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Jonathan K Watts PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentRNA Therapeutics Institute
AddressUniversity of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01605
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - School of Medicine
    DepartmentRNA Therapeutics Institute


    Collapse Biography 
    Collapse education and training
    Dalhousie University, Halifax, NS, CanadaBSChemistry
    McGill University, Montreal, QC, CanadaPHDBio-organic Chemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ghanta KS, Chen Z, Mir A, Dokshin GA, Krishnamurthy PM, Yoon Y, Gallant J, Xu P, Zhang XO, Ozturk AR, Shin M, Idrizi F, Liu P, Gneid H, Edraki A, Lawson ND, Rivera-PĂ©rez JA, Sontheimer E, Watts JK, Mello CC. 5' modifications improve potency and efficacy of DNA donors for precision genome editing. Elife. 2021 Oct 19; 10. PMID: 34665130.
      View in: PubMed
    2. Oomen ME, Hedger AK, Watts JK, Dekker J. Detecting chromatin interactions between and along sister chromatids with SisterC. Nat Methods. 2020 Sep 23. PMID: 32968250.
      View in: PubMed
    3. Watts JK, Ockene IS. RNA Interference for the Masses? siRNA Targeting PCSK9 Promises Prevention of Cardiovascular Disease. Nucleic Acid Ther. 2020 Jan 13. PMID: 31928497.
      View in: PubMed
    4. Watts JK, Brown RH, Khvorova A. Nucleic Acid Therapeutics for Neurological Diseases. Neurotherapeutics. 2019 Apr 29. PMID: 31037650.
      View in: PubMed
    5. Debacker AJ, Sharma VK, Meda Krishnamurthy P, O'Reilly D, Greenhill R, Watts JK. Next-Generation Peptide Nucleic Acid Chimeras Exhibit High Affinity and Potent Gene Silencing. Biochemistry. 2019 Feb 12; 58(6):582-589. PMID: 30520300.
      View in: PubMed
    6. Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ. Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing. Nat Commun. 2018 Jul 06; 9(1):2641. PMID: 29980686.
      View in: PubMed
    7. Osborn MF, Coles AH, Golebiowski D, Echeverria D, Moazami MP, Watts JK, Sena-Esteves M, Khvorova A. Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs. Mol Cancer Ther. 2018 Jun; 17(6):1251-1258. PMID: 29654062.
      View in: PubMed
    8. Sharma VK, Singh SK, Krishnamurthy PM, Alterman JF, Haraszti RA, Khvorova A, Prasad AK, Watts JK. Synthesis and biological properties of triazole-linked locked nucleic acid. Chem Commun (Camb). 2017 Aug 03; 53(63):8906-8909. PMID: 28736781.
      View in: PubMed
    9. Khvorova A, Watts JK. The chemical evolution of oligonucleotide therapies of clinical utility. Nat Biotechnol. 2017 Mar; 35(3):238-248. PMID: 28244990.
      View in: PubMed
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