Caspase Inhibitors

"Caspase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Endogenous and exogenous compounds and that either inhibit CASPASES or prevent their activation.

Descriptor ID	D061945
MeSH Number(s)	D27.505.519.389.745.325.500
Concept/Terms	Caspase Inhibitors Caspase Inhibitors Inhibitors, Caspase Caspase Blockers Blockers, Caspase Caspase Activation Inhibitors Caspase Activation Inhibitors Activation Inhibitors, Caspase Inhibitors, Caspase Activation Caspase Activation Blockers Activation Blockers, Caspase Blockers, Caspase Activation Capase Activation Inhibitors Activation Inhibitors, Capase Inhibitors, Capase Activation

Below are MeSH descriptors whose meaning is more general than "Caspase Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Protease Inhibitors [D27.505.519.389.745]
Cysteine Proteinase Inhibitors [D27.505.519.389.745.325]
Caspase Inhibitors [D27.505.519.389.745.325.500]

Below are MeSH descriptors whose meaning is related to "Caspase Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Caspase Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Caspase Inhibitors" by people in this website by year, and whether "Caspase Inhibitors" was a major or minor topic of these publications.

Bar chart showing 21 publications over 12 distinct years, with a maximum of 5 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2002	0	2	2
2004	1	1	2
2005	2	3	5
2006	1	1	2
2008	1	0	1
2009	0	2	2
2011	0	1	1
2012	1	0	1
2014	0	2	2
2018	0	1	1
2022	1	0	1

Below are the most recent publications written about "Caspase Inhibitors" by people in Profiles.

Peukert K, Steinhagen F, Fox M, Feuerborn C, Schulz S, Seeliger B, Schuss P, Schneider M, Frede S, Sauer A, Putensen C, Latz E, Wilhelm C, Bode C. Tetracycline ameliorates silica-induced pulmonary inflammation and fibrosis via inhibition of caspase-1. Respir Res. 2022 Feb 07; 23(1):21.

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Uetake Y, Sluder G. Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation. Mol Biol Cell. 2018 11 01; 29(22):2632-2643.

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Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenm?ller W, Latz E. The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation. Nat Immunol. 2014 Aug; 15(8):727-37.

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Dagbay K, Eron SJ, Serrano BP, Vel?zquez-Delgado EM, Zhao Y, Lin D, Vaidya S, Hardy JA. A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases. Methods Enzymol. 2014; 544:215-49.

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Huber KL, Ghosh S, Hardy JA. Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface. Biopolymers. 2012; 98(5):451-65.

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Gogada R, Amadori M, Zhang H, Jones A, Verone A, Pitarresi J, Jandhyam S, Prabhu V, Black JD, Chandra D. Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis. Cell Cycle. 2011 Dec 01; 10(23):4128-37.

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Charrier JD, Durrant SJ, Studley J, Lawes L, Weber P. Synthesis and evaluation of novel prodrugs of caspase inhibitors. Bioorg Med Chem Lett. 2012 Jan 01; 22(1):485-8.

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Weber P, Wang P, Maddens S, Wang PSh, Wu R, Miksa M, Dong W, Mortimore M, Golec JM, Charlton P. VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis. Crit Care. 2009; 13(5):R146.

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Alosi JA, McDonald DE, Schneider JS, Privette AR, McFadden DW. Pterostilbene inhibits breast cancer in vitro through mitochondrial depolarization and induction of caspase-dependent apoptosis. J Surg Res. 2010 Jun 15; 161(2):195-201.

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Hardy JA, Wells JA. Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. J Biol Chem. 2009 Sep 18; 284(38):26063-9.

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