Epithelial-Mesenchymal Transition

"Epithelial-Mesenchymal Transition" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition.

Descriptor ID	D058750
MeSH Number(s)	G04.356.500
Concept/Terms	Epithelial-Mesenchymal Transition Epithelial-Mesenchymal Transition Epithelial Mesenchymal Transition Epithelial-Mesenchymal Transitions Transition, Epithelial-Mesenchymal Transitions, Epithelial-Mesenchymal Epithelial-Mesenchymal Transformation Epithelial Mesenchymal Transformation Epithelial-Mesenchymal Transformations Transformation, Epithelial-Mesenchymal Transformations, Epithelial-Mesenchymal

Below are MeSH descriptors whose meaning is more general than "Epithelial-Mesenchymal Transition".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cell Transdifferentiation [G04.356]
Epithelial-Mesenchymal Transition [G04.356.500]

Below are MeSH descriptors whose meaning is related to "Epithelial-Mesenchymal Transition".

Below are MeSH descriptors whose meaning is more specific than "Epithelial-Mesenchymal Transition".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epithelial-Mesenchymal Transition" by people in this website by year, and whether "Epithelial-Mesenchymal Transition" was a major or minor topic of these publications.

Bar chart showing 67 publications over 16 distinct years, with a maximum of 9 publications in 2018 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	0	1	1
2011	2	2	4
2012	2	3	5
2013	2	3	5
2014	2	1	3
2015	4	1	5
2016	1	3	4
2017	3	2	5
2018	4	5	9
2019	2	7	9
2020	2	3	5
2021	2	1	3
2023	0	1	1
2024	1	3	4
2025	1	1	2
2026	0	2	2

Below are the most recent publications written about "Epithelial-Mesenchymal Transition" by people in Profiles.

Yu JX, Suh JM, Popova KD, Garcia K, Joshi T, Culbertson B, Spinelli JB, Subramanyam V, Lou K, Charbonneau T, Shokat KM, Weissman J, Goodarzi H. The GENEVA platform models tumor mosaicism to reveal variations of responses to KRAS inhibitors and identify improved drug combinations. Nat Cancer. 2026 Mar; 7(3):522-537.

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Tocheny CE, Buchwald JE, Dahlke CD, Fakih HH, Morgan JS, Summers A, Silva CA, Jackson SO, Lee JS, Card MA, Echeverria D, Peterson C, Mercurio AM, Khvorova A, Shaw LM. Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth. Mol Ther. 2026 May 06; 34(5):2963-2982.

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Peura J, Johnson C, Pitarresi JR. To EMT or Not to EMT: Ablation of Mesenchymal Tumor Cell Lineages Reveals the Essential Role of EMT in Pancreatic Cancer Initiation and Evolution. Cancer Res. 2025 Jun 16; 85(12):2146-2148.

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Weissenrieder JS, Peura J, Paudel U, Bhalerao N, Weinmann N, Johnson C, Wengyn M, Drager R, Furth EE, Simin K, Ruscetti M, Stanger BZ, Rustgi AK, Pitarresi JR, Foskett JK. Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity. Cell Rep. 2025 May 27; 44(5):115627.

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Peng Z, Wang H, Zheng J, Chen H, Wang J, Weber HC, Yuan L, Qin X, Xiang Y, Liu C, Ji M, Liu H, Qu X. Attenuation of renal fibrosis in mice due to lack of bombesin receptor-activated protein homologue. Clin Exp Pharmacol Physiol. 2024 10; 51(10):e13916.

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Qin L, Yao Y, Wang W, Qin Q, Liu J, Liu H, Yuan L, Yuan Y, Du X, Zhao B, Wu X, Qing B, Huang L, Wang G, Xiang Y, Qu X, Zhang X, Yang M, Xia Z, Liu C. Airway epithelial overexpressed cathepsin K induces airway remodelling through epithelial-mesenchymal trophic unit activation in asthma. Br J Pharmacol. 2024 Oct; 181(19):3700-3716.

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Brown BA, Myers PJ, Adair SJ, Pitarresi JR, Sah-Teli SK, Campbell LA, Hart WS, Barbeau MC, Leong K, Seyler N, Kane W, Lee KE, Stelow E, Jones M, Simon MC, Koivunen P, Bauer TW, Stanger BZ, Lazzara MJ. A Histone Methylation-MAPK Signaling Axis Drives Durable Epithelial-Mesenchymal Transition in Hypoxic Pancreatic Cancer. Cancer Res. 2024 Jun 04; 84(11):1764-1780.

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Han D, Labaf M, Zhao Y, Owiredu J, Zhang S, Patel K, Venkataramani K, Steinfeld JS, Han W, Li M, Liu M, Wang Z, Besschetnova A, Patalano S, Mulhearn MJ, Macoska JA, Yuan X, Balk SP, Nelson PS, Plymate SR, Gao S, Siegfried KR, Liu R, Stangis MM, Foxa G, Czernik PJ, Williams BO, Zarringhalam K, Li X, Cai C. Androgen receptor splice variants drive castration-resistant prostate cancer metastasis by activating distinct transcriptional programs. J Clin Invest. 2024 Apr 30; 134(11).

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Landshammer A, Bolondi A, Kretzmer H, Much C, Buschow R, Rose A, Wu HJ, Mackowiak SD, Braendl B, Giesselmann P, Tornisiello R, Parsi KM, Huey J, Mielke T, Meierhofer D, Maehr R, Hnisz D, Michor F, Rinn JL, Meissner A. T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation. Elife. 2023 01 31; 12.

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Garcia E, Ladak Z, Landry T, Wollin M, Persad ARL, Sergi CM, Huynh HQ, Persad R, Persad S. Epithelial-mesenchymal transition, regulated by ?-catenin and Twist, leads to esophageal wall remodeling in pediatric eosinophilic esophagitis. PLoS One. 2022; 17(3):e0264622.

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