"Disulfiram" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Descriptor ID |
D004221
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MeSH Number(s) |
D02.241.081.251.869.220.250 D02.886.520.150.175 D02.886.706.200.200
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Concept/Terms |
Disulfiram- Disulfiram
- Bis(diethylthiocarbamoyl) Disulfide
- Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2
- Tetraethylthiuram Disulfide
- Disulfide, Tetraethylthiuram
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Below are MeSH descriptors whose meaning is more general than "Disulfiram".
Below are MeSH descriptors whose meaning is more specific than "Disulfiram".
This graph shows the total number of publications written about "Disulfiram" by people in this website by year, and whether "Disulfiram" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2010 | 1 | 0 | 1 |
2014 | 0 | 1 | 1 |
2016 | 0 | 1 | 1 |
2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Disulfiram" by people in Profiles.
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Schmidt FI, Latz E. Jack of all trades inhibits inflammation (in sober people). Nat Immunol. 2020 07; 21(7):718-719.
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Grant JE, Potenza MN, Kraus SW, Petrakis IL. Naltrexone and Disulfiram Treatment Response in Veterans With Alcohol Dependence and Co-Occurring Problem-Gambling Features. J Clin Psychiatry. 2017 Nov/Dec; 78(9):e1299-e1306.
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Harris AH, Bowe T, Hagedorn H, Nevedal A, Finlay AK, Gidwani R, Rosen C, Kay C, Christopher M. Multifaceted academic detailing program to increase pharmacotherapy for alcohol use disorder: interrupted time series evaluation of effectiveness. Addict Sci Clin Pract. 2016 09 15; 11(1):15.
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Park TW, Friedmann PD. Medications for addiction treatment: an opportunity for prescribing clinicians to facilitate remission from alcohol and opioid use disorders. R I Med J (2013). 2014 Oct 01; 97(10):20-4.
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Oliveto A, Poling J, Mancino MJ, Feldman Z, Cubells JF, Pruzinsky R, Gonsai K, Cargile C, Sofuoglu M, Chopra MP, Gonzalez-Haddad G, Carroll KM, Kosten TR. Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients. Drug Alcohol Depend. 2011 Jan 15; 113(2-3):184-91.
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Munday R, Smith BL, Munday CM. Effect of inducers of DT-diaphorase on the haemolytic activity and nephrotoxicity of 2-amino-1,4-naphthoquinone in rats. Chem Biol Interact. 2005 Aug 15; 155(3):140-7.