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Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics.
High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice.
Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation.
A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.
DUBbing down innate immunity.
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DUBbing down innate immunity.
Silverman N, Fitzgerald K. DUBbing down innate immunity. Nat Immunol. 2004 Oct; 5(10):1010-2.
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PubMed
subject areas
Animals
Antigens, CD
Cysteine Endopeptidases
Immunity, Innate
Interleukin-1
Intracellular Signaling Peptides and Proteins
Membrane Glycoproteins
Mice
NF-kappa B
Nuclear Proteins
Proteins
Receptors, Cell Surface
Receptors, Tumor Necrosis Factor
Receptors, Tumor Necrosis Factor, Type I
Toll-Like Receptors
Tumor Necrosis Factor alpha-Induced Protein 3
authors with profiles
Neal Silverman PhD
Katherine A Fitzgerald PhD