Toll-Like Receptor 4

"Toll-Like Receptor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA.

Descriptor ID	D051197
MeSH Number(s)	D12.776.543.750.705.910.500.400
Concept/Terms	Toll-Like Receptor 4 Toll-Like Receptor 4 Toll Like Receptor 4 Toll-4 Receptor Toll 4 Receptor TLR4 Receptor Receptor, TLR4

Below are MeSH descriptors whose meaning is more general than "Toll-Like Receptor 4".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Pattern Recognition [D12.776.543.750.705.910]
Toll-Like Receptors [D12.776.543.750.705.910.500]
Toll-Like Receptor 4 [D12.776.543.750.705.910.500.400]

Below are MeSH descriptors whose meaning is related to "Toll-Like Receptor 4".

Below are MeSH descriptors whose meaning is more specific than "Toll-Like Receptor 4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Toll-Like Receptor 4" by people in this website by year, and whether "Toll-Like Receptor 4" was a major or minor topic of these publications.

Bar chart showing 227 publications over 26 distinct years, with a maximum of 20 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	6	6
2000	0	6	6
2001	0	12	12
2002	0	15	15
2003	0	10	10
2004	0	20	20
2005	5	11	16
2006	11	4	15
2007	8	7	15
2008	6	2	8
2009	10	5	15
2010	7	3	10
2011	6	4	10
2012	4	5	9
2013	5	3	8
2014	8	2	10
2015	3	2	5
2016	1	7	8
2017	1	5	6
2018	2	2	4
2019	3	2	5
2020	2	2	4
2021	2	2	4
2022	0	1	1
2023	3	0	3
2024	1	1	2

Below are the most recent publications written about "Toll-Like Receptor 4" by people in Profiles.

Chibaya L, DeMarco KD, Lusi CF, Kane GI, Brassil ML, Parikh CN, Murphy KC, Chowdhury SR, Li J, Ma B, Naylor TE, Cerrutti J, Mori H, Diaz-Infante M, Peura J, Pitarresi JR, Zhu LJ, Fitzgerald KA, Atukorale PU, Ruscetti M. Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer. Sci Transl Med. 2024 Aug 28; 16(762):eadj9366.

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Nagesh PT, Cho Y, Zhuang Y, Babuta M, Ortega-Ribera M, Joshi R, Brezani V, Patel A, Datta AA, Brezani V, Hsieh YC, Ramos A, Mehta J, Copeland C, Kanata E, Jiang ZG, Vlachos I, Asara J, Szabo G. In vivo Bruton's tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis. Sci Transl Med. 2024 Aug 07; 16(759):eadg1915.

View in: PubMed
Nilsen KE, Zhang B, Skjesol A, Ryan L, Vagle H, B?e MH, Orning P, Kim H, Bakke SS, Elamurugan K, Mestvedt IB, Stenvik J, Husebye H, Lien E, Espevik T, Yurchenko M. Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo. Life Sci Alliance. 2023 12; 6(12).

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Zezulin AU, Yen D, Ye D, Howell ED, Bresciani E, Diemer J, Ren JG, Ahmad MH, Castilla LH, Touw IP, Minn AJ, Tong W, Liu PP, Tan K, Yu W, Speck NA. RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils. Genes Dev. 2023 07 01; 37(13-14):605-620.

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Aryee KE, Shultz LD, Burzenski LM, Greiner DL, Brehm MA. NOD-scid IL2r?null mice lacking TLR4 support human immune system development and the study of human-specific innate immunity. J Leukoc Biol. 2023 05 02; 113(5):418-433.

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Pereira M, Durso DF, Bryant CE, Kurt-Jones EA, Silverman N, Golenbock DT, Gazzinelli RT. The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways. Cell Rep. 2022 08 16; 40(7):111225.

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Rodrigues da Cunha GM, Azevedo MA, Nogueira DS, Cl?maco MC, Valencia Ayala E, Jimenez Chunga JA, La Valle RJY, da Cunha Galv?o LM, Chiari E, Brito CRN, Soares RP, Nogueira PM, Fujiwara RT, Gazzinelli R, Hincapie R, Chaves CS, Oliveira FMS, Finn MG, Marques AF. a-Gal immunization positively impacts Trypanosoma cruzi colonization of heart tissue in a mouse model. PLoS Negl Trop Dis. 2021 07; 15(7):e0009613.

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Silva-Gotay A, Davis J, Tavares ER, Richardson HN. Alcohol drinking during early adolescence activates microglial cells and increases frontolimbic Interleukin-1 beta and Toll-like receptor 4 gene expression, with heightened sensitivity in male rats compared to females. Neuropharmacology. 2021 10 01; 197:108698.

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Thada S, Horvath GL, M?ller MM, Dittrich N, Conrad ML, Sur S, Hussain A, Pelka K, Gaddam SL, Latz E, Slevogt H, Schumann RR, Burkert S. Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis. Int J Mol Sci. 2021 Feb 04; 22(4).

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Smulan LJ, Martinez N, Kiritsy MC, Kativhu C, Cavallo K, Sassetti CM, Singhal A, Remold HG, Kornfeld H. Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death. mBio. 2021 02 02; 12(1).

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