Phosphatidylinositol 4,5-Diphosphate
"Phosphatidylinositol 4,5-Diphosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)
| Descriptor ID |
D019269
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| MeSH Number(s) |
D10.570.755.375.760.400.942.625.900
|
| Concept/Terms |
Phosphatidylinositol 4,5-Diphosphate- Phosphatidylinositol 4,5-Diphosphate
- 4,5-Diphosphate, Phosphatidylinositol
- Phosphatidylinositol 4,5 Diphosphate
- Phosphatidylinositol Phosphate, PtdIns(4,5)P2
- PtIns 4,5-P2
- PtdIns(4,5)P2
- PtdInsP
- PtdInsP2
- Phosphatidylinositol 4,5-Biphosphate
- 4,5-Biphosphate, Phosphatidylinositol
- Phosphatidylinositol 4,5 Biphosphate
- Phosphatidylinositol-4,5-Biphosphate
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Below are MeSH descriptors whose meaning is more general than "Phosphatidylinositol 4,5-Diphosphate".
Below are MeSH descriptors whose meaning is more specific than "Phosphatidylinositol 4,5-Diphosphate".
This graph shows the total number of publications written about "Phosphatidylinositol 4,5-Diphosphate" by people in this website by year, and whether "Phosphatidylinositol 4,5-Diphosphate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Phosphatidylinositol 4,5-Diphosphate" by people in Profiles.
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Das S, Malaby AW, Nawrotek A, Zhang W, Zeghouf M, Maslen S, Skehel M, Chakravarthy S, Irving TC, Bilsel O, Cherfils J, Lambright DG. Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes. Structure. 2019 12 03; 27(12):1782-1797.e7.
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Sharma S, Agarwal S, Bharadwaj R, Bhattacharya S, Bhattacharya A. Novel regulatory roles of PtdIns(4,5)P2 generating enzyme EhPIPKI in actin dynamics and phagocytosis of Entamoeba histolytica. Cell Microbiol. 2019 Oct; 21(10):e13087.
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Bharadwaj R, Arya R, Shahid Mansuri M, Bhattacharya S, Bhattacharya A. EhRho1 regulates plasma membrane blebbing through PI3 kinase in Entamoeba histolytica. Cell Microbiol. 2017 10; 19(10).
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Gericke A, Leslie NR, L?sche M, Ross AH. PtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanism. Adv Exp Med Biol. 2013; 991:85-104.
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Leikina E, Melikov K, Sanyal S, Verma SK, Eun B, Gebert C, Pfeifer K, Lizunov VA, Kozlov MM, Chernomordik LV. Extracellular annexins and dynamin are important for sequential steps in myoblast fusion. J Cell Biol. 2013 Jan 07; 200(1):109-23.
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Redfern RE, Daou MC, Li L, Munson M, Gericke A, Ross AH. A mutant form of PTEN linked to autism. Protein Sci. 2010 Oct; 19(10):1948-56.
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Dasgupta U, Bamba T, Chiantia S, Karim P, Tayoun AN, Yonamine I, Rawat SS, Rao RP, Nagashima K, Fukusaki E, Puri V, Dolph PJ, Schwille P, Acharya JK, Acharya U. Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):20063-8.
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Roberts-Crowley ML, Mitra-Ganguli T, Liu L, Rittenhouse AR. Regulation of voltage-gated Ca2+ channels by lipids. Cell Calcium. 2009 Jun; 45(6):589-601.
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Rittenhouse AR. PIP2 PIP2 hooray for maxi K+. J Gen Physiol. 2008 Jul; 132(1):5-8.
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Liu L, Heneghan JF, Mitra-Ganguli T, Roberts-Crowley ML, Rittenhouse AR. Role of PIP2 in regulating versus modulating Ca2+ channel activity. J Physiol. 2007 Sep 15; 583(Pt 3):1165-6; author reply 1167.