Computational Biology

"Computational Biology" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.

Descriptor ID	D019295
MeSH Number(s)	H01.158.273.180 L01.313.124
Concept/Terms	Computational Biology Computational Biology Biology, Computational Computational Molecular Biology Computational Molecular Biology Biologies, Computational Molecular Biology, Computational Molecular Computational Molecular Biologies Molecular Biologies, Computational Molecular Biology, Computational Bio-Informatics Bio-Informatics Bio Informatics Bio-Informatic Bioinformatics Bioinformatic

Below are MeSH descriptors whose meaning is more general than "Computational Biology".

Natural Sciences [H]
Natural Science Disciplines [H01]
Biological Science Disciplines [H01.158]
Biology [H01.158.273]
Computational Biology [H01.158.273.180]
Information Science [L]
Information Science [L01]
Informatics [L01.313]
Computational Biology [L01.313.124]

Below are MeSH descriptors whose meaning is related to "Computational Biology".

Below are MeSH descriptors whose meaning is more specific than "Computational Biology".

Computational Biology
Genomics
Metabolomics
Systems Biology

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Computational Biology" by people in this website by year, and whether "Computational Biology" was a major or minor topic of these publications.

Bar chart showing 269 publications over 25 distinct years, with a maximum of 19 publications in 2012 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2001	1	2	3
2002	1	4	5
2003	1	5	6
2004	4	4	8
2005	1	9	10
2006	6	5	11
2007	4	7	11
2008	9	7	16
2009	4	10	14
2010	7	9	16
2011	5	8	13
2012	6	13	19
2013	4	14	18
2014	5	7	12
2015	4	10	14
2016	5	10	15
2017	1	14	15
2018	5	14	19
2019	1	7	8
2020	3	7	10
2021	3	8	11
2023	1	1	2
2024	5	4	9
2025	3	0	3

Below are the most recent publications written about "Computational Biology" by people in Profiles.

Peng FZ, Wang C, Chen T, Schussheim B, Vincoff S, Chatterjee P. PTM-Mamba: a PTM-aware protein language model with bidirectional gated Mamba blocks. Nat Methods. 2025 May; 22(5):945-949.

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Seamann A, Bennett-Boehm M, Ehrlich R, Gil A, Selin L, Ghersi D. TRain: T-cell receptor automated immunoinformatics. BMC Bioinformatics. 2025 Mar 06; 26(1):76.

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Zhou P, Li Z, Liu F, Kwon E, Hsieh TC, Ye S, Vasudevan S, Lee JA, Tran KV, Zhou C. BAMBI integrates biostatistical and artificial intelligence methods to improve RNA biomarker discovery. Brief Bioinform. 2025 Mar 04; 26(2).

View in: PubMed
Calvo-Roitberg E, Daniels RF, Pai AA. Challenges in identifying mRNA transcript starts and ends from long-read sequencing data. Genome Res. 2024 Nov 20; 34(11):1719-1734.

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Blanchard MW, Sigmon JS, Brennan J, Ahulamibe C, Allen ME, Ardery S, Baric RS, Bell TA, Farrington J, Ciavatta D, Cruz Cisneros MC, Drushal M, Ferris MT, Fry RC, Gaines C, Gu B, Heise MT, Hock P, Hodges RA, Hulgin M, Kafri T, Lynch RM, Magnuson T, Miller DR, Murphy CEY, Nguyen DT, Noll KE, Proulx MK, Sassetti CM, Schoenrock SA, Shaw GD, Simon JM, Smith CM, Styblo M, Tarantino LM, Woo J, Pardo Manuel de Villena F. The updated mouse universal genotyping array bioinformatic pipeline improves genetic QC in laboratory mice. G3 (Bethesda). 2024 Oct 07; 14(10).

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de Oliveira DC, Cheikh Sleiman H, Payette K, Hutter J, Story L, Hajnal JV, Alexander DC, Shipley RJ, Slator PJ. A flexible generative algorithm for growing in silico placentas. PLoS Comput Biol. 2024 Oct; 20(10):e1012470.

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Puebla I, Ascoli GA, Blume J, Chodacki J, Finnell J, Kennedy DN, Mair B, Martone ME, Wittenberg J, Poline JB. Ten simple rules for recognizing data and software contributions in hiring, promotion, and tenure. PLoS Comput Biol. 2024 Aug; 20(8):e1012296.

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Ali MZ, Guharajan S, Parisutham V, Brewster RC. Regulatory properties of transcription factors with diverse mechanistic function. PLoS Comput Biol. 2024 Jun; 20(6):e1012194.

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Abdennur N, Fudenberg G, Flyamer IM, Galitsyna AA, Goloborodko A, Imakaev M, Venev SV. Pairtools: From sequencing data to chromosome contacts. PLoS Comput Biol. 2024 May; 20(5):e1012164.

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Abdennur N, Abraham S, Fudenberg G, Flyamer IM, Galitsyna AA, Goloborodko A, Imakaev M, Oksuz BA, Venev SV, Xiao Y. Cooltools: Enabling high-resolution Hi-C analysis in Python. PLoS Comput Biol. 2024 May; 20(5):e1012067.

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