RNA-Directed DNA Polymerase
"RNA-Directed DNA Polymerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49.
| Descriptor ID |
D012194
|
| MeSH Number(s) |
D08.811.913.696.445.308.300.750 D12.776.964.775.375.750 D12.776.964.970.600.850.375.750
|
| Concept/Terms |
RNA-Directed DNA Polymerase- RNA-Directed DNA Polymerase
- RNA Directed DNA Polymerase
- Reverse Transcriptase
- RNA Transcriptase
- DNA Polymerase, RNA-Directed
- DNA Polymerase, RNA Directed
- RNA-Dependent DNA Polymerase
- DNA Polymerase, RNA-Dependent
- RNA Dependent DNA Polymerase
- Revertase
|
Below are MeSH descriptors whose meaning is more general than "RNA-Directed DNA Polymerase".
Below are MeSH descriptors whose meaning is more specific than "RNA-Directed DNA Polymerase".
This graph shows the total number of publications written about "RNA-Directed DNA Polymerase" by people in this website by year, and whether "RNA-Directed DNA Polymerase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 2 | 2 |
| 2001 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "RNA-Directed DNA Polymerase" by people in Profiles.
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Liu B, Dong X, Cheng H, Zheng C, Chen Z, Rodr?guez TC, Liang SQ, Xue W, Sontheimer EJ. A split prime editor with untethered reverse transcriptase and circular RNA template. Nat Biotechnol. 2022 09; 40(9):1388-1393.
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Zheng C, Liang SQ, Liu B, Liu P, Kwan SY, Wolfe SA, Xue W. A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver. Mol Ther. 2022 03 02; 30(3):1343-1351.
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Boateng JO, Wachman EM, Turcinovic J, Devera J, Jain M, Jean-Sicard S, Woodard E, Cruikshank A, Sinha B, Bartolome R, Barnett ED, Parker MG, Yarrington C, Connor JH, Taglauer E, Sabharwal V. SARS-CoV-2 in infant urine and fecal samples after in utero COVID-19 exposure. Pediatr Res. 2022 08; 92(2):536-540.
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Pederson T. The 50th anniversary of reverse transcriptase-and its ironic legacy in the time of coronavirus. FASEB J. 2020 06; 34(6):7219-7221.
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Flotte TR, Gao G. Prime Editing: A Novel Cas9-Reverse Transcriptase Fusion May Revolutionize Genome Editing. Hum Gene Ther. 2019 12; 30(12):1445-1446.
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Sontheimer EJ, Marraffini LA. RNA. CRISPR goes retro. Science. 2016 Feb 26; 351(6276):920-1.
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Gibson RM, Meyer AM, Winner D, Archer J, Feyertag F, Ruiz-Mateos E, Leal M, Robertson DL, Schmotzer CL, Qui?ones-Mateu ME. Sensitive deep-sequencing-based HIV-1 genotyping assay to simultaneously determine susceptibility to protease, reverse transcriptase, integrase, and maturation inhibitors, as well as HIV-1 coreceptor tropism. Antimicrob Agents Chemother. 2014; 58(4):2167-85.
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Pinto FL, Lindblad P. A guide for in-house design of template-switch-based 5' rapid amplification of cDNA ends systems. Anal Biochem. 2010 Feb 15; 397(2):227-32.
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Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D. Exploitation of binding energy for catalysis and design. Nature. 2009 Oct 29; 461(7268):1300-4.
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Richards KH, Clapham PR. Effects of vpu start-codon mutations on human immunodeficiency virus type 1 replication in macrophages. J Gen Virol. 2007 Oct; 88(Pt 10):2780-2792.