Myelin Sheath

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"Myelin Sheath" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.

Descriptor ID	D009186
MeSH Number(s)	A08.637.600.500 A08.637.800.500 A08.675.542.512.560 A08.800.800.690.500 A10.755.503 A11.284.149.165.600 A11.650.600.500 A11.650.800.500 A11.671.501.512.560 A11.671.514.553
Concept/Terms	Myelin Sheath Myelin Sheath Myelin Sheaths Sheath, Myelin Sheaths, Myelin Myelin Myelin

Below are MeSH descriptors whose meaning is more general than "Myelin Sheath".

Anatomy [A]
Nervous System [A08]
Neuroglia [A08.637]
Oligodendroglia [A08.637.600]
Myelin Sheath [A08.637.600.500]
Schwann Cells [A08.637.800]
Myelin Sheath [A08.637.800.500]
Neurons [A08.675]
Nerve Fibers [A08.675.542]
Nerve Fibers, Myelinated [A08.675.542.512]
Myelin Sheath [A08.675.542.512.560]
Peripheral Nervous System [A08.800]
Peripheral Nerves [A08.800.800]
Schwann Cells [A08.800.800.690]
Myelin Sheath [A08.800.800.690.500]
Tissues [A10]
Nerve Tissue [A10.755]
Myelin Sheath [A10.755.503]
Cells [A11]
Cellular Structures [A11.284]
Cell Membrane [A11.284.149]
Cell Membrane Structures [A11.284.149.165]
Myelin Sheath [A11.284.149.165.600]
Neuroglia [A11.650]
Oligodendroglia [A11.650.600]
Myelin Sheath [A11.650.600.500]
Schwann Cells [A11.650.800]
Myelin Sheath [A11.650.800.500]
Neurons [A11.671]
Nerve Fibers [A11.671.501]
Nerve Fibers, Myelinated [A11.671.501.512]
Myelin Sheath [A11.671.501.512.560]
Nerve Fibers, Myelinated [A11.671.514]
Myelin Sheath [A11.671.514.553]

Below are MeSH descriptors whose meaning is related to "Myelin Sheath".

Below are MeSH descriptors whose meaning is more specific than "Myelin Sheath".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Myelin Sheath" by people in this website by year, and whether "Myelin Sheath" was a major or minor topic of these publications.

Bar chart showing 23 publications over 16 distinct years, with a maximum of 3 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2001	1	0	1
2005	1	1	2
2006	1	0	1
2008	1	1	2
2010	0	1	1
2012	0	1	1
2013	1	0	1
2014	1	0	1
2017	1	0	1
2018	2	0	2
2019	1	2	3
2022	0	1	1
2023	0	2	2
2024	0	2	2
2025	1	0	1

Below are the most recent publications written about "Myelin Sheath" by people in Profiles.

Gross PS, Dur?n-Laforet V, Ho LT, Melchor GS, Zia S, Manavi Z, Barclay WE, Lee SH, Shults N, Selva S, Alvarez E, Plemel JR, Fu MM, Schafer DP, Huang JK. Senescent-like microglia limit remyelination through the senescence associated secretory phenotype. Nat Commun. 2025 Mar 07; 16(1):2283.

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Beiter RM, Sheehan PW, Schafer DP. Microglia phagocytic mechanisms: Development informing disease. Curr Opin Neurobiol. 2024 Jun; 86:102877.

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Yusuf IO, Parsi S, Ostrow LW, Brown RH, Thompson PR, Xu Z. PAD2 dysregulation and aberrant protein citrullination feature prominently in reactive astrogliosis and myelin protein aggregation in sporadic ALS. Neurobiol Dis. 2024 Mar; 192:106414.

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Lotun A, Li D, Xu H, Su Q, Tuncer S, Sanmiguel J, Mooney M, Baer CE, Ulbrich R, Eyles SJ, Strittmatter L, Hayward LJ, Gessler DJ, Gao G. Renewal of oligodendrocyte lineage reverses dysmyelination and CNS neurodegeneration through corrected N-acetylaspartate metabolism. Prog Neurobiol. 2023 Jul; 226:102460.

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Barletta VT, Herranz E, Treaba CA, Mehndiratta A, Ouellette R, Granberg T, Klawiter EC, Ionete C, Sloane JA, Mainero C. In vivo characterization of microglia and myelin relation in multiple sclerosis by combined 11C-PBR28 PET and synthetic MRI. J Neurol. 2023 Jun; 270(6):3091-3102.

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Yusuf IO, Qiao T, Parsi S, Tilvawala R, Thompson PR, Xu Z. Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models. Acta Neuropathol Commun. 2022 09 08; 10(1):135.

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Farley BJ, Morozova E, Dion J, Wang B, Harvey BD, Gianni D, Wipke B, Cadavid D, Wittmann M, Hajos M. Evoked potentials as a translatable biomarker to track functional remyelination. Mol Cell Neurosci. 2019 09; 99:103393.

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Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, Vistnes S, Stockley JH, Young A, Steindel M, Tung B, Goyal N, Bhaduri A, Mayer S, Engler JB, Bayraktar OA, Franklin RJM, Haeussler M, Reynolds R, Schafer DP, Friese MA, Shiow LR, Kriegstein AR, Rowitch DH. Neuronal vulnerability and multilineage diversity in multiple sclerosis. Nature. 2019 09; 573(7772):75-82.

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Barak B, Zhang Z, Liu Y, Nir A, Trangle SS, Ennis M, Levandowski KM, Wang D, Quast K, Boulting GL, Li Y, Bayarsaihan D, He Z, Feng G. Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug. Nat Neurosci. 2019 05; 22(5):700-708.

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McDougall S, Vargas Riad W, Silva-Gotay A, Tavares ER, Harpalani D, Li GL, Richardson HN. Myelination of Axons Corresponds with Faster Transmission Speed in the Prefrontal Cortex of Developing Male Rats. eNeuro. 2018 Jul-Aug; 5(4).

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