Phosphodiesterase Inhibitors

"Phosphodiesterase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.

Descriptor ID	D010726
MeSH Number(s)	D27.505.519.389.735
Concept/Terms	Phosphodiesterase Inhibitors Phosphodiesterase Inhibitors Phosphodiesterase Antagonists Phosphoric Diester Hydrolase Inhibitors Antiphosphodiesterases

Below are MeSH descriptors whose meaning is more general than "Phosphodiesterase Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Phosphodiesterase Inhibitors [D27.505.519.389.735]

Below are MeSH descriptors whose meaning is related to "Phosphodiesterase Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Phosphodiesterase Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Phosphodiesterase Inhibitors" by people in this website by year, and whether "Phosphodiesterase Inhibitors" was a major or minor topic of these publications.

Bar chart showing 19 publications over 11 distinct years, with a maximum of 4 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	2	2
1998	0	1	1
2000	1	0	1
2001	2	0	2
2002	1	3	4
2005	1	1	2
2006	0	2	2
2009	0	2	2
2011	0	1	1
2017	0	1	1
2018	1	0	1

Below are the most recent publications written about "Phosphodiesterase Inhibitors" by people in Profiles.

Charnigo RJ, Beidler D, Rybin D, Pittman DD, Tan B, Howard J, Michelson AD, Frelinger AL, Clarke N. PF-04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo-Controlled Study. Clin Transl Sci. 2019 03; 12(2):180-188.

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Nigwekar SU, Weiser JM, Kalim S, Xu D, Wibecan JL, Dougherty SM, Mercier-Lafond L, Corapi KM, Eneanya ND, Holbrook EH, Brown D, Thadhani RI, P?unescu TG. Characterization and Correction of Olfactory Deficits in Kidney Disease. J Am Soc Nephrol. 2017 Nov; 28(11):3395-3403.

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Münzel T, Gori T, Keaney JF, Maack C, Daiber A. Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications. Eur Heart J. 2015 Oct 07; 36(38):2555-64.

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Tan X, Sanderson MJ. Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity. Br J Pharmacol. 2014 Feb; 171(3):646-62.

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E X, Pickering MT, Debatis M, Castillo J, Lagadinos A, Wang S, Lu S, Kowalik TF. An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus. PLoS Pathog. 2011 May; 7(5):e1001342.

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Michelson AD. Advances in antiplatelet therapy. Hematology Am Soc Hematol Educ Program. 2011; 2011:62-9.

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Silver B, McCarthy S, Lu M, Mitsias P, Russman AN, Katramados A, Morris DC, Lewandowski CA, Chopp M. Sildenafil treatment of subacute ischemic stroke: a safety study at 25-mg daily for 2 weeks. J Stroke Cerebrovasc Dis. 2009 Sep-Oct; 18(5):381-3.

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Fenton RA, Komatsu S, Ikebe M, Shea LG, Dobson JG. Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H718-25.

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Ellsworth P, Kirshenbaum EM. Current concepts in the evaluation and management of erectile dysfunction. Urol Nurs. 2008 Oct; 28(5):357-69.

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Zhang L, Zhang Z, Zhang RL, Cui Y, LaPointe MC, Silver B, Chopp M. Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke. Brain Res. 2006 Nov 06; 1118(1):192-8.

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