Receptor, Serotonin, 5-HT2A

"Receptor, Serotonin, 5-HT2A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A serotonin receptor subtype found widely distributed in peripheral tissues where it mediates the contractile responses of variety of tissues that contain SMOOTH MUSCLE. Selective 5-HT2A receptor antagonists include KETANSERIN. The 5-HT2A subtype is also located in BASAL GANGLIA and CEREBRAL CORTEX of the BRAIN where it mediates the effects of HALLUCINOGENS such as LSD.

Descriptor ID	D044402
MeSH Number(s)	D12.776.543.750.670.800.200.100 D12.776.543.750.695.800.200.100 D12.776.543.750.720.850.200.100
Concept/Terms	Receptor, Serotonin, 5-HT2A Receptor, Serotonin, 5-HT2A 5-HT2A Receptor 5 HT2A Receptor Receptor, 5-HT2A Serotonin 2A Receptors Receptors, Serotonin 2A Serotonin 2A Receptor 5-HT(2A) Receptor Receptor, Serotonin 2A

Below are MeSH descriptors whose meaning is more general than "Receptor, Serotonin, 5-HT2A".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Biogenic Amine [D12.776.543.750.670]
Receptors, Serotonin [D12.776.543.750.670.800]
Receptors, Serotonin, 5-HT2 [D12.776.543.750.670.800.200]
Receptor, Serotonin, 5-HT2A [D12.776.543.750.670.800.200.100]
Receptors, G-Protein-Coupled [D12.776.543.750.695]
Receptors, Serotonin [D12.776.543.750.695.800]
Receptors, Serotonin, 5-HT2 [D12.776.543.750.695.800.200]
Receptor, Serotonin, 5-HT2A [D12.776.543.750.695.800.200.100]
Receptors, Neurotransmitter [D12.776.543.750.720]
Receptors, Serotonin [D12.776.543.750.720.850]
Receptors, Serotonin, 5-HT2 [D12.776.543.750.720.850.200]
Receptor, Serotonin, 5-HT2A [D12.776.543.750.720.850.200.100]

Below are MeSH descriptors whose meaning is related to "Receptor, Serotonin, 5-HT2A".

Below are MeSH descriptors whose meaning is more specific than "Receptor, Serotonin, 5-HT2A".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptor, Serotonin, 5-HT2A" by people in this website by year, and whether "Receptor, Serotonin, 5-HT2A" was a major or minor topic of these publications.

Bar chart showing 12 publications over 11 distinct years, with a maximum of 2 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	2	2
2003	0	1	1
2004	1	0	1
2005	0	1	1
2006	1	0	1
2008	0	1	1
2009	0	1	1
2010	1	0	1
2013	1	0	1
2019	0	1	1
2024	1	0	1

Below are the most recent publications written about "Receptor, Serotonin, 5-HT2A" by people in Profiles.

Wakeford AGP, Nye JA, Morin EL, Mun J, Meyer JS, Goodman M, Howell LL, Sanchez MM. Alterations in adolescent brain serotonin (5HT)1A, 5HT2A, and dopamine (D)2 receptor systems in a nonhuman primate model of early life adversity. Neuropsychopharmacology. 2024 Jul; 49(8):1227-1235.

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Greden JF, Parikh SV, Rothschild AJ, Thase ME, Dunlop BW, DeBattista C, Conway CR, Forester BP, Mondimore FM, Shelton RC, Macaluso M, Li J, Brown K, Gilbert A, Burns L, Jablonski MR, Dechairo B. Impact of pharmacogenomics on clinical outcomes in major depressive disorder in the GUIDED trial: A large, patient- and rater-blinded, randomized, controlled study. J Psychiatr Res. 2019 04; 111:59-67.

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Assetta B, Maginnis MS, Gracia Ahufinger I, Haley SA, Gee GV, Nelson CD, O'Hara BA, Allen Ramdial SA, Atwood WJ. 5-HT2 receptors facilitate JC polyomavirus entry. J Virol. 2013 Dec; 87(24):13490-8.

View in: PubMed
Maginnis MS, Haley SA, Gee GV, Atwood WJ. Role of N-linked glycosylation of the 5-HT2A receptor in JC virus infection. J Virol. 2010 Oct; 84(19):9677-84.

View in: PubMed
Przyklenk K, Frelinger AL, Linden MD, Whittaker P, Li Y, Barnard MR, Adams J, Morgan M, Al-Shamma H, Michelson AD. Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis. J Thromb Haemost. 2010 Feb; 8(2):331-40.

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Biezonski DK, Courtemanche AB, Hong SB, Piper BJ, Meyer JS. Repeated adolescent MDMA ("Ecstasy") exposure in rats increases behavioral and neuroendocrine responses to a 5-HT2A/2C agonist. Brain Res. 2009 Feb 03; 1252:87-93.

View in: PubMed
Bai Y, Zhang M, Sanderson MJ. Contractility and Ca2+ signaling of smooth muscle cells in different generations of mouse airways. Am J Respir Cell Mol Biol. 2007 Jan; 36(1):122-30.

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Zhao A, Urban JF, Morimoto M, Elfrey JE, Madden KB, Finkelman FD, Shea-Donohue T. Contribution of 5-HT2A receptor in nematode infection-induced murine intestinal smooth muscle hypercontractility. Gastroenterology. 2006 Aug; 131(2):568-78.

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McLean TH, Chambers JJ, Parrish JC, Braden MR, Marona-Lewicka D, Kurrasch-Orbaugh D, Nichols DE. C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor. J Med Chem. 2006 Jul 13; 49(14):4269-74.

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Rios M, Lambe EK, Liu R, Teillon S, Liu J, Akbarian S, Roffler-Tarlov S, Jaenisch R, Aghajanian GK. Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. J Neurobiol. 2006 Mar; 66(4):408-20.

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