14-3-3 Proteins

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"14-3-3 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.

Descriptor ID	D048948
MeSH Number(s)	D12.644.360.024.050 D12.776.157.057.002 D12.776.476.024.050
Concept/Terms	14-3-3 Proteins 14-3-3 Proteins 14 3 3 Proteins 14-3-3 Protein 14 3 3 Protein Brain 14-3-3 Protein 14-3-3 Protein, Brain Brain 14 3 3 Protein Protein 14-3-3 14-3-3 Protein, tau Isoform 14-3-3 Protein, tau Isoform 14 3 3 Protein, tau Isoform 14-3-3tau Protein 14 3 3tau Protein Protein, 14-3-3tau 14-3-3 tau Protein 14 3 3 tau Protein 14-3-3 Protein, zeta Isoform 14-3-3 Protein, zeta Isoform 14 3 3 Protein, zeta Isoform 14-3-3zeta Protein 14 3 3zeta Protein 14-3-3 zeta Protein 14 3 3 zeta Protein 14-3-3 Protein, eta Isoform 14-3-3 Protein, eta Isoform 14 3 3 Protein, eta Isoform 14-3-3eta Protein 14 3 3eta Protein 14-3-3 eta Protein 14 3 3 eta Protein eta Protein, 14-3-3 14-3-3 Protein, epsilon Isoform 14-3-3 Protein, epsilon Isoform 14 3 3 Protein, epsilon Isoform 14-3-3 epsilon Protein 14 3 3 epsilon Protein 14-3-3epsilon Protein 14 3 3epsilon Protein 14-3-3 Protein, gamma Isoform 14-3-3 Protein, gamma Isoform 14 3 3 Protein, gamma Isoform 14-3-3gamma Protein 14 3 3gamma Protein 14-3-3 gamma Protein 14 3 3 gamma Protein 14-3-3 Protein, beta Isoform 14-3-3 Protein, beta Isoform 14 3 3 Protein, beta Isoform 14-3-3beta Protein 14 3 3beta Protein 14-3-3 beta Protein 14 3 3 beta Protein

Below are MeSH descriptors whose meaning is more general than "14-3-3 Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
14-3-3 Proteins [D12.644.360.024.050]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
14-3-3 Proteins [D12.776.157.057.002]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
14-3-3 Proteins [D12.776.476.024.050]

Below are MeSH descriptors whose meaning is related to "14-3-3 Proteins".

Below are MeSH descriptors whose meaning is more specific than "14-3-3 Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "14-3-3 Proteins" by people in this website by year, and whether "14-3-3 Proteins" was a major or minor topic of these publications.

Bar chart showing 13 publications over 8 distinct years, with a maximum of 3 publications in 2008 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2006	1	1	2
2008	0	3	3
2009	1	0	1
2012	1	2	3
2014	1	0	1
2017	1	0	1
2024	1	0	1

Below are the most recent publications written about "14-3-3 Proteins" by people in Profiles.

Frelinger AL, Haynes RL, Goldstein RD, Berny-Lang MA, Gerrits AJ, Riehs M, Haas EA, Paunovic B, Mena OJ, Campman SC, Milne GL, Sleeper LA, Kinney HC, Michelson AD. Dysregulation of platelet serotonin, 14-3-3, and GPIX in sudden infant death syndrome. Sci Rep. 2024 05 15; 14(1):11092.

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Hemming ML, Wagner AJ, Nucci MR, Chiang S, Wang L, Hensley ML, George S. YWHAE-rearranged high-grade endometrial stromal sarcoma: Two-center case series and response to chemotherapy. Gynecol Oncol. 2017 06; 145(3):531-535.

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Kim HS, Ullevig SL, Nguyen HN, Vanegas D, Asmis R. Redox regulation of 14-3-3? controls monocyte migration. Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7):1514-21.

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Ramteke MP, Shelke P, Ramamoorthy V, Somavarapu AK, Gautam AK, Nanaware PP, Karanam S, Mukhopadhyay S, Venkatraman P. Identification of a novel ATPase activity in 14-3-3 proteins--evidence from enzyme kinetics, structure guided modeling and mutagenesis studies. FEBS Lett. 2014 Jan 03; 588(1):71-8.

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Singer S, Zhao R, Barsotti AM, Ouwehand A, Fazollahi M, Coutavas E, Breuhahn K, Neumann O, Longerich T, Pusterla T, Powers MA, Giles KM, Leedman PJ, Hess J, Grunwald D, Bussemaker HJ, Singer RH, Schirmacher P, Prives C. Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. Mol Cell. 2012 Dec 14; 48(5):799-810.

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Tan SX, Ng Y, Burchfield JG, Ramm G, Lambright DG, St?ckli J, James DE. The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes. Mol Cell Biol. 2012 Dec; 32(24):4946-59.

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Gabriel L, Lvov A, Orthodoxou D, Rittenhouse AR, Kobertz WR, Melikian HE. The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3?-dependent, protein kinase C (PKC)-mediated endocytic trafficking. J Biol Chem. 2012 Sep 21; 287(39):32354-66.

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Drachman DA. Comment: Tau vs 14-3-3 protein--adjuncts for the diagnosis of CJD. Neurology. 2012 Aug 07; 79(6):551.

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Ravi D, Chen Y, Karia B, Brown A, Gu TT, Li J, Carey MS, Hennessy BT, Bishop AJ. 14-3-3 s expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis. PLoS One. 2011 Jan 10; 6(1):e15864.

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Nutt LK, Buchakjian MR, Gan E, Darbandi R, Yoon SY, Wu JQ, Miyamoto YJ, Gibbons JA, Gibbon JA, Andersen JL, Freel CD, Tang W, He C, Kurokawa M, Wang Y, Margolis SS, Fissore RA, Kornbluth S. Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2. Dev Cell. 2009 Jun; 16(6):856-66.

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