 Antigens, CD40
"Antigens, CD40" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
| Descriptor ID |
D019013
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| MeSH Number(s) |
D12.776.543.750.705.852.760.097 D23.050.301.264.035.140 D23.050.301.264.051.140 D23.101.100.110.140 D23.101.100.150.140
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| Concept/Terms |
Antigens, CD40- Antigens, CD40
- CD40 Antigens
- TNFRSF5 Receptor
- Receptor, TNFRSF5
- Tumor Necrosis Factor Receptor Superfamily, Member 5
- CD40 Antigen
- Antigen, CD40
- CDw40 Antigen
- Antigen, CDw40
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Below are MeSH descriptors whose meaning is more general than "Antigens, CD40".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Cytokine [D12.776.543.750.705.852]
- Receptors, Tumor Necrosis Factor [D12.776.543.750.705.852.760]
- Antigens, CD40 [D12.776.543.750.705.852.760.097]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, CD [D23.050.301.264.035]
- Antigens, CD40 [D23.050.301.264.035.140]
- Antigens, Differentiation, B-Lymphocyte [D23.050.301.264.051]
- Antigens, CD40 [D23.050.301.264.051.140]
- Biological Markers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, CD [D23.101.100.110]
- Antigens, CD40 [D23.101.100.110.140]
- Antigens, Differentiation, B-Lymphocyte [D23.101.100.150]
- Antigens, CD40 [D23.101.100.150.140]
Below are MeSH descriptors whose meaning is more specific than "Antigens, CD40".
This graph shows the total number of publications written about "Antigens, CD40" by people in this website by year, and whether "Antigens, CD40" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1996 | 2 | 2 | 4 | | 1998 | 2 | 1 | 3 | | 1999 | 1 | 3 | 4 | | 2000 | 2 | 5 | 7 | | 2001 | 0 | 1 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 2 | 1 | 3 | | 2004 | 0 | 1 | 1 | | 2005 | 2 | 1 | 3 | | 2006 | 0 | 1 | 1 | | 2007 | 2 | 0 | 2 | | 2008 | 3 | 0 | 3 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2013 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Antigens, CD40" by people in Profiles.
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Mohiuddin MM, Singh AK, Corcoran PC, Thomas ML, Clark T, Lewis BG, Hoyt RF, Eckhaus M, Pierson RN, Belli AJ, Wolf E, Klymiuk N, Phelps C, Reimann KA, Ayares D, Horvath KA. Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft. Nat Commun. 2016 Apr 05; 7:11138.
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Mohiuddin MM, Singh AK, Corcoran PC, Hoyt RF, Thomas ML, Lewis BG, Eckhaus M, Dabkowski NL, Belli AJ, Reimann KA, Ayares D, Horvath KA. Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model. Xenotransplantation. 2014 Jan-Feb; 21(1):35-45.
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Baumjohann D, Preite S, Reboldi A, Ronchi F, Ansel KM, Lanzavecchia A, Sallusto F. Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity. 2013 Mar 21; 38(3):596-605.
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Guo CA, Kogan S, Amano SU, Wang M, Dagdeviren S, Friedline RH, Aouadi M, Kim JK, Czech MP. CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance. Am J Physiol Endocrinol Metab. 2013 May 1; 304(9):E951-63.
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Chakrabarti S, Rizvi M, Morin K, Garg R, Freedman JE. The role of CD40L and VEGF in the modulation of angiogenesis and inflammation. Vascul Pharmacol. 2010 Sep-Oct; 53(3-4):130-7.
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Chakrabarti S, Rizvi M, Pathak D, Kirber MT, Freedman JE. Hypoxia influences CD40-CD40L mediated inflammation in endothelial and monocytic cells. Immunol Lett. 2009 Feb 21; 122(2):170-84.
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Rizvi M, Pathak D, Freedman JE, Chakrabarti S. CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease. Trends Mol Med. 2008 Dec; 14(12):530-8.
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Hernandez MG, Shen L, Rock KL. CD40 on APCs is needed for optimal programming, maintenance, and recall of CD8+ T cell memory even in the absence of CD4+ T cell help. J Immunol. 2008 Apr 1; 180(7):4382-90.
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Vanichakarn P, Blair P, Wu C, Freedman JE, Chakrabarti S. Neutrophil CD40 enhances platelet-mediated inflammation. Thromb Res. 2008; 122(3):346-58.
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Chakrabarti S, Blair P, Freedman JE. CD40-40L signaling in vascular inflammation. J Biol Chem. 2007 Jun 22; 282(25):18307-17.
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