"RNA Precursors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
RNA transcripts of the DNA that are in some unfinished stage of post-transcriptional processing (RNA PROCESSING, POST-TRANSCRIPTIONAL) required for function. RNA precursors may undergo several steps of RNA SPLICING during which the phosphodiester bonds at exon-intron boundaries are cleaved and the introns are excised. Consequently a new bond is formed between the ends of the exons. Resulting mature RNAs can then be used; for example, mature mRNA (RNA, MESSENGER) is used as a template for protein production.
Descriptor ID |
D012322
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MeSH Number(s) |
D13.400.730 D13.444.735.640
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Concept/Terms |
RNA Precursor- RNA Precursor
- Precursor, RNA
- Precursor RNA
- RNA, Precursor
Primary RNA Transcript- Primary RNA Transcript
- RNA Transcript, Primary
- Transcript, Primary RNA
- Primary Transcript, RNA
- RNA Primary Transcript
- Transcript, RNA Primary
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Below are MeSH descriptors whose meaning is more general than "RNA Precursors".
Below are MeSH descriptors whose meaning is more specific than "RNA Precursors".
This graph shows the total number of publications written about "RNA Precursors" by people in this website by year, and whether "RNA Precursors" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1997 | 1 | 0 | 1 |
1999 | 2 | 0 | 2 |
2000 | 2 | 1 | 3 |
2001 | 1 | 2 | 3 |
2002 | 3 | 3 | 6 |
2003 | 0 | 1 | 1 |
2004 | 1 | 2 | 3 |
2006 | 2 | 2 | 4 |
2007 | 2 | 2 | 4 |
2008 | 2 | 1 | 3 |
2009 | 2 | 1 | 3 |
2010 | 1 | 1 | 2 |
2011 | 3 | 0 | 3 |
2012 | 1 | 2 | 3 |
2013 | 0 | 3 | 3 |
2015 | 1 | 1 | 2 |
2016 | 2 | 0 | 2 |
2017 | 1 | 1 | 2 |
2018 | 2 | 2 | 4 |
2019 | 0 | 1 | 1 |
2020 | 0 | 1 | 1 |
2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "RNA Precursors" by people in Profiles.
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Torres-Ulloa L, Calvo-Roitberg E, Pai AA. Genome-wide kinetic profiling of pre-mRNA 3' end cleavage. RNA. 2024 02 16; 30(3):256-270.
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Humphries F, Fitzgerald KA. Loosening the grip on nuclear cGAS. Nat Genet. 2020 12; 52(12):1269-1270.
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Kaiser RWJ, Ignarski M, Van Nostrand EL, Frese CK, Jain M, Cukoski S, Heinen H, Schaechter M, Seufert L, Bunte K, Frommolt P, Keller P, Helm M, Bohl K, H?hne M, Schermer B, Benzing T, H?pker K, Dieterich C, Yeo GW, M?ller RU, Fabretti F. A protein-RNA interaction atlas of the ribosome biogenesis factor AATF. Sci Rep. 2019 07 30; 9(1):11071.
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Montes M, Sanford BL, Comiskey DF, Chandler DS. RNA Splicing and Disease: Animal Models to Therapies. Trends Genet. 2019 01; 35(1):68-87.
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Metkar M, Ozadam H, Lajoie BR, Imakaev M, Mirny LA, Dekker J, Moore MJ. Higher-Order Organization Principles of Pre-translational mRNPs. Mol Cell. 2018 11 15; 72(4):715-726.e3.
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Pai AA, Paggi JM, Yan P, Adelman K, Burge CB. Numerous recursive sites contribute to accuracy of splicing in long introns in flies. PLoS Genet. 2018 08; 14(8):e1007588.
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Braun JE, Friedman LJ, Gelles J, Moore MJ. Synergistic assembly of human pre-spliceosomes across introns and exons. Elife. 2018 06 22; 7.
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Kotwal GJ, Martin MD, Chien S. Significant upregulation of U1 and U4 spliceosomal snRNAs by ATP nanoliposomes explains acceleration of wound healing, due to increased pre-mRNA processing to functional mRNA. Nanomedicine. 2018 06; 14(4):1289-1299.
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Pai AA, Henriques T, McCue K, Burkholder A, Adelman K, Burge CB. The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture. Elife. 2017 12 27; 6.
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Celik A, Baker R, He F, Jacobson A. High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection. RNA. 2017 05; 23(5):735-748.