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Ingolf M Bach PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB-513
Worcester MA 01605
Phone508-856-5627
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionUMMS - School of Medicine
    DepartmentRadiology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Konstanz University of Applied Sciences, Konstanz, , GermanyBSBiology
    Konstanz University of Applied Sciences, Konstanz, , GermanyMAMolecular Biology
    Paris Diderot University, Paris, , FrancePHDBiotechnology

    Collapse Overview 
    Collapse overview

    Academic Background

    Ingolf Bach carried out his doctoral work at the Pasteur Institute in Paris, supported by the Boehringer Ingelheim Foundation. He received his Ph.D. in 1993 from the University of Paris VII. Supported by fellowships from EMBO and HFSPO, he was a post-doctoral fellow from 1993 to 1996 and, later, an Assistant Research Biologist at the University of California, San Diego. From 1998 to 2005, he was an Assistant Professor and Heisenberg Scholar at the Center for Molecular Neurobiology at the University of Hamburg. Dr. Bach joined the Program in Gene Function and Expression at the University of Massachusetts Medical School as an Associate Professor in June of 2005.

    Neuronal Cell Fate Specification

    Photo: Ingolf Bach, Ph.D.

    A fundamental question in biology is how protein complexes consisting of multiple proteins regulate basic biological processes such as embryogenesis and, when disturbed, cause human disease. Our research investigates molecular mechanisms by which LIM domain proteins and associated cofactors regulate differential gene expression during cell fate specification events.

    The LIM domain mediates protein-protein interactions and is found in various proteins including LIM homeodomain transcription factors (LIM-HD), LIM-only (LMO) proteins and LIM kinases (LIMK). We are particularly interested in functions and regulation of LIM-HD proteins that specify cell lineages and regulate neuronal differentiation and brain morphogenesis during vertebrate and invertebrate development. The biological activity of LIM-HDs is regulated by LIM domain-associated cofactors CLIM/Lbd and RLIM/Rnf12. These cofactors are widely expressed and also exert important functions in the mammary gland and during X chromosome inactivation in female mice.

    To carry out our studies we apply molecular, biochemical and genetic methods using mouse development as model system. Current research projects in the laboratory comprise studies on the roles of LIM domain proteins / associated cofactors 1) for cell fate decisions during nervous system development, 2) for X chromosome inactivation, and 3) for mammary gland development, differentiation and breast cancer. Results of this research are intended to illuminate mechanisms of how cell fate decisions are orchestrated and how disturbances can lead to human disease.



    Collapse Rotation Projects

    Rotation Projects

    For rotation projects, please inquire with Dr. Bach.



    Collapse Post Docs

    A postdoctoral position is available to study in this laboratory. Contact Dr. Bach for additional details.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wang F, McCannell KN, Boškovic A, Zhu X, Shin J, Yu J, Gallant J, Byron M, Lawrence JB, Zhu LJ, Jones SN, Rando OJ, Fazzio TG, Bach I. Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs. Cell Rep. 2017 Dec 26; 21(13):3691-3699. PMID: 29281819.
      View in: PubMed
    2. Acharya D, Hainer SJ, Yoon Y, Wang F, Bach I, Rivera-Pérez JA, Fazzio TG. KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency. Cell Rep. 2017 Apr 25; 19(4):671-679. PMID: 28445719.
      View in: PubMed
    3. Wang F, Shin J, Shea JM, Yu J, Boškovic A, Byron M, Zhu X, Shalek AK, Regev A, Lawrence JB, Torres EM, Zhu LJ, Rando OJ, Bach I. Regulation of X-linked gene expression during early mouse development by Rlim. Elife. 2016 Sep 19; 5. PMID: 27642011.
      View in: PubMed
    4. Tan K, An L, Miao K, Ren L, Hou Z, Tao L, Zhang Z, Wang X, Xia W, Liu J, Wang Z, Xi G, Gao S, Sui L, Zhu DS, Wang S, Wu Z, Bach I, Chen DB, Tian J. Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3197-202. PMID: 26951653.
      View in: PubMed
    5. Shin J, Wallingford MC, Gallant J, Marcho C, Jiao B, Byron M, Bossenz M, Lawrence JB, Jones SN, Mager J, Bach I. RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast. Nature. 2014 Jul 3; 511(7507):86-9. PMID: 24870238.
      View in: PubMed
    6. Jiao B, Taniguchi-Ishigaki N, Güngör C, Peters MA, Chen YW, Riethdorf S, Drung A, Ahronian LG, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC, Johnsen SA, Bach I. Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling. Mol Biol Cell. 2013 Oct; 24(19):3085-96. PMID: 23904271.
      View in: PubMed
    7. Bach I. Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation. Cell Res. 2012 Nov; 22(11):1524-6. PMID: 22785560.
      View in: PubMed
    8. Jiao B, Ma H, Shokhirev MN, Drung A, Yang Q, Shin J, Lu S, Byron M, Kalantry S, Mercurio AM, Lawrence JB, Hoffmann A, Bach I. Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell. 2012 Apr 27; 149(3):630-41. PMID: 22541433.
      View in: PubMed
    9. Zhong Z, Ohnmacht J, Reimer MM, Bach I, Becker T, Becker CG. Chondrolectin mediates growth cone interactions of motor axons with an intermediate target. J Neurosci. 2012 Mar 28; 32(13):4426-39. PMID: 22457492.
      View in: PubMed
    10. Subramanian L, Sarkar A, Shetty AS, Muralidharan B, Padmanabhan H, Piper M, Monuki ES, Bach I, Gronostajski RM, Richards LJ, Tole S. Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus. Proc Natl Acad Sci U S A. 2011 Jul 5; 108(27):E265-74. PMID: 21690374.
      View in: PubMed
    11. Peter CJ, Evans M, Thayanithy V, Taniguchi-Ishigaki N, Bach I, Kolpak A, Bassell GJ, Rossoll W, Lorson CL, Bao ZZ, Androphy EJ. The COPI vesicle complex binds and moves with survival motor neuron within axons. Hum Mol Genet. 2011 May 1; 20(9):1701-11. PMID: 21300694.
      View in: PubMed
    12. Zhong Z, Ma H, Taniguchi-Ishigaki N, Nagarajan L, Becker CG, Bach I, Becker T. SSDP cofactors regulate neural patterning and differentiation of specific axonal projections. Dev Biol. 2011 Jan 15; 349(2):213-24. PMID: 21056553.
      View in: PubMed
    13. Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi-Ishigaki N, Zhu X, Jiao B, Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB, Bach I. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature. 2010 Oct 21; 467(7318):977-81. PMID: 20962847.
      View in: PubMed
    14. Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I. Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. Cancer Res. 2009 Jan 1; 69(1):128-36. PMID: 19117995.
      View in: PubMed
    15. Bhati M, Lee C, Nancarrow AL, Lee M, Craig VJ, Bach I, Guss JM, Mackay JP, Matthews JM. Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes. EMBO J. 2008 Jul 23; 27(14):2018-29. PMID: 18583962.
      View in: PubMed
    16. Bhati M, Lee M, Nancarrow AL, Bach I, Guss JM, Matthews JM. Crystallization of an Lhx3-Isl1 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Apr 1; 64(Pt 4):297-9. PMID: 18391431.
      View in: PubMed
    17. Güngör C, Taniguchi-Ishigaki N, Ma H, Drung A, Tursun B, Ostendorff HP, Bossenz M, Becker CG, Becker T, Bach I. Proteasomal selection of multiprotein complexes recruited by LIM homeodomain transcription factors. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):15000-5. PMID: 17848518.
      View in: PubMed
    18. Ostendorff HP, Tursun B, Cornils K, Schlüter A, Drung A, Güngör C, Bach I. Dynamic expression of LIM cofactors in the developing mouse neural tube. Dev Dyn. 2006 Mar; 235(3):786-91. PMID: 16395690.
      View in: PubMed
    19. Lee C, Nancarrow AL, Bach I, Mackay JP, Matthews JM. 1H, 15N and 13C assignments of an intramolecular Lhx3:ldb1 complex. J Biomol NMR. 2005 Nov; 33(3):198. PMID: 16331426.
      View in: PubMed
    20. Tursun B, Schlüter A, Peters MA, Viehweger B, Ostendorff HP, Soosairajah J, Drung A, Bossenz M, Johnsen SA, Schweizer M, Bernard O, Bach I. The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones. Genes Dev. 2005 Oct 1; 19(19):2307-19. PMID: 16204183.
      View in: PubMed
    21. Mollé B, Père S, Failli V, Bach I, Rétaux S. Lhx9 and lhx9alpha: differential biochemical properties and effects on neuronal differentiation. DNA Cell Biol. 2004 Nov; 23(11):761-8. PMID: 15585134.
      View in: PubMed
    22. Krämer OH, Zhu P, Ostendorff HP, Golebiewski M, Tiefenbach J, Peters MA, Brill B, Groner B, Bach I, Heinzel T, Göttlicher M. The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. EMBO J. 2003 Jul 1; 22(13):3411-20. PMID: 12840003.
      View in: PubMed
    23. Bach I, Ostendorff HP. Orchestrating nuclear functions: ubiquitin sets the rhythm. Trends Biochem Sci. 2003 Apr; 28(4):189-95. PMID: 12713902.
      View in: PubMed
    24. Becker T, Bossenz M, Tursun B, Schlüter A, Peters MA, Becker CG, Ostendorff HP, Bach I. Comparing protein stabilities during zebrafish embryogenesis. Methods Cell Sci. 2003; 25(1-2):85-9. PMID: 14739592.
      View in: PubMed
    25. Gimnopoulos D, Becker CG, Ostendorff HP, Bach I, Schachner M, Becker T. Expression of the zebrafish recognition molecule F3/F11/contactin in a subset of differentiating neurons is regulated by cofactors associated with LIM domains. Mech Dev. 2002 Dec; 119 Suppl 1:S135-41. PMID: 14516675.
      View in: PubMed
    26. Gimnopoulos D, Becker CG, Ostendorff HP, Bach I, Schachner M, Becker T. Expression of the zebrafish recognition molecule F3/F11/contactin in a subset of differentiating neurons is regulated by cofactors associated with LIM domains. Gene Expr Patterns. 2002 Nov; 2(1-2):137-43. PMID: 12617852.
      View in: PubMed
    27. Becker T, Ostendorff HP, Bossenz M, Schlüter A, Becker CG, Peirano RI, Bach I. Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development. Mech Dev. 2002 Sep; 117(1-2):75-85. PMID: 12204249.
      View in: PubMed
    28. Ostendorff HP, Peirano RI, Peters MA, Schlüter A, Bossenz M, Scheffner M, Bach I. Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature. 2002 Mar 7; 416(6876):99-103. PMID: 11882901.
      View in: PubMed
    29. Ostendorff HP, Bossenz M, Mincheva A, Copeland NG, Gilbert DJ, Jenkins NA, Lichter P, Bach I. Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors. Genomics. 2000 Oct 1; 69(1):120-30. PMID: 11013082.
      View in: PubMed
    30. Bach I. The LIM domain: regulation by association. Mech Dev. 2000 Mar 1; 91(1-2):5-17. PMID: 10704826.
      View in: PubMed
    31. Bach I, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW, Glass CK, Andersen B, Izpisúa Belmonte JC, Rosenfeld MG. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet. 1999 Aug; 22(4):394-9. PMID: 10431247.
      View in: PubMed
    32. Rétaux S, Rogard M, Bach I, Failli V, Besson MJ. Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain. J Neurosci. 1999 Jan 15; 19(2):783-93. PMID: 9880598.
      View in: PubMed
    33. Tucker AS, Al Khamis A, Ferguson CA, Bach I, Rosenfeld MG, Sharpe PT. Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development. Development. 1999 Jan; 126(2):221-8. PMID: 9847236.
      View in: PubMed
    34. Sugihara TM, Bach I, Kioussi C, Rosenfeld MG, Andersen B. Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15418-23. PMID: 9860983.
      View in: PubMed
    35. Bach I, Carrière C, Ostendorff HP, Andersen B, Rosenfeld MG. A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes Dev. 1997 Jun 1; 11(11):1370-80. PMID: 9192866.
      View in: PubMed
    36. Rosenfeld MG, Bach I, Erkman L, Li P, Lin C, Lin S, McEvilly R, Ryan A, Rhodes S, Schonnemann M, Scully K. Transcriptional control of cell phenotypes in the neuroendocrine system. Recent Prog Horm Res. 1996; 51:217-38; discussion 238-9. PMID: 8701080.
      View in: PubMed
    37. Bach I, Rhodes SJ, Pearse RV, Heinzel T, Gloss B, Scully KM, Sawchenko PE, Rosenfeld MG. P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2720-4. PMID: 7708713.
      View in: PubMed
    38. Bach I, Yaniv M. More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing. EMBO J. 1993 Nov; 12(11):4229-42. PMID: 7900999.
      View in: PubMed
    39. Christova R, Bach I, Galcheva-Gargova Z. Sequences of DNA fragments contacting the nuclear lamina in vivo. DNA Cell Biol. 1992 Oct; 11(8):627-36. PMID: 1339329.
      View in: PubMed
    40. Bach I, Pontoglio M, Yaniv M. Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1). Nucleic Acids Res. 1992 Aug 25; 20(16):4199-204. PMID: 1354855.
      View in: PubMed
    41. Bach I, Mattei MG, Cereghini S, Yaniv M. Two members of an HNF1 homeoprotein family are expressed in human liver. Nucleic Acids Res. 1991 Jul 11; 19(13):3553-9. PMID: 1677179.
      View in: PubMed
    42. Chouard T, Blumenfeld M, Bach I, Vandekerckhove J, Cereghini S, Yaniv M. A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain. Nucleic Acids Res. 1990 Oct 11; 18(19):5853-63. PMID: 2216777.
      View in: PubMed
    43. Bach I, Galcheva-Gargova Z, Mattei MG, Simon-Chazottes D, Guénet JL, Cereghini S, Yaniv M. Cloning of human hepatic nuclear factor 1 (HNF1) and chromosomal localization of its gene in man and mouse. Genomics. 1990 Sep; 8(1):155-64. PMID: 1707031.
      View in: PubMed
    44. Tronche F, Rollier A, Herbomel P, Bach I, Cereghini S, Weiss M, Yaniv M. Anatomy of the rat albumin promoter. Mol Biol Med. 1990 Apr; 7(2):173-85. PMID: 2188062.
      View in: PubMed
    45. Tronche F, Rollier A, Bach I, Weiss MC, Yaniv M. The rat albumin promoter: cooperation with upstream elements is required when binding of APF/HNF1 to the proximal element is partially impaired by mutation or bacterial methylation. Mol Cell Biol. 1989 Nov; 9(11):4759-66. PMID: 2689864.
      View in: PubMed
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