Topoisomerase II Inhibitors

"Topoisomerase II Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.

Descriptor ID	D059005
MeSH Number(s)	D27.505.519.389.892.750 D27.505.954.248.794.750
Concept/Terms	Topoisomerase II Inhibitors Topoisomerase II Inhibitors Inhibitors, Topoisomerase II DNA Type 2 Topoisomerase Inhibitors Topoisomerase 2 Inhibitors Inhibitors, Topoisomerase 2 DNA Topoisomerase II Inhibitors DNA Gyrase Inhibitors DNA Gyrase Inhibitors Gyrase Inhibitors, DNA Inhibitors, DNA Gyrase

Below are MeSH descriptors whose meaning is more general than "Topoisomerase II Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Topoisomerase Inhibitors [D27.505.519.389.892]
Topoisomerase II Inhibitors [D27.505.519.389.892.750]
Therapeutic Uses [D27.505.954]
Antineoplastic Agents [D27.505.954.248]
Topoisomerase Inhibitors [D27.505.954.248.794]
Topoisomerase II Inhibitors [D27.505.954.248.794.750]

Below are MeSH descriptors whose meaning is related to "Topoisomerase II Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Topoisomerase II Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Topoisomerase II Inhibitors" by people in this website by year, and whether "Topoisomerase II Inhibitors" was a major or minor topic of these publications.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	1	1	2
2014	1	0	1
2015	1	0	1
2019	0	1	1
2020	0	1	1

Below are the most recent publications written about "Topoisomerase II Inhibitors" by people in Profiles.

Jolly SM, Gainetdinov I, Jouravleva K, Zhang H, Strittmatter L, Bailey SM, Hendricks GM, Dhabaria A, Ueberheide B, Zamore PD. Thermus thermophilus Argonaute Functions in the Completion of DNA Replication. Cell. 2020 09 17; 182(6):1545-1559.e18.

View in: PubMed
Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature. 2019 07; 571(7763):72-78.

View in: PubMed
Su XH, Wang BX, Le WJ, Liu YR, Wan C, Li S, Alm RA, Mueller JP, Rice PA. Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914). Antimicrob Agents Chemother. 2016 01; 60(1):621-3.

View in: PubMed
Alm RA, Lahiri SD, Kutschke A, Otterson LG, McLaughlin RE, Whiteaker JD, Lewis LA, Su X, Huband MD, Gardner H, Mueller JP. Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2015 Mar; 59(3):1478-86.

View in: PubMed
Butler MM, Lamarr WA, Foster KA, Barnes MH, Skow DJ, Lyden PT, Kustigian LM, Zhi C, Brown NC, Wright GE, Bowlin TL. Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound. Antimicrob Agents Chemother. 2007 Jan; 51(1):119-27.

View in: PubMed
Zhi C, Long ZY, Manikowski A, Comstock J, Xu WC, Brown NC, Tarantino PM, Holm KA, Dix EJ, Wright GE, Barnes MH, Butler MM, Foster KA, LaMarr WA, Bachand B, Bethell R, Cadilhac C, Charron S, Lamothe S, Motorina I, Storer R. Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. J Med Chem. 2006 Feb 23; 49(4):1455-65.

View in: PubMed

People

Explore

Similar Concepts

Top Journals