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Sally C Kent PhD

TitleAssociate Professor
Endowed TitleGeorge F. and Sybil H. Fuller Foundation Term Chair in Diabetes
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
368 Plantation Street, AS7-2012
Worcester MA 01605
Phone508-856-2044
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionDiabetes


    Collapse Biography 
    Collapse education and training
    Union College, Schenectady, NY, United StatesBSBiology
    Loyola University Stritch School of Medicine, Maywood, IL, United StatesPHDMicrobiology and Immunology

    Collapse Overview 
    Collapse overview

    RESEARCHINTERESTS

     

    Autoreactive T cell specificity and function in human Type 1 diabetes

    Development of autoreactive T cell memory in humanType 1 diabetes

    Anergy induction in human Type 1 diabetes

    Enterovirus in human Type 1 diabetes

     

     

     

     

    EDUCATIONand TRAINING

     

    Ph.D.

    Loyola University of Chicago, Stritch School of Medicine

     

    Postdoctoral Fellowships:

    University of Rochester School of Medicine andDentistry

    Brigham and Women’s Hospital and Harvard MedicalSchool

     

    ACADEMICAPPOINTMENTS

     

    Instructor in Neurology

    Harvard Medical School

     

    Associate Immunologist

    Brigham and Women’s Hospital

     

    Assistant Professor in Neurology

    Harvard Medical School

     

    Assistant Professor in Medicine           

    University of Massachusetts Medical School, Diabetes Center of Excellence

     

    Associate Professor in Medicine           

    University of Massachusetts Medical School, Diabetes Center of Excellence




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Rodriguez-Calvo T, Christoffersson G, Bender C, von Herrath MG, Mallone R, Kent SC, James EA. Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes? Front Immunol. 2021; 12:683091. PMID: 34220832.
      View in: PubMed
    2. Landry LG, Anderson AM, Russ HA, Yu L, Kent SC, Atkinson MA, Mathews CE, Michels AW, Nakayama M. Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors. Front Endocrinol (Lausanne). 2021; 12:622647. PMID: 33841327.
      View in: PubMed
    3. James EA, Mallone R, Kent SC, DiLorenzo TP. T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal. Diabetes. 2020 Jul; 69(7):1311-1335. PMID: 32561620.
      View in: PubMed
    4. Russell MA, Redick SD, Blodgett DM, Richardson SJ, Leete P, Krogvold L, Dahl-Jørgensen K, Bottino R, Brissova M, Spaeth JM, Babon JAB, Haliyur R, Powers AC, Yang C, Kent SC, Derr AG, Kucukural A, Garber MG, Morgan NG, Harlan DM. HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of islet ß-Cells from Donors with Type 1 Diabetes. Diabetes. 2019 Mar 04. PMID: 30833470.
      View in: PubMed
    5. Williams T, Krovi HS, Landry LG, Crawford F, Jin N, Hohenstein A, DeNicola ME, Michels AW, Davidson HW, Kent SC, Gapin L, Kappler JW, Nakayama M. Development of T cell lines sensitive to antigen stimulation. J Immunol Methods. 2018 Aug 28. PMID: 30165064.
      View in: PubMed
    6. Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC. Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI Insight. 2018 Apr 19; 3(8). PMID: 29669939.
      View in: PubMed
    7. Marre ML, McGinty JW, Chow IT, DeNicola ME, Beck NW, Kent SC, Powers AC, Bottino R, Harlan DM, Greenbaum CJ, Kwok WW, Piganelli JD, James EA. Modifying Enzymes are Elicited by ER Stress, Generating Epitopes that are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes. Diabetes. 2018 Apr 13. PMID: 29654212.
      View in: PubMed
    8. Kent SC, Mannering SI, Michels AW, Babon JAB. Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the "Scene of the Crime". Curr Diab Rep. 2017 Sep 02; 17(10):95. PMID: 28864875.
      View in: PubMed
    9. Babon JAB, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2017 08 04; 23(8):1004. PMID: 28777787.
      View in: PubMed
    10. Willcox A, Richardson SJ, Walker LS, Kent SC, Morgan NG, Gillespie KM. Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes. Diabetologia. 2017 Feb 17. PMID: 28213757.
      View in: PubMed
    11. Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2017 Feb 07; 23(2):264. PMID: 28170374.
      View in: PubMed
    12. Kent SC, Babon JA. Narrowing in on the anti-ß cell-specific T cells: looking 'where the action is'. Curr Opin Endocrinol Diabetes Obes. 2017 Jan 17. PMID: 28099204.
      View in: PubMed
    13. Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2016 Dec; 22(12):1482-1487. PMID: 27798614.
      View in: PubMed
    14. Yeste A, Takenaka MC, Mascanfroni ID, Nadeau M, Kenison JE, Patel B, Tukpah AM, Babon JA, DeNicola M, Kent SC, Pozo D, Quintana FJ. Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2. Sci Signal. 2016; 9(433):ra61. PMID: 27330188.
      View in: PubMed
    15. Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K. Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science. 2016 Feb 12; 351(6274):711-4. PMID: 26912858.
      View in: PubMed
    16. Blodgett DM, Nowosielska A, Afik S, Pechhold S, Cura AJ, Kennedy NJ, Kim S, Kucukural A, Davis RJ, Kent SC, Greiner DL, Garber MG, Harlan DM, diIorio P. Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets. Diabetes. 2015 Sep; 64(9):3172-81. PMID: 25931473.
      View in: PubMed
    17. Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA. Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. J Immunol. 2011 Jul 15; 187(2):1039-46. PMID: 21653833.
      View in: PubMed
    18. Song Q, Han Q, Bradshaw EM, Kent SC, Raddassi K, Nilsson B, Nepom GT, Hafler DA, Love JC. On-chip activation and subsequent detection of individual antigen-specific T cells. Anal Chem. 2010 Jan 15; 82(2):473-7. PMID: 20000848.
      View in: PubMed
    19. Sharma AK, Ling Y, Greer AB, Hafler DA, Kent SC, Zhang Y, Rigby AC. Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry. J Phys Chem B. 2010 Jan 14; 114(1):585-91. PMID: 19954153.
      View in: PubMed
    20. Gianani R, Campbell-Thompson M, Sarkar SA, Wasserfall C, Pugliese A, Solis JM, Kent SC, Hering BJ, West E, Steck A, Bonner-Weir S, Atkinson MA, Coppieters K, von Herrath M, Eisenbarth GS. Dimorphic histopathology of long-standing childhood-onset diabetes. Diabetologia. 2010 Apr; 53(4):690-8. PMID: 20062967.
      View in: PubMed
    21. Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol. 2009 Oct 01; 183(7):4432-9. PMID: 19748982.
      View in: PubMed
    22. Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009 Sep; 39(9):2492-501. PMID: 19676072.
      View in: PubMed
    23. Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, Love JC. Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol. 2008 Oct; 129(1):10-8. PMID: 18675591.
      View in: PubMed
    24. Hava DL, van der Wel N, Cohen N, Dascher CC, Houben D, León L, Agarwal S, Sugita M, van Zon M, Kent SC, Shams H, Peters PJ, Brenner MB. Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11281-6. PMID: 18685099.
      View in: PubMed
    25. Smith RN, Kent SC, Nagle J, Selig M, Iafrate AJ, Najafian N, Hafler DA, Auchincloss H, Orban T, Cagliero E. Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss. Transplantation. 2008 Jul 15; 86(1):54-62. PMID: 18622278.
      View in: PubMed
    26. Waziri A, Killory B, Ogden AT, Canoll P, Anderson RC, Kent SC, Anderson DE, Bruce JN. Preferential in situ CD4+CD56+ T cell activation and expansion within human glioblastoma. J Immunol. 2008 Jun 1; 180(11):7673-80. PMID: 18490770.
      View in: PubMed
    27. Costantino CM, Hang HC, Kent SC, Hafler DA, Ploegh HL. Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. J Immunol. 2008 Mar 1; 180(5):2876-85. PMID: 18292509.
      View in: PubMed
    28. Kis J, Engelmann P, Farkas K, Richman G, Eck S, Lolley J, Jalahej H, Borowiec M, Kent SC, Treszl A, Orban T. Reduced CD4+ subset and Th1 bias of the human iNKT cells in Type 1 diabetes mellitus. J Leukoc Biol. 2007 Mar; 81(3):654-62. PMID: 17151140.
      View in: PubMed
    29. van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature. 2005 Oct 6; 437(7060):906-10. PMID: 16208376.
      View in: PubMed
    30. Kent SC, Chen Y, Clemmings SM, Viglietta V, Kenyon NS, Ricordi C, Hering B, Hafler DA. Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells. J Immunol. 2005 Oct 1; 175(7):4458-64. PMID: 16177088.
      View in: PubMed
    31. Quintana FJ, Gerber D, Kent SC, Cohen IR, Shai Y. HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation. J Clin Invest. 2005 Aug; 115(8):2149-58. PMID: 16007266.
      View in: PubMed
    32. Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature. 2005 May 12; 435(7039):224-8. PMID: 15889096.
      View in: PubMed
    33. Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol. 2003 Dec; 4(12):1230-7. PMID: 14578883.
      View in: PubMed
    34. Viglietta V, Kent SC, Orban T, Hafler DA. GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J Clin Invest. 2002 Apr; 109(7):895-903. PMID: 11927616.
      View in: PubMed
    35. Brandvold KA, Ewert DL, Kent SC, Neiman P, Ruddell A. Blocked B cell differentiation and emigration support the early growth of Myc-induced lymphomas. Oncogene. 2001 May 31; 20(25):3226-34. PMID: 11423972.
      View in: PubMed
    36. Orban T, Kent SC, Malik P, Milner JD, Schuster K, Jackson RA, Hafler DA. Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset. Autoimmunity. 2001; 34(4):247-64. PMID: 11905851.
      View in: PubMed
    37. Wilson SB, Kent SC, Horton HF, Hill AA, Bollyky PL, Hafler DA, Strominger JL, Byrne MC. Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7411-6. PMID: 10840051.
      View in: PubMed
    38. Kent SC, Hafler DA, Strominger JL, Wilson SB. Noncanonical Valpha24JalphaQ T cells with conservative alpha chain CDR3 region amino acid substitutions are restricted by CD1d. Hum Immunol. 1999 Nov; 60(11):1080-9. PMID: 10600006.
      View in: PubMed
    39. Milner JD, Kent SC, Ashley TA, Wilson SB, Strominger JL, Hafler DA. Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone. J Immunol. 1999 Sep 1; 163(5):2522-9. PMID: 10452989.
      View in: PubMed
    40. Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M, Porcelli S, Schatz DA, Atkinson MA, Balk SP, Strominger JL, Hafler DA. Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature. 1998 Jan 8; 391(6663):177-81. PMID: 9428763.
      View in: PubMed
    41. Scott DW, Warner GL, Yao XR, Kent SC. Pathways and regulation of B-cell responsiveness and tolerance. Chem Immunol. 1994; 58:34-66. PMID: 8011158.
      View in: PubMed
    42. Fischer G, Kent SC, Joseph L, Green DR, Scott DW. Lymphoma models for B cell activation and tolerance. X. Anti-mu-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc. J Exp Med. 1994 Jan 1; 179(1):221-8. PMID: 8270867.
      View in: PubMed
    43. Ludlum DB, Kent S, Mehta JR. Formation of O6-ethylthioethylguanine in DNA by reaction with the sulfur mustard, chloroethyl sulfide, and its apparent lack of repair by O6-alkylguanine-DNA alkyltransferase. Carcinogenesis. 1986 Jul; 7(7):1203-6. PMID: 3719912.
      View in: PubMed
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