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The challenge of developing robust drugs to overcome resistance.
Covariation of amino acid positions in HIV-1 protease.
Cyclic pentapeptides as models for reverse turns: determination of the equilibrium distribution between type I and type II conformations of Pro-Asn and Pro-Ala beta-turns.
Post-reductionist protein science, or putting Humpty Dumpty back together again.
Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases.
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Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases.
Meng X, Noyes MB, Zhu LJ, Lawson ND, Wolfe SA. Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases. Nat Biotechnol. 2008 Jun; 26(6):695-701.
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PubMed
subject areas
Animals
Animals, Genetically Modified
Deoxyribonucleases
Gene Silencing
Gene Targeting
Genetic Engineering
Mutagenesis, Site-Directed
Protein Engineering
Zebrafish
Zebrafish Proteins
Zinc Fingers
authors with profiles
Scot Wolfe PhD
Nathan Lawson PhD
Lihua Zhu PhD