Receptor, Interferon alpha-beta

"Receptor, Interferon alpha-beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for signal transduction. The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE.

Descriptor ID	D053633
MeSH Number(s)	D12.776.543.750.705.852.400.500
Concept/Terms	Receptor, Interferon alpha-beta Receptor, Interferon alpha-beta Receptor, Interferon alpha beta IFN-alphaR Interferon alpha Receptor alpha Receptor, Interferon Type I Interferon Receptor Interferon alpha-beta Receptor Interferon alpha beta Receptor Interferon alphabeta Receptors Receptors, Interferon alphabeta Receptor, Interferon alpha IFN-alphabetaR IFN alphabetaR Interferon alpha Receptors Receptors, Interferon alpha alpha Receptors, Interferon Interferon alpha-beta Receptor Chain 2 Interferon alpha-beta Receptor Chain 2 Interferon alpha beta Receptor Chain 2 Interferon alpha-beta Receptor IFNAR2 Subunit Interferon alpha beta Receptor IFNAR2 Subunit Interferon alpha-beta Receptor-2 Interferon alpha beta Receptor 2 Receptor-2, Interferon alpha-beta alpha-beta Receptor-2, Interferon IFNAR2 Subunit, Interferon alpha-beta Receptor IFNAR2 Subunit, Interferon alpha beta Receptor Interferon alpha-beta Receptor Chain 1 Interferon alpha-beta Receptor Chain 1 Interferon alpha beta Receptor Chain 1 Interferon alpha-beta Receptor IFNAR1 Subunit Interferon alpha beta Receptor IFNAR1 Subunit Interferon alpha-beta Receptor-1 Interferon alpha beta Receptor 1 Receptor-1, Interferon alpha-beta alpha-beta Receptor-1, Interferon IFNAR1 Subunit, Interferon alpha-beta Receptor IFNAR1 Subunit, Interferon alpha beta Receptor IFNAR2.1 Subunit, Interferon alpha-beta Receptor IFNAR2.1 Subunit, Interferon alpha-beta Receptor IFNAR2.1 Subunit, Interferon alpha beta Receptor IFNAR2.2 Subunit, Interferon alpha-beta Receptor IFNAR2.2 Subunit, Interferon alpha-beta Receptor IFNAR2.2 Subunit, Interferon alpha beta Receptor

Below are MeSH descriptors whose meaning is more general than "Receptor, Interferon alpha-beta".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Cytokine [D12.776.543.750.705.852]
Receptors, Interferon [D12.776.543.750.705.852.400]
Receptor, Interferon alpha-beta [D12.776.543.750.705.852.400.500]

Below are MeSH descriptors whose meaning is related to "Receptor, Interferon alpha-beta".

Below are MeSH descriptors whose meaning is more specific than "Receptor, Interferon alpha-beta".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptor, Interferon alpha-beta" by people in this website by year, and whether "Receptor, Interferon alpha-beta" was a major or minor topic of these publications.

Bar chart showing 24 publications over 16 distinct years, with a maximum of 3 publications in 2011 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2004	0	1	1
2007	1	0	1
2008	0	1	1
2009	0	2	2
2010	0	1	1
2011	0	3	3
2013	0	1	1
2014	0	1	1
2015	0	2	2
2016	3	0	3
2017	0	1	1
2019	0	1	1
2020	0	1	1
2021	1	1	2
2025	0	2	2

Below are the most recent publications written about "Receptor, Interferon alpha-beta" by people in Profiles.

Kurt-Jones EA, Gulati S, King M, de Oliveira RB, Rice PA, Zheng B, Shaughnessy J, Edwards JL, Hertzog PJ, Ram S, Golenbock DT. Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism. Cell Host Microbe. 2025 Jul 09; 33(7):1133-1145.e4.

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Arowosegbe A, Guo Z, Vanderleeden E, Derr AG, Wang JP. Janus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats. J Autoimmun. 2025 Feb; 151:103358.

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Kim H, Subbannayya Y, Humphries F, Skejsol A, Pinto SM, Giambelluca M, Espevik T, Fitzgerald KA, Kandasamy RK. UMP-CMP kinase 2 gene expression in macrophages is dependent on the IRF3-IFNAR signaling axis. PLoS One. 2021; 16(10):e0258989.

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Qaisar N, Arowosegbe A, Derr AG, Kucukural A, Satish B, Racicot R, Guo Z, Trombly MI, Wang JP. Type I IFN-Driven Immune Cell Dysregulation in Rat Autoimmune Diabetes. Immunohorizons. 2021 10 26; 5(10):855-869.

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Riding RL, Richmond JM, Fukuda K, Harris JE. Type I interferon signaling limits viral vector priming of CD8+ T cells during initiation of vitiligo and melanoma immunotherapy. Pigment Cell Melanoma Res. 2021 07; 34(4):683-695.

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Lee MH, Gallo PM, Hooper KM, Corradetti C, Ganea D, Caricchio R, Gallucci S. The cytokine network type I IFN-IL-27-IL-10 is augmented in murine and human lupus. J Leukoc Biol. 2019 10; 106(4):967-975.

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King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R. IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nat Med. 2017 Dec; 23(12):1481-1487.

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Iracheta-Vellve A, Petrasek J, Gyongyosi B, Satishchandran A, Lowe P, Kodys K, Catalano D, Calenda CD, Kurt-Jones EA, Fitzgerald KA, Szabo G. Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes. J Biol Chem. 2016 Dec 23; 291(52):26794-26805.

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Qaisar N, Lin S, Ryan G, Yang C, Oikemus SR, Brodsky MH, Bortell R, Mordes JP, Wang JP. A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats. Diabetes. 2017 Jan; 66(1):145-157.

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Xu J, Lee MH, Chakhtoura M, Green BL, Kotredes KP, Chain RW, Sriram U, Gamero AM, Gallucci S. STAT2 Is Required for TLR-Induced Murine Dendritic Cell Activation and Cross-Presentation. J Immunol. 2016 07 01; 197(1):326-36.

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