T-Lymphocytes, Regulatory

"T-Lymphocytes, Regulatory" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.

Descriptor ID	D050378
MeSH Number(s)	A11.118.637.555.567.550.500.700 A11.118.637.555.567.569.200.700 A11.118.637.555.567.569.500.700 A15.145.229.637.555.567.550.500.700 A15.145.229.637.555.567.569.200.700 A15.145.229.637.555.567.569.500.700 A15.382.490.555.567.550.500.700 A15.382.490.555.567.569.200.700 A15.382.490.555.567.569.500.700
Concept/Terms	T-Lymphocytes, Regulatory T-Lymphocytes, Regulatory T Lymphocytes, Regulatory Regulatory T-Lymphocytes Regulatory T Lymphocytes Regulatory T-Lymphocyte T-Lymphocyte, Regulatory Regulatory T-Cells Regulatory T Cells T-Cells, Regulatory T Cells, Regulatory Treg Cells Cell, Treg Cells, Treg Treg Cell Th3 Cells Th3 Cells Cell, Th3 Cells, Th3 Th3 Cell Suppressor T-Lymphocytes, Naturally-Occurring Suppressor T-Lymphocytes, Naturally-Occurring Naturally-Occurring Suppressor T-Lymphocyte Naturally-Occurring Suppressor T-Lymphocytes Suppressor T Lymphocytes, Naturally Occurring Suppressor T-Lymphocyte, Naturally-Occurring Suppressor T-Cells, Naturally-Occurring Naturally-Occurring Suppressor T-Cell Naturally-Occurring Suppressor T-Cells Suppressor T Cells, Naturally Occurring Suppressor T-Cell, Naturally-Occurring T-Cell, Naturally-Occurring Suppressor T-Cells, Naturally-Occurring Suppressor Tr1 Cells Tr1 Cells Cell, Tr1 Cells, Tr1 Tr1 Cell

Below are MeSH descriptors whose meaning is more general than "T-Lymphocytes, Regulatory".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Lymphocytes [A11.118.637.555.567]
Lymphocyte Subsets [A11.118.637.555.567.550]
T-Lymphocyte Subsets [A11.118.637.555.567.550.500]
T-Lymphocytes, Regulatory [A11.118.637.555.567.550.500.700]
T-Lymphocytes [A11.118.637.555.567.569]
CD4-Positive T-Lymphocytes [A11.118.637.555.567.569.200]
T-Lymphocytes, Regulatory [A11.118.637.555.567.569.200.700]
T-Lymphocyte Subsets [A11.118.637.555.567.569.500]
T-Lymphocytes, Regulatory [A11.118.637.555.567.569.500.700]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Lymphocytes [A15.145.229.637.555.567]
Lymphocyte Subsets [A15.145.229.637.555.567.550]
T-Lymphocyte Subsets [A15.145.229.637.555.567.550.500]
T-Lymphocytes, Regulatory [A15.145.229.637.555.567.550.500.700]
T-Lymphocytes [A15.145.229.637.555.567.569]
CD4-Positive T-Lymphocytes [A15.145.229.637.555.567.569.200]
T-Lymphocytes, Regulatory [A15.145.229.637.555.567.569.200.700]
T-Lymphocyte Subsets [A15.145.229.637.555.567.569.500]
T-Lymphocytes, Regulatory [A15.145.229.637.555.567.569.500.700]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Lymphocytes [A15.382.490.555.567]
Lymphocyte Subsets [A15.382.490.555.567.550]
T-Lymphocyte Subsets [A15.382.490.555.567.550.500]
T-Lymphocytes, Regulatory [A15.382.490.555.567.550.500.700]
T-Lymphocytes [A15.382.490.555.567.569]
CD4-Positive T-Lymphocytes [A15.382.490.555.567.569.200]
T-Lymphocytes, Regulatory [A15.382.490.555.567.569.200.700]
T-Lymphocyte Subsets [A15.382.490.555.567.569.500]
T-Lymphocytes, Regulatory [A15.382.490.555.567.569.500.700]

Below are MeSH descriptors whose meaning is related to "T-Lymphocytes, Regulatory".

Below are MeSH descriptors whose meaning is more specific than "T-Lymphocytes, Regulatory".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "T-Lymphocytes, Regulatory" by people in this website by year, and whether "T-Lymphocytes, Regulatory" was a major or minor topic of these publications.

Bar chart showing 159 publications over 25 distinct years, with a maximum of 12 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1998	0	2	2
2003	1	1	2
2004	2	0	2
2006	2	2	4
2007	6	1	7
2008	6	3	9
2009	6	2	8
2010	3	3	6
2011	4	6	10
2012	7	5	12
2013	7	2	9
2014	2	1	3
2015	6	3	9
2016	9	1	10
2017	8	2	10
2018	8	2	10
2019	3	5	8
2020	8	3	11
2021	1	0	1
2022	3	3	6
2023	1	3	4
2024	1	0	1
2025	3	5	8
2026	4	1	5

Below are the most recent publications written about "T-Lymphocytes, Regulatory" by people in Profiles.

Gonçalves-Pereira MH, Queiroz-Glauss C, Figueiredo MM, Quintino-de-Carvalho IL, Ramos MF, Bento GA, Magalhães TVB, Mafra AA, Diniz LMO, Costa ÚLD, Gollob KJ, Nogueira ML, Antonelli LRDV, Santiago HDC. DENV-Specific IL-10-Producing Regulatory T Cells Are Associated With Mild Clinical Outcomes in Dengue. J Med Virol. 2026 May; 98(5):e70956.

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Dwyer JR, Racine JJ, Chapman HD, Bell A, Quinlan A, Stafford GA, Serreze DV. Multiple Mechanisms Contribute to Robust Type 1 Diabetes Protection in Nfkbid- Overexpressing NOD Mice. Diabetes. 2026 May 01; 75(5):816-824.

View in: PubMed
Funsten M, de Pooter R, Varanasi V, Burrows M, Block K, Kuznetsov A, Serreze D, Huang H, Chervonsky A. B cells enable autoreactive T cells to avoid suppression. Proc Natl Acad Sci U S A. 2026 Apr 14; 123(15):e2536291123.

View in: PubMed
Siniscalco ER, Fisher C, Lu MP, Grassmann JDS, Mack CD, Yaakoubi R, Jacobsen D, Chen Q, Lee D, Rajamanimuthu P, Simoneau T, Preece K, Gray P, Okada S, Boisson B, Kayaoglu B, Danielson J, Freeman AF, Casanova JL, Chatila TA, Su HC, Ma CS, Williams A, Eisenbarth SC, Gowthaman U. DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. J Exp Med. 2026 Mar 02; 223(3).

View in: PubMed
Tripathi S, Julé AM, Zhuo Z, Schreiber BL, Martin-Moreno PL, Sui SH, Waaga-Gasser AM, Chandraker A. Single-cell and multi-omic characterization of ex vivo expanded ASTRLs from stable kidney transplant recipients reveals a regulatory T cell phenotype. Sci Rep. 2026 Jan 14; 16(1):3619.

View in: PubMed
Racine JJ, Dwyer JR, Chapman HD, Bell A, Robledo RF, Serreze DV. Direct-in-NOD genetic ablation of Bcl3 leads to complete type 1 diabetes protection. J Immunol. 2025 Nov 01; 214(11):2847-2860.

View in: PubMed
Stadinski BD, Mills EA, Humphries PA, Cleveland SB, Dow P, Murakami K, Li YR, Murakami M, Ono M, Au-Yeung BB, Morris GP, Zúñiga-Pflücker JC, Campbell RA, Griffiths ER, Huseby ES, Lo WL. Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire. Nat Immunol. 2025 Dec; 26(12):2256-2269.

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Zhou W, Zhou JZ, Ahmed A, Kim MJ, Guo CJ, Sonnenberg GF. ILC3s sense gut microbiota through STING to initiate immune tolerance. Immunity. 2025 Jul 08; 58(7):1762-1777.e7.

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Dostal J, Peters K, McDonald T, Lee DJ. Resolution of Autoimmune Uveitis Requires CCL20-Dependent Regulatory T Cells. Eur J Immunol. 2025 06; 55(6):e51854.

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Ahn M, Dostal J, Hegde P, Lee DJ. CTLA-4 expression on tregs is needed for suppression of autoimmune uveitis. Sci Rep. 2025 May 22; 15(1):17745.

View in: PubMed

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