"Caspase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
| Descriptor ID |
D053143
|
| MeSH Number(s) |
D08.811.277.656.262.500.126.550.200 D08.811.277.656.300.200.126.550.200 D12.644.360.075.405.550.200 D12.776.476.075.405.550.200
|
| Concept/Terms |
Caspase 2- Caspase 2
- ICH-1 Protease
- ICH 1 Protease
- Caspase-2
Procaspase-2- Procaspase-2
- Procaspase 2
- Pro-Caspase-2
- Pro Caspase 2
|
Below are MeSH descriptors whose meaning is more general than "Caspase 2".
Below are MeSH descriptors whose meaning is more specific than "Caspase 2".
This graph shows the total number of publications written about "Caspase 2" by people in this website by year, and whether "Caspase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Caspase 2" by people in Profiles.
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Jang HN, Lee M, Loh TJ, Choi SW, Oh HK, Moon H, Cho S, Hong SE, Kim DH, Sheng Z, Green MR, Park D, Zheng X, Shen H. Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8. Biochim Biophys Acta. 2014 Jan; 1839(1):25-32.
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Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T. Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Mol Cell. 2011 Jul 08; 43(1):57-71.