An X-linked recessive disorder characterized by the accumulation of saturated very long chain fatty acids in the LYSOSOMES of ADRENAL CORTEX and the white matter of CENTRAL NERVOUS SYSTEM. This disease occurs almost exclusively in the males. Clinical features include the childhood onset of ATAXIA; NEUROBEHAVIORAL MANIFESTATIONS; HYPERPIGMENTATION; ADRENAL INSUFFICIENCY; SEIZURES; MUSCLE SPASTICITY; and DEMENTIA. The slowly progressive adult form is called adrenomyeloneuropathy. The defective gene ABCD1 is located at Xq28, and encodes the adrenoleukodystrophy protein (ATP-BINDING CASSETTE TRANSPORTERS).

Descriptor ID	D000326
MeSH Number(s)	C10.228.140.163.100.084 C10.228.140.163.100.362.250 C10.228.140.695.625.250 C10.314.400.250 C10.597.606.643.455.124 C16.320.322.500.124 C16.320.400.525.124 C16.320.565.189.084 C16.320.565.189.362.250 C16.320.565.663.100 C18.452.132.100.084 C18.452.132.100.362.250 C18.452.648.189.084 C18.452.648.189.362.250 C18.452.648.663.100 C19.053.500.270
Concept/Terms	Adrenoleukodystrophy Adrenoleukodystrophy Melanodermic Leukodystrophy Leukodystrophies, Melanodermic Leukodystrophy, Melanodermic Siemerling-Creutzfeldt Disease Siemerling Creutzfeldt Disease Addison Disease and Cerebral Sclerosis X-ALD X ALD Bronze Schilder Disease X-Linked Adrenoleukodystrophy Adrenoleukodystrophy, X-Linked X Linked Adrenoleukodystrophy ALD (Adrenoleukodystrophy) X-ALD (X-Linked Adrenoleukodystrophy) X ALD (X Linked Adrenoleukodystrophy) Schilder-Addison Complex Schilder Addison Complex Adrenomyeloneuropathy Adrenomyeloneuropathy

Below are MeSH descriptors whose meaning is more general than "Adrenoleukodystrophy".

Below are MeSH descriptors whose meaning is related to "Adrenoleukodystrophy".

Below are MeSH descriptors whose meaning is more specific than "Adrenoleukodystrophy".