Copper-transporting ATPases
"Copper-transporting ATPases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.
| Descriptor ID |
D000073840
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| MeSH Number(s) |
D08.811.277.040.025.314.500 D12.776.157.530.450.250.656 D12.776.157.530.813.500 D12.776.543.585.450.250.656 D12.776.543.585.813.500
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| Concept/Terms |
Copper-transporting ATPases- Copper-transporting ATPases
- ATPases, Copper-transporting
- Copper transporting ATPases
- Cu(+)-transporting ATPases
- Copper-transporting Adenosine Triphosphatases
- Adenosine Triphosphatases, Copper-transporting
- Copper transporting Adenosine Triphosphatases
- Triphosphatases, Copper-transporting Adenosine
- Copper-transporting ATPase
- ATPase, Copper-transporting
- Copper transporting ATPase
- Cu-transporting ATPases
- ATPases, Cu-transporting
- Cu transporting ATPases
Wilson Disease Protein- Wilson Disease Protein
- ATP7B Cu-binding P type ATPase
- ATP7B Cu binding P type ATPase
- Copper-transporting ATPase 2
- Copper transporting ATPase 2
- ATPase, Cu++ transporting, beta Polypeptide (Wilson Disease)
- Wilson Disease Cu-binding P Type ATPase
- Wilson Disease Cu binding P Type ATPase
Copper-transporting ATPase 1- Copper-transporting ATPase 1
- ATPase 1, Copper-transporting
- Copper transporting ATPase 1
- Copper Pump 1
- Menkes Disease-associated Protein
- Menkes Disease associated Protein
- ATP7A Protein
- ATPase Copper Transporting alpha
Pineal Night-specific ATPase- Pineal Night-specific ATPase
- ATPase, Pineal Night-specific
- Night-specific ATPase, Pineal
- Pineal Night specific ATPase
- PINA Enzyme
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Below are MeSH descriptors whose meaning is more general than "Copper-transporting ATPases".
Below are MeSH descriptors whose meaning is more specific than "Copper-transporting ATPases".
This graph shows the total number of publications written about "Copper-transporting ATPases" by people in this website by year, and whether "Copper-transporting ATPases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Copper-transporting ATPases" by people in Profiles.
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Maung MT, Carlson A, Olea-Flores M, Elkhadragy L, Schachtschneider KM, Navarro-Tito N, Padilla-Benavides T. The molecular and cellular basis of copper dysregulation and its relationship with human pathologies. FASEB J. 2021 09; 35(9):e21810.
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Vest KE, Paskavitz AL, Lee JB, Padilla-Benavides T. Dynamic changes in copper homeostasis and post-transcriptional regulation of Atp7a during myogenic differentiation. Metallomics. 2018 02 21; 10(2):309-322.
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Protasova MS, Grigorenko AP, Tyazhelova TV, Andreeva TV, Reshetov DA, Gusev FE, Laptenko AE, Kuznetsova IL, Goltsov AY, Klyushnikov SA, Illarioshkin SN, Rogaev EI. Whole-genome sequencing identifies a novel ABCB7 gene mutation for X-linked congenital cerebellar ataxia in a large family of Mongolian ancestry. Eur J Hum Genet. 2016 Apr; 24(4):550-5.
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Padilla-Benavides T, George Thompson AM, McEvoy MM, Arg?ello JM. Mechanism of ATPase-mediated Cu+ export and delivery to periplasmic chaperones: the interaction of Escherichia coli CopA and CusF. J Biol Chem. 2014 Jul 25; 289(30):20492-501.
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Patel SJ, Padilla-Benavides T, Collins JM, Arg?ello JM. Functional diversity of five homologous Cu+-ATPases present in Sinorhizobium meliloti. Microbiology (Reading). 2014 Jun; 160(Pt 6):1237-1251.
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Padilla-Benavides T, McCann CJ, Arg?ello JM. The mechanism of Cu+ transport ATPases: interaction with CU+ chaperones and the role of transient metal-binding sites. J Biol Chem. 2013 Jan 04; 288(1):69-78.
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Terwel D, L?schmann YN, Schmidt HH, Sch?ler HR, Cantz T, Heneka MT. Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease. J Neurochem. 2011 Jul; 118(1):105-12.