"Trans-Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.
- Trans Splicing
- Splicing, Trans
- RNA Trans-Splicing
- RNA Trans Splicing
- Trans-Splicings, RNA
- Trans RNA Splicing
- RNA Splicing, Trans
Below are MeSH descriptors whose meaning is more general than "Trans-Splicing".
Below are MeSH descriptors whose meaning is more specific than "Trans-Splicing".
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Below are the most recent publications written about "Trans-Splicing" by people in Profiles.
Nelson C, Ambros V. Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity. Development. 2019 03 04; 146(5).