Central Nervous System

"Central Nervous System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.

Descriptor ID	D002490
MeSH Number(s)	A08.186
Concept/Terms	Central Nervous System Central Nervous System Central Nervous Systems Nervous System, Central Nervous Systems, Central System, Central Nervous Systems, Central Nervous Cerebrospinal Axis Axi, Cerebrospinal Axis, Cerebrospinal Cerebrospinal Axi

Below are MeSH descriptors whose meaning is more general than "Central Nervous System".

Anatomy [A]
Nervous System [A08]
Central Nervous System [A08.186]

Below are MeSH descriptors whose meaning is related to "Central Nervous System".

Below are MeSH descriptors whose meaning is more specific than "Central Nervous System".

Central Nervous System
Brain
Meninges
Spinal Cord

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Central Nervous System" by people in this website by year, and whether "Central Nervous System" was a major or minor topic of these publications.

Bar chart showing 112 publications over 29 distinct years, with a maximum of 12 publications in 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	2	2
1996	0	1	1
1997	2	0	2
1998	1	1	2
1999	0	2	2
2000	1	1	2
2001	0	2	2
2002	3	0	3
2003	3	1	4
2004	1	0	1
2005	3	4	7
2006	3	3	6
2007	1	2	3
2009	2	0	2
2010	4	0	4
2011	4	2	6
2012	4	0	4
2013	5	1	6
2014	5	1	6
2015	4	2	6
2016	2	0	2
2017	0	2	2
2018	2	0	2
2019	4	3	7
2020	1	2	3
2021	2	2	4
2022	1	2	3
2023	1	5	6
2024	6	6	12

Below are the most recent publications written about "Central Nervous System" by people in Profiles.

Zhang W, Oh JH, Zhang W, Aldrich CC, Sirianni RW, Elmquist WF. Central nervous system distributional kinetics of selected histone deacetylase inhibitors. J Pharmacol Exp Ther. 2025 Jan; 392(1):100014.

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Stillman JM, Kiniwa T, Schafer DP. Nucleic acid sensing in the central nervous system: Implications for neural circuit development, function, and degeneration. Immunol Rev. 2024 10; 327(1):71-82.

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Tastan B, Heneka MT. The impact of neuroinflammation on neuronal integrity. Immunol Rev. 2024 10; 327(1):8-32.

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Moazami MP, Rembetsy-Brown JM, Sarli SL, McEachern HR, Wang F, Ohara M, Wagh A, Kelly K, Krishnamurthy PM, Weiss A, Marosfoi M, King RM, Motwani M, Gray-Edwards H, Fitzgerald KA, Brown RH, Watts JK. Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system. Mol Ther. 2024 Dec 04; 32(12):4401-4417.

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Benatti HR, Anagnostakou V, Taghian T, Hall EF, Nath S, Heilman CB, Beneduce BM, Leporati A, Raskett C, Epshtein M, King R, Gounis MJ, Malek AM, Gray-Edwards HL. A minimally invasive endovascular approach to the cerebellopontine angle cistern enables broad CNS biodistribution of scAAV9-CB-GFP. Mol Ther. 2024 Oct 02; 32(10):3346-3355.

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Harkins AL, Ambegaokar PP, Keeler AM. Immune responses to central nervous system directed adeno-associated virus gene therapy: Does direct CNS delivery make a difference? Neurotherapeutics. 2024 Jul; 21(4):e00435.

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Belgrad J, Tang Q, Hildebrand S, Summers A, Sapp E, Echeverria D, O'Reilly D, Luu E, Bramato B, Allen S, Cooper D, Alterman J, Yamada K, Aronin N, DiFiglia M, Khvorova A. A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system. Nucleic Acids Res. 2024 Jun 24; 52(11):6099-6113.

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Ferguson CM, Godinho BMDC, Echeverria D, Hassler M, Vangjeli L, Sousa J, McHugh N, Alterman J, Hariharan V, Krishnamurthy PM, Watts J, Rogaev E, Khvorova A. A combinatorial approach for achieving CNS-selective RNAi. Nucleic Acids Res. 2024 May 22; 52(9):5273-5284.

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Beiter RM, Sheehan PW, Schafer DP. Microglia phagocytic mechanisms: Development informing disease. Curr Opin Neurobiol. 2024 Jun; 86:102877.

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Das S, Rruga F, Montepeloso A, Dimartino A, Spadini S, Corre G, Patel J, Cavalca E, Ferro F, Gatti A, Milazzo R, Galy A, Politi LS, Rizzardi GP, Vallanti G, Poletti V, Biffi A. An empowered, clinically viable hematopoietic stem cell gene therapy for the treatment of multisystemic mucopolysaccharidosis type II. Mol Ther. 2024 Mar 06; 32(3):619-636.

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