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Dale L Greiner PhD

TitleProfessor
Endowed TitleHerman G. Berkman Chair in Diabetes Care Innovation
InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressUMass Chan Medical School
368 Plantation Street AS7.2051
Worcester MA 01605
Phone508-856-1911
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    University of Iowa, Iowa City, IA, United StatesBSScience
    University of Iowa, Iowa City, IA, United StatesPHDMicrobiology

    Collapse Overview 
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    Academic Background

    Dale Greiner is currently Professor of Molecular Medicine at the University of Massachusetts Medical School. His research focuses on three areas: transplantation, autoimmunity, and the use of humanized mice to study human diseases and infections. Dr. Greiner graduated from the University of Iowa with a Bachelor of Science degree and Medical Technology degree in 1974 and with a Doctor of Philosophy degree in 1978. He did postdoctoral fellowships at the University of Pittsburgh and at the University of Connecticut Health Center in Farmington, CT. He was appointed Assistant Professor at UConn in 1983, Associate Professor in 1989, joined the Department of Medicine at the University of Massachusetts as Professor in 1991 and abecame a Professor od Molecular Medicine in 2010. He became Co-Director with Dr. David Harlan of the Diabetes Center of Excellence in 2010 and the Dr. Eileen L. Berman and Stanley I. Berman Foundation Chair in Biomedical Research Professor in 2013.

    To date, Dr. Greiner has co-authored more than 300 publications. He has served as a member of the editorial board of Diabetes, and as a regular member of the National Institutes of Health Immunology Sciences Study Section and the Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section. He has served as chair of the Veterans Administration Immunology Review Subcommittee B and has served as chair of many ad hoc NIH and JDRF study sections. He has also served as Chair of the Medical Science Review Committee for the Juvenile Diabetes Research Foundation, International, Chairman of the American Diabetes Association Scientific Sessions Committee, Program Chair of the American Diabetes Association Council on Immunology, Immunogenetics and Transplantation, and Council Chair, American Diabetes Association Council on Immunology, Immunogenetics and Transplantation.

    Dr. Greiner has received numerous awards for his research, including the A.J. Julian Scholarship for Academic Excellence, the Basil O'Connor Scholar Research Award from the March of Dimes, and the Kayla and Gerald Grodsky and David Rumbough Awards from the Juvenile Diabetes Research Foundation, Int.   

    Transplantation tolerance and autoimmune diabetes

    Our major area of investigation is to understand the etiology and pathogenesis of autoimmune type 1 diabetes mellitus (T1D). Our approach focuses on two main areas, the understanding of the pathogenesis of type 1 diabetes so as to formulate means to prevent or reverse the disease, and the cure of those who are diabetic by induction of transplantation tolerance to islets of Langerhans. Over 25 years ago, we and others accomplished these goals in spontaneously diabetic mouse and rat models of T1D, but these accomplishments have not yet been successfully translated to humans. We believe there are two major obstacles that prevent the achievement of these goals in humans: 1) Lack of understanding of the biology of how human insulin-secreting beta cells die during the development of T1D. 2) Lack of understanding of how a human immune system mediates the destruction of human beta cells in vivo. Our laboratory is focusing on the development of “humanized” mice to study human T1D in collaboration with Dr. Leonard Shultz at The Jackson Laboratory. We have developed unique strains of mice that can be engrafted with functional human cells and tissues, including human islets and human immune systems. We are now using these mice to understand how human beta cells resist killing by a human autoimmune system in vivo, how human beta cells replicate and regenerate in vivo, how human autoreactive cells develop in a human diabetes-susceptible immune system, and how a human immune system targets and kills beta cells in vivo. These approaches are allowing us to understand and dissect mechanisms important in human T1D that cannot be studied directly in humans. Moreover, because these mice readily accept human cells and tissues, we are now using them to study human regenerative medicine, immunity, human-specific infectious agents and cancer. Our studies in humanized mice have the potential to guide human clinical trials by determining the mechanisms by which therapeutic approaches such as those based on the new technology of RNAi can act directly on human immune systems, islets, and cancers in vivo, facilitating the direct translation of these agents into the clinic.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Coate KC, Dai C, Singh A, Stanley J, Covington BA, Bradley A, Oladipupo F, Gong Y, Wisniewski S, Sellick K, Spears E, Poffenberger G, Schornack AMR, Bustabad A, Rodgers T, Dey N, Shultz LD, Greiner DL, Yan H, Powers AC, Chen W, Dean ED. Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners. Mol Metab. 2024 Dec; 90:102050. PMID: 39433176.
      Citations:    
    2. Coate KC, Dai C, Singh A, Stanley J, Covington BA, Bradley A, Oladipupo F, Gong Y, Wisniewski S, Spears E, Poffenberger G, Bustabad A, Rodgers T, Dey N, Shultz LD, Greiner DL, Yan H, Powers AC, Chen W, Dean ED. Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners. bioRxiv. 2024 Aug 07. PMID: 39149351.
      Citations:    
    3. Friedline RH, Noh HL, Suk S, Albusharif M, Dagdeviren S, Saengnipanthkul S, Kim B, Kim AM, Kim LH, Tauer LA, Baez Torres NM, Choi S, Kim BY, Rao SD, Kasina K, Sun C, Toles BJ, Zhou C, Li Z, Benoit VM, Patel PR, Zheng DXT, Inashima K, Beaverson A, Hu X, Tran DA, Muller W, Greiner DL, Mullen AC, Lee KW, Kim JK. Author Correction: IFN?-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease. Nat Commun. 2024 Jul 23; 15(1):6195. PMID: 39043691.
      Citations:    
    4. Friedline RH, Noh HL, Suk S, Albusharif M, Dagdeviren S, Saengnipanthkul S, Kim B, Kim AM, Kim LH, Tauer LA, Baez Torres NM, Choi S, Kim BY, Rao SD, Kasina K, Sun C, Toles BJ, Zhou C, Li Z, Benoit VM, Patel PR, Zheng DXT, Inashima K, Beaverson A, Hu X, Tran DA, Muller W, Greiner DL, Mullen AC, Lee KW, Kim JK. IFN?-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease. Nat Commun. 2024 Jun 29; 15(1):5506. PMID: 38951527.
      Citations:    
    5. Amdare NP, Shultz LD, Greiner DL, DiLorenzo TP. Human insulin as both antigen and protector in type 1 diabetes. Eur J Immunol. 2024 Sep; 54(9):e2350949. PMID: 38778498.
      Citations:    
    6. Stepien TA, Singletary LA, Guerra FE, Karlinsey JE, Libby SJ, Jaslow SL, Gaggioli MR, Gibbs KD, Ko DC, Brehm MA, Greiner DL, Shultz LD, Fang FC. Nuclear factor kappa B-dependent persistence of Salmonella Typhi and Paratyphi in human macrophages. mBio. 2024 Apr 10; 15(4):e0045424. PMID: 38497655.
      Citations:    
    7. Walker JT, Saunders DC, Rai V, Chen HH, Orchard P, Dai C, Pettway YD, Hopkirk AL, Reihsmann CV, Tao Y, Fan S, Shrestha S, Varshney A, Petty LE, Wright JJ, Ventresca C, Agarwala S, Aramandla R, Poffenberger G, Jenkins R, Mei S, Hart NJ, Phillips S, Kang H, Greiner DL, Shultz LD, Bottino R, Liu J, Below JE, Parker SCJ, Powers AC, Brissova M. Genetic risk converges on regulatory networks mediating early type 2 diabetes. Nature. 2023 Dec; 624(7992):621-629. PMID: 38049589.
      Citations:    Fields:    Translation:HumansCells
    8. Doloff JC, Ma M, Sadraei A, Tam HH, Farah S, Hollister-Lock J, Vegas AJ, Veiseh O, Quiroz VM, Rakoski A, Aresta-DaSilva S, Bader AR, Griffin M, Weir GC, Brehm MA, Shultz LD, Langer R, Greiner DL, Anderson DG. Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response. Sci Adv. 2023 06 16; 9(24):eade9488. PMID: 37327334.
      Citations:    Fields:    Translation:HumansAnimals
    9. Yang J, Jiao J, Draheim KM, Yang G, Yang H, Yao LC, Shultz LD, Greiner DL, Rajagopal D, Vessillier S, Maier CC, Mohanan S, Cai D, Cheng M, Brehm MA, Keck JG. Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model. FASEB J. 2023 06; 37(6):e22995. PMID: 37219526.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. Aryee KE, Shultz LD, Burzenski LM, Greiner DL, Brehm MA. NOD-scid IL2r?null mice lacking TLR4 support human immune system development and the study of human-specific innate immunity. J Leukoc Biol. 2023 05 02; 113(5):418-433. PMID: 36801998.
      Citations:    Fields:    Translation:HumansAnimals
    11. Stadinski BD, Cleveland SB, Brehm MA, Greiner DL, Huseby PG, Huseby ES. I-Ag7 ?56/57 polymorphisms regulate non-cognate negative selection to CD4+ T cell orchestrators of type 1 diabetes. Nat Immunol. 2023 04; 24(4):652-663. PMID: 36807641.
      Citations: 1     Fields:    Translation:AnimalsCells
    12. Derr AG, Arowosegbe A, Satish B, Redick SD, Qaisar N, Guo Z, Vanderleeden E, Trombly MI, Baer CE, Harlan DM, Greiner DL, Garber M, Wang JP. An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes. Diabetes. 2023 Feb 01; 72(2):261-274. PMID: 36346618.
      Citations: 1     Fields:    Translation:HumansAnimals
    13. Chuprin J, Buettner H, Seedhom MO, Greiner DL, Keck JG, Ishikawa F, Shultz LD, Brehm MA. Humanized mouse models for immuno-oncology research. Nat Rev Clin Oncol. 2023 03; 20(3):192-206. PMID: 36635480.
      Citations: 27     Fields:    Translation:HumansAnimals
    14. Jung S, Jiang L, Zhao J, Shultz LD, Greiner DL, Bae M, Li X, Ordikhani F, Kuai R, Joseph J, Kasinath V, Elmaleh DR, Abdi R. Clathrin light chain-conjugated drug delivery for cancer. Bioeng Transl Med. 2023 Jan; 8(1):e10273. PMID: 36684105.
      Citations:    
    15. Aryee KE, Burzenski LM, Yao LC, Keck JG, Greiner DL, Shultz LD, Brehm MA. Enhanced development of functional human NK cells in NOD-scid-IL2rgnull mice expressing human IL15. FASEB J. 2022 09; 36(9):e22476. PMID: 35959876.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    16. Stepien TA, Libby SJ, Karlinsey JE, Brehm MA, Greiner DL, Shultz LD, Brabb T, Fang FC. Analysis of Salmonella Typhi Pathogenesis in a Humanized Mouse Model. Methods Mol Biol. 2022; 2427:215-234. PMID: 35619037.
      Citations:    Fields:    Translation:AnimalsCells
    17. Khosravi-Maharlooei M, Madley R, Borsotti C, Ferreira LMR, Sharp RC, Brehm MA, Greiner DL, Parent AV, Anderson MS, Sykes M, Creusot RJ. Modeling human T1D-associated autoimmune processes. Mol Metab. 2022 02; 56:101417. PMID: 34902607.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    18. Yang K, O'Cearbhaill ED, Liu SS, Zhou A, Chitnis GD, Hamilos AE, Xu J, Verma MKS, Giraldo JA, Kudo Y, Lee EA, Lee Y, Pop R, Langer R, Melton DA, Greiner DL, Karp JM. A therapeutic convection-enhanced macroencapsulation device for enhancing ? cell viability and insulin secretion. Proc Natl Acad Sci U S A. 2021 09 14; 118(37). PMID: 34504013.
      Citations: 12     Fields:    Translation:AnimalsCells
    19. Doloff JC, Veiseh O, Vegas AJ, Tam HH, Farah S, Ma M, Li J, Bader A, Chiu A, Sadraei A, Aresta-Dasilva S, Griffin M, Jhunjhunwala S, Webber M, Siebert S, Tang K, Chen M, Langan E, Dholakia N, Thakrar R, Qi M, Oberholzer J, Greiner DL, Langer R, Anderson DG. Author Correction: Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates. Nat Mater. 2021 Jul; 20(7):1038. PMID: 34012046.
      Citations:    Fields:    
    20. Roderick JE, Gallagher KM, Murphy LC, O'Connor KW, Tang K, Zhang B, Brehm MA, Greiner DL, Yu J, Zhu LJ, Green MR, Kelliher MA. Prostaglandin E2 stimulates cAMP signaling and resensitizes human leukemia cells to glucocorticoid-induced cell death. Blood. 2021 01 28; 137(4):500-512. PMID: 33507291.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    21. Jiang L, Wang YJ, Zhao J, Uehara M, Hou Q, Kasinath V, Ichimura T, Banouni N, Dai L, Li X, Greiner DL, Shultz LD, Zhang X, Sun ZJ, Curtin I, Vangos NE, Yeoh ZC, Geffken EA, Seo HS, Liu ZX, Heffron GJ, Shah K, Dhe-Paganon S, Abdi R. Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy. Cell. 2020 11 25; 183(5):1219-1233.e18. PMID: 33242418.
      Citations: 27     Fields:    Translation:AnimalsCells
    22. Ye C, Yang H, Cheng M, Shultz LD, Greiner DL, Brehm MA, Keck JG. A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome. FASEB J. 2020 09; 34(9):12963-12975. PMID: 32772418.
      Citations: 17     Fields:    Translation:AnimalsCells
    23. Dai C, Walker JT, Shostak A, Bouchi Y, Poffenberger G, Hart NJ, Jacobson DA, Calcutt MW, Bottino R, Greiner DL, Shultz LD, McGuinness OP, Dean ED, Powers AC. Dapagliflozin Does Not Directly Affect Human a or ? Cells. Endocrinology. 2020 08 01; 161(8). PMID: 32428240.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    24. Leite NC, Sintov E, Meissner TB, Brehm MA, Greiner DL, Harlan DM, Melton DA. Modeling Type 1 Diabetes In?Vitro Using Human Pluripotent Stem Cells. Cell Rep. 2020 07 14; 32(2):107894. PMID: 32668238.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    25. Bose S, Volpatti LR, Thiono D, Yesilyurt V, McGladrigan C, Tang Y, Facklam A, Wang A, Jhunjhunwala S, Veiseh O, Hollister-Lock J, Bhattacharya C, Weir GC, Greiner DL, Langer R, Anderson DG. A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells. Nat Biomed Eng. 2020 08; 4(8):814-826. PMID: 32231313.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    26. Nyalwidhe JO, Jurczyk A, Satish B, Redick S, Qaisar N, Trombly MI, Vangala P, Racicot R, Bortell R, Harlan DM, Greiner DL, Brehm MA, Nadler JL, Wang JP. Proteomic and Transcriptional Profiles of Human Stem Cell-Derived ? Cells Following Enteroviral Challenge. Microorganisms. 2020 Feb 20; 8(2). PMID: 32093375.
      Citations:    
    27. Dai C, Walker JT, Shostak A, Padgett A, Spears E, Wisniewski S, Poffenberger G, Aramandla R, Dean ED, Prasad N, Levy SE, Greiner DL, Shultz LD, Bottino R, Powers AC. Tacrolimus- and sirolimus-induced human ? cell dysfunction is reversible and preventable. JCI Insight. 2020 01 16; 5(1). PMID: 31941840.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    28. Redick SD, Leehy L, Rittenhouse AR, Blodgett DM, Derr AG, Kucukural A, Garber MG, Shultz LD, Greiner DL, Wang JP, Harlan DM, Bortell R, Jurczyk A. Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice. FASEB J. 2020 01; 34(1):1901-1911. PMID: 31914605.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    29. Karlinsey JE, Stepien TA, Mayho M, Singletary LA, Bingham-Ramos LK, Brehm MA, Greiner DL, Shultz LD, Gallagher LA, Bawn M, Kingsley RA, Libby SJ, Fang FC. Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features. Cell Host Microbe. 2019 09 11; 26(3):426-434.e6. PMID: 31447308.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    30. Youngblood BA, Brock EC, Leung J, Falahati R, Bryce PJ, Bright J, Williams J, Shultz LD, Greiner DL, Brehm MA, Bebbington C, Tomasevic N. AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice. Int Arch Allergy Immunol. 2019; 180(2):91-102. PMID: 31401630.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    31. Farah S, Doloff JC, M?ller P, Sadraei A, Han HJ, Olafson K, Vyas K, Tam HH, Hollister-Lock J, Kowalski PS, Griffin M, Meng A, McAvoy M, Graham AC, McGarrigle J, Oberholzer J, Weir GC, Greiner DL, Langer R, Anderson DG. Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations. Nat Mater. 2019 08; 18(8):892-904. PMID: 31235902.
      Citations: 50     Fields:    Translation:AnimalsCells
    32. Shultz LD, Keck J, Burzenski L, Jangalwe S, Vaidya S, Greiner DL, Brehm MA. Humanized mouse models of immunological diseases and precision medicine. Mamm Genome. 2019 06; 30(5-6):123-142. PMID: 30847553.
      Citations: 50     Fields:    Translation:HumansAnimals
    33. Gawron MA, Duval M, Carbone C, Jaiswal S, Wallace A, Martin JC, Dauphin A, Brehm MA, Greiner DL, Shultz LD, Luban J, Cavacini LA. Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1. J Immunol. 2019 02 01; 202(3):799-804. PMID: 30593536.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    34. Bahmani B, Uehara M, Ordikhani F, Li X, Jiang L, Banouni N, Ichimura T, Kasinath V, Eskandari SK, Annabi N, Bromberg JS, Shultz LD, Greiner DL, Abdi R. Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery. EBioMedicine. 2018 Dec; 38:79-88. PMID: 30497977.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    35. Saunders DC, Brissova M, Phillips N, Shrestha S, Walker JT, Aramandla R, Poffenberger G, Flaherty DK, Weller KP, Pelletier J, Cooper T, Goff MT, Virostko J, Shostak A, Dean ED, Greiner DL, Shultz LD, Prasad N, Levy SE, Carnahan RH, Dai C, S?vigny J, Powers AC. Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic ? Cells for In?Vitro and In?Vivo Analysis. Cell Metab. 2019 03 05; 29(3):745-754.e4. PMID: 30449685.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    36. Brehm MA, Kenney LL, Wiles MV, Low BE, Tisch RM, Burzenski L, Mueller C, Greiner DL, Shultz LD. Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression. FASEB J. 2019 03; 33(3):3137-3151. PMID: 30383447.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    37. Bochenek MA, Veiseh O, Vegas AJ, McGarrigle JJ, Qi M, Marchese E, Omami M, Doloff JC, Mendoza-Elias J, Nourmohammadzadeh M, Khan A, Yeh CC, Xing Y, Isa D, Ghani S, Li J, Landry C, Bader AR, Olejnik K, Chen M, Hollister-Lock J, Wang Y, Greiner DL, Weir GC, Strand BL, Rokstad AMA, Lacik I, Langer R, Anderson DG, Oberholzer J. Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques. Nat Biomed Eng. 2018 Nov; 2(11):810-821. PMID: 30873298.
      Citations: 99     Fields:    
    38. Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A. Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation. 2018 08; 102(8):1223-1229. PMID: 29781950.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    39. Brissova M, Haliyur R, Saunders D, Shrestha S, Dai C, Blodgett DM, Bottino R, Campbell-Thompson M, Aramandla R, Poffenberger G, Lindner J, Pan FC, von Herrath MG, Greiner DL, Shultz LD, Sanyoura M, Philipson LH, Atkinson M, Harlan DM, Levy SE, Prasad N, Stein R, Powers AC. a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes. Cell Rep. 2018 03 06; 22(10):2667-2676. PMID: 29514095.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    40. Wang M, Yao LC, Cheng M, Cai D, Martinek J, Pan CX, Shi W, Ma AH, De Vere White RW, Airhart S, Liu ET, Banchereau J, Brehm MA, Greiner DL, Shultz LD, Palucka K, Keck JG. Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. FASEB J. 2018 03; 32(3):1537-1549. PMID: 29146734.
      Citations: 163     Fields:    Translation:HumansAnimalsCells
    41. Borel F, Tang Q, Gernoux G, Greer C, Wang Z, Barzel A, Kay MA, Shultz LD, Greiner DL, Flotte TR, Brehm MA, Mueller C. Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of a-1 Antitrypsin Deficiency. Mol Ther. 2017 11 01; 25(11):2477-2489. PMID: 29032169.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    42. Dai C, Hang Y, Shostak A, Poffenberger G, Hart N, Prasad N, Phillips N, Levy SE, Greiner DL, Shultz LD, Bottino R, Kim SK, Powers AC. Age-dependent human ? cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. J Clin Invest. 2017 Oct 02; 127(10):3835-3844. PMID: 28920919.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    43. Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC. Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Cell Rep. 2017 Aug 22; 20(8):1978-1990. PMID: 28834758.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    44. Roberts FR, Hupple C, Norowski E, Walsh NC, Przewozniak N, Aryee KE, Van Dessel FM, Jurczyk A, Harlan DM, Greiner DL, Bortell R, Yang C. Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR model. PLoS One. 2017; 12(6):e0178641. PMID: 28605395.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    45. Lee J, Dykstra B, Spencer JA, Kenney LL, Greiner DL, Shultz LD, Brehm MA, Lin CP, Sackstein R, Rossi DJ. mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors. J Clin Invest. 2017 Jun 01; 127(6):2433-2437. PMID: 28481220.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    46. Verma MK, Clemens J, Burzenski L, Sampson SB, Brehm MA, Greiner DL, Shultz LD. A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo. J Immunol Methods. 2017 07; 446:47-53. PMID: 28390927.
      Citations: 16     Fields:    Translation:AnimalsCells
    47. Doloff JC, Veiseh O, Vegas AJ, Tam HH, Farah S, Ma M, Li J, Bader A, Chiu A, Sadraei A, Aresta-Dasilva S, Griffin M, Jhunjhunwala S, Webber M, Siebert S, Tang K, Chen M, Langan E, Dholokia N, Thakrar R, Qi M, Oberholzer J, Greiner DL, Langer R, Anderson DG. Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human?primates. Nat Mater. 2017 06; 16(6):671-680. PMID: 28319612.
      Citations: 95     Fields:    Translation:Animals
    48. Filion TM, Skelly JD, Huang H, Greiner DL, Ayers DC, Song J. Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue. Stem Cell Res Ther. 2017 03 11; 8(1):65. PMID: 28283030.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    49. Walsh NC, Kenney LL, Jangalwe S, Aryee KE, Greiner DL, Brehm MA, Shultz LD. Humanized Mouse Models of Clinical Disease. Annu Rev Pathol. 2017 Jan 24; 12:187-215. PMID: 27959627.
      Citations: 260     Fields:    Translation:HumansAnimals
    50. Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, L?pez-Gir?ldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM. In vivo correction of anaemia in ?-thalassemic mice by ?PNA-mediated gene editing with nanoparticle delivery. Nat Commun. 2016 10 26; 7:13304. PMID: 27782131.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    51. Moser J, van Ark J, van Dijk MC, Greiner DL, Shultz LD, van Goor H, Hillebrands JL. Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury. Sci Rep. 2016 10 19; 6:35387. PMID: 27759053.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    52. Ortiz-Miranda S, Ji R, Jurczyk A, Aryee KE, Mo S, Fletcher T, Shaffer SA, Greiner DL, Bortell R, Gregg RG, Cheng A, Hennings LJ, Rittenhouse AR. A novel transgenic mouse model of lysosomal storage disorder. Am J Physiol Gastrointest Liver Physiol. 2016 11 01; 311(5):G903-G919. PMID: 27659423.
      Citations: 2     Fields:    Translation:AnimalsCells
    53. Boudreau JE, Liu XR, Zhao Z, Zhang A, Shultz LD, Greiner DL, Dupont B, Hsu KC. Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I. Immunity. 2016 08 16; 45(2):280-91. PMID: 27496730.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    54. Ali R, Babad J, Follenzi A, Gebe JA, Brehm MA, Nepom GT, Shultz LD, Greiner DL, DiLorenzo TP. Genetically modified human CD4(+) T cells can be evaluated in?vivo without lethal graft-versus-host disease. Immunology. 2016 08; 148(4):339-51. PMID: 27124592.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    55. Derr A, Yang C, Zilionis R, Sergushichev A, Blodgett DM, Redick S, Bortell R, Luban J, Harlan DM, Kadener S, Greiner DL, Klein A, Artyomov MN, Garber M. End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data. Genome Res. 2016 10; 26(10):1397-1410. PMID: 27470110.
      Citations: 36     Fields:    Translation:AnimalsCells
    56. Mercado-Lubo R, Zhang Y, Zhao L, Rossi K, Wu X, Zou Y, Castillo A, Leonard J, Bortell R, Greiner DL, Shultz LD, Han G, McCormick BA. A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours. Nat Commun. 2016 07 25; 7:12225. PMID: 27452236.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    57. Vegas AJ, Veiseh O, Doloff JC, Ma M, Tam HH, Bratlie K, Li J, Bader AR, Langan E, Olejnik K, Fenton P, Kang JW, Hollister-Locke J, Bochenek MA, Chiu A, Siebert S, Tang K, Jhunjhunwala S, Aresta-Dasilva S, Dholakia N, Thakrar R, Vietti T, Chen M, Cohen J, Siniakowicz K, Qi M, McGarrigle J, Lyle S, Harlan DM, Greiner DL, Oberholzer J, Weir GC, Langer R, Anderson DG. Corrigendum: Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol. 2016 06 09; 34(6):666. PMID: 27281428.
      Citations: 6     Fields:    
    58. Dai C, Kayton NS, Shostak A, Poffenberger G, Cyphert HA, Aramandla R, Thompson C, Papagiannis IG, Emfinger C, Shiota M, Stafford JM, Greiner DL, Herrera PL, Shultz LD, Stein R, Powers AC. Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. J Clin Invest. 2016 05 02; 126(5):1857-70. PMID: 27064285.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    59. Bryce PJ, Falahati R, Kenney LL, Leung J, Bebbington C, Tomasevic N, Krier RA, Hsu CL, Shultz LD, Greiner DL, Brehm MA. Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis. J Allergy Clin Immunol. 2016 09; 138(3):769-779. PMID: 27139822.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    60. Vegas AJ, Veiseh O, G?rtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG. Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med. 2016 Apr; 22(4):446. PMID: 27050590.
      Citations: 5     Fields:    
    61. Jhunjhunwala S, Alvarez D, Aresta-DaSilva S, Tang K, Tang BC, Greiner DL, Newburger PE, von Andrian UH, Langer R, Anderson DG. Frontline Science: Splenic progenitors aid in maintaining high neutrophil numbers at sites of sterile chronic inflammation. J Leukoc Biol. 2016 08; 100(2):253-60. PMID: 26965635.
      Citations: 4     Fields:    Translation:AnimalsCells
    62. Goel HL, Pursell B, Shultz LD, Greiner DL, Brekken RA, Vander Kooi CW, Mercurio AM. P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer. Cell Rep. 2016 Mar 08; 14(9):2193-2208. PMID: 26923603.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    63. Vegas AJ, Veiseh O, Doloff JC, Ma M, Tam HH, Bratlie K, Li J, Bader AR, Langan E, Olejnik K, Fenton P, Kang JW, Hollister-Locke J, Bochenek MA, Chiu A, Siebert S, Tang K, Jhunjhunwala S, Aresta-Dasilva S, Dholakia N, Thakrar R, Vietti T, Chen M, Cohen J, Siniakowicz K, Qi M, McGarrigle J, Graham AC, Lyle S, Harlan DM, Greiner DL, Oberholzer J, Weir GC, Langer R, Anderson DG. Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol. 2016 03; 34(3):345-52. PMID: 26807527.
      Citations: 161     Fields:    Translation:HumansAnimalsCells
    64. Vegas AJ, Veiseh O, G?rtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG. Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med. 2016 Mar; 22(3):306-11. PMID: 26808346.
      Citations: 246     Fields:    Translation:HumansAnimalsCells
    65. Hasgur S, Aryee KE, Shultz LD, Greiner DL, Brehm MA. Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells. Methods Mol Biol. 2016; 1438:67-78. PMID: 27150084.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    66. Friedline RH, Ko HJ, Jung DY, Lee Y, Bortell R, Dagdeviren S, Patel PR, Hu X, Inashima K, Kearns C, Tsitsilianos N, Shafiq U, Shultz LD, Lee KW, Greiner DL, Kim JK. Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance. FASEB J. 2016 Mar; 30(3):1328-38. PMID: 26644351.
      Citations: 8     Fields:    Translation:AnimalsCells
    67. Kenney LL, Shultz LD, Greiner DL, Brehm MA. Humanized Mouse Models for Transplant Immunology. Am J Transplant. 2016 Feb; 16(2):389-97. PMID: 26588186.
      Citations: 41     Fields:    Translation:HumansAnimals
    68. Li J, Zhang Z, Liu X, Wang Y, Mao F, Mao J, Lu X, Jiang D, Wan Y, Lv JY, Cao G, Zhang J, Zhao N, Atkinson M, Greiner DL, Prud'homme GJ, Jiao Z, Li Y, Wang Q. Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics. Front Pharmacol. 2015; 6:260. PMID: 26617516.
      Citations:    
    69. Jurczyk A, Nowosielska A, Przewozniak N, Aryee KE, DiIorio P, Blodgett D, Yang C, Campbell-Thompson M, Atkinson M, Shultz L, Rittenhouse A, Harlan D, Greiner D, Bortell R. Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ?-cell function via glycogen synthase kinase-3?. FASEB J. 2016 Feb; 30(2):983-93. PMID: 26546129.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    70. Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, Shultz LD, Mempel TR, Bjorkman PJ, Kumar P, Mothes W. Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection. Science. 2015 Oct 30; 350(6260):563-567. PMID: 26429886.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    71. Li S, Ling C, Zhong L, Li M, Su Q, He R, Tang Q, Greiner DL, Shultz LD, Brehm MA, Flotte TR, Mueller C, Srivastava A, Gao G. Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors. Mol Ther. 2015 Dec; 23(12):1867-76. PMID: 26403887.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    72. Jhunjhunwala S, Aresta-DaSilva S, Tang K, Alvarez D, Webber MJ, Tang BC, Lavin DM, Veiseh O, Doloff JC, Bose S, Vegas A, Ma M, Sahay G, Chiu A, Bader A, Langan E, Siebert S, Li J, Greiner DL, Newburger PE, von Andrian UH, Langer R, Anderson DG. Neutrophil Responses to Sterile Implant Materials. PLoS One. 2015; 10(9):e0137550. PMID: 26355958.
      Citations: 34     Fields:    Translation:AnimalsCells
    73. Yang C, Loehn M, Jurczyk A, Przewozniak N, Leehy L, Herrera PL, Shultz LD, Greiner DL, Harlan DM, Bortell R. Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets. Diabetes Metab Syndr Obes. 2015; 8:387-98. PMID: 26316789.
      Citations:    
    74. Presa M, Chen YG, Grier AE, Leiter EH, Brehm MA, Greiner DL, Shultz LD, Serreze DV. The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice. J Immunol. 2015 Oct 01; 195(7):3011-9. PMID: 26283479.
      Citations: 10     Fields:    Translation:AnimalsCells
    75. Dou S, Virostko J, Greiner DL, Powers AC, Liu G. Quantitative Correlation of in Vivo Properties with in Vitro Assay Results: The in Vitro Binding of a Biotin-DNA Analogue Modifier with Streptavidin Predicts the in Vivo Avidin-Induced Clearability of the Analogue-Modified Antibody. Mol Pharm. 2015 Aug 03; 12(8):3097-103. PMID: 26103429.
      Citations: 1     Fields:    Translation:AnimalsCells
    76. Veiseh O, Doloff JC, Ma M, Vegas AJ, Tam HH, Bader AR, Li J, Langan E, Wyckoff J, Loo WS, Jhunjhunwala S, Chiu A, Siebert S, Tang K, Hollister-Lock J, Aresta-Dasilva S, Bochenek M, Mendoza-Elias J, Wang Y, Qi M, Lavin DM, Chen M, Dholakia N, Thakrar R, Lac?k I, Weir GC, Oberholzer J, Greiner DL, Langer R, Anderson DG. Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates. Nat Mater. 2015 Jun; 14(6):643-51. PMID: 25985456.
      Citations: 260     Fields:    Translation:Animals
    77. Samanta S, Sun H, Goel HL, Pursell B, Chang C, Khan A, Greiner DL, Cao S, Lim E, Shultz LD, Mercurio AM. IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG. Oncogene. 2016 Mar 03; 35(9):1111-21. PMID: 25982283.
      Citations: 34     Fields:    Translation:HumansCells
    78. Blodgett DM, Nowosielska A, Afik S, Pechhold S, Cura AJ, Kennedy NJ, Kim S, Kucukural A, Davis RJ, Kent SC, Greiner DL, Garber MG, Harlan DM, diIorio P. Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets. Diabetes. 2015 Sep; 64(9):3172-81. PMID: 25931473.
      Citations: 162     Fields:    Translation:HumansCells
    79. Nostro MC, Sarangi F, Yang C, Holland A, Elefanty AG, Stanley EG, Greiner DL, Keller G. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines. Stem Cell Reports. 2015 Apr 14; 4(4):591-604. PMID: 25843049.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    80. Babad J, Mukherjee G, Follenzi A, Ali R, Roep BO, Shultz LD, Santamaria P, Yang OO, Goldstein H, Greiner DL, DiLorenzo TP. Generation of ? cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice. Clin Exp Immunol. 2015 Mar; 179(3):398-413. PMID: 25302633.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    81. Dou S, Virostko J, Greiner DL, Powers AC, Liu G. A feasible approach to evaluate the relative reactivity of NHS-ester activated group with primary amine-derivatized DNA analogue and non-derivatized impurity. Nucleosides Nucleotides Nucleic Acids. 2015; 34(2):69-78. PMID: 25621701.
      Citations: 2     Fields:    
    82. Chang C, Goel HL, Gao H, Pursell B, Shultz LD, Greiner DL, Ingerpuu S, Patarroyo M, Cao S, Lim E, Mao J, McKee KK, Yurchenco PD, Mercurio AM. A laminin 511 matrix is regulated by TAZ and functions as the ligand for the a6B?1 integrin to sustain breast cancer stem cells. Genes Dev. 2015 Jan 01; 29(1):1-6. PMID: 25561492.
      Citations: 67     Fields:    Translation:HumansCells
    83. Gallagher GR, Brehm MA, Finberg RW, Barton BA, Shultz LD, Greiner DL, Bortell R, Wang JP. Viral infection of engrafted human islets leads to diabetes. Diabetes. 2015 Apr; 64(4):1358-69. PMID: 25392246.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    84. Pagliuca FW, Millman JR, G?rtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D, Melton DA. Generation of functional human pancreatic ? cells in vitro. Cell. 2014 Oct 09; 159(2):428-39. PMID: 25303535.
      Citations: 857     Fields:    Translation:HumansAnimalsCells
    85. Wilson EM, Bial J, Tarlow B, Bial G, Jensen B, Greiner DL, Brehm MA, Grompe M. Extensive double humanization of both liver and hematopoiesis in FRGN mice. Stem Cell Res. 2014 Nov; 13(3 Pt A):404-12. PMID: 25310256.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    86. Jaiswal S, Smith K, Ramirez A, Woda M, Pazoles P, Shultz LD, Greiner DL, Brehm MA, Mathew A. Dengue virus infection induces broadly cross-reactive human IgM antibodies that recognize intact virions in humanized BLT-NSG mice. Exp Biol Med (Maywood). 2015 Jan; 240(1):67-78. PMID: 25125497.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    87. Dou S, Virostko J, Rusckowski M, Greiner DL, Powers AC, Liu G. Differentiation between temporary and real non-clearability of biotinylated IgG antibody by avidin in mice. Front Pharmacol. 2014; 5:172. PMID: 25104938.
      Citations:    
    88. Purwana I, Zheng J, Li X, Deurloo M, Son DO, Zhang Z, Liang C, Shen E, Tadkase A, Feng ZP, Li Y, Hasilo C, Paraskevas S, Bortell R, Greiner DL, Atkinson M, Prud'homme GJ, Wang Q. GABA promotes human ?-cell proliferation and modulates glucose homeostasis. Diabetes. 2014 Dec; 63(12):4197-205. PMID: 25008178.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    89. Trabucco SE, Gerstein RM, Evens AM, Bradner JE, Shultz LD, Greiner DL, Zhang H. Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma. Clin Cancer Res. 2015 Jan 01; 21(1):113-22. PMID: 25009295.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    90. Shultz LD, Goodwin N, Ishikawa F, Hosur V, Lyons BL, Greiner DL. Human cancer growth and therapy in immunodeficient mouse models. Cold Spring Harb Protoc. 2014 Jul 01; 2014(7):694-708. PMID: 24987146.
      Citations: 103     Fields:    Translation:HumansAnimals
    91. Shultz LD, Goodwin N, Ishikawa F, Hosur V, Lyons BL, Greiner DL. Subcapsular transplantation of tissue in the kidney. Cold Spring Harb Protoc. 2014 Jul 01; 2014(7):737-40. PMID: 24987138.
      Citations: 15     Fields:    Translation:HumansAnimals
    92. Maykel J, Liu JH, Li H, Shultz LD, Greiner DL, Houghton J. NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer. Dig Dis Sci. 2014 Jun; 59(6):1169-79. PMID: 24798995.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    93. Goel HL, Gritsko T, Pursell B, Chang C, Shultz LD, Greiner DL, Norum JH, Toftgard R, Shaw LM, Mercurio AM. Regulated splicing of the a6 integrin cytoplasmic domain determines the fate of breast cancer stem cells. Cell Rep. 2014 May 08; 7(3):747-61. PMID: 24767994.
      Citations: 68     Fields:    Translation:HumansCells
    94. Brehm MA, Wiles MV, Greiner DL, Shultz LD. Generation of improved humanized mouse models for human infectious diseases. J Immunol Methods. 2014 Aug; 410:3-17. PMID: 24607601.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    95. Knoechel B, Roderick JE, Williamson KE, Zhu J, Lohr JG, Cotton MJ, Gillespie SM, Fernandez D, Ku M, Wang H, Piccioni F, Silver SJ, Jain M, Pearson D, Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A, Stegmaier K, Kung AL, Root DE, Bradner JE, Aster JC, Kelliher MA, Bernstein BE. An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nat Genet. 2014 Apr; 46(4):364-70. PMID: 24584072.
      Citations: 196     Fields:    Translation:HumansAnimalsCells
    96. Kochupurakkal NM, Kruger AJ, Tripathi S, Zhu B, Adams LT, Rainbow DB, Rossini A, Greiner DL, Sayegh MH, Wicker LS, Guleria I. Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes. PLoS One. 2014; 9(2):e89561. PMID: 24586872.
      Citations: 28     Fields:    Translation:AnimalsCells
    97. Roderick JE, Tesell J, Shultz LD, Brehm MA, Greiner DL, Harris MH, Silverman LB, Sallan SE, Gutierrez A, Look AT, Qi J, Bradner JE, Kelliher MA. c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood. 2014 Feb 13; 123(7):1040-50. PMID: 24394663.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    98. Jurczyk A, Diiorio P, Brostowin D, Leehy L, Yang C, Urano F, Harlan DM, Shultz LD, Greiner DL, Bortell R. Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2r?(null) mice treated with alogliptin. Diabetes Metab Syndr Obes. 2013; 6:493-9. PMID: 24376359.
      Citations:    
    99. Lee J, Brehm MA, Greiner D, Shultz LD, Kornfeld H. Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice. BMC Immunol. 2013 Dec 07; 14:53. PMID: 24313934.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    100. Jain N, Miu B, Jiang JK, McKinstry KK, Prince A, Swain SL, Greiner DL, Thomas CJ, Sanderson MJ, Berg LJ, Kang J. CD28 and ITK signals regulate autoreactive T cell trafficking. Nat Med. 2013 Dec; 19(12):1632-7. PMID: 24270545.
      Citations: 24     Fields:    Translation:AnimalsCells
    101. Schleifman EB, McNeer NA, Jackson A, Yamtich J, Brehm MA, Shultz LD, Greiner DL, Kumar P, Saltzman WM, Glazer PM. Site-specific Genome Editing in PBMCs With PLGA Nanoparticle-delivered PNAs Confers HIV-1 Resistance in Humanized Mice. Mol Ther Nucleic Acids. 2013 Nov 19; 2:e135. PMID: 24253260.
      Citations:    
    102. Brehm MA, Shultz LD, Luban J, Greiner DL. Overcoming current limitations in humanized mouse research. J Infect Dis. 2013 Nov; 208 Suppl 2:S125-30. PMID: 24151318.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    103. Yang C, Jurczyk A, diIorio P, Norowski E, Brehm MA, Grant CW, Guberski DL, Greiner DL, Bortell R. Salicylate prevents virus-induced type 1 diabetes in the BBDR rat. PLoS One. 2013; 8(10):e78050. PMID: 24147110.
      Citations: 6     Fields:    Translation:AnimalsCells
    104. Dou S, Wang Y, Barton B, Chen L, Rusckowski M, Shultz LD, Greiner DL, Liu G. Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach. Nucl Med Biol. 2014 Jan; 41(1):127-31. PMID: 24210286.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    105. Brehm MA, Jouvet N, Greiner DL, Shultz LD. Humanized mice for the study of infectious diseases. Curr Opin Immunol. 2013 Aug; 25(4):428-35. PMID: 23751490.
      Citations: 38     Fields:    Translation:HumansAnimals
    106. Wheeler LA, Vrbanac V, Trifonova R, Brehm MA, Gilboa-Geffen A, Tanno S, Greiner DL, Luster AD, Tager AM, Lieberman J. Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther. 2013 Jul; 21(7):1378-89. PMID: 23629001.
      Citations: 35     Fields:    Translation:HumansAnimals
    107. Priyadharshini B, Thornley TB, Daniels KA, Cuthbert A, Welsh RM, Greiner DL, Brehm MA. Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death. Immunology. 2013 Apr; 138(4):322-32. PMID: 23190301.
      Citations: 5     Fields:    Translation:AnimalsCells
    108. Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM. GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med. 2013 Apr; 5(4):488-508. PMID: 23436775.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    109. Hickey RD, Galivo F, Schug J, Brehm MA, Haft A, Wang Y, Benedetti E, Gu G, Magnuson MA, Shultz LD, Lagasse E, Greiner DL, Kaestner KH, Grompe M. Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Res. 2013 Jul; 11(1):503-15. PMID: 23562832.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    110. Unger WW, Pearson T, Abreu JR, Laban S, van der Slik AR, der Kracht SM, Kester MG, Serreze DV, Shultz LD, Griffioen M, Drijfhout JW, Greiner DL, Roep BO. Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice. PLoS One. 2012; 7(11):e49213. PMID: 23155466.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    111. McNeer NA, Schleifman EB, Cuthbert A, Brehm M, Jackson A, Cheng C, Anandalingam K, Kumar P, Shultz LD, Greiner DL, Mark Saltzman W, Glazer PM. Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo. Gene Ther. 2013 Jun; 20(6):658-69. PMID: 23076379.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    112. Shultz LD, Brehm MA, Garcia-Martinez JV, Greiner DL. Humanized mice for immune system investigation: progress, promise and challenges. Nat Rev Immunol. 2012 Nov; 12(11):786-98. PMID: 23059428.
      Citations: 465     Fields:    Translation:HumansAnimals
    113. Oslowski CM, Hara T, O'Sullivan-Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Zhu LJ, Hayashi E, Hui ST, Greiner D, Kaufman RJ, Bortell R, Urano F. Thioredoxin-interacting protein mediates ER stress-induced ? cell death through initiation of the inflammasome. Cell Metab. 2012 Aug 08; 16(2):265-73. PMID: 22883234.
      Citations: 311     Fields:    Translation:HumansAnimalsCells
    114. H?bner A, Mulholland DJ, Standen CL, Karasarides M, Cavanagh-Kyros J, Barrett T, Chi H, Greiner DL, Tournier C, Sawyers CL, Flavell RA, Wu H, Davis RJ. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12046-51. PMID: 22753496.
      Citations: 52     Fields:    Translation:AnimalsCells
    115. Jaiswal S, Pazoles P, Woda M, Shultz LD, Greiner DL, Brehm MA, Mathew A. Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice. Immunology. 2012 Jul; 136(3):334-43. PMID: 22384859.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    116. Brehm MA, Powers AC, Shultz LD, Greiner DL. Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice. Cold Spring Harb Perspect Med. 2012 May; 2(5):a007757. PMID: 22553498.
      Citations: 24     Fields:    Translation:HumansAnimals
    117. Abe Y, Aberle C, Akiri T, dos Anjos JC, Ardellier F, Barbosa AF, Baxter A, Bergevin M, Bernstein A, Bezerra TJ, Bezrukhov L, Blucher E, Bongrand M, Bowden NS, Buck C, Busenitz J, Cabrera A, Caden E, Camilleri L, Carr R, Cerrada M, Chang PJ, Chimenti P, Classen T, Collin AP, Conover E, Conrad JM, Cormon S, Crespo-Anad?n JI, Cribier M, Crum K, Cucoanes A, D'Agostino MV, Damon E, Dawson JV, Dazeley S, Dierckxsens M, Dietrich D, Djurcic Z, Dracos M, Durand V, Efremenko Y, Elnimr M, Endo Y, Etenko A, Falk E, Fallot M, Fechner M, von Feilitzsch F, Felde J, Fernandes SM, Franco D, Franke AJ, Franke M, Furuta H, Gama R, Gil-Botella I, Giot L, G?ger-Neff M, Gonzalez LF, Goodman MC, Goon JT, Greiner D, Guillon B, Haag N, Hagner C, Hara T, Hartmann FX, Hartnell J, Haruna T, Haser J, Hatzikoutelis A, Hayakawa T, Hofmann M, Horton-Smith GA, Ishitsuka M, Jochum J, Jollet C, Jones CL, Kaether F, Kalousis L, Kamyshkov Y, Kaplan DM, Kawasaki T, Keefer G, Kemp E, de Kerret H, Kibe Y, Konno T, Kryn D, Kuze M, Lachenmaier T, Lane CE, Langbrandtner C, Lasserre T, Letourneau A, Lhuillier D, Lima HP, Lindner M, Liu Y, L?pez-Castan? JM, LoSecco JM, Lubsandorzhiev BK, Lucht S, McKee D, Maeda J, Maesano CN, Mariani C, Maricic J, Martino J, Matsubara T, Mention G, Meregaglia A, Miletic T, Milincic R, Milzstajn A, Miyata H, Motta D, Mueller TA, Nagasaka Y, Nakajima K, Novella P, Obolensky M, Oberauer L, Onillon A, Osborn A, Ostrovskiy I, Palomares C, Peeters SJ, Pepe IM, Perasso S, Perrin P, Pfahler P, Porta A, Potzel W, Queval R, Reichenbacher J, Reinhold B, Remoto A, Reyna D, R?hling M, Roth S, Rubin HA, Sakamoto Y, Santorelli R, Sato F, Sch?nert S, Schoppmann S, Schwan U, Schwetz T, Shaevitz MH, Shrestha D, Sida JL, Sinev V, Skorokhvatov M, Smith E, Spitz J, Stahl A, Stancu I, Strait M, St?ken A, Suekane F, Sukhotin S, Sumiyoshi T, Sun Y, Sun Z, Svoboda R, Tabata H, Tamura N, Terao K, Tonazzo A, Toups M, Trinh Thi HH, Veyssiere C, Wagner S, Watanabe H, White B, Wiebusch C, Winslow L, Worcester M, Wurm M, Yanovitch E, Yermia F, Zbiri K, Zimmer V. Indication of reactor ?(e) disappearance in the Double Chooz experiment. Phys Rev Lett. 2012 Mar 30; 108(13):131801. PMID: 22540693.
      Citations: 4     Fields:    
    118. Liu Z, Cort L, Eberwine R, Herrmann T, Leif JH, Greiner DL, Yahalom B, Blankenhorn EP, Mordes JP. Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: V?13 as a therapeutic target and biomarker. Diabetes. 2012 May; 61(5):1160-8. PMID: 22368175.
      Citations: 18     Fields:    Translation:AnimalsCells
    119. Liu G, Dou S, Akalin A, Rusckowski M, Streeter PR, Shultz LD, Greiner DL. Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody. Nucl Med Biol. 2012 Jul; 39(5):645-51. PMID: 22316614.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    120. Brehm MA, Racki WJ, Leif J, Burzenski L, Hosur V, Wetmore A, Gott B, Herlihy M, Ignotz R, Dunn R, Shultz LD, Greiner DL. Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF. Blood. 2012 Mar 22; 119(12):2778-88. PMID: 22246028.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    121. Shultz LD, Brehm MA, Bavari S, Greiner DL. Humanized mice as a preclinical tool for infectious disease and biomedical research. Ann N Y Acad Sci. 2011 Dec; 1245:50-4. PMID: 22211979.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    122. Greiner DL, Brehm MA, Hosur V, Harlan DM, Powers AC, Shultz LD. Humanized mice for the study of type 1 and type 2 diabetes. Ann N Y Acad Sci. 2011 Dec; 1245:55-8. PMID: 22211980.
      Citations: 22     Fields:    Translation:HumansAnimals
    123. Priyadharshini B, Greiner DL, Brehm MA. T-cell activation and transplantation tolerance. Transplant Rev (Orlando). 2012 Jul; 26(3):212-22. PMID: 22074786.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    124. Medarova Z, Greiner DL, Ifediba M, Dai G, Bolotin E, Castillo G, Bogdanov A, Kumar M, Moore A. Imaging the pancreatic vasculature in diabetes models. Diabetes Metab Res Rev. 2011 Nov; 27(8):767-72. PMID: 22069257.
      Citations: 7     Fields:    Translation:Animals
    125. Diiorio P, Jurczyk A, Yang C, Racki WJ, Brehm MA, Atkinson MA, Powers AC, Shultz LD, Greiner DL, Bortell R. Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice. Pancreas. 2011 Oct; 40(7):1147-9. PMID: 21926555.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    126. Schleifman EB, Bindra R, Leif J, del Campo J, Rogers FA, Uchil P, Kutsch O, Shultz LD, Kumar P, Greiner DL, Glazer PM. Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids. Chem Biol. 2011 Sep 23; 18(9):1189-98. PMID: 21944757.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    127. Dorrell C, Grompe MT, Pan FC, Zhong Y, Canaday PS, Shultz LD, Greiner DL, Wright CV, Streeter PR, Grompe M. Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol Cell Endocrinol. 2011 Jun 06; 339(1-2):144-50. PMID: 21539888.
      Citations: 29     Fields:    Translation:AnimalsCells
    128. Liu G, Dou S, Cheng D, Leif J, Rusckowski M, Streeter PR, Shultz LD, Hnatowich DJ, Greiner DL. Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model. Mol Pharm. 2011 Jun 06; 8(3):767-73. PMID: 21361360.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    129. Das M, Garlick DS, Greiner DL, Davis RJ. The role of JNK in the development of hepatocellular carcinoma. Genes Dev. 2011 Mar 15; 25(6):634-45. PMID: 21406557.
      Citations: 103     Fields:    Translation:AnimalsCells
    130. Wigglesworth KM, Racki WJ, Mishra R, Szomolanyi-Tsuda E, Greiner DL, Galili U. Rapid recruitment and activation of macrophages by anti-Gal/a-Gal liposome interaction accelerates wound healing. J Immunol. 2011 Apr 01; 186(7):4422-32. PMID: 21357545.
      Citations: 26     Fields:    Translation:AnimalsCells
    131. Niens M, Grier AE, Marron M, Kay TW, Greiner DL, Serreze DV. Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach. Diabetes. 2011 Apr; 60(4):1229-36. PMID: 21346176.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    132. Priyadharshini B, Welsh RM, Greiner DL, Gerstein RM, Brehm MA. Maturation-dependent licensing of naive T cells for rapid TNF production. PLoS One. 2010 Nov 24; 5(11):e15038. PMID: 21124839.
      Citations: 29     Fields:    Translation:AnimalsCells
    133. Kruger AJ, Yang C, Tam SW, Hinerfeld D, Evans JE, Green KM, Leszyk J, Yang K, Guberski DL, Mordes JP, Greiner DL, Rossini AA, Bortell R. Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats. Exp Biol Med (Maywood). 2010 Nov; 235(11):1328-37. PMID: 20975081.
      Citations: 10     Fields:    Translation:AnimalsCells
    134. Liu G, Dou S, Liu Y, Liang M, Chen L, Cheng D, Greiner D, Rusckowski M, Hnatowich DJ. Unexpected side products in the conjugation of an amine-derivatized morpholino oligomer with p-isothiocyanate benzyl DTPA and their removal. Nucl Med Biol. 2011 Feb; 38(2):159-63. PMID: 21315270.
      Citations: 2     Fields:    Translation:AnimalsCells
    135. Jurczyk A, Roy N, Bajwa R, Gut P, Lipson K, Yang C, Covassin L, Racki WJ, Rossini AA, Phillips N, Stainier DY, Greiner DL, Brehm MA, Bortell R, diIorio P. Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish. Gen Comp Endocrinol. 2011 Jan 15; 170(2):334-45. PMID: 20965191.
      Citations: 50     Fields:    Translation:AnimalsCells
    136. Przyklenk K, Maynard M, Greiner DL, Whittaker P. Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes. Antioxid Redox Signal. 2011 Mar 01; 14(5):781-90. PMID: 20578962.
      Citations: 59     Fields:    Translation:Animals
    137. Libby SJ, Brehm MA, Greiner DL, Shultz LD, McClelland M, Smith KD, Cookson BT, Karlinsey JE, Kinkel TL, Porwollik S, Canals R, Cummings LA, Fang FC. Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15589-94. PMID: 20713716.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    138. Kruger AJ, Yang C, Lipson KL, Pino SC, Leif JH, Hogan CM, Whalen BJ, Guberski DL, Lee Y, Unger RH, Greiner DL, Rossini AA, Bortell R. Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats. Autoimmunity. 2011 Mar; 44(2):137-48. PMID: 20695765.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    139. Brehm MA, Daniels KA, Priyadharshini B, Thornley TB, Greiner DL, Rossini AA, Welsh RM. Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity. Am J Transplant. 2010 Aug; 10(8):1738-48. PMID: 20659086.
      Citations: 20     Fields:    Translation:AnimalsCells
    140. Jurczyk A, Pino SC, O'Sullivan-Murphy B, Addorio M, Lidstone EA, Diiorio P, Lipson KL, Standley C, Fogarty K, Lifshitz L, Urano F, Mordes JP, Greiner DL, Rossini AA, Bortell R. A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells. PLoS One. 2010 Jul 27; 5(7):e11812. PMID: 20676397.
      Citations: 12     Fields:    Translation:AnimalsCells
    141. Brehm MA, Bortell R, Diiorio P, Leif J, Laning J, Cuthbert A, Yang C, Herlihy M, Burzenski L, Gott B, Foreman O, Powers AC, Greiner DL, Shultz LD. Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice. Diabetes. 2010 Sep; 59(9):2265-70. PMID: 20570944.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    142. Brehm MA, Shultz LD, Greiner DL. Humanized mouse models to study human diseases. Curr Opin Endocrinol Diabetes Obes. 2010 Apr; 17(2):120-5. PMID: 20150806.
      Citations: 88     Fields:    Translation:HumansAnimals
    143. Racki WJ, Covassin L, Brehm M, Pino S, Ignotz R, Dunn R, Laning J, Graves SK, Rossini AA, Shultz LD, Greiner DL. NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection. Transplantation. 2010 Mar 15; 89(5):527-36. PMID: 20134397.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    144. Liu G, Dou S, Rusckowski M, Greiner D, Hnatowich D. Preparation of (111)In-DTPA morpholino oligomer for low abdominal accumulation. Appl Radiat Isot. 2010 Sep; 68(9):1709-14. PMID: 20359901.
      Citations: 3     Fields:    Translation:HumansAnimals
    145. Brehm MA, Cuthbert A, Yang C, Miller DM, DiIorio P, Laning J, Burzenski L, Gott B, Foreman O, Kavirayani A, Herlihy M, Rossini AA, Shultz LD, Greiner DL. Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin Immunol. 2010 Apr; 135(1):84-98. PMID: 20096637.
      Citations: 143     Fields:    Translation:HumansAnimalsCells
    146. Pino S, Brehm MA, Covassin-Barberis L, King M, Gott B, Chase TH, Wagner J, Burzenski L, Foreman O, Greiner DL, Shultz LD. Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease. Methods Mol Biol. 2010; 602:105-17. PMID: 20012395.
      Citations: 23     Fields:    Translation:HumansAnimals
    147. Subramanya S, Kim SS, Abraham S, Yao J, Kumar M, Kumar P, Haridas V, Lee SK, Shultz LD, Greiner D, N M, Shankar P. Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production. J Virol. 2010 Mar; 84(5):2490-501. PMID: 20015996.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    148. Ishigaki S, Fonseca SG, Oslowski CM, Jurczyk A, Shearstone JR, Zhu LJ, Permutt MA, Greiner DL, Bortell R, Urano F. AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1. Cell Death Differ. 2010 May; 17(5):774-86. PMID: 19911006.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    149. Jaiswal S, Pearson T, Friberg H, Shultz LD, Greiner DL, Rothman AL, Mathew A. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One. 2009 Oct 05; 4(10):e7251. PMID: 19802382.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    150. Tirabassi RS, Guberski DL, Blankenhorn EP, Leif JH, Woda BA, Liu Z, Winans D, Greiner DL, Mordes JP. Infection with viruses from several families triggers autoimmune diabetes in LEW*1WR1 rats: prevention of diabetes by maternal immunization. Diabetes. 2010 Jan; 59(1):110-8. PMID: 19794063.
      Citations: 22     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    151. Blankenhorn EP, Cort L, Greiner DL, Guberski DL, Mordes JP. Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex. Diabetes. 2009 Dec; 58(12):2930-8. PMID: 19720792.
      Citations: 13     Fields:    Translation:AnimalsCells
    152. King MA, Covassin L, Brehm MA, Racki W, Pearson T, Leif J, Laning J, Fodor W, Foreman O, Burzenski L, Chase TH, Gott B, Rossini AA, Bortell R, Shultz LD, Greiner DL. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol. 2009 Jul; 157(1):104-18. PMID: 19659776.
      Citations: 189     Fields:    Translation:HumansAnimalsCells
    153. Pino SC, O'Sullivan-Murphy B, Lidstone EA, Yang C, Lipson KL, Jurczyk A, diIorio P, Brehm MA, Mordes JP, Greiner DL, Rossini AA, Bortell R. CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. PLoS One. 2009; 4(5):e5468. PMID: 19424493.
      Citations: 19     Fields:    Translation:AnimalsCells
    154. Miller DM, Thornley TB, Pearson T, Kruger AJ, Yamazaki M, Shultz LD, Welsh RM, Brehm MA, Rossini AA, Greiner DL. TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade. J Immunol. 2009 May 01; 182(9):5547-59. PMID: 19380803.
      Citations: 6     Fields:    Translation:AnimalsCells
    155. Chopra P, Diiorio P, Pino SC, Wilson SB, Phillips NE, Mordes JP, Rossini AA, Greiner DL, Shultz LD, Bortell R. Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat. In Vivo. 2009 Mar-Apr; 23(2):195-201. PMID: 19414403.
      Citations: 4     Fields:    Translation:AnimalsCells
    156. Bishop KD, Harris JE, Mordes JP, Greiner DL, Rossini AA, Czech MP, Phillips NE. Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism. Cell Immunol. 2009; 256(1-2):86-91. PMID: 19230866.
      Citations: 11     Fields:    Translation:AnimalsCells
    157. Mordes JP, Cort L, Norowski E, Leif J, Fuller JM, Lernmark A, Greiner DL, Blankenhorn EP. Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus. Mamm Genome. 2009 Mar; 20(3):162-9. PMID: 19205800.
      Citations: 20     Fields:    Translation:HumansAnimals
    158. Miller DM, Thornley T, Pearson T, Yamazaki M, Brehm MA, Rossini AA, Greiner DL. TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance. Ann N Y Acad Sci. 2008 Dec; 1150:149-51. PMID: 19120285.
      Citations: 2     Fields:    Translation:AnimalsCells
    159. Bortell R, Pino SC, Greiner DL, Zipris D, Rossini AA. Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes. Ann N Y Acad Sci. 2008 Dec; 1150:112-22. PMID: 19120279.
      Citations: 8     Fields:    Translation:HumansAnimals
    160. King M, Pearson T, Rossini AA, Shultz LD, Greiner DL. Humanized mice for the study of type 1 diabetes and beta cell function. Ann N Y Acad Sci. 2008 Dec; 1150:46-53. PMID: 19120266.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    161. Mangada J, Pearson T, Brehm MA, Wicker LS, Peterson LB, Shultz LD, Serreze DV, Rossini AA, Greiner DL. Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. Diabetes. 2009 Jan; 58(1):165-73. PMID: 18984741.
      Citations: 5     Fields:    Translation:AnimalsCells
    162. Schmidt MR, Appel MC, Giassi LJ, Greiner DL, Shultz LD, Woodland RT. Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice. PLoS One. 2008 Sep 11; 3(9):e3192. PMID: 18784835.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    163. Pearson T, Shultz LD, Miller D, King M, Laning J, Fodor W, Cuthbert A, Burzenski L, Gott B, Lyons B, Foreman O, Rossini AA, Greiner DL. Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin Exp Immunol. 2008 Nov; 154(2):270-84. PMID: 18785974.
      Citations: 111     Fields:    Translation:HumansAnimals
    164. Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL, Laouar A, Yao J, Haridas V, Habiro K, Yang YG, Jeong JH, Lee KY, Kim YH, Kim SW, Peipp M, Fey GH, Manjunath N, Shultz LD, Lee SK, Shankar P. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell. 2008 Aug 22; 134(4):577-86. PMID: 18691745.
      Citations: 244     Fields:    Translation:HumansAnimalsCells
    165. Giassi LJ, Pearson T, Shultz LD, Laning J, Biber K, Kraus M, Woda BA, Schmidt MR, Woodland RT, Rossini AA, Greiner DL. Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice. Exp Biol Med (Maywood). 2008 Aug; 233(8):997-1012. PMID: 18653783.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    166. Pearson T, Shultz LD, Lief J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL. A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia. 2008 Aug; 51(8):1449-56. PMID: 18563383.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    167. Pearson T, Greiner DL, Shultz LD. Creation of "humanized" mice to study human immunity. Curr Protoc Immunol. 2008 May; Chapter 15:15.21.1-15.21.21. PMID: 18491294.
      Citations: 109     Fields:    Translation:HumansAnimals
    168. Pino SC, O'Sullivan-Murphy B, Lidstone EA, Thornley TB, Jurczyk A, Urano F, Greiner DL, Mordes JP, Rossini AA, Bortell R. Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response. Cell Stress Chaperones. 2008 Dec; 13(4):421-34. PMID: 18418732.
      Citations: 18     Fields:    Translation:AnimalsCells
    169. Miller DM, Thornley TB, Greiner DL, Rossini AA. Viral infection: a potent barrier to transplantation tolerance. Clin Dev Immunol. 2008; 2008:742810. PMID: 18815618.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    170. Pearson T, Greiner DL, Shultz LD. Humanized SCID mouse models for biomedical research. Curr Top Microbiol Immunol. 2008; 324:25-51. PMID: 18481451.
      Citations: 55     Fields:    Translation:HumansAnimals
    171. Miller DM, Rossini AA, Greiner DL. Role of innate immunity in transplantation tolerance. Crit Rev Immunol. 2008; 28(5):403-39. PMID: 19166387.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    172. King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol. 2008 Mar; 126(3):303-14. PMID: 18096436.
      Citations: 109     Fields:    Translation:HumansAnimalsCells
    173. Thornley TB, Phillips NE, Beaudette-Zlatanova BC, Markees TG, Bahl K, Brehm MA, Shultz LD, Kurt-Jones EA, Mordes JP, Welsh RM, Rossini AA, Greiner DL. Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance. J Immunol. 2007 Nov 15; 179(10):6620-9. PMID: 17982052.
      Citations: 40     Fields:    Translation:AnimalsCells
    174. Dash Y, Ramesh M, Greiner D, Shultz LD, Klei TR, Rajan TV. Determinants of memory in experimental filarial infections in mice. Parasite Immunol. 2007 Nov; 29(11):567-74. PMID: 17944746.
      Citations: 1     Fields:    Translation:AnimalsCells
    175. Izawa A, Yamaura K, Albin MJ, Jurewicz M, Tanaka K, Clarkson MR, Ueno T, Habicht A, Freeman GJ, Yagita H, Abdi R, Pearson T, Greiner DL, Sayegh MH, Najafian N. A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo. J Immunol. 2007 Jul 15; 179(2):786-96. PMID: 17617568.
      Citations: 21     Fields:    Translation:AnimalsCells
    176. Yamazaki M, Pearson T, Brehm MA, Miller DM, Mangada JA, Markees TG, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice. Am J Transplant. 2007 Jul; 7(7):1710-21. PMID: 17564635.
      Citations: 10     Fields:    Translation:AnimalsCells
    177. Martens GW, Arikan MC, Lee J, Ren F, Greiner D, Kornfeld H. Tuberculosis susceptibility of diabetic mice. Am J Respir Cell Mol Biol. 2007 Nov; 37(5):518-24. PMID: 17585110.
      Citations: 90     Fields:    Translation:AnimalsCells
    178. Rossini AA, Greiner DL. Diabetes research in jeopardy: the extinction of clinical diabetes researchers. Ann N Y Acad Sci. 2007 Apr; 1103:33-44. PMID: 17376823.
      Citations: 1     Fields:    Translation:Humans
    179. Blankenhorn EP, Descipio C, Rodemich L, Cort L, Leif JH, Greiner DL, Mordes JP. Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene. Ann N Y Acad Sci. 2007 Apr; 1103:128-31. PMID: 17376830.
      Citations: 8     Fields:    Translation:AnimalsCells
    180. King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson M, Wasserfall C, Herold K, Mordes JP, Rossini AA, Greiner DL. Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity. Ann N Y Acad Sci. 2007 Apr; 1103:90-3. PMID: 17376822.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    181. Shultz LD, Pearson T, King M, Giassi L, Carney L, Gott B, Lyons B, Rossini AA, Greiner DL. Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research. Ann N Y Acad Sci. 2007 Apr; 1103:77-89. PMID: 17332083.
      Citations: 36     Fields:    Translation:HumansAnimals
    182. Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nat Rev Immunol. 2007 Feb; 7(2):118-30. PMID: 17259968.
      Citations: 654     Fields:    Translation:HumansAnimals
    183. Zipris D, Lien E, Nair A, Xie JX, Greiner DL, Mordes JP, Rossini AA. TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat. J Immunol. 2007 Jan 15; 178(2):693-701. PMID: 17202329.
      Citations: 43     Fields:    Translation:AnimalsCells
    184. Hillebrands JL, Whalen B, Visser JT, Koning J, Bishop KD, Leif J, Rozing J, Mordes JP, Greiner DL, Rossini AA. A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3. J Immunol. 2006 Dec 01; 177(11):7820-32. PMID: 17114453.
      Citations: 17     Fields:    Translation:AnimalsCells
    185. Serreze DV, Osborne MA, Chen YG, Chapman HD, Pearson T, Brehm MA, Greiner DL. Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression. J Immunol. 2006 Nov 15; 177(10):6675-84. PMID: 17082580.
      Citations: 10     Fields:    Translation:AnimalsCells
    186. Phillips NE, Greiner DL, Mordes JP, Rossini AA. Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation. Transplantation. 2006 Oct 27; 82(8):1085-92. PMID: 17060858.
      Citations: 3     Fields:    Translation:AnimalsCells
    187. Brehm MA, Mangada J, Markees TG, Pearson T, Daniels KA, Thornley TB, Welsh RM, Rossini AA, Greiner DL. Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice. Blood. 2007 Jan 15; 109(2):819-26. PMID: 16973964.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    188. Morrison AR, Moss J, Stevens LA, Evans JE, Farrell C, Merithew E, Lambright DG, Greiner DL, Mordes JP, Rossini AA, Bortell R. ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose). J Biol Chem. 2006 Nov 03; 281(44):33363-72. PMID: 16931513.
      Citations: 12     Fields:    Translation:AnimalsCells
    189. Masaki H, Appel MC, Leahy L, Leif J, Paquin L, Shultz LD, Mordes JP, Greiner DL, Rossini AA. Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice. Xenotransplantation. 2006 May; 13(3):224-32. PMID: 16756565.
      Citations:    Fields:    Translation:Animals
    190. Beaudette-Zlatanova BC, Whalen B, Zipris D, Yagita H, Rozing J, Groen H, Benjamin CD, Hunig T, Drexhage HA, Ansari MJ, Leif J, Mordes JP, Greiner DL, Sayegh MH, Rossini AA. Costimulation and autoimmune diabetes in BB rats. Am J Transplant. 2006 May; 6(5 Pt 1):894-902. PMID: 16611325.
      Citations: 3     Fields:    Translation:Animals
    191. Thornley TB, Brehm MA, Markees TG, Shultz LD, Mordes JP, Welsh RM, Rossini AA, Greiner DL. TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts. J Immunol. 2006 Feb 01; 176(3):1561-70. PMID: 16424185.
      Citations: 60     Fields:    Translation:AnimalsCells
    192. Mordes JP, Guberski DL, Leif JH, Woda BA, Flanagan JF, Greiner DL, Kislauskis EH, Tirabassi RS. LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation. Diabetes. 2005 Sep; 54(9):2727-33. PMID: 16123363.
      Citations: 23     Fields:    Translation:Animals
    193. Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S, Kotb M, Gillies SD, King M, Mangada J, Greiner DL, Handgretinger R. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol. 2005 May 15; 174(10):6477-89. PMID: 15879151.
      Citations: 867     Fields:    Translation:HumansAnimalsCells
    194. Jaeschke A, Rinc?n M, Doran B, Reilly J, Neuberg D, Greiner DL, Shultz LD, Rossini AA, Flavell RA, Davis RJ. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6931-5. PMID: 15867147.
      Citations: 27     Fields:    Translation:AnimalsCells
    195. Blankenhorn EP, Rodemich L, Martin-Fernandez C, Leif J, Greiner DL, Mordes JP. The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. Diabetes. 2005 Apr; 54(4):1233-7. PMID: 15793267.
      Citations: 15     Fields:    Translation:AnimalsCells
    196. Gordon EJ, Wicker LS, Peterson LB, Serreze DV, Markees TG, Shultz LD, Rossini AA, Greiner DL, Mordes JP. Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice. Diabetes. 2005 Jan; 54(1):107-15. PMID: 15616017.
      Citations: 6     Fields:    Translation:Animals
    197. Zipris D, Lien E, Xie JX, Greiner DL, Mordes JP, Rossini AA. TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats. J Immunol. 2005 Jan 01; 174(1):131-42. PMID: 15611235.
      Citations: 48     Fields:    Translation:AnimalsCells
    198. Markees TG, Pearson T, Cuthbert A, Pearson AL, Shultz LD, Leif J, Phillips NE, Mordes JP, Greiner DL, Rossini AA. Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody. Transplantation. 2004 Dec 15; 78(11):1601-8. PMID: 15591948.
      Citations: 4     Fields:    Translation:AnimalsCells
    199. Harris JE, Bishop KD, Phillips NE, Mordes JP, Greiner DL, Rossini AA, Czech MP. Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells. J Immunol. 2004 Dec 15; 173(12):7331-8. PMID: 15585857.
      Citations: 60     Fields:    Translation:AnimalsCells
    200. Banuelos SJ, Markees TG, Phillips NE, Appel MC, Cuthbert A, Leif J, Mordes JP, Shultz LD, Rossini AA, Greiner DL. Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms. Transplantation. 2004 Sep 15; 78(5):660-7. PMID: 15371665.
      Citations: 15     Fields:    Translation:AnimalsCells
    201. Banuelos SJ, Shultz LD, Greiner DL, Burzenski LM, Gott B, Lyons BL, Rossini AA, Appel MC. Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice. Clin Immunol. 2004 Sep; 112(3):273-83. PMID: 15308121.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    202. Pearson T, Weiser P, Markees TG, Serreze DV, Wicker LS, Peterson LB, Cumisky AM, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3. Diabetes. 2004 Aug; 53(8):1972-8. PMID: 15277375.
      Citations: 10     Fields:    Translation:Animals
    203. Appel MC, Banuelos SJ, Greiner DL, Shultz LD, Mordes JP, Rossini AA. Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody. Transplantation. 2004 May 15; 77(9):1341-9. PMID: 15167588.
      Citations: 3     Fields:    Translation:Animals
    204. Todd DJ, Forsberg EM, Greiner DL, Mordes JP, Rossini AA, Bortell R. Deficiencies in gut NK cell number and function precede diabetes onset in BB rats. J Immunol. 2004 May 01; 172(9):5356-62. PMID: 15100275.
      Citations: 9     Fields:    Translation:AnimalsCells
    205. Hornum L, DeScipio C, Markholst H, Troutman SA, Novak S, Leif J, Greiner D, Mordes JP, Blankenhorn EP. Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6. Mamm Genome. 2004 Jan; 15(1):53-61. PMID: 14727142.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    206. Mordes JP, Bortell R, Blankenhorn EP, Rossini AA, Greiner DL. Rat models of type 1 diabetes: genetics, environment, and autoimmunity. ILAR J. 2004; 45(3):278-91. PMID: 15229375.
      Citations: 74     Fields:    Translation:Animals
    207. Bigazzi PE, Kosuda LL, Hannigan MO, Whalen B, Greiner DL. Lack of graft-versus-host-like pathology in mercury-induced autoimmunity of Brown Norway rats. Clin Immunol. 2003 Nov; 109(2):229-37. PMID: 14597222.
      Citations:    Fields:    Translation:Animals
    208. Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms? Ann N Y Acad Sci. 2003 Nov; 1005:148-56. PMID: 14679049.
      Citations: 11     Fields:    Translation:Animals
    209. Shultz LD, Banuelos S, Lyons B, Samuels R, Burzenski L, Gott B, Lang P, Leif J, Appel M, Rossini A, Greiner DL. NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment. Transplantation. 2003 Oct 15; 76(7):1036-42. PMID: 14557749.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    210. Turgeon NA, Banuelos SJ, Shultz LD, Lyons BL, Iwakoshi N, Greiner DL, Mordes JP, Rossini AA, Appel MC. Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice. Exp Biol Med (Maywood). 2003 Oct; 228(9):1096-104. PMID: 14530522.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    211. Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice. Rev Endocr Metab Disord. 2003 Sep; 4(3):255-61. PMID: 14501176.
      Citations: 2     Fields:    Translation:HumansAnimals
    212. Seung E, Mordes JP, Rossini AA, Greiner DL. Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning. J Clin Invest. 2003 Sep; 112(5):795-808. PMID: 12952928.
      Citations: 25     Fields:    Translation:Animals
    213. Pandarpurkar M, Wilson-Fritch L, Corvera S, Markholst H, Hornum L, Greiner DL, Mordes JP, Rossini AA, Bortell R. Ian4 is required for mitochondrial integrity and T cell survival. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10382-7. PMID: 12930893.
      Citations: 35     Fields:    Translation:AnimalsCells
    214. Seung E, Mordes JP, Greiner DL, Rossini AA. Induction of tolerance for islet transplantation for type 1 diabetes. Curr Diab Rep. 2003 Aug; 3(4):329-35. PMID: 12866997.
      Citations: 3     Fields:    Translation:HumansAnimals
    215. Pearson T, Markees TG, Serreze DV, Pierce MA, Marron MP, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol. 2003 Jul 01; 171(1):185-95. PMID: 12816997.
      Citations: 31     Fields:    Translation:AnimalsCells
    216. Shultz LD, Banuelos SJ, Leif J, Appel MC, Cunningham M, Ballen K, Burzenski L, Greiner DL. Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells. Exp Hematol. 2003 Jun; 31(6):551-8. PMID: 12829032.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    217. Brehm MA, Markees TG, Daniels KA, Greiner DL, Rossini AA, Welsh RM. Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections. J Immunol. 2003 Apr 15; 170(8):4077-86. PMID: 12682237.
      Citations: 63     Fields:    Translation:AnimalsCells
    218. Zipris D, Hillebrands JL, Welsh RM, Rozing J, Xie JX, Mordes JP, Greiner DL, Rossini AA. Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations. J Immunol. 2003 Apr 01; 170(7):3592-602. PMID: 12646622.
      Citations: 24     Fields:    Translation:AnimalsCells
    219. Phillips NE, Markees TG, Mordes JP, Greiner DL, Rossini AA. Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance. J Immunol. 2003 Mar 15; 170(6):3015-23. PMID: 12626555.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    220. Whalen BJ, Marounek J, Mordes JP, Rossini AA, Greiner DL. Type 1 cytokines polarize thymocytes during T cell development in adult thymus organ cultures. J Autoimmun. 2003 Feb; 20(1):27-42. PMID: 12604310.
      Citations: 1     Fields:    Translation:AnimalsCells
    221. Pearson T, Markees TG, Wicker LS, Serreze DV, Peterson LB, Mordes JP, Rossini AA, Greiner DL. NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction. Diabetes. 2003 Feb; 52(2):321-6. PMID: 12540603.
      Citations: 27     Fields:    Translation:Animals
    222. Mordes JP, Leif J, Novak S, DeScipio C, Greiner DL, Blankenhorn EP. The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats. Diabetes. 2002 Nov; 51(11):3254-62. PMID: 12401717.
      Citations: 14     Fields:    Translation:Animals
    223. Waegell W, Babineau M, Hart M, Dixon K, McRae B, Wallace C, Leach M, Ratnofsky S, Belanger A, Hirst G, Rossini A, Appel M, Mordes J, Greiner D, Banerjee S. A420983, a novel, small molecule inhibitor of LCK prevents allograft rejection. Transplant Proc. 2002 Aug; 34(5):1411-7. PMID: 12176420.
      Citations: 2     Fields:    Translation:AnimalsCells
    224. Forman D, Welsh RM, Markees TG, Woda BA, Mordes JP, Rossini AA, Greiner DL. Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms. J Immunol. 2002 Jun 15; 168(12):6047-56. PMID: 12055213.
      Citations: 15     Fields:    Translation:AnimalsCells
    225. Christianson SW, Greiner DL, Deluca D, Leif J, Phillips NE, Hayes SM, Hayashi S, Joliat MJ, Lyons BL, Shultz LD. T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7. J Autoimmun. 2002 Mar; 18(2):119-30. PMID: 11908944.
      Citations: 1     Fields:    Translation:AnimalsCells
    226. Adler C, Ahammed Z, Allgower C, Amonett J, Anderson BD, Anderson M, Averichev GS, Balewski J, Barannikova O, Barnby LS, Baudot J, Bekele S, Belaga VV, Bellwied R, Berger J, Bichsel H, Bland LC, Blyth CO, Bonner BE, Boucham A, Brandin A, Cadman RV, Caines H, Calder?n de la Barca S?nchez M, Cardenas A, Carroll J, Castillo J, Castro M, Cebra D, Chattopadhyay S, Chen ML, Chen Y, Chernenko SP, Cherney M, Chikanian A, Choi B, Christie W, Coffin JP, Cormier TM, Cramer JG, Crawford HJ, DeMello M, Deng WS, Derevschikov AA, Didenko L, Draper JE, Dunin VB, Dunlop JC, Eckardt V, Efimov LG, Emelianov V, Engelage J, Eppley G, Erazmus B, Fachini P, Faine V, Finch E, Fisyak Y, Flierl D, Foley KJ, Fu J, Gagunashvili N, Gans J, Gaudichet L, Germain M, Geurts F, Ghazikhanian V, Grabski J, Grachov O, Greiner D, Grigoriev V, Guedon M, Gushin E, Hallman TJ, Hardtke D, Harris JW, Heffner M, Heppelmann S, Herston T, Hippolyte B, Hirsch A, Hjort E, Hoffmann GW, Horsley M, Huang HZ, Humanic TJ, H?mmler H, Igo G, Ishihara A, Ivanshin YI, Jacobs P, Jacobs WW, Janik M, Johnson I, Jones PG, Judd E, Kaneta M, Kaplan M, Keane D, Kisiel A, Klay J, Klein SR, Klyachko A, Konstantinov AS, Kotchenda L, Kovalenko AD, Kramer M, Kravtsov P, Krueger K, Kuhn C, Kulikov AI, Kunde GJ, Kunz CL, Kutuev RK, Kuznetsov AA, Lakehal-Ayat L, Lamas-Valverde J, Lamont MA, Landgraf JM, Lange S, Lansdell CP, Lasiuk B, Laue F, Lebedev A, LeCompte T, Lednick? R, Leontiev VM, LeVine MJ, Li Q, Li Q, Lindenbaum SJ, Lisa MA, Ljubicic T, Llope WJ, LoCurto G, Long H, Longacre RS, Lopez-Noriega M, Love WA, Lynn D, Majka R, Margetis S, Martin L, Marx J, Matis HS, Matulenko YA, McShane TS, Meissner F, Melnick Y, Meschanin A, Messer M, Miller ML, Milosevich Z, Minaev NG, Mitchell J, Moiseenko VA, Moltz D, Moore CF, Morozov V, de Moura MM, Munhoz MG, Mutchler GS, Nelson JM, Nevski P, Nikitin VA, Nogach LV, Norman B, Nurushev SB, Odyniec G, Ogawa A, Okorokov V, Oldenburg M, Olson D, Paic G, Pandey SU, Panebratsev Y, Panitkin SY, Pavlinov AI, Pawlak T, Perevoztchikov V, Peryt W, Petrov VA, Platner E, Pluta J, Porile N, Porter J, Poskanzer AM, Potrebenikova E, Prindle D, Pruneau C, Radomski S, Rai G, Ravel O, Ray RL, Razin SV, Reichhold D, Reid JG, Retiere F, Ridiger A, Ritter HG, Roberts JB, Rogachevski OV, Romero JL, Roy C, Russ D, Rykov V, Sakrejda I, Sandweiss J, Saulys AC, Savin I, Schambach J, Scharenberg RP, Schmitz N, Schroeder LS, Sch?ttauf A, Schweda K, Seger J, Seliverstov D, Seyboth P, Shahaliev E, Shestermanov KE, Shimanskii SS, Shvetcov VS, Skoro G, Smirnov N, Snellings R, Sowinski J, Spinka HM, Srivastava B, Stephenson EJ, Stock R, Stolpovsky A, Strikhanov M, Stringfellow B, Struck C, Suaide AA, Sugarbaker E, Suire C, Sumbera M, Symons TJ, de Toledo AS, Szarwas P, Takahashi J, Tang AH, Thomas JH, Tikhomirov V, Trainor TA, Trentalange S, Tokarev M, Tonjes MB, Trofimov V, Tsai O, Turner K, Ullrich T, Underwood DG, Van Buren G, VanderMolen AM, Vanyashin A, Vasilevski IM, Vasiliev AN, Vigdor SE, Voloshin SA, Wang F, Ward H, Watson JW, Wells R, Wenaus T, Westfall GD, Whitten C, Wieman H, Willson R, Wissink SW, Witt R, Xu N, Xu Z, Yakutin AE, Yamamoto E, Yang J, Yepes P, Yokosawa A, Yurevich VI, Zanevski YV, Zborovsk? I, Zhang H, Zhang WM, Zoulkarneev R, Zubarev AN. d Macro and (3)He macro production in square root of s(NN) = 130 GeV Au+Au collisions. Phys Rev Lett. 2001 Dec 24; 87(26):262301. PMID: 11800829.
      Citations:    Fields:    
    227. Iwakoshi NN, Markees TG, Turgeon N, Thornley T, Cuthbert A, Leif J, Phillips NE, Mordes JP, Greiner DL, Rossini AA. Skin allograft maintenance in a new synchimeric model system of tolerance. J Immunol. 2001 Dec 01; 167(11):6623-30. PMID: 11714833.
      Citations: 22     Fields:    Translation:AnimalsCells
    228. Rossini AA, Mordes JP, Greiner DL, Stoff JS. Islet cell transplantation tolerance. Transplantation. 2001 Oct 27; 72(8 Suppl):S43-6. PMID: 11888156.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    229. Todd DJ, Greiner DL, Rossini AA, Mordes JP, Bortell R. An atypical population of NK cells that spontaneously secrete IFN-gamma and IL-4 is present in the intraepithelial lymphoid compartment of the rat. J Immunol. 2001 Oct 01; 167(7):3600-9. PMID: 11564772.
      Citations: 2     Fields:    Translation:AnimalsCells
    230. Adler C, Ahammed Z, Allgower C, Amonett J, Anderson BD, Anderson M, Averichev GS, Balewski J, Barannikova O, Barnby LS, Baudot J, Bekele S, Belaga VV, Bellwied R, Berger J, Bichsel H, Bland LC, Blyth CO, Bonner BE, Bossingham R, Boucham A, Brandin A, Caines H, Calder?n De La Barca S?nchez M, Cardenas A, Carroll J, Castillo J, Castro M, Cebra D, Chattopadhyay S, Chen ML, Chen Y, Chernenko SP, Cherney M, Chikanian A, Choi B, Christie W, Coffin JP, Conin L, Cormier TM, Cramer JG, Crawford HJ, DeMello M, Deng WS, Derevschikov AA, Didenko L, Draper JE, Dunin VB, Dunlop JC, Eckardt V, Efimov LG, Emelianov V, Engelage J, Eppley G, Erazmus B, Fachini P, Finch E, Fisyak Y, Flierl D, Foley KJ, Fu J, Gagunashvili N, Gans J, Gaudichet L, Germain M, Geurts F, Ghazikhanian V, Grabski J, Grachov O, Greiner D, Grigoriev V, Guedon M, Gushin E, Hallman TJ, Hardtke D, Harris JW, Heffner M, Heppelmann S, Herston T, Hippolyte B, Hirsch A, Hjort E, Hoffmann GW, Horsley M, Huang HZ, Humanic TJ, H?mmler H, Igo G, Ishihara A, Ivanshin YI, Jacobs P, Jacobs WW, Janik M, Johnson I, Jones PG, Judd E, Kaneta M, Kaplan M, Keane D, Kisiel A, Klay J, Klein SR, Klyachko A, Konstantinov AS, Kotchenda L, Kovalenko AD, Kramer M, Kravtsov P, Krueger K, Kuhn C, Kulikov AI, Kunde GJ, Kunz CL, Kutuev RK, Kuznetsov AA, Lakehal-Ayat L, Lamas-Valverde J, Lamont MA, Landgraf JM, Lange S, Lansdell CP, Lasiuk B, Laue F, Lebedev A, LeCompte T, Lednick? R, Leontiev VM, Leszczynski P, LeVine MJ, Li Q, Li Q, Lindenbaum SJ, Lisa MA, Ljubicic T, Llope WJ, LoCurto G, Long H, Longacre RS, Lopez-Noriega M, Love WA, Lynn D, Majka R, Maliszewski A, Margetis S, Martin L, Marx J, Matis HS, Matulenko YA, McShane TS, Meissner F, Melnick Y, Meschanin A, Messer M, Miller ML, Milosevich Z, Minaev NG, Mitchell J, Moiseenko VA, Moltz D, Moore CF, Morozov V, de Moura MM, Munhoz MG, Mutchler GS, Nelson JM, Nevski P, Nikitin VA, Nogach LV, Norman B, Nurushev SB, Odyniec G, Ogawa A, Okorokov V, Oldenburg M, Olson D, Paic G, Pandey SU, Panebratsev Y, Panitkin SY, Pavlinov AI, Pawlak T, Perevoztchikov V, Peryt W, Petrov VA, Pinganaud W, Platner E, Pluta J, Porile N, Porter J, Poskanzer AM, Potrebenikova E, Prindle D, Pruneau C, Radomski S, Rai G, Ravel O, Ray RL, Razin SV, Reichhold D, Reid JG, Retiere F, Ridiger A, Ritter HG, Roberts JB, Rogachevski OV, Romero JL, Roy C, Russ D, Rykov V, Sakrejda I, Sandweiss J, Saulys AC, Savin I, Schambach J, Scharenberg RP, Schweda K, Schmitz N, Schroeder LS, Sch?ttauf A, Seger J, Seliverstov D, Seyboth P, Shahaliev E, Shestermanov KE, Shimanskii SS, Shvetcov VS, Skoro G, Smirnov N, Snellings R, Sowinski J, Spinka HM, Srivastava B, Stephenson EJ, Stock R, Stolpovsky A, Strikhanov M, Stringfellow B, Stroebele H, Struck C, Suaide AA, Sugarbaker E, Suire C, Sumbera M, Symons TJ, Szanto De Toledo A, Szarwas P, Takahashi J, Tang AH, Thomas JH, Tikhomirov V, Trainor TA, Trentalange S, Tokarev M, Tonjes MB, Trofimov V, Tsai O, Turner K, Ullrich T, Underwood DG, Van Buren G, VanderMolen AM, Vanyashin A, Vasilevski IM, Vasiliev AN, Vigdor SE, Voloshin SA, Wang F, Ward H, Watson JW, Wells R, Wenaus T, Westfall GD, Whitten C, Wieman H, Willson R, Wissink SW, Witt R, Xu N, Xu Z, Yakutin AE, Yamamoto E, Yang J, Yepes P, Yokosawa A, Yurevich VI, Zanevski YV, Zborovsk? I, Zhang WM, Zoulkarneev R, Zubarev AN. Multiplicity distribution and spectra of negatively charged hadrons in Au+Au collisions at square root of (sNN) = 130 GeV. Phys Rev Lett. 2001 Sep 10; 87(11):112303. PMID: 11531517.
      Citations:    Fields:    
    231. Bortell R, Moss J, McKenna RC, Rigby MR, Niedzwiecki D, Stevens LA, Patton WA, Mordes JP, Greiner DL, Rossini AA. Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities. J Immunol. 2001 Aug 15; 167(4):2049-59. PMID: 11489987.
      Citations: 9     Fields:    Translation:AnimalsCells
    232. Adler C, Ahammed Z, Allgower C, Amonett J, Anderson BD, Anderson M, Averichev GS, Balewski J, Barannikova O, Barnby LS, Baudot J, Bekele S, Belaga VV, Bellwied R, Berger J, Bichsel H, Bland LC, Blyth CO, Bonner BE, Bossingham R, Boucham A, Brandin A, Cadman RV, Caines H, Calder?n De La Barca S?nchez M, Cardenas A, Carroll J, Castillo J, Castro M, Cebra D, Chattopadhyay S, Chen ML, Chen Y, Chernenko SP, Cherney M, Chikanian A, Choi B, Christie W, Coffin JP, Conin L, Cormier TM, Cramer JG, Crawford HJ, DeMello M, Deng WS, Derevschikov AA, Didenko L, Draper JE, Dunin VB, Dunlop JC, Eckardt V, Efimov LG, Emelianov V, Engelage J, Eppley G, Erazmus B, Fachini P, Faine V, Finch E, Fisyak Y, Flierl D, Foley KJ, Fu J, Gagunashvili N, Gans J, Gaudichet L, Germain M, Geurts F, Ghazikhanian V, Grabski J, Grachov O, Greiner D, Grigoriev V, Guedon M, Gushin E, Hallman TJ, Hardtke D, Harris JW, Heffner M, Heppelmann S, Herston T, Hippolyte B, Hirsch A, Hjort E, Hoffmann GW, Horsley M, Huang HZ, Humanic TJ, H?mmler H, Igo G, Ishihara A, Ivanshin YI, Jacobs P, Jacobs WW, Janik M, Johnson I, Jones PG, Judd E, Kaneta M, Kaplan M, Keane D, Kisiel A, Klay J, Klein SR, Klyachko A, Konstantinov AS, Kotchenda L, Kovalenko AD, Kramer M, Kravtsov P, Krueger K, Kuhn C, Kulikov AI, Kunde GJ, Kunz CL, Kutuev RK, Kuznetsov AA, Lakehal-Ayat L, Lamas-Valverde J, Lamont MA, Landgraf JM, Lange S, Lansdell CP, Lasiuk B, Laue F, Lebedev A, LeCompte T, Lednick? R, Leontiev VM, LeVine MJ, Li Q, Li Q, Lindenbaum SJ, Lisa MA, Ljubicic T, Llope WJ, LoCurto G, Long H, Longacre RS, Lopez-Noriega M, Love WA, Lynn D, Majka R, Margetis S, Martin L, Marx J, Matis HS, Matulenko YA, McShane TS, Meissner F, Melnick Y, Meschanin A, Messer M, Miller ML, Milosevich Z, Minaev NG, Mitchell J, Moiseenko VA, Moltz D, Moore CF, Morozov V, de Moura MM, Munhoz MG, Mutchler GS, Nelson JM, Nevski P, Nikitin VA, Nogach LV, Norman B, Nurushev SB, Odyniec G, Ogawa A, Okorokov V, Oldenburg M, Olson D, Paic G, Pandey SU, Panebratsev Y, Panitkin SY, Pavlinov AI, Pawlak T, Perevoztchikov V, Peryt W, Petrov VA, Pinganaud W, Platner E, Pluta J, Porile N, Porter J, Poskanzer AM, Potrebenikova E, Prindle D, Pruneau C, Radomski S, Rai G, Ravel O, Ray RL, Razin SV, Reichhold D, Reid JG, Retiere F, Ridiger A, Ritter HG, Roberts JB, Rogachevski OV, Romero JL, Roy C, Russ D, Rykov V, Sakrejda I, Sandweiss J, Saulys AC, Savin I, Schambach J, Scharenberg RP, Schweda K, Schmitz N, Schroeder LS, Sch?ttauf A, Seger J, Seliverstov D, Seyboth P, Shahaliev E, Shestermanov KE, Shimanskii SS, Shvetcov VS, Skoro G, Smirnov N, Snellings R, Sowinski J, Spinka HM, Srivastava B, Stephenson EJ, Stock R, Stolpovsky A, Strikhanov M, Stringfellow B, Stroebele H, Struck C, Suaide AA, Sugarbaker E, Suire C, Sumbera M, Symons TJ, Szanto De Toledo A, Szarwas P, Takahashi J, Tang AH, Thomas JH, Tikhomirov V, Trainor TA, Trentalange S, Tokarev M, Tonjes MB, Trofimov V, Tsai O, Turner K, Ullrich T, Underwood DG, Van Buren G, VanderMolen AM, Vanyashin A, Vasilevski IM, Vasiliev AN, Vigdor SE, Voloshin SA, Wang F, Ward H, Watson JW, Wells R, Wenaus T, Westfall GD, Whitten C, Wieman H, Willson R, Wissink SW, Witt R, Xu N, Xu Z, Yakutin AE, Yamamoto E, Yang J, Yepes P, Yokosawa A, Yurevich VI, Zanevski YV, Zborovsk? I, Zhang WM, Zoulkarneev R, Zubarev AN. Pion Interferometry of square root of (s(NN)) =130 GeV Au + Au collisions at RHIC. Phys Rev Lett. 2001 Aug 20; 87(8):082301. PMID: 11497937.
      Citations:    Fields:    
    233. Greiner DL, Rossini AA, Mordes JP. Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere. Clin Immunol. 2001 Aug; 100(2):134-43. PMID: 11465941.
      Citations: 10     Fields:    Translation:HumansAnimals
    234. Ballen KK, Valinski H, Greiner D, Shultz LD, Becker PS, Hsieh CC, Stewart FM, Quesenberry PJ. Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay. Br J Haematol. 2001 Jul; 114(1):211-8. PMID: 11472370.
      Citations: 4     Fields:    Translation:HumansAnimals
    235. Adler C, Ahammed Z, Allgower C, Anderson M, Averichev GS, Balewski J, Barannikova O, Barnby LS, Baudot J, Bekele S, Belaga VV, Bellwied R, Berger J, Bichsel H, Bland LC, Blyth CO, Bonner BE, Bossingham R, Boucham A, Brandin A, Caines H, de la Barca S?nchez MC, Cardenas A, Carroll J, Castillo J, Castro M, Cebra D, Chattopadhyay S, Chen ML, Chen Y, Chernenko SP, Cherney M, Chikanian A, Choi B, Christie W, Coffin JP, Conin L, Cormier TM, Cramer JG, Crawford HJ, DeMello M, Deng WS, Derevschikov AA, Didenko L, Draper JE, Dunin VB, Dunlop JC, Eckardt V, Efimov LG, Emelianov V, Engelage J, Eppley G, Erazmus B, Fachini P, Ferguson MI, Finch E, Fisyak Y, Flierl D, Foley KJ, Gagunashvili N, Gans J, Germain M, Geurts F, Ghazikhanian V, Grabski J, Grachov O, Greiner D, Grigoriev V, Gushin E, Hallman TJ, Hardtke D, Harris JW, Heffner M, Heppelmann S, Herston T, Hippolyte B, Hirsch A, Hjort E, Hoffmann GW, Horsley M, Huang HZ, Humanic TJ, H?mmler H, Igo GJ, Ishihara A, Ivanshin YI, Jacobs P, Jacobs WW, Janik M, Johnson I, Jones PG, Judd E, Kaneta M, Kaplan M, Keane D, Khodinov A, Kisiel A, Klay J, Klein SR, Klyachko A, Konstantinov AS, Kotchenda L, Kovalenko AD, Kramer M, Kravtsov P, Krueger K, Kuhn C, Kulikov AI, Kunde GJ, Kunz CL, Kutuev RK, Kuznetsov AA, Lamas-Valverde J, Lamont MA, Landgraf JM, Lange S, Lansdell CP, Lasiuk B, Laue F, Lebedev A, LeCompte T, Leontiev VM, Leszczynski P, LeVine MJ, Li Q, Li Q, Lindenbaum SJ, Lisa MA, Ljubicic T, Llope WJ, LoCurto G, Long H, Longacre RS, Lopez-Noriega M, Love WA, Lynn D, Madansky L, Majka R, Maliszewski A, Margetis S, Martin L, Marx J, Matis HS, Matulenko YA, McShane TS, Melnick Y, Meschanin A, Milosevich Z, Minaev NG, Mitchell J, Moiseenko VA, Moltz D, Moore CF, Morozov V, de Moura MM, Munhoz MG, Mutchler GS, Nelson JM, Nevski P, Nikitin VA, Nogach LV, Norman B, Nurushev SB, Nystrand J, Odyniec G, Ogawa A, Ogilvie CA, Oldenburg M, Olson D, Paic G, Pandey SU, Panebratsev Y, Panitkin SY, Pavlinov AI, Pawlak T, Perevoztchikov V, Peryt W, Petrov VA, Pinganaud W, Platner E, Pluta J, Porile N, Porter J, Poskanzer AM, Potrebenikova E, Prindle D, Pruneau C, Radomski S, Rai G, Ravel O, Ray RL, Razin SV, Reichhold D, Reid J, Retiere F, Ridiger A, Ritter HG, Roberts JB, Rogachevski OV, Roy C, Russ D, Rykov V, Sakrejda I, Sandweiss J, Saulys AC, Savin I, Schambach J, Scharenberg RP, Schmitz N, Schroeder LS, Sch?ttauf A, Seger J, Seliverstov D, Seyboth P, Shestermanov KE, Shimanskii SS, Shvetcov VS, Skoro G, Smirnov N, Snellings R, Sowinski J, Spinka HM, Srivastava B, Stephenson EJ, Stock R, Stolpovsky A, Strikhanov M, Stringfellow B, Stroebele H, Struck C, Suaide AA, Sugarbaker E, Suire C, Symons TJ, Szanto de Toledo A, Szarwas P, Takahashi J, Tang AH, Thomas JH, Tikhomirov V, Trainor T, Trentalange S, Tokarev M, Tonjes MB, Trofimov V, Tsai O, Turner K, Ullrich T, Underwood DG, Van Buren G, VanderMolen AM, Vanyashin A, Vasilevski IM, Vasiliev AN, Vigdor SE, Voloshin SA, Wang F, Ward H, Wells R, Wenaus T, Westfall GD, Whitten C, Wieman H, Willson R, Wissink SW, Witt R, Xu N, Xu Z, Yakutin AE, Yamamoto E, Yang J, Yepes P, Yokosawa A, Yurevich VI, Zanevski YV, Zhang J, Zhang WM, Zoulkarneev R, Zubarev AN. Midrapidity antiproton-to-proton ratio from Au+Au collisions at sqrt [s(NN)]=130 GeV. Phys Rev Lett. 2001 May 21; 86(21):4778-82. PMID: 11384346.
      Citations:    Fields:    
    236. Bortel R, Waite DJ, Whalen BJ, Todd D, Leif JH, Lesma E, Moss J, Mordes JP, Rossini AA, Greiner DL. Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat. Autoimmunity. 2001 May; 33(3):199-211. PMID: 11683379.
      Citations: 1     Fields:    Translation:AnimalsCells
    237. Whalen BJ, Marounek J, Weiser P, Appel MC, Greiner DL, Mordes JP, Rossini AA. BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes. Diabetes. 2001 May; 50(5):972-9. PMID: 11334440.
      Citations: 2     Fields:    Translation:AnimalsCells
    238. Kecha-Kamoun O, Achour I, Martens H, Collette J, Lefebvre PJ, Greiner DL, Geenen V. Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes. Diabetes Metab Res Rev. 2001 Mar-Apr; 17(2):146-52. PMID: 11307180.
      Citations: 12     Fields:    Translation:AnimalsCells
    239. Zipris D, Leif J, Deluca D, Lin MY, Mordes JP, Rossini AA, Greiner DL, Whalen BJ. Fetal thymi from diabetes-prone but not diabetes-resistant BB/Wor rats fail to generate mature ART2+ T-cells in organ culture. Cell Mol Biol (Noisy-le-grand). 2001 Feb; 47(1):65-74. PMID: 11292261.
      Citations:    Fields:    Translation:AnimalsCells
    240. Gordon EJ, Woda BA, Shultz LD, Rossini AA, Greiner DL, Mordes JP. Rat xenograft survival in mice treated with donor-specific transfusion and anti-CD154 antibody is enhanced by elimination of host CD4+ cells. Transplantation. 2001 Jan 27; 71(2):319-27. PMID: 11213080.
      Citations: 3     Fields:    Translation:AnimalsCells
    241. Ackermann KH, Adams N, Adler C, Ahammed Z, Ahmad S, Allgower C, Amsbaugh J, Anderson M, Anderssen E, Arnesen H, Arnold L, Averichev GS, Baldwin A, Balewski J, Barannikova O, Barnby LS, Baudot J, Beddo M, Bekele S, Belaga VV, Bellwied R, Bennett S, Bercovitz J, Berger J, Betts W, Bichsel H, Bieser F, Bland LC, Bloomer M, Blyth CO, Boehm J, Bonner BE, Bonnet D, Bossingham R, Botlo M, Boucham A, Bouillo N, Bouvier S, Bradley K, Brady FP, Braithwaite ES, Braithwaite W, Brandin A, Brown RL, Brugalette G, Byrd C, Caines H, Calder?n de la Barca S?nchez M, Cardenas A, Carr L, Carroll J, Castillo J, Caylor B, Cebra D, Chatopadhyay S, Chen ML, Chen W, Chen Y, Chernenko SP, Cherney M, Chikanian A, Choi B, Chrin J, Christie W, Coffin JP, Conin L, Consiglio C, Cormier TM, Cramer JG, Crawford HJ, Danilov VI, Dayton D, DeMello M, Deng WS, Derevschikov AA, Dialinas M, Diaz H, DeYoung PA, Didenko L, Dimassimo D, Dioguardi J, Dominik W, Drancourt C, Draper JE, Dunin VB, Dunlop JC, Eckardt V, Edwards WR, Efimov LG, Eggert T, Emelianov V, Engelage J, Eppley G, Erazmus B, Etkin A, Fachini P, Feliciano C, Ferenc D, Ferguson MI, Fessler H, Finch E, Fine V, Fisyak Y, Flierl D, Flores I, Foley KJ, Fritz D, Gagunashvili N, Gans J, Gazdzicki M, Germain M, Geurts F, Ghazikhanian V, Gojak C, Grabski J, Grachov O, Grau M, Greiner D, Greiner L, Grigoriev V, Grosnick D, Gross J, Guilloux G, Gushin E, Hall J, Hallman TJ, Hardtke D, Harper G, Harris JW, He P, Heffner M, Heppelmann S, Herston T, Hill D, Hippolyte B, Hirsch A, Hjort E, Hoffmann GW, Horsley M, Howe M, Huang HZ, Humanic TJ, H?mmler H, Hunt W, Hunter J, Igo GJ, Ishihara A, Ivanshin YI, Jacobs P, Jacobs WW, Jacobson S, Jared R, Jensen P, Johnson I, Jones PG, Judd E, Kaneta M, Kaplan M, Keane D, Kenney VP, Khodinov A, Klay J, Klein SR, Klyachko A, Koehler G, Konstantinov AS, Kormilitsyne V, Kotchenda L, Kotov I, Kovalenko AD, Kramer M, Kravtsov P, Krueger K, Krupien T, Kuczewski P, Kuhn C, Kunde GJ, Kunz CL, Kutuev RK, Kuznetsov AA, Lakehal-Ayat L, Lamas-Valverde J, Lamont MA, Landgraf JM, Lange S, Lansdell CP, Lasiuk B, Laue F, Lebedev A, LeCompte T, Leonhardt WJ, Leontiev VM, Leszczynski P, LeVine MJ, Li Q, Li Q, Li Z, Liaw CJ, Lin J, Lindenbaum SJ, Lindenstruth V, Lindstrom PJ, Lisa MA, Liu H, Ljubicic T, Llope WJ, LoCurto G, Long H, Longacre RS, Lopez-Noriega M, Lopiano D, Love WA, Lutz JR, Lynn D, Madansky L, Maier R, Majka R, Maliszewski A, Margetis S, Marks K, Marstaller R, Martin L, Marx J, Matis HS, Matulenko YA, Matyushevski EA, McParland C, McShane TS, Meier J, Melnick Y, Meschanin A, Middlekamp P, Mikhalin N, Miller B, Milosevich Z, Minaev NG, Minor B, Mitchell J, Mogavero E, Moiseenko VA, Moltz D, Moore CF, Morozov V, Morse R, de Moura MM, Munhoz MG, Mutchler GS, Nelson JM, Nevski P, Ngo T, Nguyen M, Nguyen T, Nikitin VA, Nogach LV, Noggle T, Norman B, Nurushev SB, Nussbaum T, Nystrand J, Odyniec G, Ogawa A, Ogilvie CA, Olchanski K, Oldenburg M, Olson D, Ososkov GA, Ott G, Padrazo D, Paic G, Pandey SU, Panebratsev Y, Panitkin SY, Pavlinov AI, Pawlak T, Pentia M, Perevotchikov V, Peryt W, Petrov VA, Pinganaud W, Pirogov S, Platner E, Pluta J, Polk I, Porile N, Porter J, Poskanzer AM, Potrebenikova E, Prindle D, Pruneau C, Puskar-Pasewicz J, Rai G, Rasson J, Ravel O, Ray RL, Razin SV, Reichhold D, Reid J, Renfordt RE, Retiere F, Ridiger A, Riso J, Ritter HG, Roberts JB, Roehrich D, Rogachevski OV, Romero JL, Roy C, Russ D, Rykov V, Sakrejda I, Sanchez R, Sandler Z, Sandweiss J, Sappenfield P, Saulys AC, Savin I, Schambach J, Scharenberg RP, Scheblien J, Scheetz R, Schlueter R, Schmitz N, Schroeder LS, Schulz M, Sch?ttauf A, Sedlmeir J, Seger J, Seliverstov D, Seyboth J, Seyboth P, Seymour R, Shakaliev EI, Shestermanov KE, Shi Y, Shimanskii SS, Shuman D, Shvetcov VS, Skoro G, Smirnov N, Smykov LP, Snellings R, Solberg K, Sowinski J, Spinka HM, Srivastava B, Stephenson EJ, Stock R, Stolpovsky A, Stone N, Stone R, Strikhanov M, Stringfellow B, Stroebele H, Struck C, Suaide AA, et al. Elliptic flow in Au+Au collisions at square root(S)NN = 130 GeV. Phys Rev Lett. 2001 Jan 15; 86(3):402-7. PMID: 11177841.
      Citations: 4     Fields:    
    242. Turgeon NA, Iwakoshi NN, Phillips NE, Meyers WC, Welsh RM, Greiner DL, Mordes JP, Rossini AA. Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade. J Surg Res. 2000 Sep; 93(1):63-9. PMID: 10945944.
      Citations: 8     Fields:    Translation:AnimalsCells
    243. Wagar EJ, Cromwell MA, Shultz LD, Woda BA, Sullivan JL, Hesselton RM, Greiner DL. Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice. J Immunol. 2000 Jul 01; 165(1):518-27. PMID: 10861091.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    244. Kollet O, Peled A, Byk T, Ben-Hur H, Greiner D, Shultz L, Lapidot T. beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function. Blood. 2000 May 15; 95(10):3102-5. PMID: 10807775.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    245. Seung E, Iwakoshi N, Woda BA, Markees TG, Mordes JP, Rossini AA, Greiner DL. Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice. Blood. 2000 Mar 15; 95(6):2175-82. PMID: 10706892.
      Citations: 29     Fields:    Translation:Animals
    246. Welsh RM, Markees TG, Woda BA, Daniels KA, Brehm MA, Mordes JP, Greiner DL, Rossini AA. Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody. J Virol. 2000 Mar; 74(5):2210-8. PMID: 10666251.
      Citations: 72     Fields:    Translation:AnimalsCells
    247. Shultz LD, Lang PA, Christianson SW, Gott B, Lyons B, Umeda S, Leiter E, Hesselton R, Wagar EJ, Leif JH, Kollet O, Lapidot T, Greiner DL. NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells. J Immunol. 2000 Mar 01; 164(5):2496-507. PMID: 10679087.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    248. Ballen K, Becker PS, Greiner D, Valinski H, Shearin D, Berrios V, Dooner G, Hsieh CC, Wuu J, Shultz L, Cerny J, Leif J, Stewart FM, Quesenberry P. Effect of ex vivo cytokine treatment on human cord blood engraftment in NOD-scid mice. Br J Haematol. 2000 Mar; 108(3):629-40. PMID: 10759723.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    249. Iwakoshi NN, Mordes JP, Markees TG, Phillips NE, Rossini AA, Greiner DL. Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner. J Immunol. 2000 Jan 01; 164(1):512-21. PMID: 10605049.
      Citations: 55     Fields:    Translation:AnimalsCells
    250. Martin AM, Maxson MN, Leif J, Mordes JP, Greiner DL, Blankenhorn EP. Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4. Diabetes. 1999 Nov; 48(11):2138-44. PMID: 10535446.
      Citations: 15     Fields:    Translation:AnimalsCells
    251. Whalen BJ, Love LC, Mordes JP, Rossini AA, Greiner DL. Intravital dye-labeled diabetogenic rat T cells retain dye, home to the pancreas, and induce diabetes. Transplant Proc. 1999 May; 31(3):1611-4. PMID: 10331021.
      Citations: 2     Fields:    Translation:AnimalsCells
    252. Markees TG, Serreze DV, Phillips NE, Sorli CH, Gordon EJ, Shultz LD, Noelle RJ, Woda BA, Greiner DL, Mordes JP, Rossini AA. NOD mice have a generalized defect in their response to transplantation tolerance induction. Diabetes. 1999 May; 48(5):967-74. PMID: 10331399.
      Citations: 35     Fields:    Translation:HumansAnimals
    253. Todd D, Singh AJ, Greiner DL, Mordes JP, Rossini AA, Bortell R. A new isolation method for rat intraepithelial lymphocytes. J Immunol Methods. 1999 Apr 22; 224(1-2):111-27. PMID: 10357212.
      Citations: 6     Fields:    Translation:AnimalsCells
    254. Zheng XX, Markees TG, Hancock WW, Li Y, Greiner DL, Li XC, Mordes JP, Sayegh MH, Rossini AA, Strom TB. CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment. J Immunol. 1999 Apr 15; 162(8):4983-90. PMID: 10202046.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    255. Buhlmann JE, Gonzalez M, Ginther B, Panoskaltsis-Mortari A, Blazar BR, Greiner DL, Rossini AA, Flavell R, Noelle RJ. Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease. J Immunol. 1999 Apr 15; 162(8):4373-6. PMID: 10201970.
      Citations: 17     Fields:    Translation:AnimalsCells
    256. Whalen BJ, Weiser P, Marounek J, Rossini AA, Mordes JP, Greiner DL. Recapitulation of normal and abnormal BioBreeding rat T cell development in adult thymus organ culture. J Immunol. 1999 Apr 01; 162(7):4003-12. PMID: 10201921.
      Citations: 6     Fields:    Translation:AnimalsCells
    257. Bortell R, Kanaitsuka T, Stevens LA, Moss J, Mordes JP, Rossini AA, Greiner DL. The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse. Mol Cell Biochem. 1999 Mar; 193(1-2):61-8. PMID: 10331639.
      Citations: 7     Fields:    Translation:AnimalsCells
    258. Markees TG, Phillips NE, Gordon EJ, Noelle RJ, Maliszewski C, Mordes JP, Greiner DL, Rossini AA. Prolonged skin allograft survival in mice treated with Flt3-ligand-induced dendritic cells and anti-CD154 monoclonal antibody. Transplant Proc. 1999 Feb-Mar; 31(1-2):884-5. PMID: 10083387.
      Citations: 4     Fields:    Translation:AnimalsCells
    259. Rossini AA, Mordes JP, Markees TG, Phillips NE, Gordon EJ, Greiner DL. Induction of islet transplantation tolerance using donor specific transfusion and anti-CD154 monoclonal antibody. Transplant Proc. 1999 Feb-Mar; 31(1-2):629-32. PMID: 10083269.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    260. Rossini AA, Greiner DL, Mordes JP. Induction of immunologic tolerance for transplantation. Physiol Rev. 1999 Jan; 79(1):99-141. PMID: 9922369.
      Citations: 24     Fields:    Translation:HumansAnimals
    261. Iwakoshi NN, Greiner DL, Rossini AA, Mordes JP. Diabetes prone BB rats are severely deficient in natural killer T cells. Autoimmunity. 1999; 31(1):1-14. PMID: 10593564.
      Citations: 7     Fields:    Translation:AnimalsCells
    262. Martin AM, Blankenhorn EP, Maxson MN, Zhao M, Leif J, Mordes JP, Greiner DL. Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat. Diabetes. 1999 Jan; 48(1):50-8. PMID: 9892222.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    263. Lesma E, Moss J, Brewer HB, Bortell R, Greiner D, Mordes J, Rossini AA. Characterization of high density lipoprotein-bound and soluble RT6 released following administration of anti-RT6.1 monoclonal antibody. J Immunol. 1998 Aug 01; 161(3):1212-9. PMID: 9686581.
      Citations: 1     Fields:    Translation:AnimalsCells
    264. Gordon EJ, Markees TG, Phillips NE, Noelle RJ, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Prolonged survival of rat islet and skin xenografts in mice treated with donor splenocytes and anti-CD154 monoclonal antibody. Diabetes. 1998 Aug; 47(8):1199-206. PMID: 9703317.
      Citations: 4     Fields:    Translation:HumansAnimals
    265. Markees T, Phillips N, Gordon E, Noelle RJ, Mordes JP, Greiner DL, Rossini AA. Improved skin allograft tolerance induced by treatment with donor splenocytes and an extended course of anti-CD154 monoclonal antibody. Transplant Proc. 1998 Aug; 30(5):2444-6. PMID: 9723531.
      Citations: 4     Fields:    Translation:HumansAnimals
    266. Iwakoshi NN, Goldschneider I, Tausche F, Mordes JP, Rossini AA, Greiner DL. High frequency apoptosis of recent thymic emigrants in the liver of lymphopenic diabetes-prone BioBreeding rats. J Immunol. 1998 Jun 15; 160(12):5838-50. PMID: 9637495.
      Citations: 11     Fields:    Translation:AnimalsCells
    267. Markees TG, Phillips NE, Gordon EJ, Noelle RJ, Shultz LD, Mordes JP, Greiner DL, Rossini AA. Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4. J Clin Invest. 1998 Jun 01; 101(11):2446-55. PMID: 9616216.
      Citations: 70     Fields:    Translation:AnimalsCells
    268. Rajan TV, Shultz LD, Babu S, Doukas J, Greiner D, Porte P. Diethylcarbamazine (DEC) does not induce nitric oxide (NO) synthesis. Exp Parasitol. 1998 Mar; 88(3):217-22. PMID: 9562425.
      Citations: 3     Fields:    Translation:AnimalsCells
    269. Kaufmann R, Greiner D, Kippenberger S, Bernd A. Grafting of in vitro cultured melanocytes onto laser-ablated lesions in vitiligo. Acta Derm Venereol. 1998 Mar; 78(2):136-8. PMID: 9534893.
      Citations: 9     Fields:    Translation:HumansCells
    270. Kosuda LL, Whalen B, Greiner DL, Bigazzi PE. Mercury-induced autoimmunity in Brown Norway rats: kinetics of changes in RT6+ T lymphocytes correlated with IgG isotypes of circulating autoantibodies to laminin 1. Toxicology. 1998 Feb 06; 125(2-3):215-31. PMID: 9570334.
      Citations: 2     Fields:    Translation:AnimalsCells
    271. Greiner DL, Hesselton RA, Shultz LD. SCID mouse models of human stem cell engraftment. Stem Cells. 1998; 16(3):166-77. PMID: 9617892.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    272. Foy TM, McIlraith M, Masters SR, Dunn JJ, Rossini AA, Shultz LD, Hesselton RA, Wagar EJ, Lipsky PE, Noelle RJ, Greiner DL. Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice. Cell Transplant. 1998 Jan-Feb; 7(1):25-35. PMID: 9489760.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    273. Kanaitsuka T, Bortell R, Stevens LA, Moss J, Sardinha D, Rajan TV, Zipris D, Mordes JP, Greiner DL, Rossini AA. Expression in BALB/c and C57BL/6 mice of Rt6-1 and Rt6-2 ADP-ribosyltransferases that differ in enzymatic activity: C57BL/6 Rt6-1 is a natural transferase knockout. J Immunol. 1997 Sep 15; 159(6):2741-9. PMID: 9300695.
      Citations: 6     Fields:    Translation:AnimalsCells
    274. Shultz LD, Rajan TV, Greiner DL. Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency. Trends Biotechnol. 1997 Aug; 15(8):302-7. PMID: 9263478.
      Citations: 50     Fields:    Translation:Animals
    275. Markees TG, Phillips NE, Noelle RJ, Shultz LD, Mordes JP, Greiner DL, Rossini AA. Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand. Transplantation. 1997 Jul 27; 64(2):329-35. PMID: 9256196.
      Citations: 40     Fields:    Translation:AnimalsCells
    276. Malkani S, Nompleggi D, Hansen JW, Greiner DL, Mordes JP, Rossini AA. Dietary cow's milk protein does not alter the frequency of diabetes in the BB rat. Diabetes. 1997 Jul; 46(7):1133-40. PMID: 9200647.
      Citations: 7     Fields:    Translation:Animals
    277. Whalen BJ, Doukas J, Mordes JP, Rossini AA, Greiner DL. Induction of insulin-dependent diabetes mellitus in PVG.RT1u rats. Transplant Proc. 1997 May; 29(3):1684-5. PMID: 9142232.
      Citations:    Fields:    Translation:AnimalsCells
    278. Christianson SW, Greiner DL, Hesselton RA, Leif JH, Wagar EJ, Schweitzer IB, Rajan TV, Gott B, Roopenian DC, Shultz LD. Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice. J Immunol. 1997 Apr 15; 158(8):3578-86. PMID: 9103418.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    279. Moss J, Stevens LA, Cavanaugh E, Okazaki IJ, Bortell R, Kanaitsuka T, Mordes JP, Greiner DL, Rossini AA. Characterization of mouse Rt6.1 NAD:arginine ADP-ribosyltransferase. J Biol Chem. 1997 Feb 14; 272(7):4342-6. PMID: 9020154.
      Citations: 4     Fields:    Translation:AnimalsCells
    280. Greiner DL, Malkani S, Kanaitsuka T, Bortell R, Doukas J, Rigby M, Whalen B, Stevens LA, Moss J, Mordes JP, Rossini AA. The T cell marker RT6 in a rat model of autoimmune diabetes. Adv Exp Med Biol. 1997; 419:209-16. PMID: 9193656.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    281. Kosuda LL, Greiner DL, Bigazzi PE. Effects of HgCl2 on the expression of autoimmune responses and disease in diabetes-prone (DP) BB rats. Autoimmunity. 1997; 26(3):173-87. PMID: 9550285.
      Citations: 2     Fields:    Translation:AnimalsCells
    282. Bortell R, Rigby M, Stevens L, Moss J, Kanaitsuka T, Mordes J, Greiner D, Rossini A. Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity. Adv Exp Med Biol. 1997; 419:169-73. PMID: 9193650.
      Citations: 2     Fields:    Translation:AnimalsCells
    283. Rigby MR, Bortell R, Greiner DL, Czech MP, Klarlund JK, Mordes JP, Rossini AA. The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal. Diabetes. 1996 Oct; 45(10):1419-26. PMID: 8826980.
      Citations: 4     Fields:    Translation:AnimalsCells
    284. Christianson SW, Greiner DL, Schweitzer IB, Gott B, Beamer GL, Schweitzer PA, Hesselton RM, Shultz LD. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell Immunol. 1996 Aug 01; 171(2):186-99. PMID: 8806787.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    285. Mordes JP, Bortell R, Doukas J, Rigby M, Whalen B, Zipris D, Greiner DL, Rossini AA. The BB/Wor rat and the balance hypothesis of autoimmunity. Diabetes Metab Rev. 1996 Jul; 12(2):103-9. PMID: 8877279.
      Citations: 16     Fields:    Translation:AnimalsCells
    286. Waite DJ, Appel MC, Handler ES, Mordes JP, Rossini AA, Greiner DL. Ontogeny and immunohistochemical localization of thymus-dependent and thymus-independent RT6+ cells in the rat. Am J Pathol. 1996 Jun; 148(6):2043-56. PMID: 8669488.
      Citations: 4     Fields:    Translation:AnimalsCells
    287. Rigby MR, Bortell R, Stevens LA, Moss J, Kanaitsuka T, Shigeta H, Mordes JP, Greiner DL, Rossini AA. Rat RT6.2 and mouse Rt6 locus 1 are NAD+: arginine ADP ribosyltransferases with auto-ADP ribosylation activity. J Immunol. 1996 Jun 01; 156(11):4259-65. PMID: 8666796.
      Citations: 5     Fields:    Translation:AnimalsCells
    288. Rajan TV, Greiner DL, Yates JA, Shultz LD. Growth of the human filarial parasite Brugia malayi in mice lacking major histocompatibility complex class II antigen expression. Acta Trop. 1996 May; 61(3):267-71. PMID: 8790777.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    289. Markees TG, Appel MC, Noelle RJ, Mordes JP, Greiner DL, Rossini AA. Tolerance to islet xenografts induced by dual manipulation of antigen presentation and co-stimulation. Transplant Proc. 1996 Apr; 28(2):814-5. PMID: 8623413.
      Citations: 1     Fields:    Translation:Animals
    290. Mordes JP, Schirf B, Roipko D, Greiner DL, Weiner H, Nelson P, Rossini AA. Oral insulin does not prevent insulin-dependent diabetes mellitus in BB rats. Ann N Y Acad Sci. 1996 Feb 13; 778:418-21. PMID: 8611008.
      Citations: 4     Fields:    Translation:HumansAnimals
    291. Zipris D, Greiner DL, Malkani S, Whalen B, Mordes JP, Rossini AA. Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats. J Immunol. 1996 Feb 01; 156(3):1315-21. PMID: 8558012.
      Citations: 30     Fields:    Translation:AnimalsCells
    292. Lowry PA, Shultz LD, Greiner DL, Hesselton RM, Kittler EL, Tiarks CY, Rao SS, Reilly J, Leif JH, Ramshaw H, Stewart FM, Quesenberry PJ. Improved engraftment of human cord blood stem cells in NOD/LtSz-scid/scid mice after irradiation or multiple-day injections into unirradiated recipients. Biol Blood Marrow Transplant. 1996 Feb; 2(1):15-23. PMID: 9078350.
      Citations: 24     Fields:    Translation:HumansAnimals
    293. Kosuda LL, Hannigan MO, Bigazzi PE, Leif JH, Greiner DL. Thymus atrophy and changes in thymocyte subpopulations of BN rats with mercury-induced renal autoimmune disease. Autoimmunity. 1996; 23(2):77-89. PMID: 8871763.
      Citations: 2     Fields:    Translation:AnimalsCells
    294. Zadeh HH, Greiner DL, Wu DY, Tausche F, Goldschneider I. Abnormalities in the export and fate of recent thymic emigrants in diabetes-prone BB/W rats. Autoimmunity. 1996; 24(1):35-46. PMID: 8937686.
      Citations: 11     Fields:    Translation:AnimalsCells
    295. Greiner DL, Shultz LD, Deluca D, Leif JH, Christianson SW, Hesselton RM. HIV-1 infectivity of human T cells in a human/murine chimeric fetal thymic organ culture system. In Vivo. 1996 Jan-Feb; 10(1):33-7. PMID: 8726809.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    296. Rossini AA, Parker DC, Phillips NE, Durie FH, Noelle RJ, Mordes JP, Greiner DL. Induction of immunological tolerance to islet allografts. Cell Transplant. 1996 Jan-Feb; 5(1):49-52. PMID: 8665076.
      Citations: 7     Fields:    Translation:AnimalsCells
    297. Serreze DV, Leiter EH, Hanson MS, Christianson SW, Shultz LD, Hesselton RM, Greiner DL. Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells. Diabetes. 1995 Dec; 44(12):1392-8. PMID: 7589844.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    298. Parker DC, Greiner DL, Phillips NE, Appel MC, Steele AW, Durie FH, Noelle RJ, Mordes JP, Rossini AA. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9560-4. PMID: 7568172.
      Citations: 95     Fields:    Translation:Animals
    299. Hesselton RM, Greiner DL, Mordes JP, Rajan TV, Sullivan JL, Shultz LD. High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice. J Infect Dis. 1995 Oct; 172(4):974-82. PMID: 7561218.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    300. Whalen BJ, Rossini AA, Mordes JP, Greiner DL. DR-BB rat thymus contains thymocyte populations predisposed to autoreactivity. Diabetes. 1995 Aug; 44(8):963-7. PMID: 7622003.
      Citations: 4     Fields:    Translation:AnimalsCells
    301. Rajan TV, Shultz LD, Yates J, Greiner DL. B lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi. J Parasitol. 1995 Jun; 81(3):490-3. PMID: 7776141.
      Citations: 2     Fields:    Translation:AnimalsCells
    302. Greiner DL, Shultz LD, Yates J, Appel MC, Perdrizet G, Hesselton RM, Schweitzer I, Beamer WG, Shultz KL, Pelsue SC, et al. Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice. Am J Pathol. 1995 Apr; 146(4):888-902. PMID: 7717456.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    303. Shultz LD, Schweitzer PA, Christianson SW, Gott B, Schweitzer IB, Tennent B, McKenna S, Mobraaten L, Rajan TV, Greiner DL, et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol. 1995 Jan 01; 154(1):180-91. PMID: 7995938.
      Citations: 409     Fields:    Translation:HumansAnimalsCells
    304. Rossini AA, Handler ES, Mordes JP, Greiner DL. Human autoimmune diabetes mellitus: lessons from BB rats and NOD mice--Caveat emptor. Clin Immunol Immunopathol. 1995 Jan; 74(1):2-9. PMID: 7994922.
      Citations: 11     Fields:    Translation:HumansAnimals
    305. Rajan TV, Bailis JM, Yates JA, Shultz LD, Greiner DL, Nelson FK. Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis. Acta Trop. 1994 Dec; 58(3-4):283-9. PMID: 7709867.
      Citations: 1     Fields:    Translation:Animals
    306. Doukas J, Mordes JP, Swymer C, Niedzwiecki D, Mason R, Rozing J, Rossini AA, Greiner DL. Thymic epithelial defects and predisposition to autoimmune disease in BB rats. Am J Pathol. 1994 Dec; 145(6):1517-25. PMID: 7992854.
      Citations: 3     Fields:    Translation:AnimalsCells
    307. Whalen BJ, Greiner DL, Mordes JP, Rossini AA. Adoptive transfer of autoimmune diabetes mellitus to athymic rats: synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells. J Autoimmun. 1994 Dec; 7(6):819-31. PMID: 7888038.
      Citations: 8     Fields:    Translation:AnimalsCells
    308. McKenna SD, Medlock ES, Greiner DL, Goldschneider I. A selective culture system for generating terminal deoxynucleotidyl transferase-positive lymphoid precursor cells in vitro. IV. Properties and developmental relationships of the lymphoid cells in the adherent and nonadherent compartments of the culture. Exp Hematol. 1994 Nov; 22(12):1164-70. PMID: 7925780.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    309. Kosuda LL, Hosseinzadeh H, Greiner DL, Bigazzi PE. Role of RT6+ T lymphocytes in mercury-induced renal autoimmunity: experimental manipulations of "susceptible" and "resistant" rats. J Toxicol Environ Health. 1994 Jul; 42(3):303-21. PMID: 8021964.
      Citations: 4     Fields:    Translation:AnimalsCells
    310. Rajan TV, Nelson FK, Killeen N, Shultz LD, Yates JA, Bailis JM, Littman DR, Greiner DL. CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi. Exp Parasitol. 1994 Jun; 78(4):352-60. PMID: 7911434.
      Citations: 2     Fields:    Translation:AnimalsCells
    311. Kosuda LL, Greiner DL, Bigazzi PE. Mercury-induced renal autoimmunity in BN-->LEW.1N chimeric rats. Cell Immunol. 1994 Apr 15; 155(1):77-94. PMID: 8168152.
      Citations: 3     Fields:    Translation:AnimalsCells
    312. Rajan TV, Nelson FK, Shultz LD, Shultz KL, Beamer WG, Yates J, Greiner DL. Influence of gonadal steroids on susceptibility to Brugia malayi in scid mice. Acta Trop. 1994 Apr; 56(4):307-14. PMID: 8023754.
      Citations: 7     Fields:    Translation:AnimalsPHPublic Health
    313. Battan R, Mordes JP, Abreau S, Greiner DL, Handler ES, Rossini AA. Evidence that intrathymic islet transplantation does not prevent diabetes or subsequent islet graft destruction in RT6-depleted, diabetes-resistant BioBreeding/Worcester rats. Transplantation. 1994 Mar 15; 57(5):731-6. PMID: 8140636.
      Citations: 1     Fields:    Translation:Animals
    314. Gerling IC, Friedman H, Greiner DL, Shultz LD, Leiter EH. Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes. Diabetes. 1994 Mar; 43(3):433-40. PMID: 8314017.
      Citations: 20     Fields:    Translation:AnimalsCells
    315. Serreze DV, Leiter EH, Christianson GJ, Greiner D, Roopenian DC. Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant. Diabetes. 1994 Mar; 43(3):505-9. PMID: 8314025.
      Citations: 102     Fields:    Translation:AnimalsCells
    316. Hayes SM, Shultz LD, Greiner DL. Localization of prothymocytes from wild-type and viable motheaten mice following intravenous injection into irradiated adoptive recipients. Cell Immunol. 1994 Feb; 153(2):344-55. PMID: 8118868.
      Citations:    Fields:    Translation:AnimalsCells
    317. Waite DJ, Handler ES, Mordes JP, Rossini AA, Greiner DL. The RT6 rat lymphocyte alloantigen circulates in soluble form. Cell Immunol. 1993 Nov; 152(1):82-95. PMID: 8242775.
      Citations: 2     Fields:    Translation:AnimalsCells
    318. Kosuda LL, Greiner DL, Bigazzi PE. Mercury-induced renal autoimmunity: changes in RT6+ T-lymphocytes of susceptible and resistant rats. Environ Health Perspect. 1993 Jun; 101(2):178-85. PMID: 8354205.
      Citations: 1     Fields:    Translation:AnimalsCells
    319. Tafuri A, Bowers WE, Handler ES, Appel M, Lew R, Greiner D, Mordes JP, Rossini AA. High stimulatory activity of dendritic cells from diabetes-prone BioBreeding/Worcester rats exposed to macrophage-derived factors. J Clin Invest. 1993 May; 91(5):2040-8. PMID: 8486773.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    320. Binder TA, Greiner DL, Grunnet M, Goldschneider I. Relative susceptibility of SJL/J and B10.S mice to experimental allergic encephalomyelitis (EAE) is determined by the ability of prethymic cells in bone marrow to develop into EAE effector T cells. J Neuroimmunol. 1993 Jan; 42(1):23-32. PMID: 8093702.
      Citations: 5     Fields:    Translation:AnimalsCells
    321. Rajan TV, Nelson FK, Shultz LD, Koller BH, Greiner DL. CD8+ T lymphocytes are not required for murine resistance to human filarial parasites. J Parasitol. 1992 Aug; 78(4):744-6. PMID: 1386111.
      Citations: 4     Fields:    Translation:AnimalsCells
    322. Hayes SM, Greiner DL. Evidence for elevated prothymocyte activity in the bone marrow of New Zealand Black (NZB) mice. Elevated prothymocyte activity in NZB mice. Thymus. 1992 May; 19(3):157-72. PMID: 1585412.
      Citations:    Fields:    Translation:AnimalsCells
    323. Greiner DL, Rajan TV, Shultz LD. Animal models for immunodeficiency diseases. Immunol Today. 1992 Apr; 13(4):116-7. PMID: 1349811.
      Citations: 2     Fields:    Translation:HumansAnimals
    324. Rajan TV, Nelson FK, Cupp E, Schultz LD, Greiner DL. Survival of Onchocerca volvulus in nodules implanted in immunodeficient rodents. J Parasitol. 1992 Feb; 78(1):160-3. PMID: 1738062.
      Citations: 6     Fields:    Translation:HumansAnimals
    325. Rajan TV, Shultz LD, Greiner DL. Lack of peripherally induced tolerance to established skin allografts in immunologically reconstituted scid mice. Dev Immunol. 1992; 3(1):45-50. PMID: 1343102.
      Citations: 4     Fields:    Translation:AnimalsCells
    326. Medlock ES, Migita RT, Trebasky LD, Housman JM, Elliott GS, Hendren RW, Deprince RB, Greiner DL. Rat stem-cell factor induces splenocytes capable of regenerating the thymus. Dev Immunol. 1992; 3(1):35-44. PMID: 1285280.
      Citations: 2     Fields:    Translation:AnimalsCells
    327. Hayes SM, Shultz LD, Greiner DL. Thymic involution in viable motheaten (me(v)) mice is associated with a loss of intrathymic precursor activity. Dev Immunol. 1992; 2(3):191-205. PMID: 1627951.
      Citations: 1     Fields:    Translation:Animals
    328. Kitagawa Y, Greiner DL, Reynolds CW, Ortaldo JR, Toccafondi R, Handler ES, van der Meide PH, Mordes JP, Rossini AA. Islet cells but not thyrocytes are susceptible to lysis by NK cells. J Autoimmun. 1991 Oct; 4(5):703-16. PMID: 1797021.
      Citations: 1     Fields:    Translation:AnimalsCells
    329. Greiner DL, Shultz LD, Rossini AA, Mordes JP, Handler ES, Rajan TV. Recapitulation of normal and abnormal BB rat immune system development in scid mouse/rat lymphohemopoietic chimeras. J Clin Invest. 1991 Aug; 88(2):717-9. PMID: 1864981.
      Citations: 4     Fields:    Translation:AnimalsCells
    330. Cutler LS, Rozenski D, Coolens J, Rozing J, Angelillo M, Wayne AL, Fitzgerald KM, Greiner DL. Experimental autoallergic sialadenitis in the LEW rat. I. Parameters of disease induction. Cell Immunol. 1991 Jul; 135(2):335-45. PMID: 2036674.
      Citations: 2     Fields:    Translation:Animals
    331. Greiner DL, Angelillo M, Wayne AL, Fitzgerald KM, Rozenski D, Cutler LS. Experimental autoallergic sialadenitis in the LEW rat. III. Role of CD4+ T cells in EAS induction. Cell Immunol. 1991 Jul; 135(2):354-9. PMID: 1828009.
      Citations: 2     Fields:    Translation:AnimalsCells
    332. Cutler LS, Greiner DL, Rozenski D. Experimental autoallergic sialadenitis in the LEW rat. II. Target antigens are associated with cell surface and intracellular particulate fractions derived from the submandibular gland. Cell Immunol. 1991 Jul; 135(2):346-53. PMID: 2036675.
      Citations:    Fields:    Translation:Animals
    333. Kosuda LL, Wayne A, Nahounou M, Greiner DL, Bigazzi PE. Reduction of the RT6.2+ subset of T lymphocytes in brown Norway rats with mercury-induced renal autoimmunity. Cell Immunol. 1991 Jun; 135(1):154-67. PMID: 2018977.
      Citations: 7     Fields:    Translation:AnimalsCells
    334. Gottlieb PA, Handler ES, Appel MC, Greiner DL, Mordes JP, Rossini AA. Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats. Diabetologia. 1991 May; 34(5):296-300. PMID: 1864483.
      Citations: 9     Fields:    Translation:AnimalsCells
    335. Woda BA, Handler ES, Greiner DL, Reynolds C, Mordes JP, Rossini AA. T-lymphocyte requirement for diabetes in RT6-depleted diabetes-resistant BB rats. Diabetes. 1991 Apr; 40(4):423-8. PMID: 1707018.
      Citations:    Fields:    Translation:AnimalsCells
    336. Nelson FK, Greiner DL, Shultz LD, Rajan TV. The immunodeficient scid mouse as a model for human lymphatic filariasis. J Exp Med. 1991 Mar 01; 173(3):659-63. PMID: 1997651.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    337. Chen-Woan M, Greiner DL. Mechanisms of allograft prolongation in RT6 T cell-depleted rats. Transplant Proc. 1991 Feb; 23(1 Pt 1):143-6. PMID: 1824969.
      Citations:    Fields:    Translation:AnimalsCells
    338. Thomas VA, Woda BA, Handler ES, Greiner DL, Mordes JP, Rossini AA. Altered expression of diabetes in BB/Wor rats by exposure to viral pathogens. Diabetes. 1991 Feb; 40(2):255-8. PMID: 1703973.
      Citations: 17     Fields:    Translation:AnimalsCells
    339. Rossini AA, Handler ES, Greiner DL, Mordes JP. Insulin dependent diabetes mellitus hypothesis of autoimmunity. Autoimmunity. 1991; 8(3):221-35. PMID: 1932509.
      Citations: 6     Fields:    Translation:HumansAnimals
    340. Mojcik CF, Greiner DL, Goldschneider I. Characterization of RT6-bearing rat lymphocytes. II. Developmental relationships of RT6- and RT6+ T cells. Dev Immunol. 1991; 1(3):191-201. PMID: 1821696.
      Citations: 2     Fields:    Translation:AnimalsCells
    341. Cris? L, Greiner DL, Mordes JP, MacDonald RG, Handler ES, Czech MP, Rossini AA. Biochemical studies of RT6 alloantigens in BB/Wor and normal rats. Evidence for intact unexpressed RT6a structural gene in diabetes-prone BB rats. Diabetes. 1990 Oct; 39(10):1279-88. PMID: 2210079.
      Citations: 7     Fields:    Translation:AnimalsCells
    342. McKeever U, Mordes JP, Greiner DL, Appel MC, Rozing J, Handler ES, Rossini AA. Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7618-22. PMID: 2217193.
      Citations: 16     Fields:    Translation:Animals
    343. Nakamura N, Woda BA, Tafuri A, Greiner DL, Reynolds CW, Ortaldo J, Chick W, Handler ES, Mordes JP, Rossini AA. Intrinsic cytotoxicity of natural killer cells to pancreatic islets in vitro. Diabetes. 1990 Jul; 39(7):836-43. PMID: 2191887.
      Citations: 10     Fields:    Translation:AnimalsCells
    344. Gottlieb PA, Berrios JP, Mariani G, Handler ES, Greiner D, Mordes JP, Rossini AA. Autoimmune destruction of islets transplanted into RT6-depleted diabetes-resistant BB/Wor rats. Diabetes. 1990 May; 39(5):643-5. PMID: 1970541.
      Citations: 5     Fields:    Translation:AnimalsCells
    345. Lefkowith J, Schreiner G, Cormier J, Handler ES, Driscoll HK, Greiner D, Mordes JP, Rossini AA. Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes. J Exp Med. 1990 Mar 01; 171(3):729-43. PMID: 2307932.
      Citations: 10     Fields:    Translation:AnimalsCells
    346. Chen-Woan M, Greiner DL, Mihalyo M, Schweizer RT. Depletion of RT6+ T lymphocytes prolongs skin allograft in rats. Transplant Proc. 1989 Feb; 21(1 Pt 1):165-8. PMID: 2650101.
      Citations:    Fields:    Translation:AnimalsCells
    347. Rozing J, Coolen C, Tielen FJ, Weegenaar J, Schuurman HJ, Greiner DL, Rossini AA. Defects in the thymic epithelial stroma of diabetes prone BB rats. Thymus. 1989; 14(1-3):125-35. PMID: 2623736.
      Citations: 6     Fields:    Translation:Animals
    348. Handler ES, Mordes JP, McKeever U, Nakamura N, Bernhard J, Greiner DL, Rossini AA. Effects of irradiation on diabetes in the BB/Wor rat. Autoimmunity. 1989; 4(1-2):21-30. PMID: 2491639.
      Citations: 2     Fields:    Translation:Animals
    349. Rossini AA, Mordes JP, Greiner DL. The pathogenesis of autoimmune diabetes mellitus. Curr Opin Immunol. 1989-1990 Apr; 2(4):598-603. PMID: 2700903.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    350. Burstein D, Mordes JP, Greiner DL, Stein D, Nakamura N, Handler ES, Rossini AA. Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells. Parameters that affect degree of protection. Diabetes. 1989 Jan; 38(1):24-30. PMID: 2642432.
      Citations: 10     Fields:    Translation:AnimalsCells
    351. Angelillo M, Greiner DL, Mordes JP, Handler ES, Nakamura N, McKeever U, Rossini A. Absence of RT6+ T cells in diabetes-prone biobreeding/Worcester rats is due to genetic and cell developmental defects. J Immunol. 1988 Dec 15; 141(12):4146-51. PMID: 3058800.
      Citations: 11     Fields:    Translation:AnimalsCells
    352. Mojcik CF, Greiner DL, Medlock ES, Komschlies KL, Goldschneider I. Characterization of RT6 bearing rat lymphocytes. I. Ontogeny of the RT6+ subset. Cell Immunol. 1988 Jul; 114(2):336-46. PMID: 3260542.
      Citations: 7     Fields:    Translation:AnimalsCells
    353. Nakano K, Mordes JP, Handler ES, Greiner DL, Rossini AA. Role of host immune system in BB/Wor rat. Predisposition to diabetes resides in bone marrow. Diabetes. 1988 May; 37(5):520-5. PMID: 3282942.
      Citations: 2     Fields:    Translation:Animals
    354. Greiner DL, Angelillo M, Mordes JP, Handler ES, Mojcik CF, Nakamura N, Rossini AA. Regulatory T cell control of autoimmune destruction of beta cells in the BB rat. Adv Exp Med Biol. 1988; 246:379-85. PMID: 3266909.
      Citations:    Fields:    Translation:HumansAnimalsCells
    355. Hunt SV, Medlock ES, Greiner DL, Goldschneider I, Opstelten D. Rat immunoglobulin genes have comparable patterns of JH rearrangement in normal peripheral B cells and in pre-B and cultured TdT+ cells from bone marrow. Adv Exp Med Biol. 1988; 237:63-8. PMID: 3267064.
      Citations:    Fields:    Translation:AnimalsCells
    356. Komschlies KL, Greiner DL, Shultz L, Goldschneider I. Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer. J Exp Med. 1987 Oct 01; 166(4):1162-7. PMID: 3498788.
      Citations: 3     Fields:    Translation:AnimalsCells
    357. Mojcik CF, Greiner DL, Goldschneider I, Lubaroff DM. Monoclonal antibodies to RT7 and LCA antigens in the rat: cell distribution and segregation analysis. Hybridoma. 1987 Oct; 6(5):531-43. PMID: 2960606.
      Citations: 2     Fields:    Translation:AnimalsCells
    358. Greiner DL, Mordes JP, Handler ES, Angelillo M, Nakamura N, Rossini AA. Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats. J Exp Med. 1987 Aug 01; 166(2):461-75. PMID: 3496416.
      Citations: 48     Fields:    Translation:AnimalsCells
    359. Medlock ES, Goldschneider I, Greiner DL, Shultz L. Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. II. Description of a microenvironmental defect for the generation of terminal deoxynucleotidyltransferase-positive bone marrow cells in vitro. J Immunol. 1987 Jun 01; 138(11):3590-7. PMID: 3584969.
      Citations: 7     Fields:    Translation:AnimalsCells
    360. Hale ML, Greiner DL, McCarthy KF. Characterization of rat prothymocyte with monoclonal antibodies recognizing rat lymphocyte membrane antigenic determinants. Cell Immunol. 1987 Jun; 107(1):188-200. PMID: 3581175.
      Citations:    Fields:    Translation:AnimalsCells
    361. Greiner DL, Mordes JP, Handler ES, Nakamura N, Angelillo M, Rossini AA. Prothymocyte development in diabetes-prone BB rats: description of a defect that predisposes to immune abnormalities. Transplant Proc. 1987 Feb; 19(1 Pt 2):976-8. PMID: 3274436.
      Citations: 1     Fields:    Translation:AnimalsCells
    362. Cutler LS, Bullis D, Christian CP, Rendell JR, Greiner DL. Animal models of Sj?gren's syndrome. J Dent Res. 1987 Feb; 66(2):590-1. PMID: 3497962.
      Citations:    Fields:    Translation:Animals
    363. Mordes JP, Gallina DL, Handler ES, Greiner DL, Nakamura N, Pelletier A, Rossini AA. Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat. Diabetologia. 1987 Jan; 30(1):22-6. PMID: 2952538.
      Citations: 10     Fields:    Translation:AnimalsCells
    364. Greiner DL, Goldschneider I, Komschlies KL, Medlock ES, Bollum FJ, Schultz L. Defective lymphopoiesis in bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. I. Analysis of development of prothymocytes, early B lineage cells, and terminal deoxynucleotidyl transferase-positive cells. J Exp Med. 1986 Oct 01; 164(4):1129-44. PMID: 3531380.
      Citations: 11     Fields:    Translation:AnimalsCells
    365. Sgroi D, Cohen RN, Lingenheld EG, Strong MK, Binder T, Goldschneider I, Greiner D, Grunnet M, Clark RB. T cell lines derived from the spinal cords of mice with experimental allergic encephalomyelitis are self reactive. J Immunol. 1986 Sep 15; 137(6):1850-4. PMID: 2427582.
      Citations: 7     Fields:    Translation:AnimalsCells
    366. Chen-Woan M, McGregor DD, Harris WV, Greiner DL. Monoclonal antibody analysis of Listeria monocytogenes-induced cytotoxic lymphocytes. Immunology. 1986 Apr; 57(4):505-13. PMID: 3082747.
      Citations: 1     Fields:    Translation:AnimalsCells
    367. Rossini AA, Mordes JP, Greiner DL, Nakano K, Appel MC, Handler ES. Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells. J Clin Invest. 1986 Apr; 77(4):1399-401. PMID: 3958191.
      Citations: 6     Fields:    Translation:Animals
    368. Greiner DL, Handler ES, Nakano K, Mordes JP, Rossini AA. Absence of the RT-6 T cell subset in diabetes-prone BB/W rats. J Immunol. 1986 Jan; 136(1):148-51. PMID: 3079605.
      Citations: 32     Fields:    Translation:AnimalsCells
    369. Goldschneider I, Komschlies KL, Greiner DL. Studies of thymocytopoiesis in rats and mice. I. Kinetics of appearance of thymocytes using a direct intrathymic adoptive transfer assay for thymocyte precursors. J Exp Med. 1986 Jan 01; 163(1):1-17. PMID: 3510267.
      Citations: 62     Fields:    Translation:AnimalsCells
    370. Barton RW, Greiner DL, Medlock ES, Goldschneider I. Phenotypic heterogeneity of Gross virus-induced thymic lymphomas in the rat: cellular origins and migratory properties. Cell Immunol. 1985 Aug; 94(1):113-21. PMID: 3874700.
      Citations:    Fields:    Translation:AnimalsCells
    371. Whittum J, Goldschneider I, Greiner D, Zurier R. Developmental abnormalities of terminal deoxynucleotidyl transferase positive bone marrow cells and thymocytes in New Zealand mice: effects of prostaglandin E1. J Immunol. 1985 Jul; 135(1):272-80. PMID: 3873491.
      Citations: 8     Fields:    Translation:AnimalsCells
    372. Greiner DL, Goldschneider I, Lubaroff DM. Identification of thymocyte progenitors in hemopoietic tissues of the rat. I. A quantitative assay system for thymocyte regeneration. Thymus. 1984; 6(3):181-99. PMID: 6380006.
      Citations: 4     Fields:    Translation:AnimalsCells
    373. Ely JM, Greiner DL, Lubaroff DM, Fitch FW. Characterization of monoclonal antibodies that define rat T cell alloantigens. J Immunol. 1983 Jun; 130(6):2798-803. PMID: 6343484.
      Citations: 16     Fields:    Translation:AnimalsCells
    374. Greiner DL, Goldschneider I, Barton RW. Identification of thymocyte progenitors in hemopoietic tissues of the rat. II. Enrichment of functional prothymocytes on the fluorescence-activated cell sorter. J Exp Med. 1982 Nov 01; 156(5):1448-60. PMID: 6127371.
      Citations: 5     Fields:    Translation:AnimalsCells
    375. Greiner DL, Reynolds GW, Lubaroff DM. Maturation of functional T-lymphocyte subpopulations in the rat. Thymus. 1982 Feb; 4(2):77-90. PMID: 6977897.
      Citations: 3     Fields:    Translation:AnimalsCells
    376. Greiner DL, Barton RW, Goldschneider I, Lubaroff DM. Genetic linkage and cell distribution analysis of T cell alloantigens in the rat. J Immunogenet. 1982 Feb; 9(1):43-50. PMID: 6978914.
      Citations: 6     Fields:    Translation:AnimalsCells
    377. Greiner DL, Goldschneider I, Barton RW, Lubaroff DM. A quantitative assay system for thymocyte regeneration in the rat. Transplant Proc. 1981 Jun; 13(2):1457-9. PMID: 6264653.
      Citations: 1     Fields:    Translation:AnimalsCells
    378. Kunz HW, Gill TJ, Dixon BD, Taylor FH, Greiner DL. Growth and reproduction complex in the rat. Genes linked to the major histocompatibility complex that affect development. J Exp Med. 1980 Dec 01; 152(6):1506-18. PMID: 7192724.
      Citations: 21     Fields:    Translation:Animals
    379. Lubaroff DM, Greiner DL, Reynolds CW. Investigations of T-lymphocyte subpopulations in the rat using alloantigenic markers. Transplant Proc. 1979 Mar; 11(1):1092-4. PMID: 36696.
      Citations: 6     Fields:    Translation:AnimalsCells
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