Receptor, Adenosine A2A

"Receptor, Adenosine A2A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subclass of adenosine A2 receptors found in LEUKOCYTES, the SPLEEN, the THYMUS and a variety of other tissues. It is generally considered to be a receptor for ADENOSINE that couples to the GS, STIMULATORY G-PROTEIN.

Descriptor ID	D043705
MeSH Number(s)	D12.776.543.750.695.700.700.200.100 D12.776.543.750.720.700.700.200.100
Concept/Terms	Receptor, Adenosine A2A Receptor, Adenosine A2A A2A Receptor, Adenosine Adenosine A(2A) Receptor Adenosine A2A Receptor Adenosine A2A Receptors A2A Receptors, Adenosine Receptors, Adenosine A2A

Below are MeSH descriptors whose meaning is more general than "Receptor, Adenosine A2A".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, G-Protein-Coupled [D12.776.543.750.695]
Receptors, Purinergic [D12.776.543.750.695.700]
Receptors, Purinergic P1 [D12.776.543.750.695.700.700]
Receptors, Adenosine A2 [D12.776.543.750.695.700.700.200]
Receptor, Adenosine A2A [D12.776.543.750.695.700.700.200.100]
Receptors, Neurotransmitter [D12.776.543.750.720]
Receptors, Purinergic [D12.776.543.750.720.700]
Receptors, Purinergic P1 [D12.776.543.750.720.700.700]
Receptors, Adenosine A2 [D12.776.543.750.720.700.700.200]
Receptor, Adenosine A2A [D12.776.543.750.720.700.700.200.100]

Below are MeSH descriptors whose meaning is related to "Receptor, Adenosine A2A".

Below are MeSH descriptors whose meaning is more specific than "Receptor, Adenosine A2A".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptor, Adenosine A2A" by people in this website by year, and whether "Receptor, Adenosine A2A" was a major or minor topic of these publications.

Bar chart showing 16 publications over 11 distinct years, with a maximum of 3 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	2	2
2005	2	0	2
2008	3	0	3
2012	1	0	1
2013	2	0	2
2015	0	1	1
2017	1	0	1
2020	1	0	1
2021	1	0	1
2023	0	1	1
2024	1	0	1

Below are the most recent publications written about "Receptor, Adenosine A2A" by people in Profiles.

Petersen N, McCann KE, Stavarache MA, Kim LY, Weinshenker D, Winder DG. Adenosine A2A Receptors Link Astrocytic a1-Adrenergic Signaling to Wake-Promoting Dopamine Neurons. Biol Psychiatry. 2025 May 01; 97(9):915-928.

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Peters K, McDonald T, Muhammad F, Walsh M, Drenen K, Montieth A, Stephen Foster C, Lee DJ. A2Ar-dependent PD-1+ and TIGIT+ Treg cells have distinct homing requirements to suppress autoimmune uveitis in mice. Mucosal Immunol. 2023 08; 16(4):422-431.

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McDonald T, Muhammad F, Peters K, Lee DJ. Combined Deficiency of the Melanocortin 5 Receptor and Adenosine 2A Receptor Unexpectedly Provides Resistance to Autoimmune Disease in a CD8+ T Cell-Dependent Manner. Front Immunol. 2021; 12:742154.

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Muhammad F, Wang D, McDonald T, Walsh M, Drenen K, Montieth A, Foster CS, Lee DJ. TIGIT+ A2Ar-Dependent anti-uveitic Treg cells are a novel subset of Tregs associated with resolution of autoimmune uveitis. J Autoimmun. 2020 07; 111:102441.

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Shonesy BC, Parrish WP, Haddad HK, Stephenson JR, B?ldi R, Bluett RJ, Marks CR, Centanni SW, Folkes OM, Spiess K, Augustin SM, Mackie K, Lovinger DM, Winder DG, Patel S, Colbran RJ. Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior. Biol Psychiatry. 2018 08 15; 84(4):304-315.

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Wagner CE, Pope NH, Charles EJ, Huerter ME, Sharma AK, Salmon MD, Carter BT, Stoler MH, Lau CL, Laubach VE, Kron IL. Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death. J Thorac Cardiovasc Surg. 2016 Feb; 151(2):538-45.

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Zhang J, Han C, Dai H, Hou J, Dong Y, Cui X, Xu L, Zhang M, Xia Q. Hypoxia-Inducible Factor-2a Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury. J Am Soc Nephrol. 2016 Jan; 27(1):92-106.

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Lee DJ, Taylor AW. Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice. J Immunol. 2013 Oct 15; 191(8):4103-11.

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Xiao H, Shen HY, Liu W, Xiong RP, Li P, Meng G, Yang N, Chen X, Si LY, Zhou YG. Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy. PLoS One. 2013; 8(4):e60173.

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Xiao H, Si LY, Liu W, Li N, Meng G, Yang N, Chen X, Zhou YG, Shen HY. The effects of adenosine A2A receptor knockout on renal interstitial fibrosis in a mouse model of unilateral ureteral obstruction. Acta Histochem. 2013 May; 115(4):315-9.

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