bcl-2-Associated X Protein

"bcl-2-Associated X Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.

Descriptor ID	D051028
MeSH Number(s)	D12.644.360.075.718.400 D12.776.476.075.718.400
Concept/Terms	bcl-2-Associated X Protein bcl-2-Associated X Protein Protein, bcl-2-Associated X X Protein, bcl-2-Associated bcl 2 Associated X Protein Bax Apoptosis Regulator Protein Bax Protein bcl2-Associated X Protein bcl2 Associated X Protein bcl2-Associated X Protein Isoform beta bcl2-Associated X Protein Isoform beta bcl2 Associated X Protein Isoform beta Bax-beta Protein Bax beta Protein bcl2-Associated X Protein Isoform sigma bcl2-Associated X Protein Isoform sigma bcl2 Associated X Protein Isoform sigma Bax-sigma Protein Bax sigma Protein bcl2-Associated X Protein Isoform omega bcl2-Associated X Protein Isoform omega bcl2 Associated X Protein Isoform omega Bax-omega Protein Bax omega Protein bcl2-Associated X Protein Isoform alpha bcl2-Associated X Protein Isoform alpha bcl2 Associated X Protein Isoform alpha Bax-alpha Protein Bax alpha Protein bcl2-Associated X Protein Isoform delta bcl2-Associated X Protein Isoform delta bcl2 Associated X Protein Isoform delta Bax-delta Protein Bax delta Protein

Below are MeSH descriptors whose meaning is more general than "bcl-2-Associated X Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Proto-Oncogene Proteins c-bcl-2 [D12.644.360.075.718]
bcl-2-Associated X Protein [D12.644.360.075.718.400]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Proto-Oncogene Proteins c-bcl-2 [D12.776.476.075.718]
bcl-2-Associated X Protein [D12.776.476.075.718.400]

Below are MeSH descriptors whose meaning is related to "bcl-2-Associated X Protein".

Below are MeSH descriptors whose meaning is more specific than "bcl-2-Associated X Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "bcl-2-Associated X Protein" by people in this website by year, and whether "bcl-2-Associated X Protein" was a major or minor topic of these publications.

Bar chart showing 43 publications over 22 distinct years, with a maximum of 8 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1998	0	1	1
1999	0	1	1
2001	0	2	2
2002	0	8	8
2003	0	2	2
2004	0	2	2
2005	0	1	1
2006	0	1	1
2007	3	1	4
2008	0	1	1
2009	0	1	1
2010	3	2	5
2011	0	3	3
2013	0	2	2
2014	0	2	2
2016	1	0	1
2019	0	1	1
2020	0	1	1
2021	1	0	1
2022	0	1	1
2023	0	1	1

Below are the most recent publications written about "bcl-2-Associated X Protein" by people in Profiles.

Youn DH, Kim N, Lee A, Han SW, Kim JT, Hong EP, Jung H, Jeong MS, Cho SM, Jeon JP. Autophagy and mitophagy-related extracellular mitochondrial dysfunction of cerebrospinal fluid cells in patients with hemorrhagic moyamoya disease. Sci Rep. 2023 08 23; 13(1):13753.

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Shayan M, Eslami F, Amanlou A, Solaimanian S, Rahimi N, Rashidian A, Ejtemaei-Mehr S, Ghasemi M, Dehpour AR. Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or KATP channels inhibitors. Toxicol Appl Pharmacol. 2022 11 01; 454:116254.

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Manne RK, Agrawal Y, Malonia SK, Banday S, Edachery S, Patel A, Kumar A, Shetty P, Santra MK. FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX. J Biol Chem. 2021 10; 297(4):101253.

View in: PubMed
Das A, Martinez Santos JL, Alshareef M, Porto GBF, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. In?Vitro Effect of Dovitinib (TKI258), a Multi-Target Angiokinase Inhibitor on Aggressive Meningioma Cells. Cancer Invest. 2020 Jul; 38(6):349-355.

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Das A, Alshareef M, Henderson F, Martinez Santos JL, Vandergrift WA, Lindhorst SM, Varma AK, Infinger L, Patel SJ, Cachia D. Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth. Clin Transl Oncol. 2020 Jul; 22(7):1138-1145.

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Gil J, Ramsey D, Szmida E, Leszczynski P, Pawlowski P, Bebenek M, Sasiadek MM. The BAX gene as a candidate for negative autophagy-related genes regulator on mRNA levels in colorectal cancer. Med Oncol. 2017 Feb; 34(2):16.

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Carter JR, Taylor S, Fraser TS, Kucharski CA, Dawson JL, Fraser MJ. Suppression of the Arboviruses Dengue and Chikungunya Using a Dual-Acting Group-I Intron Coupled with Conditional Expression of the Bax C-Terminal Domain. PLoS One. 2015; 10(11):e0139899.

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Carter JR, Keith JH, Fraser TS, Dawson JL, Kucharski CA, Horne KM, Higgs S, Fraser MJ. Effective suppression of dengue virus using a novel group-I intron that induces apoptotic cell death upon infection through conditional expression of the Bax C-terminal domain. Virol J. 2014 Jun 13; 11:111.

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Gauger KJ, Bassa LM, Henchey EM, Wyman J, Ser-Dolansky J, Shimono A, Schneider SS. The effects of diet induced obesity on breast cancer associated pathways in mice deficient in SFRP1. Mol Cancer. 2014 May 22; 13:117.

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Zhang W, Xiao H, Parkin KL. Apoptosis in MCF-7 breast cancer cells induced by S-alkenylmercaptocysteine (CySSR) species derived from Allium tissues in combination with sodium selenite. Food Chem Toxicol. 2014 Jun; 68:1-10.

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