beta-Thalassemia

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"beta-Thalassemia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.

Descriptor ID	D017086
MeSH Number(s)	C15.378.071.141.150.875.150 C15.378.420.826.150 C16.320.070.875.150 C16.320.365.826.150
Concept/Terms	beta-Thalassemia beta-Thalassemia Microcytemia, beta Type Microcytemias, beta Type Type Microcytemia, beta Type Microcytemias, beta beta Type Microcytemia beta Type Microcytemias beta Thalassemia Thalassemia, beta Thalassemias, beta beta Thalassemias Thalassemia, beta Type Thalassemias, beta Type Type Thalassemia, beta Type Thalassemias, beta beta Type Thalassemia beta Type Thalassemias Thalassemia Intermedia Thalassemia Intermedia Intermedia, Thalassemia Intermedias, Thalassemia Thalassemia Intermedias Thalassemia Minor Thalassemia Minor Thalassemia Minor (beta-Thalassemia Minor) Minor, Thalassemia (beta-Thalassemia Minor) Minors, Thalassemia (beta-Thalassemia Minor) Thalassemia Minor (beta Thalassemia Minor) Thalassemia Minors (beta-Thalassemia Minor) Hemoglobin F Disease Hemoglobin F Disease Disease, Hemoglobin F Thalassemia Major Thalassemia Major Anemia, Erythroblastic Anemias, Erythroblastic Erythroblastic Anemia Thalassemia Major (beta-Thalassemia Major) Major, Thalassemia (beta-Thalassemia Major) Majors, Thalassemia (beta-Thalassemia Major) Thalassemia Major (beta Thalassemia Major) Thalassemia Majors (beta-Thalassemia Major) Mediterranean Anemia Anemias, Mediterranean Mediterranean Anemias Anemia, Cooley's Anemia, Cooley Anemia, Cooleys Cooley's Anemia Anemia, Mediterranean

Below are MeSH descriptors whose meaning is more general than "beta-Thalassemia".

Diseases [C]
Hemic and Lymphatic Diseases [C15]
Hematologic Diseases [C15.378]
Anemia [C15.378.071]
Anemia, Hemolytic [C15.378.071.141]
Anemia, Hemolytic, Congenital [C15.378.071.141.150]
Thalassemia [C15.378.071.141.150.875]
beta-Thalassemia [C15.378.071.141.150.875.150]
Hemoglobinopathies [C15.378.420]
Thalassemia [C15.378.420.826]
beta-Thalassemia [C15.378.420.826.150]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Anemia, Hemolytic, Congenital [C16.320.070]
Thalassemia [C16.320.070.875]
beta-Thalassemia [C16.320.070.875.150]
Hemoglobinopathies [C16.320.365]
Thalassemia [C16.320.365.826]
beta-Thalassemia [C16.320.365.826.150]

Below are MeSH descriptors whose meaning is related to "beta-Thalassemia".

Below are MeSH descriptors whose meaning is more specific than "beta-Thalassemia".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "beta-Thalassemia" by people in this website by year, and whether "beta-Thalassemia" was a major or minor topic of these publications.

Bar chart showing 10 publications over 9 distinct years, with a maximum of 2 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
2008	1	0	1
2011	1	0	1
2013	1	0	1
2016	1	0	1
2017	1	0	1
2019	1	1	2
2020	0	1	1
2021	1	0	1

Below are the most recent publications written about "beta-Thalassemia" by people in Profiles.

Flotte TR. Gene Therapy in Global Health: Meeting the Needs of Chinese Patients with Beta-Thalassemia. Hum Gene Ther. 2021 May; 32(9-10):449-450.

View in: PubMed
Zeng J, Wu Y, Ren C, Bonanno J, Shen AH, Shea D, Gehrke JM, Clement K, Luk K, Yao Q, Kim R, Wolfe SA, Manis JP, Pinello L, Joung JK, Bauer DE. Therapeutic base editing of human hematopoietic stem cells. Nat Med. 2020 04; 26(4):535-541.

View in: PubMed
Wu Y, Zeng J, Roscoe BP, Liu P, Yao Q, Lazzarotto CR, Clement K, Cole MA, Luk K, Baricordi C, Shen AH, Ren C, Esrick EB, Manis JP, Dorfman DM, Williams DA, Biffi A, Brugnara C, Biasco L, Brendel C, Pinello L, Tsai SQ, Wolfe SA, Bauer DE. Highly efficient therapeutic gene editing of human hematopoietic stem cells. Nat Med. 2019 May; 25(5):776-783.

View in: PubMed
Xu S, Luk K, Yao Q, Shen AH, Zeng J, Wu Y, Luo HY, Brendel C, Pinello L, Chui DHK, Wolfe SA, Bauer DE. Editing aberrant splice sites efficiently restores ?-globin expression in ?-thalassemia. Blood. 2019 05 23; 133(21):2255-2262.

View in: PubMed
Taher AT, Saliba AN, Kuo KH, Giardina PJ, Cohen AR, Neufeld EJ, Aydinok Y, Kwiatkowski JL, Jeglinski BI, Pietropaolo K, Berk G, Viprakasit V. Safety and pharmacokinetics of the oral iron chelator SP-420 in ?-thalassemia. Am J Hematol. 2017 Dec; 92(12):1356-1361.

View in: PubMed
Gaines P, Halene S. Rusty neutrophils in ?-thalassemia: no traction! Blood. 2017 06 08; 129(23):3046-3047.

View in: PubMed
Wilburn CR, Bernard DW, Zieske AW, Andrieni J, Miller T, Wang P. The Prevalence and Role of Hemoglobin Variants in Biometric Screening of a Multiethnic Population: One Large Health System's Experience. Am J Clin Pathol. 2017 Jun 01; 147(6):589-595.

View in: PubMed
Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, L?pez-Gir?ldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM. In vivo correction of anaemia in ?-thalassemic mice by ?PNA-mediated gene editing with nanoparticle delivery. Nat Commun. 2016 10 26; 7:13304.

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Spitzer B, Giardina PJ, O'Reilly RJ, Boulad F. Late complications of mixed chimerism following allogeneic bone marrow transplantation for thalassemia major. Pediatr Blood Cancer. 2015 Jul; 62(7):1303-4.

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Boulad F, Wang X, Qu J, Taylor C, Ferro L, Karponi G, Bartido S, Giardina P, Heller G, Prockop SE, Maggio A, Sadelain M, Rivi?re I. Safe mobilization of CD34+ cells in adults with ?-thalassemia and validation of effective globin gene transfer for clinical investigation. Blood. 2014 Mar 06; 123(10):1483-6.

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