Sally C Kent PhD
Title | Associate Professor |
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Endowed Title | George F. and Sybil H. Fuller Foundation Term Chair in Diabetes |
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Institution | University of Massachusetts Medical School |
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Department | Medicine |
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Address | University of Massachusetts Medical School 368 Plantation Street, AS7-2012 Worcester MA 01605
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Phone | 508-856-2044 |
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vCard | Download vCard |
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Institution | UMMS - School of Medicine |
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Department | Medicine |
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Division | Diabetes |
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Biography Union College, Schenectady, NY, United States | BS | | Biology | Loyola University Stritch School of Medicine, Maywood, IL, United States | PHD | | Microbiology and Immunology |
Overview RESEARCHINTERESTS Autoreactive T cell specificity and function in human Type 1 diabetes Development of autoreactive T cell memory in humanType 1 diabetes Anergy induction in human Type 1 diabetes Enterovirus in human Type 1 diabetes EDUCATIONand TRAINING Ph.D. Loyola University of Chicago, Stritch School of Medicine Postdoctoral Fellowships: University of Rochester School of Medicine andDentistry Brigham and Women’s Hospital and Harvard MedicalSchool ACADEMICAPPOINTMENTS Instructor in Neurology Harvard Medical School Associate Immunologist Brigham and Women’s Hospital Assistant Professor in Neurology Harvard Medical School Assistant Professor in Medicine University of Massachusetts Medical School, Diabetes Center of Excellence Associate Professor in Medicine University of Massachusetts Medical School, Diabetes Center of Excellence Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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James EA, Mallone R, Kent SC, DiLorenzo TP. T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal. Diabetes. 2020 Jul; 69(7):1311-1335. PMID: 32561620.
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Russell MA, Redick SD, Blodgett DM, Richardson SJ, Leete P, Krogvold L, Dahl-Jørgensen K, Bottino R, Brissova M, Spaeth JM, Babon JAB, Haliyur R, Powers AC, Yang C, Kent SC, Derr AG, Kucukural A, Garber MG, Morgan NG, Harlan DM. HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of islet ß-Cells from Donors with Type 1 Diabetes. Diabetes. 2019 Mar 04. PMID: 30833470.
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Williams T, Krovi HS, Landry LG, Crawford F, Jin N, Hohenstein A, DeNicola ME, Michels AW, Davidson HW, Kent SC, Gapin L, Kappler JW, Nakayama M. Development of T cell lines sensitive to antigen stimulation. J Immunol Methods. 2018 Aug 28. PMID: 30165064.
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Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC. Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI Insight. 2018 Apr 19; 3(8). PMID: 29669939.
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Marre ML, McGinty JW, Chow IT, DeNicola ME, Beck NW, Kent SC, Powers AC, Bottino R, Harlan DM, Greenbaum CJ, Kwok WW, Piganelli JD, James EA. Modifying Enzymes are Elicited by ER Stress, Generating Epitopes that are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes. Diabetes. 2018 Apr 13. PMID: 29654212.
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Kent SC, Mannering SI, Michels AW, Babon JAB. Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the "Scene of the Crime". Curr Diab Rep. 2017 Sep 02; 17(10):95. PMID: 28864875.
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Babon JAB, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2017 08 04; 23(8):1004. PMID: 28777787.
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Willcox A, Richardson SJ, Walker LS, Kent SC, Morgan NG, Gillespie KM. Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes. Diabetologia. 2017 Feb 17. PMID: 28213757.
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Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2017 Feb 07; 23(2):264. PMID: 28170374.
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Kent SC, Babon JA. Narrowing in on the anti-ß cell-specific T cells: looking 'where the action is'. Curr Opin Endocrinol Diabetes Obes. 2017 Jan 17. PMID: 28099204.
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Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2016 Dec; 22(12):1482-1487. PMID: 27798614.
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Yeste A, Takenaka MC, Mascanfroni ID, Nadeau M, Kenison JE, Patel B, Tukpah AM, Babon JA, DeNicola M, Kent SC, Pozo D, Quintana FJ. Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2. Sci Signal. 2016; 9(433):ra61. PMID: 27330188.
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Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K. Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science. 2016 Feb 12; 351(6274):711-4. PMID: 26912858.
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Blodgett DM, Nowosielska A, Afik S, Pechhold S, Cura AJ, Kennedy NJ, Kim S, Kucukural A, Davis RJ, Kent SC, Greiner DL, Garber MG, Harlan DM, diIorio P. Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets. Diabetes. 2015 Sep; 64(9):3172-81. PMID: 25931473.
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Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA. Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. J Immunol. 2011 Jul 15; 187(2):1039-46. PMID: 21653833.
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Song Q, Han Q, Bradshaw EM, Kent SC, Raddassi K, Nilsson B, Nepom GT, Hafler DA, Love JC. On-chip activation and subsequent detection of individual antigen-specific T cells. Anal Chem. 2010 Jan 15; 82(2):473-7. PMID: 20000848.
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Sharma AK, Ling Y, Greer AB, Hafler DA, Kent SC, Zhang Y, Rigby AC. Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry. J Phys Chem B. 2010 Jan 14; 114(1):585-91. PMID: 19954153.
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Gianani R, Campbell-Thompson M, Sarkar SA, Wasserfall C, Pugliese A, Solis JM, Kent SC, Hering BJ, West E, Steck A, Bonner-Weir S, Atkinson MA, Coppieters K, von Herrath M, Eisenbarth GS. Dimorphic histopathology of long-standing childhood-onset diabetes. Diabetologia. 2010 Apr; 53(4):690-8. PMID: 20062967.
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Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol. 2009 Oct 01; 183(7):4432-9. PMID: 19748982.
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Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009 Sep; 39(9):2492-501. PMID: 19676072.
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Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, Love JC. Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol. 2008 Oct; 129(1):10-8. PMID: 18675591.
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Hava DL, van der Wel N, Cohen N, Dascher CC, Houben D, León L, Agarwal S, Sugita M, van Zon M, Kent SC, Shams H, Peters PJ, Brenner MB. Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11281-6. PMID: 18685099.
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Smith RN, Kent SC, Nagle J, Selig M, Iafrate AJ, Najafian N, Hafler DA, Auchincloss H, Orban T, Cagliero E. Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss. Transplantation. 2008 Jul 15; 86(1):54-62. PMID: 18622278.
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Waziri A, Killory B, Ogden AT, Canoll P, Anderson RC, Kent SC, Anderson DE, Bruce JN. Preferential in situ CD4+CD56+ T cell activation and expansion within human glioblastoma. J Immunol. 2008 Jun 1; 180(11):7673-80. PMID: 18490770.
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Costantino CM, Hang HC, Kent SC, Hafler DA, Ploegh HL. Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. J Immunol. 2008 Mar 1; 180(5):2876-85. PMID: 18292509.
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Kis J, Engelmann P, Farkas K, Richman G, Eck S, Lolley J, Jalahej H, Borowiec M, Kent SC, Treszl A, Orban T. Reduced CD4+ subset and Th1 bias of the human iNKT cells in Type 1 diabetes mellitus. J Leukoc Biol. 2007 Mar; 81(3):654-62. PMID: 17151140.
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van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature. 2005 Oct 6; 437(7060):906-10. PMID: 16208376.
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Kent SC, Chen Y, Clemmings SM, Viglietta V, Kenyon NS, Ricordi C, Hering B, Hafler DA. Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells. J Immunol. 2005 Oct 1; 175(7):4458-64. PMID: 16177088.
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Quintana FJ, Gerber D, Kent SC, Cohen IR, Shai Y. HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation. J Clin Invest. 2005 Aug; 115(8):2149-58. PMID: 16007266.
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Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature. 2005 May 12; 435(7039):224-8. PMID: 15889096.
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Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol. 2003 Dec; 4(12):1230-7. PMID: 14578883.
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Viglietta V, Kent SC, Orban T, Hafler DA. GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J Clin Invest. 2002 Apr; 109(7):895-903. PMID: 11927616.
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Brandvold KA, Ewert DL, Kent SC, Neiman P, Ruddell A. Blocked B cell differentiation and emigration support the early growth of Myc-induced lymphomas. Oncogene. 2001 May 31; 20(25):3226-34. PMID: 11423972.
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Orban T, Kent SC, Malik P, Milner JD, Schuster K, Jackson RA, Hafler DA. Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset. Autoimmunity. 2001; 34(4):247-64. PMID: 11905851.
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Wilson SB, Kent SC, Horton HF, Hill AA, Bollyky PL, Hafler DA, Strominger JL, Byrne MC. Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7411-6. PMID: 10840051.
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Kent SC, Hafler DA, Strominger JL, Wilson SB. Noncanonical Valpha24JalphaQ T cells with conservative alpha chain CDR3 region amino acid substitutions are restricted by CD1d. Hum Immunol. 1999 Nov; 60(11):1080-9. PMID: 10600006.
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Milner JD, Kent SC, Ashley TA, Wilson SB, Strominger JL, Hafler DA. Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone. J Immunol. 1999 Sep 1; 163(5):2522-9. PMID: 10452989.
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Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M, Porcelli S, Schatz DA, Atkinson MA, Balk SP, Strominger JL, Hafler DA. Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature. 1998 Jan 8; 391(6663):177-81. PMID: 9428763.
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Scott DW, Warner GL, Yao XR, Kent SC. Pathways and regulation of B-cell responsiveness and tolerance. Chem Immunol. 1994; 58:34-66. PMID: 8011158.
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Fischer G, Kent SC, Joseph L, Green DR, Scott DW. Lymphoma models for B cell activation and tolerance. X. Anti-mu-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc. J Exp Med. 1994 Jan 1; 179(1):221-8. PMID: 8270867.
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Ludlum DB, Kent S, Mehta JR. Formation of O6-ethylthioethylguanine in DNA by reaction with the sulfur mustard, chloroethyl sulfide, and its apparent lack of repair by O6-alkylguanine-DNA alkyltransferase. Carcinogenesis. 1986 Jul; 7(7):1203-6. PMID: 3719912.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1986 | 1 | 1994 | 2 | 1998 | 1 | 1999 | 2 | 2000 | 1 | 2001 | 2 | 2002 | 1 | 2003 | 1 | 2005 | 4 | 2006 | 1 | 2008 | 5 | 2009 | 2 | 2010 | 3 | 2011 | 1 | 2015 | 1 | 2016 | 3 | 2017 | 5 | 2018 | 3 | 2019 | 1 | 2020 | 1 |
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