Epithelial-Mesenchymal Transition

"Epithelial-Mesenchymal Transition" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition.

Descriptor ID	D058750
MeSH Number(s)	G04.356.500
Concept/Terms	Epithelial-Mesenchymal Transition Epithelial-Mesenchymal Transition Epithelial Mesenchymal Transition Epithelial-Mesenchymal Transitions Transition, Epithelial-Mesenchymal Transitions, Epithelial-Mesenchymal Epithelial-Mesenchymal Transformation Epithelial Mesenchymal Transformation Epithelial-Mesenchymal Transformations Transformation, Epithelial-Mesenchymal Transformations, Epithelial-Mesenchymal

Below are MeSH descriptors whose meaning is more general than "Epithelial-Mesenchymal Transition".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cell Transdifferentiation [G04.356]
Epithelial-Mesenchymal Transition [G04.356.500]

Below are MeSH descriptors whose meaning is related to "Epithelial-Mesenchymal Transition".

Below are MeSH descriptors whose meaning is more specific than "Epithelial-Mesenchymal Transition".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epithelial-Mesenchymal Transition" by people in this website by year, and whether "Epithelial-Mesenchymal Transition" was a major or minor topic of these publications.

Bar chart showing 57 publications over 15 distinct years, with a maximum of 9 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	0	1	1
2011	2	2	4
2012	2	3	5
2013	1	3	4
2014	2	1	3
2015	4	1	5
2016	1	2	3
2017	3	2	5
2018	4	5	9
2019	1	6	7
2020	1	2	3
2021	2	1	3
2023	0	2	2
2024	1	0	1
2025	1	1	2

Below are the most recent publications written about "Epithelial-Mesenchymal Transition" by people in Profiles.

Peura J, Johnson C, Pitarresi JR. To EMT or Not to EMT: Ablation of Mesenchymal Tumor Cell Lineages Reveals the Essential Role of EMT in Pancreatic Cancer Initiation and Evolution. Cancer Res. 2025 Jun 16; 85(12):2146-2148.

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Weissenrieder JS, Peura J, Paudel U, Bhalerao N, Weinmann N, Johnson C, Wengyn M, Drager R, Furth EE, Simin K, Ruscetti M, Stanger BZ, Rustgi AK, Pitarresi JR, Foskett JK. Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity. Cell Rep. 2025 May 27; 44(5):115627.

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Brown BA, Myers PJ, Adair SJ, Pitarresi JR, Sah-Teli SK, Campbell LA, Hart WS, Barbeau MC, Leong K, Seyler N, Kane W, Lee KE, Stelow E, Jones M, Simon MC, Koivunen P, Bauer TW, Stanger BZ, Lazzara MJ. A Histone Methylation-MAPK Signaling Axis Drives Durable Epithelial-Mesenchymal Transition in Hypoxic Pancreatic Cancer. Cancer Res. 2024 Jun 04; 84(11):1764-1780.

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Landshammer A, Bolondi A, Kretzmer H, Much C, Buschow R, Rose A, Wu HJ, Mackowiak SD, Braendl B, Giesselmann P, Tornisiello R, Parsi KM, Huey J, Mielke T, Meierhofer D, Maehr R, Hnisz D, Michor F, Rinn JL, Meissner A. T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation. Elife. 2023 01 31; 12.

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Azuma K, Sakamoto M, Katayama S, Matsui A, Nakamichi K, Goshima N, Watanabe S, Nakayama J, Semba K. HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells. Genes Cells. 2023 Apr; 28(4):277-287.

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Garcia E, Ladak Z, Landry T, Wollin M, Persad ARL, Sergi CM, Huynh HQ, Persad R, Persad S. Epithelial-mesenchymal transition, regulated by ?-catenin and Twist, leads to esophageal wall remodeling in pediatric eosinophilic esophagitis. PLoS One. 2022; 17(3):e0264622.

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Kant S, Tran KV, Kvandova M, Caliz AD, Yoo HJ, Learnard H, Dolan AC, Craige SM, Hall JD, Jim?nez JM, St Hilaire C, Schulz E, Kr?ller-Sch?n S, Keaney JF. PGC1a Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1. Arterioscler Thromb Vasc Biol. 2022 01; 42(1):19-34.

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Norgard RJ, Pitarresi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW, Rosario-Berrios DN, Kim IK, Bassett JB, Payne R, Berry CT, Feng X, Sun K, Cioffi M, Chakraborty P, Jolly MK, Gutkind JS, Lyden D, Freedman BD, Foskett JK, Rustgi AK, Stanger BZ. Calcium signaling induces a partial EMT. EMBO Rep. 2021 09 06; 22(9):e51872.

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Huna A, Nawrocki-Raby B, Padilla-Benavides T, Gavard J, Coscoy S, Bernard D, Boissan M. Loss of the Metastasis Suppressor NME1, But Not of Its Highly Related Isoform NME2, Induces a Hybrid Epithelial-Mesenchymal State in Cancer Cells. Int J Mol Sci. 2021 Apr 02; 22(7).

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Bakir B, Chiarella AM, Pitarresi JR, Rustgi AK. EMT, MET, Plasticity, and Tumor Metastasis. Trends Cell Biol. 2020 10; 30(10):764-776.

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