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Ingolf M Bach PhD

InstitutionUMass Chan Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUMass Chan Medical School
364 Plantation Street LRB-513
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionT.H. Chan School of Medicine
    DivisionCellular Biology & Imaging

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    Collapse Biography 
    Collapse education and training
    University of Konstanz, Konstanz, , GermanyBABiology
    University of Konstanz, Konstanz, , GermanyMAMolecular Biology
    Paris Diderot University, Paris, , FrancePHDBiotechnology

    Collapse Overview 
    Collapse overview

    Academic Background

    Ingolf Bach carried out his doctoral work at the Pasteur Institute in Paris, supported by the Boehringer Ingelheim Foundation. He received his Ph.D. in 1993 from the University of Paris VII. Supported by fellowships from EMBO and HFSPO, he was a post-doctoral fellow from 1993 to 1996 and, later, an Assistant Research Biologist at the University of California, San Diego. From 1998 to 2005, he was an Assistant Professor and Heisenberg Scholar at the Center for Molecular Neurobiology at the University of Hamburg. Dr. Bach joined the Program in Gene Function and Expression at the University of Massachusetts Medical School as an Associate Professor in June of 2005.

    Neuronal Cell Fate Specification

    Photo: Ingolf Bach, Ph.D.

    A fundamental question in biology is how protein complexes consisting of multiple proteins regulate basic biological processes such as embryogenesis and, when disturbed, cause human disease. Our research investigates molecular mechanisms by which LIM domain proteins and associated cofactors regulate differential gene expression during cell fate specification events.

    The LIM domain mediates protein-protein interactions and is found in various proteins including LIM homeodomain transcription factors (LIM-HD), LIM-only (LMO) proteins and LIM kinases (LIMK). We are particularly interested in functions and regulation of LIM-HD proteins that specify cell lineages and regulate neuronal differentiation and brain morphogenesis during vertebrate and invertebrate development. The biological activity of LIM-HDs is regulated by LIM domain-associated cofactors CLIM/Lbd and RLIM/Rnf12. These cofactors are widely expressed and also exert important functions in the mammary gland and during X chromosome inactivation in female mice.

    To carry out our studies we apply molecular, biochemical and genetic methods using mouse development as model system. Current research projects in the laboratory comprise studies on the roles of LIM domain proteins / associated cofactors 1) for cell fate decisions during nervous system development, 2) for X chromosome inactivation, and 3) for mammary gland development, differentiation and breast cancer. Results of this research are intended to illuminate mechanisms of how cell fate decisions are orchestrated and how disturbances can lead to human disease.

    Collapse Rotation Projects

    Rotation Projects

    For rotation projects, please inquire with Dr. Bach.

    Collapse Post Docs

    A postdoctoral position is available to study in this laboratory. Contact Dr. Bach for additional details.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang F, Mehta P, Bach I. How does the Xist activator Rlim/Rnf12 regulate Xist expression? Biochem Soc Trans. 2024 Jun 26; 52(3):1099-1107. PMID: 38747697.
    2. Wang F, Chander A, Yoon Y, Welton JM, Wallingford MC, Espejo-Serrano C, Bustos F, Findlay GM, Mager J, Bach I. Roles of the Rlim-Rex1 axis during X chromosome inactivation in mice. Proc Natl Acad Sci U S A. 2023 Dec 26; 120(52):e2313200120. PMID: 38113263.
      Citations:    Fields:    Translation:AnimalsCells
    3. Segarra-Fas A, Espejo-Serrano C, Bustos F, Zhou H, Wang F, Toth R, Macartney T, Bach I, Nardocci G, Findlay GM. An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations. Sci Signal. 2022 07 12; 15(742):eabm5995. PMID: 35857630.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    4. Wang F, Gervasi MG, Bo?kovic A, Sun F, Rinaldi VD, Yu J, Wallingford MC, Tourzani DA, Mager J, Zhu LJ, Rando OJ, Visconti PE, Strittmatter L, Bach I. Deficient spermiogenesis in mice lacking Rlim. Elife. 2021 02 23; 10. PMID: 33620316.
      Citations: 4     Fields:    Translation:AnimalsCells
    5. Wang F, Bach I. Rlim/Rnf12, Rex1, and X Chromosome Inactivation. Front Cell Dev Biol. 2019; 7:258. PMID: 31737626.
    6. Wang F, McCannell KN, Bo?kovic A, Zhu X, Shin J, Yu J, Gallant J, Byron M, Lawrence JB, Zhu LJ, Jones SN, Rando OJ, Fazzio TG, Bach I. Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs. Cell Rep. 2017 12 26; 21(13):3691-3699. PMID: 29281819.
      Citations: 11     Fields:    Translation:AnimalsCells
    7. Acharya D, Hainer SJ, Yoon Y, Wang F, Bach I, Rivera-P?rez JA, Fazzio TG. KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency. Cell Rep. 2017 04 25; 19(4):671-679. PMID: 28445719.
      Citations: 17     Fields:    Translation:AnimalsCells
    8. Wang F, Shin J, Shea JM, Yu J, Bo?kovic A, Byron M, Zhu X, Shalek AK, Regev A, Lawrence JB, Torres EM, Zhu LJ, Rando OJ, Bach I. Regulation of X-linked gene expression during early mouse development by Rlim. Elife. 2016 09 19; 5. PMID: 27642011.
      Citations: 25     Fields:    Translation:Animals
    9. Tan K, An L, Miao K, Ren L, Hou Z, Tao L, Zhang Z, Wang X, Xia W, Liu J, Wang Z, Xi G, Gao S, Sui L, Zhu DS, Wang S, Wu Z, Bach I, Chen DB, Tian J. Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3197-202. PMID: 26951653.
      Citations: 24     Fields:    Translation:HumansCells
    10. Shin J, Wallingford MC, Gallant J, Marcho C, Jiao B, Byron M, Bossenz M, Lawrence JB, Jones SN, Mager J, Bach I. RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast. Nature. 2014 Jul 03; 511(7507):86-9. PMID: 24870238.
      Citations: 35     Fields:    Translation:AnimalsCells
    11. Jiao B, Taniguchi-Ishigaki N, G?ng?r C, Peters MA, Chen YW, Riethdorf S, Drung A, Ahronian LG, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC, Johnsen SA, Bach I. Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling. Mol Biol Cell. 2013 Oct; 24(19):3085-96. PMID: 23904271.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    12. Bach I. Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation. Cell Res. 2012 Nov; 22(11):1524-6. PMID: 22785560.
      Citations: 2     Fields:    Translation:AnimalsCells
    13. Jiao B, Ma H, Shokhirev MN, Drung A, Yang Q, Shin J, Lu S, Byron M, Kalantry S, Mercurio AM, Lawrence JB, Hoffmann A, Bach I. Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell. 2012 Apr 27; 149(3):630-41. PMID: 22541433.
      Citations: 20     Fields:    Translation:Animals
    14. Zhong Z, Ohnmacht J, Reimer MM, Bach I, Becker T, Becker CG. Chondrolectin mediates growth cone interactions of motor axons with an intermediate target. J Neurosci. 2012 Mar 28; 32(13):4426-39. PMID: 22457492.
      Citations: 11     Fields:    Translation:AnimalsCells
    15. Subramanian L, Sarkar A, Shetty AS, Muralidharan B, Padmanabhan H, Piper M, Monuki ES, Bach I, Gronostajski RM, Richards LJ, Tole S. Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):E265-74. PMID: 21690374.
      Citations: 58     Fields:    Translation:AnimalsCells
    16. Peter CJ, Evans M, Thayanithy V, Taniguchi-Ishigaki N, Bach I, Kolpak A, Bassell GJ, Rossoll W, Lorson CL, Bao ZZ, Androphy EJ. The COPI vesicle complex binds and moves with survival motor neuron within axons. Hum Mol Genet. 2011 May 01; 20(9):1701-11. PMID: 21300694.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    17. Zhong Z, Ma H, Taniguchi-Ishigaki N, Nagarajan L, Becker CG, Bach I, Becker T. SSDP cofactors regulate neural patterning and differentiation of specific axonal projections. Dev Biol. 2011 Jan 15; 349(2):213-24. PMID: 21056553.
      Citations: 4     Fields:    Translation:AnimalsCells
    18. Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi-Ishigaki N, Zhu X, Jiao B, Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB, Bach I. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature. 2010 Oct 21; 467(7318):977-81. PMID: 20962847.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    19. Johnsen SA, G?ng?r C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I. Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. Cancer Res. 2009 Jan 01; 69(1):128-36. PMID: 19117995.
      Citations: 33     Fields:    Translation:HumansCells
    20. Bhati M, Lee C, Nancarrow AL, Lee M, Craig VJ, Bach I, Guss JM, Mackay JP, Matthews JM. Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes. EMBO J. 2008 Jul 23; 27(14):2018-29. PMID: 18583962.
      Citations: 38     Fields:    Translation:HumansCells
    21. Bhati M, Lee M, Nancarrow AL, Bach I, Guss JM, Matthews JM. Crystallization of an Lhx3-Isl1 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Apr 01; 64(Pt 4):297-9. PMID: 18391431.
      Citations: 11     Fields:    Translation:Cells
    22. G?ng?r C, Taniguchi-Ishigaki N, Ma H, Drung A, Tursun B, Ostendorff HP, Bossenz M, Becker CG, Becker T, Bach I. Proteasomal selection of multiprotein complexes recruited by LIM homeodomain transcription factors. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):15000-5. PMID: 17848518.
      Citations: 33     Fields:    Translation:Cells
    23. Ostendorff HP, Tursun B, Cornils K, Schl?ter A, Drung A, G?ng?r C, Bach I. Dynamic expression of LIM cofactors in the developing mouse neural tube. Dev Dyn. 2006 Mar; 235(3):786-91. PMID: 16395690.
      Citations: 21     Fields:    Translation:Animals
    24. Lee C, Nancarrow AL, Bach I, Mackay JP, Matthews JM. 1H, 15N and 13C assignments of an intramolecular Lhx3:ldb1 complex. J Biomol NMR. 2005 Nov; 33(3):198. PMID: 16331426.
      Citations: 7     Fields:    Translation:Humans
    25. Tursun B, Schl?ter A, Peters MA, Viehweger B, Ostendorff HP, Soosairajah J, Drung A, Bossenz M, Johnsen SA, Schweizer M, Bernard O, Bach I. The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones. Genes Dev. 2005 Oct 01; 19(19):2307-19. PMID: 16204183.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    26. Moll? B, P?re S, Failli V, Bach I, R?taux S. Lhx9 and lhx9alpha: differential biochemical properties and effects on neuronal differentiation. DNA Cell Biol. 2004 Nov; 23(11):761-8. PMID: 15585134.
      Citations: 5     Fields:    Translation:AnimalsCells
    27. Kr?mer OH, Zhu P, Ostendorff HP, Golebiewski M, Tiefenbach J, Peters MA, Brill B, Groner B, Bach I, Heinzel T, G?ttlicher M. The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. EMBO J. 2003 Jul 01; 22(13):3411-20. PMID: 12840003.
      Citations: 196     Fields:    Translation:AnimalsCells
    28. Bach I, Ostendorff HP. Orchestrating nuclear functions: ubiquitin sets the rhythm. Trends Biochem Sci. 2003 Apr; 28(4):189-95. PMID: 12713902.
      Citations: 22     Fields:    Translation:AnimalsCells
    29. Becker T, Bossenz M, Tursun B, Schl?ter A, Peters MA, Becker CG, Ostendorff HP, Bach I. Comparing protein stabilities during zebrafish embryogenesis. Methods Cell Sci. 2003; 25(1-2):85-9. PMID: 14739592.
      Citations: 3     Fields:    Translation:AnimalsCells
    30. Gimnopoulos D, Becker CG, Ostendorff HP, Bach I, Schachner M, Becker T. Expression of the zebrafish recognition molecule F3/F11/contactin in a subset of differentiating neurons is regulated by cofactors associated with LIM domains. Mech Dev. 2002 Dec; 119 Suppl 1:S135-41. PMID: 14516675.
      Citations: 1     Fields:    Translation:AnimalsCells
    31. Gimnopoulos D, Becker CG, Ostendorff HP, Bach I, Schachner M, Becker T. Expression of the zebrafish recognition molecule F3/F11/contactin in a subset of differentiating neurons is regulated by cofactors associated with LIM domains. Gene Expr Patterns. 2002 Nov; 2(1-2):137-43. PMID: 12617852.
      Citations: 1     Fields:    Translation:AnimalsCells
    32. Becker T, Ostendorff HP, Bossenz M, Schl?ter A, Becker CG, Peirano RI, Bach I. Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development. Mech Dev. 2002 Sep; 117(1-2):75-85. PMID: 12204249.
      Citations: 24     Fields:    Translation:AnimalsCells
    33. Ostendorff HP, Peirano RI, Peters MA, Schl?ter A, Bossenz M, Scheffner M, Bach I. Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature. 2002 Mar 07; 416(6876):99-103. PMID: 11882901.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    34. Ostendorff HP, Bossenz M, Mincheva A, Copeland NG, Gilbert DJ, Jenkins NA, Lichter P, Bach I. Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors. Genomics. 2000 Oct 01; 69(1):120-30. PMID: 11013082.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    35. Bach I. The LIM domain: regulation by association. Mech Dev. 2000 Mar 01; 91(1-2):5-17. PMID: 10704826.
      Citations: 179     Fields:    Translation:HumansAnimalsCells
    36. Bach I, Rodriguez-Esteban C, Carri?re C, Bhushan A, Krones A, Rose DW, Glass CK, Andersen B, Izpis?a Belmonte JC, Rosenfeld MG. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet. 1999 Aug; 22(4):394-9. PMID: 10431247.
      Citations: 55     Fields:    Translation:AnimalsCells
    37. R?taux S, Rogard M, Bach I, Failli V, Besson MJ. Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain. J Neurosci. 1999 Jan 15; 19(2):783-93. PMID: 9880598.
      Citations: 55     Fields:    Translation:AnimalsCells
    38. Tucker AS, Al Khamis A, Ferguson CA, Bach I, Rosenfeld MG, Sharpe PT. Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development. Development. 1999 Jan; 126(2):221-8. PMID: 9847236.
      Citations: 18     Fields:    Translation:Animals
    39. Sugihara TM, Bach I, Kioussi C, Rosenfeld MG, Andersen B. Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15418-23. PMID: 9860983.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    40. Bach I, Carri?re C, Ostendorff HP, Andersen B, Rosenfeld MG. A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes Dev. 1997 Jun 01; 11(11):1370-80. PMID: 9192866.
      Citations: 90     Fields:    Translation:AnimalsCells
    41. Rosenfeld MG, Bach I, Erkman L, Li P, Lin C, Lin S, McEvilly R, Ryan A, Rhodes S, Schonnemann M, Scully K. Transcriptional control of cell phenotypes in the neuroendocrine system. Recent Prog Horm Res. 1996; 51:217-38; discussion 238-9. PMID: 8701080.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    42. Bach I, Rhodes SJ, Pearse RV, Heinzel T, Gloss B, Scully KM, Sawchenko PE, Rosenfeld MG. P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2720-4. PMID: 7708713.
      Citations: 67     Fields:    Translation:AnimalsCells
    43. Bach I, Yaniv M. More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing. EMBO J. 1993 Nov; 12(11):4229-42. PMID: 7900999.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    44. Christova R, Bach I, Galcheva-Gargova Z. Sequences of DNA fragments contacting the nuclear lamina in vivo. DNA Cell Biol. 1992 Oct; 11(8):627-36. PMID: 1339329.
      Citations: 2     Fields:    Translation:AnimalsCells
    45. Bach I, Pontoglio M, Yaniv M. Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1). Nucleic Acids Res. 1992 Aug 25; 20(16):4199-204. PMID: 1354855.
      Citations: 7     Fields:    Translation:AnimalsCells
    46. Bach I, Mattei MG, Cereghini S, Yaniv M. Two members of an HNF1 homeoprotein family are expressed in human liver. Nucleic Acids Res. 1991 Jul 11; 19(13):3553-9. PMID: 1677179.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    47. Chouard T, Blumenfeld M, Bach I, Vandekerckhove J, Cereghini S, Yaniv M. A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain. Nucleic Acids Res. 1990 Oct 11; 18(19):5853-63. PMID: 2216777.
      Citations: 42     Fields:    Translation:AnimalsCells
    48. Bach I, Galcheva-Gargova Z, Mattei MG, Simon-Chazottes D, Gu?net JL, Cereghini S, Yaniv M. Cloning of human hepatic nuclear factor 1 (HNF1) and chromosomal localization of its gene in man and mouse. Genomics. 1990 Sep; 8(1):155-64. PMID: 1707031.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    49. Tronche F, Rollier A, Herbomel P, Bach I, Cereghini S, Weiss M, Yaniv M. Anatomy of the rat albumin promoter. Mol Biol Med. 1990 Apr; 7(2):173-85. PMID: 2188062.
      Citations: 11     Fields:    Translation:AnimalsCells
    50. Tronche F, Rollier A, Bach I, Weiss MC, Yaniv M. The rat albumin promoter: cooperation with upstream elements is required when binding of APF/HNF1 to the proximal element is partially impaired by mutation or bacterial methylation. Mol Cell Biol. 1989 Nov; 9(11):4759-66. PMID: 2689864.
      Citations: 39     Fields:    Translation:AnimalsCells
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