STAT2 Transcription Factor
"STAT2 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to TYPE I INTERFERONS. Stat2 protein is associated constitutively with INTERFERON REGULATORY FACTOR-9. After PHOSPHORYLATION Stat2 forms the IFN-STIMULATED GENE FACTOR 3 COMPLEX to regulate expression of target GENES.
| Descriptor ID |
D050795
|
| MeSH Number(s) |
D12.644.360.024.303.500.750 D12.644.360.024.342.200 D12.776.157.057.061.500.750 D12.776.157.057.186.200 D12.776.260.513.249.750 D12.776.476.024.386.500.750 D12.776.476.024.430.200 D12.776.930.354.249.750 D12.776.930.840.200
|
| Concept/Terms |
STAT2 Transcription Factor- STAT2 Transcription Factor
- Transcription Factor, STAT2
- Transcription Factor STAT2
- Factor STAT2, Transcription
- STAT2 Protein
- Signal Transducer and Activator of Transcription 2
|
Below are MeSH descriptors whose meaning is more general than "STAT2 Transcription Factor".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Adaptor Proteins, Signal Transducing [D12.644.360.024]
- Interferon-Stimulated Gene Factor 3 [D12.644.360.024.303]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.644.360.024.303.500]
- STAT2 Transcription Factor [D12.644.360.024.303.500.750]
- STAT Transcription Factors [D12.644.360.024.342]
- STAT2 Transcription Factor [D12.644.360.024.342.200]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Adaptor Proteins, Signal Transducing [D12.776.157.057]
- Interferon-Stimulated Gene Factor 3 [D12.776.157.057.061]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.157.057.061.500]
- STAT2 Transcription Factor [D12.776.157.057.061.500.750]
- STAT Transcription Factors [D12.776.157.057.186]
- STAT2 Transcription Factor [D12.776.157.057.186.200]
- DNA-Binding Proteins [D12.776.260]
- Interferon-Stimulated Gene Factor 3 [D12.776.260.513]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.260.513.249]
- STAT2 Transcription Factor [D12.776.260.513.249.750]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Adaptor Proteins, Signal Transducing [D12.776.476.024]
- Interferon-Stimulated Gene Factor 3 [D12.776.476.024.386]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.476.024.386.500]
- STAT2 Transcription Factor [D12.776.476.024.386.500.750]
- STAT Transcription Factors [D12.776.476.024.430]
- STAT2 Transcription Factor [D12.776.476.024.430.200]
- Transcription Factors [D12.776.930]
- Interferon-Stimulated Gene Factor 3 [D12.776.930.354]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.930.354.249]
- STAT2 Transcription Factor [D12.776.930.354.249.750]
- STAT Transcription Factors [D12.776.930.840]
- STAT2 Transcription Factor [D12.776.930.840.200]
Below are MeSH descriptors whose meaning is more specific than "STAT2 Transcription Factor".
This graph shows the total number of publications written about "STAT2 Transcription Factor" by people in this website by year, and whether "STAT2 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2014 | 1 | 2 | 3 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "STAT2 Transcription Factor" by people in Profiles.
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Qiu CC, Kotredes KP, Cremers T, Patel S, Afanassiev A, Slifker M, Gallucci S, Gamero AM. Targeted Stat2 deletion in conventional dendritic cells impairs CTL responses but does not affect antibody production. Oncoimmunology. 2020 12 29; 10(1):1860477.
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Seliga A, Lee MH, Fernandes NC, Zuluaga-Ramirez V, Didukh M, Persidsky Y, Potula R, Gallucci S, Sriram U. Kallikrein-Kinin System Suppresses Type I Interferon Responses: A Novel Pathway of Interferon Regulation. Front Immunol. 2018; 9:156.
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Xu J, Lee MH, Chakhtoura M, Green BL, Kotredes KP, Chain RW, Sriram U, Gamero AM, Gallucci S. STAT2 Is Required for TLR-Induced Murine Dendritic Cell Activation and Cross-Presentation. J Immunol. 2016 07 01; 197(1):326-36.
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Yue C, Xu J, Tan Estioko MD, Kotredes KP, Lopez-Otalora Y, Hilliard BA, Baker DP, Gallucci S, Gamero AM. Host STAT2/type I interferon axis controls tumor growth. Int J Cancer. 2015 Jan 01; 136(1):117-26.
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Xu J, Zoltick PW, Gamero AM, Gallucci S. TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-?B-dependent signaling pathways. J Leukoc Biol. 2014 Jul; 96(1):93-103.
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Sriram U, Xu J, Chain RW, Varghese L, Chakhtoura M, Bennett HL, Zoltick PW, Gallucci S. IL-4 suppresses the responses to TLR7 and TLR9 stimulation and increases the permissiveness to retroviral infection of murine conventional dendritic cells. PLoS One. 2014; 9(1):e87668.
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Sriram U, Biswas C, Behrens EM, Dinnall JA, Shivers DK, Monestier M, Argon Y, Gallucci S. IL-4 suppresses dendritic cell response to type I interferons. J Immunol. 2007 Nov 15; 179(10):6446-55.