"Synucleins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of homologous proteins of low MOLECULAR WEIGHT that are predominately expressed in the BRAIN and that have been implicated in a variety of human diseases. They were originally isolated from CHOLINERGIC FIBERS of TORPEDO.
| Descriptor ID |
D051843
|
| MeSH Number(s) |
D12.776.631.860
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Synucleins".
Below are MeSH descriptors whose meaning is more specific than "Synucleins".
This graph shows the total number of publications written about "Synucleins" by people in this website by year, and whether "Synucleins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Synucleins" by people in Profiles.
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Chang HT, Cortez S, Vonsattel JP, Stopa EG, Schelper RL. Familial frontotemporal dementia: a report of three cases of severe cerebral atrophy with rare inclusions that are negative for tau and synuclein, but positive for ubiquitin. Acta Neuropathol. 2004 Jul; 108(1):10-6.
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Giasson BI, Mabon ME, Duda JE, Montine TJ, Robertson D, Hurtig HI, Lee VM, Trojanowski JQ. Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy. Acta Neuropathol. 2003 Sep; 106(3):243-50.
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Schwartz LM, Nambu JR, Wang Z. Parkinsonism proteolysis and proteasomes. Cell Death Differ. 2002 May; 9(5):479-82.
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Lippa CF, Fujiwara H, Mann DM, Giasson B, Baba M, Schmidt ML, Nee LE, O'Connell B, Pollen DA, St George-Hyslop P, Ghetti B, Nochlin D, Bird TD, Cairns NJ, Lee VM, Iwatsubo T, Trojanowski JQ. Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am J Pathol. 1998 Nov; 153(5):1365-70.