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Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.
RIP kinase 1-dependent endothelial necroptosis underlies systemic inflammatory response syndrome.
The rheumatoid arthritis treat-to-target trial: a cluster randomized trial within the Corrona rheumatology network.
NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-?B-Dependent and -Independent Functions.
Role of alpha-1 antitrypsin in Bruch's membrane integrity.
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Role of alpha-1 antitrypsin in Bruch's membrane integrity.
Cheng SY, Giguere D, Silverstein I, Conza A, Seddon JM, Kim S, Iwata T, Mueller C, Punzo C. Role of alpha-1 antitrypsin in Bruch's membrane integrity. Sci Rep. 2025 Apr 10; 15(1):12223.
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PubMed
subject areas
alpha 1-Antitrypsin
Animals
Bruch Membrane
Collagen
Complement Factor H
Elastin
Female
Humans
Laminin
Macular Degeneration
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Retinal Pigment Epithelium
authors with profiles
Claudio Punzo PhD
Johanna Margaret Seddon MD, ScM