STAT3 Transcription Factor

"STAT3 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.

Descriptor ID	D050796
MeSH Number(s)	D12.644.360.024.342.300 D12.776.157.057.186.300 D12.776.476.024.430.300 D12.776.930.840.300
Concept/Terms	STAT3 Transcription Factor STAT3 Transcription Factor Transcription Factor, STAT3 LIF-Response Factor LIF Response Factor Acute-Phase Response Factor Acute Phase Response Factor Response Factor, Acute-Phase APRF Transcription Factor Transcription Factor, APRF Signal Transducer and Activator of Transcription 3 IL6-Response Factor IL6 Response Factor STAT3 Protein STAT3b Transcription Factor STAT3b Transcription Factor Transcription Factor, STAT3b Stat3beta Transcription Factor Transcription Factor, Stat3beta STAT3a Transcription Factor STAT3a Transcription Factor Transcription Factor, STAT3a Stat3alpha Transcription Factor Transcription Factor, Stat3alpha

Below are MeSH descriptors whose meaning is more general than "STAT3 Transcription Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
STAT Transcription Factors [D12.644.360.024.342]
STAT3 Transcription Factor [D12.644.360.024.342.300]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
STAT Transcription Factors [D12.776.157.057.186]
STAT3 Transcription Factor [D12.776.157.057.186.300]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
STAT Transcription Factors [D12.776.476.024.430]
STAT3 Transcription Factor [D12.776.476.024.430.300]
Transcription Factors [D12.776.930]
STAT Transcription Factors [D12.776.930.840]
STAT3 Transcription Factor [D12.776.930.840.300]

Below are MeSH descriptors whose meaning is related to "STAT3 Transcription Factor".

Below are MeSH descriptors whose meaning is more specific than "STAT3 Transcription Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "STAT3 Transcription Factor" by people in this website by year, and whether "STAT3 Transcription Factor" was a major or minor topic of these publications.

Bar chart showing 54 publications over 19 distinct years, with a maximum of 9 publications in 2012 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2005	1	1	2
2007	2	1	3
2008	2	2	4
2009	0	2	2
2010	1	1	2
2011	1	0	1
2012	5	4	9
2013	1	2	3
2014	1	1	2
2015	7	2	9
2016	2	1	3
2017	2	1	3
2018	1	2	3
2019	0	2	2
2020	1	0	1
2021	1	1	2
2022	0	1	1
2024	0	1	1

Below are the most recent publications written about "STAT3 Transcription Factor" by people in Profiles.

Kohal R, Bisht P, Gupta GD, Verma SK. Targeting JAK2/STAT3 for the treatment of cancer: A review on recent advancements in molecular development using structural analysis and SAR investigations. Bioorg Chem. 2024 Feb; 143:107095.

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Gardner HL, Fenger JM, Roberts RD, London CA. Characterizing the metabolic role of STAT3 in canine osteosarcoma. Vet Comp Oncol. 2022 Dec; 20(4):817-824.

View in: PubMed
Faust TE, Schafer DP. IL-6 boosts synaptogenesis STAT! Immunity. 2021 11 09; 54(11):2444-2446.

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Odom CV, Kim Y, Burgess CL, Baird LA, Korkmaz FT, Na E, Shenoy AT, Arafa EI, Lam TT, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. Liver-Dependent Lung Remodeling during Systemic Inflammation Shapes Responses to Secondary Infection. J Immunol. 2021 10 01; 207(7):1891-1902.

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Santoni M, Miccini F, Cimadamore A, Piva F, Massari F, Cheng L, Lopez-Beltran A, Montironi R, Battelli N. An update on investigational therapies that target STAT3 for the treatment of cancer. Expert Opin Investig Drugs. 2021 Mar; 30(3):245-251.

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Balic JJ, Albargy H, Luu K, Kirby FJ, Jayasekara WSN, Mansell F, Garama DJ, De Nardo D, Baschuk N, Louis C, Humphries F, Fitzgerald K, Latz E, Gough DJ, Mansell A. STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression. Nat Commun. 2020 07 30; 11(1):3816.

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Kim Y, Allen E, Baird LA, Symer EM, Korkmaz FT, Na E, Odom CV, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. NF-?B RelA Is Required for Hepatoprotection during Pneumonia and Sepsis. Infect Immun. 2019 08; 87(8).

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Rakariyatham K, Du Z, Yuan B, Gao Z, Song M, Pan C, Han Y, Wu X, Tang Z, Zhang G, Xiao H. Inhibitory effects of 7,7'-bromo-curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation. Eur J Pharmacol. 2019 Sep 05; 858:172479.

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Katayama M, Wiklander OPB, Fritz T, Caidahl K, El-Andaloussi S, Zierath JR, Krook A. Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle. Diabetes. 2019 03; 68(3):515-526.

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Whitley SK, Balasubramani A, Zindl CL, Sen R, Shibata Y, Crawford GE, Weathington NM, Hatton RD, Weaver CT. IL-1R signaling promotes STAT3 and NF-?B factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription. J Biol Chem. 2018 10 12; 293(41):15790-15800.

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