Chemical and Drug Induced Liver Injury

"Chemical and Drug Induced Liver Injury" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.

Descriptor ID	D056486
MeSH Number(s)	C06.552.195 C25.100.562 C25.723.260
Concept/Terms	Chemical and Drug Induced Liver Injury Chemical and Drug Induced Liver Injury Chemically-Induced Liver Toxicity Chemically-Induced Liver Toxicity Chemically Induced Liver Toxicity Chemically-Induced Liver Toxicities Liver Toxicities, Chemically-Induced Liver Toxicity, Chemically-Induced Toxicities, Chemically-Induced Liver Toxicity, Chemically-Induced Liver Drug-Induced Acute Liver Injury Drug-Induced Acute Liver Injury Drug Induced Acute Liver Injury Liver Injury, Drug-Induced, Acute Acute Liver Injury, Drug-Induced Acute Liver Injury, Drug Induced Hepatitis, Toxic Hepatitis, Toxic Toxic Hepatitis Hepatitides, Toxic Toxic Hepatitides Drug-Induced Liver Disease Drug-Induced Liver Disease Disease, Drug-Induced Liver Diseases, Drug-Induced Liver Drug Induced Liver Disease Drug-Induced Liver Diseases Liver Disease, Drug-Induced Liver Diseases, Drug-Induced Drug-Induced Liver Injury Drug Induced Liver Injury Drug-Induced Liver Injuries Injuries, Drug-Induced Liver Injury, Drug-Induced Liver Liver Injuries, Drug-Induced Liver Injury, Drug-Induced Liver Injury, Drug Induced Hepatitis, Drug-Induced Hepatitis, Drug-Induced Drug-Induced Hepatitides Drug-Induced Hepatitis Hepatitides, Drug-Induced Hepatitis, Drug Induced

Below are MeSH descriptors whose meaning is more general than "Chemical and Drug Induced Liver Injury".

Diseases [C]
Digestive System Diseases [C06]
Liver Diseases [C06.552]
Chemical and Drug Induced Liver Injury [C06.552.195]
Chemically-Induced Disorders [C25]
Drug-Related Side Effects and Adverse Reactions [C25.100]
Chemical and Drug Induced Liver Injury [C25.100.562]
Poisoning [C25.723]
Chemical and Drug Induced Liver Injury [C25.723.260]

Below are MeSH descriptors whose meaning is related to "Chemical and Drug Induced Liver Injury".

Below are MeSH descriptors whose meaning is more specific than "Chemical and Drug Induced Liver Injury".

Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury, Chronic

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Chemical and Drug Induced Liver Injury" by people in this website by year, and whether "Chemical and Drug Induced Liver Injury" was a major or minor topic of these publications.

Bar chart showing 38 publications over 20 distinct years, with a maximum of 5 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
2002	1	0	1
2003	1	0	1
2007	1	1	2
2008	1	0	1
2009	1	0	1
2010	2	0	2
2011	3	0	3
2012	5	0	5
2013	1	0	1
2014	2	1	3
2015	2	1	3
2016	1	1	2
2017	3	0	3
2018	1	0	1
2019	2	0	2
2020	3	0	3
2021	0	1	1
2024	0	1	1
2025	0	1	1

Below are the most recent publications written about "Chemical and Drug Induced Liver Injury" by people in Profiles.

Sato R, Liu K, Shibata T, Hoshino K, Yamaguchi K, Miyazaki T, Hiranuma R, Fukui R, Motoi Y, Fukuda-Ohta Y, Zhang Y, Reuter T, Ishida Y, Kondo T, Chiba T, Asahara H, Taoka M, Yamauchi Y, Isobe T, Kaisho T, Furukawa Y, Latz E, Nakatani K, Izumi Y, Nie Y, Taniguchi H, Miyake K. RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells. J Exp Med. 2025 Mar 03; 222(3).

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Han Q, Liu Y, Liu X, Geng Y, Wu Q, Xiao H. Palmitoleic Acid Inhibits Hepatotoxic Effects by Reducing Trimethylamine-N-Oxide (TMAO) Formation in High L-Carnitine-Treated Mice. Nutrients. 2024 Oct 23; 16(21).

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Day JW, Mendell JR, Mercuri E, Finkel RS, Strauss KA, Kleyn A, Tauscher-Wisniewski S, Tukov FF, Reyna SP, Chand DH. Clinical Trial and Postmarketing Safety of Onasemnogene Abeparvovec Therapy. Drug Saf. 2021 10; 44(10):1109-1119.

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Schneider KM, Elfers C, Ghallab A, Schneider CV, Galvez EJC, Mohs A, Gui W, Candels LS, Wirtz TH, Zuehlke S, Spiteller M, Myllys M, Roulet A, Ouzerdine A, Lelouvier B, Kilic K, Liao L, Nier A, Latz E, Bergheim I, Thaiss CA, Hengstler JG, Strowig T, Trautwein C. Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury. Cell Mol Gastroenterol Hepatol. 2021; 11(4):909-933.

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Lu Y, Wu Y, Chen X, Yang X, Xiao H. Water extract of shepherd's purse prevents high-fructose induced-liver injury by regulating glucolipid metabolism and gut microbiota. Food Chem. 2021 Apr 16; 342:128536.

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Dai J, Yang X, Yuan Y, Jia Y, Liu G, Lin N, Xiao H, Zhang L, Chen J. Toxicity, gut microbiota and metabolome effects after copper exposure during early life in SD rats. Toxicology. 2020 03 30; 433-434:152395.

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Carreiro S, Marvel-Coen J, Lee R, Chapman B, Ambros V. Circulating microRNA Profiles in Acetaminophen Toxicity. J Med Toxicol. 2020 04; 16(2):177-187.

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Win S, Min RW, Chen CQ, Zhang J, Chen Y, Li M, Suzuki A, Abdelmalek MF, Wang Y, Aghajan M, Aung FW, Diehl AM, Davis RJ, Than TA, Kaplowitz N. Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. J Clin Invest. 2019 12 02; 129(12):5278-5293.

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Khan FS, Akram M, Aslam N, Zaheer J, Mustafa SB, Kausar S, Khan AH, Khan IA, Munir N, Shah SMA, Tahir IM, Sharif A. Phytochemical analysis and hepatoprotective effect of polyherbal formulation on CCl4 induced hepatotoxicity in mice. Pak J Pharm Sci. 2018 Nov; 31(6 (Supplementary):2719-2723.

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Iracheta-Vellve A, Szabo G. IL-1a in acetaminophen toxicity: a sterile danger signal. Cell Mol Immunol. 2018 Mar; 15(3):284-285.

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