O(6)-Methylguanine-DNA Methyltransferase
"O(6)-Methylguanine-DNA Methyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA, to a cysteine residue in itself, thus repairing alkylated DNA in a single-step reaction. EC 2.1.1.63.
| Descriptor ID |
D019853
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| MeSH Number(s) |
D08.811.913.555.500.800.650
|
| Concept/Terms |
O(6)-Methylguanine-DNA Methyltransferase- O(6)-Methylguanine-DNA Methyltransferase
- Methylated-DNA-Protein-Cysteine S-Methyltransferase
- Methylated DNA Protein Cysteine S Methyltransferase
- S-Methyltransferase, Methylated-DNA-Protein-Cysteine
- O(6)-Methylguanine Methyltransferase
- O(6)-Alkylguanine-DNA Alkyltransferase
- O(6)-MeG-DNA Methyltransferase
- O(6)-Methylguanine DNA Transmethylase
- Guanine-O(6)-Alkyltransferase
- O(6)-AGT
|
Below are MeSH descriptors whose meaning is more general than "O(6)-Methylguanine-DNA Methyltransferase".
Below are MeSH descriptors whose meaning is more specific than "O(6)-Methylguanine-DNA Methyltransferase".
This graph shows the total number of publications written about "O(6)-Methylguanine-DNA Methyltransferase" by people in this website by year, and whether "O(6)-Methylguanine-DNA Methyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "O(6)-Methylguanine-DNA Methyltransferase" by people in Profiles.
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Serebrov V, Moore MJ. Single Molecule Approaches in RNA-Protein Interactions. Adv Exp Med Biol. 2016; 907:89-106.
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Beard BC, Trobridge GD, Ironside C, McCune JS, Adair JE, Kiem HP. Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates. J Clin Invest. 2010 Jul; 120(7):2345-54.
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Calmann MA, Evans JE, Marinus MG. MutS inhibits RecA-mediated strand transfer with methylated DNA substrates. Nucleic Acids Res. 2005; 33(11):3591-7.
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Xu-Welliver M, Leit?o J, Kanugula S, Meehan WJ, Pegg AE. Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine. Biochem Pharmacol. 1999 Oct 15; 58(8):1279-85.
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Ludlum DB, Kent S, Mehta JR. Formation of O6-ethylthioethylguanine in DNA by reaction with the sulfur mustard, chloroethyl sulfide, and its apparent lack of repair by O6-alkylguanine-DNA alkyltransferase. Carcinogenesis. 1986 Jul; 7(7):1203-6.