"Antibody Diversity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS.
| Descriptor ID |
D000916
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| MeSH Number(s) |
G05.365.036 G12.500.199
|
| Concept/Terms |
Antibody Diversity- Antibody Diversity
- Antibody Diversities
- Diversities, Antibody
- Diversity, Antibody
Germ Line Theory- Germ Line Theory
- Germ Line Theories
- Theories, Germ Line
- Theory, Germ Line
|
Below are MeSH descriptors whose meaning is more general than "Antibody Diversity".
Below are MeSH descriptors whose meaning is more specific than "Antibody Diversity".
This graph shows the total number of publications written about "Antibody Diversity" by people in this website by year, and whether "Antibody Diversity" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Antibody Diversity" by people in Profiles.
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Butler JE, Sun X, Wertz N, Lager KM, Chaloner K, Urban J, Francis DL, Nara PL, Tobin GJ. Antibody repertoire development in fetal and neonatal piglets XXI. Usage of most VH genes remains constant during fetal and postnatal development. Mol Immunol. 2011 Dec; 49(3):483-94.
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Min IM, Rothlein LR, Schrader CE, Stavnezer J, Selsing E. Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2. J Exp Med. 2005 Jun 20; 201(12):1885-90.
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Jeong Y, Osborne BA, Goldsby RA. Early Vlambda diversification in sheep. Immunology. 2001 May; 103(1):26-34.
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Lucier MR, Thompson RE, Waire J, Lin AW, Osborne BA, Goldsby RA. Multiple sites of V lambda diversification in cattle. J Immunol. 1998 Nov 15; 161(10):5438-44.
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Meyer A, Parng CL, Hansal SA, Osborne BA, Goldsby RA. Immunoglobulin gene diversification in cattle. Int Rev Immunol. 1997; 15(3-4):165-83.
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Parng CL, Hansal S, Goldsby RA, Osborne BA. Gene conversion contributes to Ig light chain diversity in cattle. J Immunol. 1996 Dec 15; 157(12):5478-86.
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Hagiya M, Davis DD, Shultz LD, Sakano H. Non-germ-line elements (NGE) are present in the T cell receptor beta-chain genes isolated from the mutant mouse, motheaten (me/me). J Immunol. 1986 Apr 01; 136(7):2697-700.