Sodium-Potassium-Exchanging ATPase

"Sodium-Potassium-Exchanging ATPase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.

Descriptor ID	D000254
MeSH Number(s)	D08.811.277.040.025.314.750 D12.776.157.530.450.162.780 D12.776.157.530.450.250.880 D12.776.157.530.813.750 D12.776.543.585.450.162.800 D12.776.543.585.450.250.890 D12.776.543.585.813.750
Concept/Terms	Sodium-Potassium-Exchanging ATPase Sodium-Potassium-Exchanging ATPase ATPase, Sodium-Potassium-Exchanging Sodium Potassium Exchanging ATPase Sodium, Potassium Adenosinetriphosphatase Adenosinetriphosphatase Sodium, Potassium ATPase, Sodium, Potassium Sodium, Potassium ATPase ATPase Sodium, Potassium Potassium Pump Pump, Potassium Sodium, Potassium Adenosine Triphosphatase Sodium-Potassium Pump Pump, Sodium-Potassium Sodium Potassium Pump Na(+) K(+)-Transporting ATPase Na(+)-K(+)-Transporting ATPase Na(+)-K(+)-Exchanging ATPase Adenosine Triphosphatase, Sodium, Potassium Adenosinetriphosphatase, Sodium, Potassium Sodium Pump Pump, Sodium

Below are MeSH descriptors whose meaning is more general than "Sodium-Potassium-Exchanging ATPase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
Adenosine Triphosphatases [D08.811.277.040.025]
P-type ATPases [D08.811.277.040.025.314]
Sodium-Potassium-Exchanging ATPase [D08.811.277.040.025.314.750]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Pumps [D12.776.157.530.450]
Antiporters [D12.776.157.530.450.162]
Sodium-Potassium-Exchanging ATPase [D12.776.157.530.450.162.780]
Cation Transport Proteins [D12.776.157.530.450.250]
Sodium-Potassium-Exchanging ATPase [D12.776.157.530.450.250.880]
P-type ATPases [D12.776.157.530.813]
Sodium-Potassium-Exchanging ATPase [D12.776.157.530.813.750]
Membrane Proteins [D12.776.543]
Membrane Transport Proteins [D12.776.543.585]
Ion Pumps [D12.776.543.585.450]
Antiporters [D12.776.543.585.450.162]
Sodium-Potassium-Exchanging ATPase [D12.776.543.585.450.162.800]
Cation Transport Proteins [D12.776.543.585.450.250]
Sodium-Potassium-Exchanging ATPase [D12.776.543.585.450.250.890]
P-type ATPases [D12.776.543.585.813]
Sodium-Potassium-Exchanging ATPase [D12.776.543.585.813.750]

Below are MeSH descriptors whose meaning is more specific than "Sodium-Potassium-Exchanging ATPase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Sodium-Potassium-Exchanging ATPase" by people in this website by year, and whether "Sodium-Potassium-Exchanging ATPase" was a major or minor topic of these publications.

Bar chart showing 22 publications over 11 distinct years, with a maximum of 4 publications in 2008 and 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	1	0	1
2008	3	1	4
2009	2	2	4
2010	2	1	3
2011	1	1	2
2012	1	0	1
2016	0	1	1
2019	2	0	2
2021	0	1	1
2023	0	2	2
2025	1	0	1

Below are the most recent publications written about "Sodium-Potassium-Exchanging ATPase" by people in Profiles.

Hunanyan AS, Verma A, Bidzimou MT, Biswas DD, Da Cruz E, Srour MK, Marek J, Hume C, Elmallah MK, Landstrom AP, Mikati MA. Progressive central cardiorespiratory rate downregulation and intensifying epilepsy lead to sudden unexpected death in epilepsy in mouse model of the most common human ATP1A3 mutation. Epilepsia. 2025 Mar; 66(3):899-913.

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Thamby J, Prange L, Boggs A, Subei MO, Myers C, Uchitel J, ElMallah M, Bartlett-Lee B, Riviello JJ, Mikati MA. Characteristics of non-sleep related apneas in children with alternating hemiplegia of childhood. Eur J Paediatr Neurol. 2024 Jan; 48:101-108.

View in: PubMed
You Y, Zhang Z, Sultana N, Ericsson M, Martens YA, Sun M, Kanekiyo T, Ikezu S, Shaffer SA, Ikezu T. ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids. Sci Adv. 2023 09 15; 9(37):eadi3647.

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Hunanyan AS, Kantor B, Puranam RS, Elliott C, McCall A, Dhindsa J, Pagadala P, Wallace K, Poe J, Gunduz T, Asokan A, Koeberl DD, ElMallah MK, Mikati MA. Adeno-Associated Virus-Mediated Gene Therapy in the Mashlool, Atp1a3Mashl/+, Mouse Model of Alternating Hemiplegia of Childhood. Hum Gene Ther. 2021 04; 32(7-8):405-419.

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Verdejo-Torres O, Flores-Maldonado C, Padilla-Benavides T, Campos-Bl?zquez JP, Larr? I, Lara-Lemus R, Perez Salazar E, Cereijido M, Contreras RG. Ouabain Accelerates Collective Cell Migration Through a cSrc and ERK1/2 Sensitive Metalloproteinase Activity. J Membr Biol. 2019 12; 252(6):549-559.

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Vilchis-Nestor CA, Rold?n ML, Leonardi A, Navea JG, Padilla-Benavides T, Shoshani L. Ouabain Enhances Cell-Cell Adhesion Mediated by ?1 Subunits of the Na+,K+-ATPase in CHO Fibroblasts. Int J Mol Sci. 2019 Apr 29; 20(9).

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Silva-Filho JL, Peruchetti DB, Moraes-Santos F, Landgraf SS, Silva LS, Sirtoli GM, Zamith-Miranda D, Takiya CM, Pinheiro AA, Diaz BL, Caruso-Neves C. Group V Secretory Phospholipase A2 Is Involved in Tubular Integrity and Sodium Handling in the Kidney. PLoS One. 2016; 11(1):e0147785.

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Luan Z, Quigley C, Li HS. The putative Na?/Cl?-dependent neurotransmitter/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis. Sci Rep. 2015 Jan 23; 5:7993.

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Luan Z, Reddig K, Li HS. Loss of Na(+)/K(+)-ATPase in Drosophila photoreceptors leads to blindness and age-dependent neurodegeneration. Exp Neurol. 2014 Nov; 261:791-801.

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Benziane B, Bj?rnholm M, Pirkmajer S, Austin RL, Kotova O, Viollet B, Zierath JR, Chibalin AV. Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells. J Biol Chem. 2012 Jul 06; 287(28):23451-63.

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