable elements. Proc Natl Acad Sci U S A. 2021 Oct 12; 118(41). PMID: 34620709.
      View in: PubMed
    2. Zhu YJ, Wu XY, Wang W, Chang XS, Zhan DD, Diao DC, Xiao J, Li Y, Ma D, Hu M, Li JC, Wan J, Wu GN, Ke CF, Sun KY, Huang ZL, Cao TY, Zhai XH, Chen YD, Peng JJ, Mao JJ, Zhang HB. Acupuncture for Quality of Life in Gastric Cancer Patients Undergoing Adjuvant Chemotherapy. J Pain Symptom Manage. 2021 Sep 23. PMID: 34563627.
      View in: PubMed
    3. Jung R, Janardhan HP, Dresser K, Cotton JL, Hutchinson L, Mao J, Trivedi CM. Response by Jung et al to Letter Regarding Article, "Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma". Arterioscler Thromb Vasc Biol. 2021 Oct; 41(10):e493-e495. PMID: 34550712.
      View in: PubMed
    4. Mia MM, Cibi DM, Binte Abdul Ghani SA, Singh A, Tee N, Sivakumar V, Bogireddi H, Cook SA, Mao J, Singh MK. Loss of Yap/taz in cardiac fibroblasts attenuates adverse remodeling and improves cardiac function. Cardiovasc Res. 2021 Jun 16. PMID: 34132780.
      View in: PubMed
    5. Jung R, Janardhan HP, Dresser K, Cotton JL, Hutchinson L, Mao J, Trivedi CM. Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma. Arterioscler Thromb Vasc Biol. 2021 Jun 03; ATVBAHA121316300. PMID: 34078092.
      View in: PubMed
    6. Carter P, Schnell U, Chaney C, Tong B, Pan X, Ye J, Mernaugh G, Cotton JL, Margulis V, Mao J, Zent R, Evers BM, Kapur P, Carroll TJ. Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma. J Clin Invest. 2021 Jun 01; 131(11). PMID: 34060480.
      View in: PubMed
    7. Mia MM, Cibi DM, Abdul Ghani SAB, Song W, Tee N, Ghosh S, Mao J, Olson EN, Singh MK. YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction. PLoS Biol. 2020 Dec; 18(12):e3000941. PMID: 33264286.
      View in: PubMed
    8. Cheung P, Xiol J, Dill MT, Yuan WC, Panero R, Roper J, Osorio FG, Maglic D, Li Q, Gurung B, Calogero RA, Yilmaz ÖH, Mao J, Camargo FD. Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer. Cell Stem Cell. 2020 Oct 01; 27(4):590-604.e9. PMID: 32730753.
      View in: PubMed
    9. Li Q, Sun Y, Jarugumilli GK, Liu S, Dang K, Cotton JL, Xiol J, Chan PY, DeRan M, Ma L, Li R, Zhu LJ, Li JH, Leiter AB, Ip YT, Camargo FD, Luo X, Johnson RL, Wu X, Mao J. Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription. Cell Stem Cell. 2020 Apr 02. PMID: 32259481.
      View in: PubMed
    10. Li H, Li Q, Dang K, Ma S, Cotton JL, Yang S, Zhu LJ, Deng AC, Ip YT, Johnson RL, Wu X, Punzo C, Mao J. YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression. Cell Rep. 2019 Dec 03; 29(10):3200-3211.e4. PMID: 31801083.
      View in: PubMed
    11. Li Q, Nirala NK, Chen HJ, Nie Y, Wang W, Zhang B, Czech MP, Wang Q, Xu L, Mao J, Ip YT. The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium. J Cell Physiol. 2019 May 01. PMID: 31042012.
      View in: PubMed
    12. Vincent-Mistiaen Z, Elbediwy A, Vanyai H, Cotton J, Stamp G, Nye E, Spencer-Dene B, Thomas GJ, Mao J, Thompson B. YAP drives cutaneous squamous cell carcinoma formation and progression. Elife. 2018 09 20; 7. PMID: 30231971.
      View in: PubMed
    13. Li Q, Nirala NK, Nie Y, Chen HJ, Ostroff G, Mao J, Wang Q, Xu L, Ip YT. Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth. Dev Cell. 2018 05 21; 45(4):433-449.e6. PMID: 29754801.
      View in: PubMed
    14. Zia FZ, Olaku O, Bao T, Berger A, Deng G, Fan AY, Garcia MK, Herman PM, Kaptchuk TJ, Ladas EJ, Langevin HM, Lao L, Lu W, Napadow V, Niemtzow RC, Vickers AJ, Shelley Wang X, Witt CM, Mao JJ. The National Cancer Institute's Conference on Acupuncture for Symptom Management in Oncology: State of the Science, Evidence, and Research Gaps. J Natl Cancer Inst Monogr. 2017 11 01; 2017(52). PMID: 29140486.
      View in: PubMed
    15. Cotton JL, Li Q, Ma L, Park JS, Wang J, Ou J, Zhu LJ, Ip YT, Johnson RL, Mao J. YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme. Dev Cell. 2017 Oct 09; 43(1):35-47.e4. PMID: 28943241.
      View in: PubMed
    16. Rajurkar M, Dang K, Fernandez-Barrena MG, Liu X, Fernandez-Zapico ME, Lewis BC, Mao J. IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis. Cancer Res. 2017 Jan 15; 77(2):320-329. PMID: 28069799.
      View in: PubMed
    17. Tang CM, Lee TE, Syed SA, Burgoyne AM, Leonard SY, Gao F, Chan JC, Shi E, Chmielecki J, Morosini D, Wang K, Ross JS, Kendrick ML, Bardsley MR, Siena M, Mao J, Harismendy O, Ordog T, Sicklick JK. Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. Oncotarget. 2016 Nov 29; 7(48):78226-78241. PMID: 27793025.
      View in: PubMed
    18. Liu X, Li H, Rajurkar M, Li Q, Cotton JL, Ou J, Zhu LJ, Goel HL, Mercurio AM, Park JS, Davis RJ, Mao J. Tead and AP1 Coordinate Transcription and Motility. Cell Rep. 2016 Feb 09; 14(5):1169-80. PMID: 26832411.
      View in: PubMed
    19. Hettmer S, Lin MM, Tchessalova D, Tortorici SJ, Castiglioni A, Desai T, Mao J, McMahon AP, Wagers AJ. Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity. Exp Cell Res. 2016 Jan 01; 340(1):43-52. PMID: 26460176.
      View in: PubMed
    20. Chang C, Goel HL, Gao H, Pursell B, Shultz LD, Greiner DL, Ingerpuu S, Patarroyo M, Cao S, Lim E, Mao J, McKee KK, Yurchenco PD, Mercurio AM. A laminin 511 matrix is regulated by TAZ and functions as the ligand for the a6Bß1 integrin to sustain breast cancer stem cells. Genes Dev. 2015 Jan 01; 29(1):1-6. PMID: 25561492.
      View in: PubMed
    21. Junker JP, Peterson KA, Nishi Y, Mao J, McMahon AP, van Oudenaarden A. A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning. Dev Cell. 2014 Nov 24; 31(4):448-60. PMID: 25458012.
      View in: PubMed
    22. Li Q, Li S, Mana-Capelli S, Roth Flach RJ, Danai LV, Amcheslavsky A, Nie Y, Kaneko S, Yao X, Chen X, Cotton JL, Mao J, McCollum D, Jiang J, Czech MP, Xu L, Ip YT. The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila. Dev Cell. 2014 Nov 10; 31(3):291-304. PMID: 25453828.
      View in: PubMed
    23. Rajurkar M, Huang H, Cotton JL, Brooks JK, Sicklick J, McMahon AP, Mao J. Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis. Oncogene. 2014 Nov 13; 33(46):5370-8. PMID: 24276242.
      View in: PubMed
    24. Hettmer S, Teot LA, van Hummelen P, MacConaill L, Bronson RT, Dall'Osso C, Mao J, McMahon AP, Gruber PJ, Grier HE, Rodriguez-Galindo C, Fletcher CD, Wagers AJ. Mutations in Hedgehog pathway genes in fetal rhabdomyomas. J Pathol. 2013 Sep; 231(1):44-52. PMID: 23780909.
      View in: PubMed
    25. Wang J, Park JS, Wei Y, Rajurkar M, Cotton JL, Fan Q, Lewis BC, Ji H, Mao J. TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPa function. Mol Cell. 2013 Jul 25; 51(2):211-25. PMID: 23769673.
      View in: PubMed
    26. Huang H, Cotton JL, Wang Y, Rajurkar M, Zhu LJ, Lewis BC, Mao J. Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development. J Biol Chem. 2013 Jun 14; 288(24):17589-96. PMID: 23645682.
      View in: PubMed
    27. Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM. GLI1 regulates a novel neuropilin-2/a6ß1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med. 2013 Apr; 5(4):488-508. PMID: 23436775.
      View in: PubMed
    28. Kamberov YG, Wang S, Tan J, Gerbault P, Wark A, Tan L, Yang Y, Li S, Tang K, Chen H, Powell A, Itan Y, Fuller D, Lohmueller J, Mao J, Schachar A, Paymer M, Hostetter E, Byrne E, Burnett M, McMahon AP, Thomas MG, Lieberman DE, Jin L, Tabin CJ, Morgan BA, Sabeti PC. Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell. 2013 Feb 14; 152(4):691-702. PMID: 23415220.
      View in: PubMed
    29. Rajurkar M, De Jesus-Monge WE, Driscoll DR, Appleman VA, Huang H, Cotton JL, Klimstra DS, Zhu LJ, Simin K, Xu L, McMahon AP, Lewis BC, Mao J. The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):E1038-47. PMID: 22493246.
      View in: PubMed
    30. Kim TH, Kim BM, Mao J, Rowan S, Shivdasani RA. Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme. Development. 2011 Aug; 138(15):3225-33. PMID: 21750033.
      View in: PubMed
    31. Kaneko S, Chen X, Lu P, Yao X, Wright TG, Rajurkar M, Kariya K, Mao J, Ip YT, Xu L. Smad inhibition by the Ste20 kinase Misshapen. Proc Natl Acad Sci U S A. 2011 Jul 5; 108(27):11127-32. PMID: 21690388.
      View in: PubMed
    32. Mao J, Kim BM, Rajurkar M, Shivdasani RA, McMahon AP. Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development. 2010 May; 137(10):1721-9. PMID: 20430747.
      View in: PubMed
    33. Hofmann I, Stover EH, Cullen DE, Mao J, Morgan KJ, Lee BH, Kharas MG, Miller PG, Cornejo MG, Okabe R, Armstrong SA, Ghilardi N, Gould S, de Sauvage FJ, McMahon AP, Gilliland DG. Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell. 2009 Jun 5; 4(6):559-67. PMID: 19497284.
      View in: PubMed
    34. Mao J, McGlinn E, Huang P, Tabin CJ, McMahon AP. Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell. 2009 Apr; 16(4):600-6. PMID: 19386268.
      View in: PubMed
    35. Schüller U, Heine VM, Mao J, Kho AT, Dillon AK, Han YG, Huillard E, Sun T, Ligon AH, Qian Y, Ma Q, Alvarez-Buylla A, McMahon AP, Rowitch DH, Ligon KL. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell. 2008 Aug 12; 14(2):123-34. PMID: 18691547.
      View in: PubMed
    36. Kim BM, Miletich I, Mao J, McMahon AP, Sharpe PA, Shivdasani RA. Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development. 2007 Oct; 134(20):3603-13. PMID: 17855428.
      View in: PubMed
    37. Kim BM, Mao J, Taketo MM, Shivdasani RA. Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology. 2007 Aug; 133(2):529-38. PMID: 17681174.
      View in: PubMed
    38. Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, McMahon AP. A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res. 2006 Oct 15; 66(20):10171-8. PMID: 17047082.
      View in: PubMed
    39. Mao J, Barrow J, McMahon J, Vaughan J, McMahon AP. An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo. Nucleic Acids Res. 2005 Oct 12; 33(18):e155. PMID: 16221970.
      View in: PubMed
    40. Zhang Y, Wang Y, Li X, Zhang J, Mao J, Li Z, Zheng J, Li L, Harris S, Wu D. The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol Cell Biol. 2004 Jun; 24(11):4677-84. PMID: 15143163.
      View in: PubMed
    41. Jeong J, Mao J, Tenzen T, Kottmann AH, McMahon AP. Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 2004 Apr 15; 18(8):937-51. PMID: 15107405.
      View in: PubMed
    42. Weaver C, Farr GH, Pan W, Rowning BA, Wang J, Mao J, Wu D, Li L, Larabell CA, Kimelman D. GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs. Development. 2003 Nov; 130(22):5425-36. PMID: 14507779.
      View in: PubMed
    43. Mao J, Maye P, Kogerman P, Tejedor FJ, Toftgard R, Xie W, Wu G, Wu D. Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J Biol Chem. 2002 Sep 20; 277(38):35156-61. PMID: 12138125.
      View in: PubMed
    44. Boyden LM, Mao J, Belsky J, Mitzner L, Farhi A, Mitnick MA, Wu D, Insogna K, Lifton RP. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med. 2002 May 16; 346(20):1513-21. PMID: 12015390.
      View in: PubMed
    45. Mao J, Wu D. Functional interaction of G alpha 13 with p115RhoGEF determined with transcriptional reporter system. Methods Enzymol. 2002; 345:404-10. PMID: 11665624.
      View in: PubMed
    46. Li L, Mao J, Sun L, Liu W, Wu D. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem. 2002 Feb 22; 277(8):5977-81. PMID: 11742004.
      View in: PubMed
    47. Mao J, Wang J, Liu B, Pan W, Farr GH, Flynn C, Yuan H, Takada S, Kimelman D, Li L, Wu D. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell. 2001 Apr; 7(4):801-9. PMID: 11336703.
      View in: PubMed
    48. Wong HC, Mao J, Nguyen JT, Srinivas S, Zhang W, Liu B, Li L, Wu D, Zheng J. Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat Struct Biol. 2000 Dec; 7(12):1178-84. PMID: 11101902.
      View in: PubMed
    49. Yuan H, Mao J, Li L, Wu D. Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation. J Biol Chem. 1999 Oct 22; 274(43):30419-23. PMID: 10521419.
      View in: PubMed
    50. Li L, Yuan H, Weaver CD, Mao J, Farr GH, Sussman DJ, Jonkers J, Kimelman D, Wu D. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J. 1999 Aug 2; 18(15):4233-40. PMID: 10428961.
      View in: PubMed
    51. Li L, Yuan H, Xie W, Mao J, Caruso AM, McMahon A, Sussman DJ, Wu D. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. J Biol Chem. 1999 Jan 1; 274(1):129-34. PMID: 9867820.
      View in: PubMed
    52. Mao J, Yuan H, Xie W, Wu D. Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):12973-6. PMID: 9789025.
      View in: PubMed
    53. Mao J, Yuan H, Xie W, Simon MI, Wu D. Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors. J Biol Chem. 1998 Oct 16; 273(42):27118-23. PMID: 9765229.
      View in: PubMed
    54. Mao J, Xie W, Yuan H, Simon MI, Mano H, Wu D. Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13. EMBO J. 1998 Oct 1; 17(19):5638-46. PMID: 9755164.
      View in: PubMed
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