"Single-Chain Antibodies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.
| Descriptor ID |
D057127
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| MeSH Number(s) |
D12.644.541.500.650.500.800 D12.776.124.486.485.114.224.785 D12.776.124.486.485.680.650.500.800 D12.776.124.790.651.680.650.500.800 D12.776.377.715.548.680.650.500.795
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| Concept/Terms |
Single-Chain Antibodies- Single-Chain Antibodies
- Antibodies, Single-Chain
- Single Chain Antibodies
- ScFv Antibodies
- Antibodies, ScFv
- Single-Chain Fv
- Fv, Single-Chain
- Single Chain Fv
- Single-Chain Fv Antibody
- Antibody, Single-Chain Fv
- Fv Antibody, Single-Chain
- Single Chain Fv Antibody
- Single-Chain Variable Fragment
- Fragment, Single-Chain Variable
- Single Chain Variable Fragment
- Variable Fragment, Single-Chain
- Single-Chain Variable Fragment Antibodies
- Single Chain Variable Fragment Antibodies
- Single-Chain Variable Fragment Antibody
- Single Chain Variable Fragment Antibody
- Single-Chain Variable Fragments
- Fragments, Single-Chain Variable
- Single Chain Variable Fragments
- Variable Fragments, Single-Chain
- Fv Antibody Fragments, Single-Chain
- Fv Antibody Fragments, Single Chain
- Single-Chain Fv Antibody Fragments
- Single Chain Fv Antibody Fragments
|
Below are MeSH descriptors whose meaning is more general than "Single-Chain Antibodies".
Below are MeSH descriptors whose meaning is more specific than "Single-Chain Antibodies".
This graph shows the total number of publications written about "Single-Chain Antibodies" by people in this website by year, and whether "Single-Chain Antibodies" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 2 | 2 |
| 2022 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Single-Chain Antibodies" by people in Profiles.
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Fierle JK, Abram-Saliba J, Atsaves V, Brioschi M, de Tiani M, Reichenbach P, Irving M, Coukos G, Dunn SM. A cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors. Sci Rep. 2022 01 21; 12(1):1136.
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Fierle JK, Brioschi M, de Tiani M, Wetterwald L, Atsaves V, Abram-Saliba J, Petrova TV, Coukos G, Dunn SM. Soluble trivalent engagers redirect cytolytic T?cell activity toward tumor endothelial marker 1. Cell Rep Med. 2021 08 17; 2(8):100362.
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van de Donk NWCJ, Usmani SZ, Yong K. CAR T-cell therapy for multiple myeloma: state of the art and prospects. Lancet Haematol. 2021 Jun; 8(6):e446-e461.
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D'Onofrio A, Gano L, Melo R, Mendes F, Oliveira MC, Deno?l T, Schaefer N, Viertl D, Fierle J, Coukos G, Dunn S, Prior JO, Paulo A. Biological evaluation of new TEM1 targeting recombinant antibodies for radioimmunotherapy: In vitro, in vivo and in silico studies. Eur J Pharm Biopharm. 2021 Jan; 158:233-244.
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Fierle JK, Abram-Saliba J, Brioschi M, deTiani M, Coukos G, Dunn SM. Integrating SpyCatcher/SpyTag covalent fusion technology into phage display workflows for rapid antibody discovery. Sci Rep. 2019 09 06; 9(1):12815.
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Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N. CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol. 2017 06 16; 429(12):1829-1839.
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Yu X, Duval M, Gawron M, Posner MR, Cavacini LA. Overcoming the Constraints of Anti-HIV/CD89 Bispecific Antibodies That Limit Viral Inhibition. J Immunol Res. 2016; 2016:9425172.
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Arora SK, Sharma R, Kaur G, Bhoria P, Sharma M, Luthra-Guptasarma M. Towards an indirect screening technique facilitating detection of cellular populations bearing specific cell surface markers. Biotechnol Prog. 2010 Nov-Dec; 26(6):1544-50.