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Dan Wang PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentGenetic and Cellular Medicine
AddressUMass Chan Medical School
368 Plantation Street AS6-2011
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentGene Therapy Center

    InstitutionT.H. Chan School of Medicine
    DepartmentGenetic and Cellular Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Fudan University, Shanghai, 31, ChinaBSLife Sciences
    University of Alabama, Birmingham, Birmingham, AL, United StatesPHDGenetics & Genomic Sciences

    Collapse Overview 
    Collapse overview

    Our research centers around gene therapy using adeno-associated virus (AAV) vectors. We carry out translational gene therapy studies targeting several neurological and metabolic diseases. In addition to targeting specific diseases, we develop therapeutic platforms based on molecular approaches such as genome editing and RNA-based methods. We also develop platform technologies to facilitate AAV-based gene therapy, such as animal modeling and AAV vector production.

    In 2020, the lab starts accepting graduate students, postdoctoral researchers, and research associates. Send in your application and get in touch today!


    Collapse Rotation Projects

    - AAV gene therapy for genetic diseases

    - Therapeutic genome editing

    - RNA-based approaches to treating genetic diseases

    - Interactions between AAV vector and host cell

    - AAV vector capsid engineering


    Collapse Post Docs

    We are looking for motivated postdoctoral researchers. Send in your application and get in touch today!



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ho TC, Vignolle GA, Wang DJJ, Church A. Permeability of the intestinal epithelial and blood-brain barriers as therapeutic targets in inflammatory depression. Brain Behav Immun. 2026 Sep 26; 107028. PMID: 42800571.
      Citations:    
    2. Guo F, Zhao C, Bhatt RR, Liu Z, Kim AJ, Yang Z, Xu S, Jann K, Shao X, Mather M, Jahanshad N, Wang DJ. Assessing molecular, cellular and transcriptomic bases of laminar perfusion and cytoarchitecture coupling in the human cortex. Nat Commun. 2026 Aug 13; 17(1). PMID: 42733079.
      Citations:    
    3. Deng Z, Xu S, Zhang J, Tang J, Zhang J, Wang DJ, Yan L, Shi Y. Self-supervised small vessel segmentation with shape-aware geometric models and attention. Med Image Anal. 2026 Nov; 114:104229. PMID: 42612517.
      Citations:    
    4. Liu H, Du A, Liu N, Kapadia M, Chen X, Liang J, Lee JS, Xie J, Gao G, Wang D. Viral gene replication enhances AAV vector quality and reduces manufacturing costs. Mol Ther. 2026 Aug 11. PMID: 42581546.
      Citations:    
    5. Link-Sourani D, Avisdris N, Shao X, Schonberger D, Rabinowich A, Fadida BS, Wexler Y, Joskowicz L, Sira LB, Hiersch L, Wang DJJ, Bashat DB. In Vivo Assessment of Placental Structure and Perfusion in Late-Gestation Pregnancies and Their Association With Fetal Growth. NMR Biomed. 2026 Aug; 39(8):e70346. PMID: 42387322.
      Citations:    
    6. Michels L, Jones J, O'Gorman Tuura R, Huber R, Wang DJJ, Kay DB. Relative Cerebral Blood Flow Differences in Individuals With Insomnia Across Sleep-Wake States Compared to Good Sleeper Controls: A Sleep Neuroimaging Study Using Arterial Spin Labelling. J Sleep Res. 2026 Oct; 35(5):e70397. PMID: 42458639.
      Citations:    
    7. Wijesinghe D, Lynch K, Aksman L, Delis DC, Wang DJ, Jann K. Lifespan trajectories of the brain's functional complexity characterized by multiscale sample entropy. Neuroimage. 2026 Sep; 338:122085. PMID: 42386108.
      Citations:    
    8. Wang J, Turgeon CT, Loken PR, Gray-Edwards H, Gao G, Tortorelli S, Wang D, Strauss KA. Systemic dual-gene therapy reverses biochemical intoxication in the central metabolic compartment of Bckdha-/- mice. Mol Ther. 2026 Aug 05; 34(8):4569-4580. PMID: 42136029.
      Citations:    
    9. Liu D, Shao X, Silva FM, Sanatkhani S, Lee R, Konofagou EE, Wang DJ, Ferrera VP. Alteration of water exchange rates following focused ultrasound-mediated BBB opening in the dorsal striatum of non-human primates: A diffusion-prepared pCASL study. Neuroimage. 2026 Mar; 328:121805. PMID: 41690338.
      Citations:    
    10. Zhao C, Guo F, Yang Z, Shao X, Ma SJ, Beckett AJS, Vu AT, Feinberg DA, Wang DJJ. Next Generation 7?Tesla Arterial Spin Labeling With Rotated Spiral Acquisition Enables Mesoscale Resolution in 3D Brain Perfusion and Functional MRI. Magn Reson Med. 2026 05; 95(5):2702-2717. PMID: 41612124.
      Citations:    
    11. Xu M, Liu H, Wang J, Vieira AFC, Zhou X, Liu N, Liang J, Du A, Chen X, Xing R, Yang Y, Gonzalez-Perez MP, Kumar V, Wang D. An engineered UGA suppressor tRNA gene for disease-agnostic AAV delivery. Nat Biotechnol. 2026 Jan 19. PMID: 41555020.
      Citations:    
    12. Stringer MS, Shao X, Lee H, Vallatos A, Arteaga-Reyes C, Clancy U, Chappell F, Manning C, Valdes-Hernandez M, Jaime Garcia D, Brown R, Doubal FN, Benveniste H, Thrippleton MJ, Wang DJ, Wardlaw JM. Gadolinium- and water-based blood-brain barrier dysfunction measures in patients with sporadic small vessel disease. Cereb Circ Cogn Behav. 2026; 10:100528. PMID: 41631279.
      Citations:    
    13. Wang DJ, Shao X, Zhao L, Thomas DL, Parkes LM. Editorial for special issue: Emerging methods for mapping neurofluid circulation and exchange. Neuroimage. 2025 Dec 01; 323:121595. PMID: 41265718.
      Citations:    
    14. Beutler BD, Chan J, Tsuruda J, Wang DJ, Chin CT, Patel DB, Gevorkian M, Rajagopalan P. The lumbosacral plexus: Anatomy, clinical imaging, and proof-of-concept insights with ultra-high-field 7 Tesla MRI. Clin Imaging. 2026 Jan; 129:110675. PMID: 41252793.
      Citations:    
    15. Goldwaser EL, Yuen A, Marshall W, Adhikari BM, Chiappelli J, van der Vaart A, Kvarta M, Ma Y, Du X, Gao S, Bruce H, Donnelly P, Mitchell B, Hong C, Wang DJJ, Kochunov P, Hong LE. Peripheral Microvascular and Cerebral White Matter Dysfunction in Schizophrenia: Implications of a Body-Brain Endothelial Pathophysiology. Schizophr Bull. 2025 11 10; 51(6):1658-1667. PMID: 40036787.
      Citations:    
    16. Guo F, Zhao C, Bhatt RR, Liu Z, Kim AJ, Yang Z, Xu S, Jann K, Mather M, Jahanshad N, Wang DJ. Assessing molecular, cellular and transcriptomic bases of laminar perfusion and cytoarchitecture coupling in the human cortex. bioRxiv. 2025 Nov 05. PMID: 41279822.
      Citations:    
    17. Engstrom AC, Dutt S, Alitin JPM, Kapoor A, Lohman T, Sible IJ, Marshall AJ, Shenasa F, Joyce JL, Gaubert A, Ferrer F, Nguyen A, Shao X, Wang DJJ, Nation DA. Age differences in spontaneous cerebrovascular reactivity at rest. Geroscience. 2026 Aug; 48(4):5547-5560. PMID: 41166037.
      Citations:    
    18. Shou Q, Cen S, Chen NK, Ringman JM, Kim H, Jack CR, Borowski BJ, Senjem ML, Arani A, Wang DJJ. Generative diffusion model enables quantification of calibration-free arterial spin labeling perfusion magnetic resonance imaging data in an Alzheimer's disease cohort. Alzheimers Dement (Amst). 2025 Oct-Dec; 17(4):e70214. PMID: 41181519.
      Citations:    
    19. Kroth JB, Handfas B, Rodrigues G, Zepeda F, Oliveira MA, Wang DJJ, de Azevedo Neto RM, Silva GS, Amaro E, Sorinola IO, Conforto AB. Correction: Effects of repetitive peripheral sensory stimulation in the subacute and chronic phases after stroke: study protocol for a pilot randomized trial. Front Neurol. 2025; 16:1713834. PMID: 41180529.
      Citations:    
    20. Kim AJ, Zhao C, Guo F, Pappas I, Dahl MJ, Jacobs HIL, Wang DJJ, Mather M. Arousal increases locus coeruleus blood flow, salience-related brain responses, and modulates negative-valence attentional biases. bioRxiv. 2025 Oct 13. PMID: 41279392.
      Citations:    
    21. Xing R, Xu M, Reil D, Destefano A, Cui M, Liu N, Liang J, Xu G, Luo L, Xu M, Zhang F, Tai PWL, Wei Y, Gruntman AM, Flotte TR, Gao G, Wang D. A single amino acid variant in the variable region I of AAV capsid confers liver detargeting. PLoS Pathog. 2025 09; 21(9):e1013533. PMID: 40961169.
      Citations:    
    22. Liu D, Shao X, Silva FM, Sanatkhani S, Lee R, Konofagou EE, Wang DJ, Ferrera VP. Alteration of Water Exchange Rates Following Focused Ultrasound-Mediated BBB Opening in the Dorsal Striatum of Non-Human Primates: A Diffusion-Prepared pCASL Study. bioRxiv. 2025 Aug 01. PMID: 40766706.
      Citations:    
    23. Rowsthorn E, Sim MA, O'Brien WT, McDonald SJ, Franks K, Sinclair B, Chong TT, Yiallourou S, Cavuoto M, Vivash L, O'Brien TJ, Shao X, Wang DJJ, Law M, Harding IH, Pase MP. Factor analysis of multimodal MRI, biofluid, and vascular biomarkers reveals latent constructs of brain health. Geroscience. 2026 04; 48(2):1885-1903. PMID: 40627123.
      Citations:    
    24. Dong TS, Jann K, Wang DJJ, Church A. Understanding whole person systems in brain-gut-microbiome research through ultra-high-field MRI imaging. Neuroimage. 2025 08 15; 317:121360. PMID: 40614884.
      Citations:    
    25. Rowsthorn E, Cribb L, Sinclair B, Pham W, Chong TT, Yiallourou S, Cavuoto M, Vivash L, O'Brien TJ, Shao X, Wang DJJ, Law M, Pase MP, Harding IH. Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study. Fluids Barriers CNS. 2025 Jun 16; 22(1):59. PMID: 40524195.
      Citations:    
    26. Xing R, Xu M, Reil D, Destefano A, Cui M, Liu N, Liang J, Xu G, Luo L, Xu M, Zhang F, Tai PWL, Wei Y, Gruntman AM, Flotte TR, Gao G, Wang D. A single amino acid variant in the variable region I of AAV capsid confers liver detargeting. bioRxiv. 2025 Jun 14. PMID: 40093067.
      Citations:    
    27. Zhang Z, Zhang J, Chen X, Deming BA, Kant S, Mandal P, Kothandaraman H, SanMiguel PJ, Halurkar MS, Abeyaratna AD, Robinson MJ, Zhao Y, Vitko Y, Gaykema RP, Yuan C, Lanman NA, Tegtmeyer MT, Wang D, Gao G, Shi R, Perez-Reyes E, Yang Y. Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice. bioRxiv. 2025 Jun 06. PMID: 40501831.
      Citations:    
    28. Kochunov P, Adhikari BM, Keator D, Amen D, Gao S, Karcher NR, Labate D, Azencott R, Huang Y, Syed H, Ke H, Thompson PM, Wang DJJ, Mitchell BD, Turner JA, van Erp TGM, Jahanshad N, Ma Y, Du X, Burroughs W, Chen S, Ma T, Soares JC, Hong LE. Functional vs Structural Cortical Deficit Pattern Biomarkers for Major Depressive Disorder. JAMA Psychiatry. 2025 Jun 01; 82(6):582-590. PMID: 40172866.
      Citations:    
    29. Torturo CL, Du A, Kerker K, Gresack J, DeGrave C, Funk K, Agnihotri P, Hsieh F, Gunn TM, Ramboz S, Bettencourt B, Reich S, Gao G, Wang D, Sah DWY. Behavioral efficacy of AAV FOXG1 gene replacement therapy in a mouse model of FOXG1 syndrome. bioRxiv. 2025. View Publication.
    30. Liu H, Liu N, Zhou C, Du A, Kapadia M, Tai PWL, Barton E, Gao G, Wang D. High-purity AAV vector production utilizing recombination-dependent minicircle formation and genetic coupling. EMBO Mol Med. 2025 06; 17(6):1475-1494. PMID: 40379974.
      Citations:    
    31. Pappas I, Lohman T, Dutt S, Kapoor A, Engstrom AC, Alitin JPM, Barnes S, Chakhoyan A, Saca L, Gaggar R, Nourollahimoghadam E, Wang DJJ, Lai MHC, Joe EB, Ringman JM, Yassine HN, Schneider LS, Chui HC, Toga AW, Zlokovic BV, Nation DA. Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers. Geroscience. 2025 06; 47(3):4973-4986. PMID: 40220152.
      Citations:    
    32. Chen G, Li H, Shao X, Wang DJJ, Hu W, Han Y, Yang Q. Decreased water exchange rate across the blood-brain barrier throughout the Alzheimer's disease continuum: Evidence from Chinese data. Alzheimers Dement. 2025 03; 21(3):e70089. PMID: 40145328.
      Citations:    
    33. Wang D, Stevens G, Flotte TR. Gene therapy then and now: A look back at changes in the field over the past 25 years. Mol Ther. 2025 May 07; 33(5):1889-1902. PMID: 40022444.
      Citations:    
    34. Wang J, Poskitt LE, Gallagher J, Puffenberger EG, Wynn RM, Shishodia G, Chuang DT, Beever J, Hardin DL, Brigatti KW, Baker WC, Gately R, Bertrand S, Rodrigues A, Benatti HR, Taghian T, Hall E, Prestigiacomo R, Liang J, Chen G, Zhou X, Ren L, Liu N, He R, Su Q, Xie J, Jiang Z, Gruntman A, Gray-Edwards H, Gao G, Strauss KA, Wang D. BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease. Sci Transl Med. 2025 02 26; 17(787):eads0539. PMID: 40009698.
      Citations:    
    35. Pappas C, Bauer CE, Zachariou V, Libecap TJ, Rodolpho B, Sudduth TL, Nelson PT, Jicha GA, Hartz AM, Shao X, Wang DJJ, Gold BT. Synergistic effects of plasma S100B and MRI measures of cerebrovascular disease on cognition in older adults. Geroscience. 2025 06; 47(3):3131-3146. PMID: 39907937.
      Citations:    
    36. Shou Q, Zhao C, Shao X, Herting MM, Wang DJ. High resolution multi-delay arterial spin labeling with self-supervised deep learning denoising for pediatric choroid plexus perfusion MRI. Neuroimage. 2025 03; 308:121070. PMID: 39889809.
      Citations:    
    37. Walkey CJ, Snow KJ, Bulcha J, Cox AR, Martinez AE, Ljungberg MC, Lanza DG, De Giorgi M, Chuecos MA, Alves-Bezerra M, Suarez CF, Hartig SM, Hilsenbeck SG, Hsu CW, Saville E, Gaitan Y, Duryea J, Hannigan S, Dickinson ME, Mirochnitchenko O, Wang D, Lutz CM, Heaney JD, Gao G, Murray SA, Lagor WR. A comprehensive atlas of AAV tropism in the mouse. Mol Ther. 2025 Mar 05; 33(3):1282-1299. PMID: 39863928.
      Citations:    
    38. Zhang R, Cen S, Wijesinghe D, Aksman L, Murray SB, Duval CJ, Wang DJJ, Jann K. Elucidating distinct and common fMRI-complexity patterns in pre-adolescent children with Attention-Deficit/Hyperactivity Disorder, Oppositional Defiant Disorder, and Obsessive-Compulsive Disorder diagnoses. medRxiv. 2025 Jan 18. PMID: 39867408.
      Citations:    
    39. Liu X, Maillard P, Barisano G, Caprihan A, Cen S, Shao X, Jann K, Ringman JM, Lu H, Arfanakis K, DeCarli CS, Gold BT, Seshadri S, Satizabal CL, Beiser AS, Habes M, Kramer JH, Stables L, Singh H, Helmer KG, Greenberg SM, Wang DJJ. MRI free water mediates the association between diffusion tensor image analysis along the perivascular space and executive function in four independent middle to aged cohorts. Alzheimers Dement. 2025 02; 21(2):e14453. PMID: 39740225.
      Citations:    
    40. Engstrom AC, Alitin JPM, Kapoor A, Dutt S, Lohman T, Sible IJ, Marshall AJ, Shenasa F, Gaubert A, Ferrer F, Nguyen A, Bradford DR, Rodgers K, Sordo L, Head E, Shao X, Wang DJJ, Nation DA. Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits. Alzheimers Dement. 2025 01; 21(1):e14396. PMID: 39555916.
      Citations:    
    41. Shao X, Guo F, Kim J, Ress D, Zhao C, Shou Q, Jann K, Wang DJ. Laminar multi-contrast fMRI at 7T allows differentiation of neuronal excitation and inhibition underlying positive and negative BOLD responses. Imaging Neurosci (Camb). 2024; 2. PMID: 40656773.
      Citations:    
    42. Du A, Yang K, Zhou X, Ren L, Liu N, Zhou C, Liang J, Yan N, Gao G, Wang D. Systemic gene therapy corrects the neurological phenotype in a mouse model of NGLY1 deficiency. JCI Insight. 2024 10 08; 9(19). PMID: 39137042.
      Citations:    
    43. Morgan CA, Thomas DL, Shao X, Mahroo A, Manson TJ, Suresh V, Jansson D, Ohene Y, Günther M, Wang DJJ, Tippett LJ, Dragunow M. Measurement of blood-brain barrier water exchange rate using diffusion-prepared and multi-echo arterial spin labelling: Comparison of quantitative values and age dependence. NMR Biomed. 2024 12; 37(12):e5256. PMID: 39252500.
      Citations:    
    44. Pike NA, Roy B, Cabrera-Mino C, Halnon NJ, Lewis AB, Shao X, Wang DJJ, Kumar R. Compromised Cerebral Arterial Perfusion, Altered Brain Tissue Integrity, and Cognitive Impairment in Adolescents with Complex Congenital Heart Disease. J Cardiovasc Dev Dis. 2024 Jul 29; 11(8). PMID: 39195144.
      Citations:    
    45. Chang E, Kapoor A, Lohman T, Dutt S, Alitin JPM, Sible IJ, Ho JK, Gaubert A, Blanken AE, Mather M, Shao X, Wang DJJ, Nation DA. Older Adults With Smaller and Less Complex Social Networks Show Deficits in Medial Temporal Cerebrovascular Reactivity. J Am Heart Assoc. 2024 08 06; 13(15):e034390. PMID: 39011958.
      Citations:    
    46. Liang SQ, Navia AW, Ramseier M, Zhou X, Martinez M, Lee C, Zhou C, Wu J, Xie J, Su Q, Wang D, Flotte TR, Anderson DG, Tarantal AF, Shalek AK, Gao G, Xue W. AAV5 Delivery of CRISPR/Cas9 Mediates Genome Editing in the Lungs of Young Rhesus Monkeys. Hum Gene Ther. 2024 10; 35(19-20):814-824. PMID: 38767512.
      Citations:    
    47. Wang J, Gao G, Wang D. Developing AAV-delivered nonsense suppressor tRNAs for neurological disorders. Neurotherapeutics. 2024 07; 21(4):e00391. PMID: 38959711.
      Citations:    
    48. Liu P, Lin Z, Hazel K, Pottanat G, Xu C, Jiang D, Pillai JJ, Lucke E, Bauer CE, Gold BT, Greenberg SM, Helmer KG, Jann K, Jicha G, Kramer J, Maillard P, Mulavelil RM, Rodriguez P, Satizabal CL, Schwab K, Seshadri S, Singh H, Velarde Dediós ÁG, Wang DJJ, Kalyani RR, Moghekar A, Rosenberg PB, Yasar S, Albert M, Lu H. Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease-related cognitive decline: Multi-site validation in the MarkVCID Consortium. Alzheimers Dement. 2024 08; 20(8):5281-5289. PMID: 38951718.
      Citations:    
    49. Engstrom AC, Alitin JP, Kapoor A, Dutt S, Lohman T, Sible IJ, Marshall AJ, Shenasa F, Gaubert A, Ferrer F, Nguyen A, Bradford DR, Rodgers K, Sordo L, Head E, Shao X, Wang DJ, Nation DA. Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits. medRxiv. 2024 Jun 19. PMID: 38946941.
      Citations:    
    50. Pappas C, Bauer CE, Zachariou V, Maillard P, Caprihan A, Shao X, Wang DJJ, Gold BT. MRI free water mediates the association between water exchange rate across the blood brain barrier and executive function among older adults. Imaging Neurosci (Camb). 2024 Jun 05; 2:1-15. PMID: 38947942.
      Citations:    
    51. Ying Y, Li Y, Yao T, Shao X, Tang W, Montagne A, Chabriat H, Wang DJJ, Wang C, Yang Q, Cheng X. Heterogeneous blood-brain barrier dysfunction in cerebral small vessel diseases. Alzheimers Dement. 2024 07; 20(7):4527-4539. PMID: 38787758.
      Citations:    
    52. Kapoor A, Dutt S, Alitin JPM, Sible IJ, Marshall A, Shenasa F, Engstrom AC, Gaubert A, Shao X, Bradford DR, Rodgers K, Mather M, Wang DJJ, Nation DA. Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden. Neurobiol Aging. 2024 07; 139:5-10. PMID: 38579393.
      Citations:    
    53. Song D, Jann K, Wang DJJ. Editorial: Methodological development and applications of nonlinear dynamic analysis for neuroimaging. Front Neurol. 2024; 15:1387356. PMID: 38550346.
      Citations:    
    54. Liu H, Zhang Y, Yip M, Ren L, Liang J, Chen X, Liu N, Du A, Wang J, Chang H, Oh H, Zhou C, Xing R, Xu M, Guo P, Gessler D, Xie J, Tai PWL, Gao G, Wang D. Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection. Mol Ther Methods Clin Dev. 2024 Jun 13; 32(2):101230. PMID: 38558570.
      Citations:    
    55. Zhang R, Murray SB, Duval CJ, Wang DJJ, Jann K. Functional connectivity and complexity analyses of resting-state fMRI in pre-adolescents demonstrating the behavioral symptoms of ADHD. Psychiatry Res. 2024 04; 334:115794. PMID: 38367454.
      Citations:    
    56. Sarabi MS, Ma SJ, Jann K, Ringman JM, Wang DJJ, Shi Y. Vessel density mapping of small cerebral vessels on 3D high resolution black blood MRI. Neuroimage. 2024 02 01; 286:120504. PMID: 38216104.
      Citations:    
    57. Shou Q, Zhao C, Shao X, Jann K, Kim H, Helmer KG, Lu H, Wang DJJ. Transformer-based deep learning denoising of single and multi-delay 3D arterial spin labeling. Magn Reson Med. 2024 02; 91(2):803-818. PMID: 37849048.
      Citations:    
    58. Chang H, Du A, Jiang J, Ren L, Liu N, Zhou X, Liang J, Gao G, Wang D. Non-canonical amino acid incorporation into AAV5 capsid enhances lung transduction in mice. Mol Ther Methods Clin Dev. 2023 Dec 14; 31:101129. PMID: 37886602.
      Citations:    
    59. Deng Z, Xu S, Zhang J, Zhang J, Wang DJ, Yan L, Shi Y. Shape-Aware 3D Small Vessel Segmentation with Local Contrast Guided Attention. Med Image Comput Comput Assist Interv. 2023 Oct; 14223:354-363. PMID: 38500803.
      Citations:    
    60. Zachariou V, Pappas C, Bauer CE, Shao X, Liu P, Lu H, Wang DJJ, Gold BT. Regional differences in the link between water exchange rate across the blood-brain barrier and cognitive performance in normal aging. Geroscience. 2024 02; 46(1):265-282. PMID: 37713089.
      Citations:    
    61. Goldwaser EL, Wang DJJ, Adhikari BM, Chiappelli J, Shao X, Yu J, Lu T, Chen S, Marshall W, Yuen A, Kvarta M, Ma Y, Du X, Gao S, Saeedi O, Bruce H, Donnelly P, O'Neill H, Shuldiner AR, Mitchell BD, Kochunov P, Hong LE. Evidence of Neurovascular Water Exchange and Endothelial Vascular Dysfunction in Schizophrenia: An Exploratory Study. Schizophr Bull. 2023 09 07; 49(5):1325-1335. PMID: 37078962.
      Citations:    
    62. Jia X, Li Y, Ying Y, Jia X, Tang W, Bian Y, Zhang J, Wang DJJ, Cheng X, Yang Q. Effect of corticosubcortical iron deposition on dysfunction in CADASIL is mediated by white matter microstructural damage. Neuroimage Clin. 2023; 39:103485. PMID: 37542975.
      Citations:    
    63. Li Y, Ying Y, Yao T, Jia X, Liang H, Tang W, Jia X, Song H, Shao X, Wang DJJ, Wang C, Cheng X, Yang Q. Decreased water exchange rate across blood-brain barrier in hereditary cerebral small vessel disease. Brain. 2023 07 03; 146(7):3079-3087. PMID: 36625892.
      Citations:    
    64. Swinford CG, Risacher SL, Vosmeier A, Deardorff R, Chumin EJ, Dzemidzic M, Wu YC, Gao S, McDonald BC, Yoder KK, Unverzagt FW, Wang S, Farlow MR, Brosch JR, Clark DG, Apostolova LG, Sims J, Wang DJ, Saykin AJ. Amyloid and tau pathology are associated with cerebral blood flow in a mixed sample of nondemented older adults with and without vascular risk factors for Alzheimer's disease. Neurobiol Aging. 2023 10; 130:103-113. PMID: 37499587.
      Citations:    
    65. Zhao C, Shao X, Shou Q, Ma SJ, Gokyar S, Graf C, Stollberger R, Wang DJ. Whole-Cerebrum distortion-free three-dimensional pseudo-continuous arterial spin labeling at 7T. Neuroimage. 2023 08 15; 277:120251. PMID: 37364741.
      Citations:    
    66. Xu L, Wang D, Zhao L, Yang Z, Liu X, Li X, Yuan T, Wang Y, Huang T, Bian N, He Y, Chen X, Tian B, Liu Z, Luo F, Si W, Gao G, Ji W, Niu Y, Wei J. C9orf72 poly(PR) aggregation in nucleus induces ALS/FTD-related neurodegeneration in cynomolgus monkeys. Neurobiol Dis. 2023 08; 184:106197. PMID: 37328037.
      Citations: 1     Fields:    Translation:AnimalsCells
    67. Vansandt LM, Meinsohn MC, Godin P, Nagykery N, Sicher N, Kano M, Kashiwagi A, Chauvin M, Saatcioglu HD, Barnes JL, Miller AG, Thompson AK, Bateman HL, Donelan EM, González R, Newsom J, Gao G, Donahoe PK, Wang D, Swanson WF, Pépin D. Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene. Nat Commun. 2023 06 06; 14(1):3140. PMID: 37280258.
      Citations:    Fields:    Translation:Animals
    68. Wang DJ, Hua J, Cao D, Ho ML. Neurofluids and the glymphatic system: anatomy, physiology, and imaging. Br J Radiol. 2023 Nov; 96(1151):20230016. PMID: 37191063.
      Citations:    
    69. Yang H, Brown RH, Wang D, Strauss KA, Gao G. Rescue of GM3 synthase deficiency by spatially controlled, rAAV-mediated ST3GAL5 delivery. JCI Insight. 2023 05 08; 8(9). PMID: 37014712.
      Citations:    Fields:    Translation:HumansAnimals
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    148. Shao X, Wang Y, Moeller S, Wang DJJ. A constrained slice-dependent background suppression scheme for simultaneous multislice pseudo-continuous arterial spin labeling. Magn Reson Med. 2018 Jan; 79(1):394-400. PMID: 28198576.
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    149. Kochunov P, Wey HY, Fox PT, Lancaster JL, Davis MD, Wang DJ, Lin AL, Bastarrachea RA, Andrade MC, Mattern V, Frost P, Higgins PB, Comuzzie AG, Voruganti VS. Changes in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (Papio hamadryas sp.). Front Neurosci. 2017; 11:49. PMID: 28261040.
      Citations:    
    150. Zhou Z, Han F, Yan L, Wang DJJ, Hu P. Golden-ratio rotated stack-of-stars acquisition for improved volumetric MRI. Magn Reson Med. 2017 Dec; 78(6):2290-2298. PMID: 28168738.
      Citations:    
    151. Kano M, Sosulski AE, Zhang L, Saatcioglu HD, Wang D, Nagykery N, Sabatini ME, Gao G, Donahoe PK, Pépin D. AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):E1688-E1697. PMID: 28137855.
      Citations: 79     Fields:    Translation:AnimalsCells
    152. Lou X, Yu S, Scalzo F, Starkman S, Ali LK, Kim D, Rao NM, Hinman JD, Vespa PM, Jahan R, Tateshima S, Gonzalez NR, Duckwiler GR, Saver JL, Yoo B, Salamon N, Lyu J, Ma L, Wang DJ, Liebeskind DS. Multi-delay ASL can identify leptomeningeal collateral perfusion in endovascular therapy of ischemic stroke. Oncotarget. 2017 Jan 10; 8(2):2437-2443. PMID: 27974692.
      Citations:    
    153. Hassanpour MS, Yan L, Wang DJ, Lapidus RC, Arevian AC, Simmons WK, Feusner JD, Khalsa SS. How the heart speaks to the brain: neural activity during cardiorespiratory interoceptive stimulation. Philos Trans R Soc Lond B Biol Sci. 2016 11 19; 371(1708). PMID: 28080974.
      Citations:    
    154. Jog MV, Smith RX, Jann K, Dunn W, Lafon B, Truong D, Wu A, Parra L, Bikson M, Wang DJ. In-vivo Imaging of Magnetic Fields Induced by Transcranial Direct Current Stimulation (tDCS) in Human Brain using MRI. Sci Rep. 2016 10 04; 6:34385. PMID: 27698358.
      Citations:    
    155. Wijtenburg SA, Wright SN, Korenic SA, Gaston FE, Ndubuizu N, Chiappelli J, McMahon RP, Chen H, Savransky A, Du X, Wang DJ, Kochunov P, Hong LE, Rowland LM. Altered Glutamate and Regional Cerebral Blood Flow Levels in Schizophrenia: A 1H-MRS and pCASL study. Neuropsychopharmacology. 2017 01; 42(2):562-571. PMID: 27562377.
      Citations:    
    156. Jann K, Smith RX, Rios Piedra EA, Dapretto M, Wang DJ. Noise Reduction in Arterial Spin Labeling Based Functional Connectivity Using Nuisance Variables. Front Neurosci. 2016; 10:371. PMID: 27601973.
      Citations:    
    157. Murlidharan G, Sakamoto K, Rao L, Corriher T, Wang D, Gao G, Sullivan P, Asokan A. CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector. Mol Ther Nucleic Acids. 2016 Jul 19; 5(7):e338. PMID: 27434683.
      Citations:    
    158. Anazodo UC, Shoemaker JK, Suskin N, Ssali T, Wang DJ, St Lawrence KS. Impaired Cerebrovascular Function in Coronary Artery Disease Patients and Recovery Following Cardiac Rehabilitation. Front Aging Neurosci. 2015; 7:224. PMID: 26779011.
      Citations:    
    159. Ai J, Wang D, Wei Q, Li H, Gao G. Adeno-associated Virus Serotype Vectors Efficiently Transduce Normal Prostate Tissue and Prostate Cancer Cells. Eur Urol. 2016 Jan; 69(1):179-81. PMID: 26526960.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    160. Pan X, Qian T, Fernandez-Seara MA, Smith RX, Li K, Ying K, Sung K, Wang DJ. Quantification of liver perfusion using multidelay pseudocontinuous arterial spin labeling. J Magn Reson Imaging. 2016 May; 43(5):1046-54. PMID: 26445928.
      Citations:    
    161. Chen JJ, Jann K, Wang DJ. Characterizing Resting-State Brain Function Using Arterial Spin Labeling. Brain Connect. 2015 Nov; 5(9):527-42. PMID: 26106930.
      Citations:    
    162. Yan L, Liu CY, Smith RX, Jog M, Langham M, Krasileva K, Chen Y, Ringman JM, Wang DJJ. Assessing intracranial vascular compliance using dynamic arterial spin labeling. Neuroimage. 2016 Jan 01; 124(Pt A):433-441. PMID: 26364865.
      Citations:    
    163. Zou Q, Miao X, Liu D, Wang DJ, Zhuo Y, Gao JH. Reliability comparison of spontaneous brain activities between BOLD and CBF contrasts in eyes-open and eyes-closed resting states. Neuroimage. 2015 Nov 01; 121:91-105. PMID: 26226087.
      Citations:    
    164. Pépin D, Sosulski A, Zhang L, Wang D, Vathipadiekal V, Hendren K, Coletti CM, Yu A, Castro CM, Birrer MJ, Gao G, Donahoe PK. AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4418-27. PMID: 26216943.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    165. Huang B, Chen CT, Chen CS, Wang YM, Hsieh HJ, Wang DL. Laminar shear flow increases hydrogen sulfide and activates a nitric oxide producing signaling cascade in endothelial cells. Biochem Biophys Res Commun. 2015 Sep 04; 464(4):1254-1259. PMID: 26212441.
      Citations:    
    166. Wang D, Mou H, Li S, Li Y, Hough S, Tran K, Li J, Yin H, Anderson DG, Sontheimer EJ, Weng Z, Gao G, Xue W. Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses. Hum Gene Ther. 2015 Jul; 26(7):432-42. PMID: 26086867.
      Citations: 160     Fields:    Translation:HumansAnimalsCells
    167. Rapacchi S, Smith RX, Wang Y, Yan L, Sigalov V, Krasileva KE, Karpouzas G, Plotnik A, Sayre J, Hernandez E, Verma A, Burkly L, Wisniacki N, Torrington J, He X, Hu P, Chiao PC, Wang DJJ. Towards the identification of multi-parametric quantitative MRI biomarkers in lupus nephritis. Magn Reson Imaging. 2015 Nov; 33(9):1066-1074. PMID: 26119419.
      Citations:    
    168. Wright SN, Hong LE, Winkler AM, Chiappelli J, Nugent K, Muellerklein F, Du X, Rowland LM, Wang DJ, Kochunov P. Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia. Hum Brain Mapp. 2015 Oct; 36(10):3793-804. PMID: 26108347.
      Citations:    
    169. Guo Y, Wang D, Qiao T, Yang C, Su Q, Gao G, Xu Z. A Single Injection of Recombinant Adeno-Associated Virus into the Lumbar Cistern Delivers Transgene Expression Throughout the Whole Spinal Cord. Mol Neurobiol. 2016 07; 53(5):3235-3248. PMID: 26050084.
      Citations: 18     Fields:    Translation:AnimalsCells
    170. Zou Q, Yuan BK, Gu H, Liu D, Wang DJ, Gao JH, Yang Y, Zang YF. Detecting static and dynamic differences between eyes-closed and eyes-open resting states using ASL and BOLD fMRI. PLoS One. 2015; 10(3):e0121757. PMID: 25816237.
      Citations:    
    171. Mutsaerts HJ, van Osch MJ, Zelaya FO, Wang DJ, Nordhøy W, Wang Y, Wastling S, Fernandez-Seara MA, Petersen ET, Pizzini FB, Fallatah S, Hendrikse J, Geier O, Günther M, Golay X, Nederveen AJ, Bjørnerud A, Groote IR. Multi-vendor reliability of arterial spin labeling perfusion MRI using a near-identical sequence: implications for multi-center studies. Neuroimage. 2015 Jun; 113:143-52. PMID: 25818685.
      Citations:    
    172. Wiest R, Abela E, Missimer J, Schroth G, Hess CW, Sturzenegger M, Wang DJ, Weder B, Federspiel A. Interhemispheric cerebral blood flow balance during recovery of motor hand function after ischemic stroke--a longitudinal MRI study using arterial spin labeling perfusion. PLoS One. 2014; 9(9):e106327. PMID: 25191858.
      Citations:    
    173. Wang D, Gao G. State-of-the-art human gene therapy: part II. Gene therapy strategies and clinical applications. Discov Med. 2014 Sep; 18(98):151-61. PMID: 25227756.
      Citations: 36     Fields:    Translation:HumansCells
    174. Wang D, Gao G. State-of-the-art human gene therapy: part I. Gene delivery technologies. Discov Med. 2014 Jul-Aug; 18(97):67-77. PMID: 25091489.
      Citations: 34     Fields:    Translation:Humans
    175. Li CX, Patel S, Wang DJ, Zhang X. Effect of high dose isoflurane on cerebral blood flow in macaque monkeys. Magn Reson Imaging. 2014 Sep; 32(7):956-60. PMID: 24890304.
      Citations:    
    176. Krause BW, Wijtenburg SA, Holcomb HH, Kochunov P, Wang DJ, Hong LE, Rowland LM. Anterior cingulate GABA levels predict whole-brain cerebral blood flow. Neurosci Lett. 2014 Feb 21; 561:188-91. PMID: 24397910.
      Citations:    
    177. Wang D, Zhong L, Nahid MA, Gao G. The potential of adeno-associated viral vectors for gene delivery to muscle tissue. Expert Opin Drug Deliv. 2014 Mar; 11(3):345-364. PMID: 24386892.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    178. Keeling KM, Wang D, Dai Y, Murugesan S, Chenna B, Clark J, Belakhov V, Kandasamy J, Velu SE, Baasov T, Bedwell DM. Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression. PLoS One. 2013; 8(4):e60478. PMID: 23593225.
      Citations: 68     Fields:    Translation:AnimalsCells
    179. Keeling KM, Wang D, Conard SE, Bedwell DM. Suppression of premature termination codons as a therapeutic approach. Crit Rev Biochem Mol Biol. 2012 Sep; 47(5):444-63. PMID: 22672057.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    180. Wang D, Belakhov V, Kandasamy J, Baasov T, Li SC, Li YT, Bedwell DM, Keeling KM. The designer aminoglycoside NB84 significantly reduces glycosaminoglycan accumulation associated with MPS I-H in the Idua-W392X mouse. Mol Genet Metab. 2012 Jan; 105(1):116-25. PMID: 22056610.
      Citations: 42     Fields:    Translation:AnimalsCells
    181. Wang D, Shukla C, Liu X, Schoeb TR, Clarke LA, Bedwell DM, Keeling KM. Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation. Mol Genet Metab. 2010 Jan; 99(1):62-71. PMID: 19751987.
      Citations: 38     Fields:    Translation:HumansAnimals
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