T-Lymphocytes, Regulatory

"T-Lymphocytes, Regulatory" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.

Descriptor ID	D050378
MeSH Number(s)	A11.118.637.555.567.550.500.700 A11.118.637.555.567.569.200.700 A11.118.637.555.567.569.500.700 A15.145.229.637.555.567.550.500.700 A15.145.229.637.555.567.569.200.700 A15.145.229.637.555.567.569.500.700 A15.382.490.555.567.550.500.700 A15.382.490.555.567.569.200.700 A15.382.490.555.567.569.500.700
Concept/Terms	T-Lymphocytes, Regulatory T-Lymphocytes, Regulatory T Lymphocytes, Regulatory Regulatory T-Lymphocytes Regulatory T Lymphocytes Regulatory T-Lymphocyte T-Lymphocyte, Regulatory Regulatory T-Cells Regulatory T Cells T-Cells, Regulatory T Cells, Regulatory Treg Cells Cell, Treg Cells, Treg Treg Cell Th3 Cells Th3 Cells Cell, Th3 Cells, Th3 Th3 Cell Suppressor T-Lymphocytes, Naturally-Occurring Suppressor T-Lymphocytes, Naturally-Occurring Naturally-Occurring Suppressor T-Lymphocyte Naturally-Occurring Suppressor T-Lymphocytes Suppressor T Lymphocytes, Naturally Occurring Suppressor T-Lymphocyte, Naturally-Occurring Suppressor T-Cells, Naturally-Occurring Naturally-Occurring Suppressor T-Cell Naturally-Occurring Suppressor T-Cells Suppressor T Cells, Naturally Occurring Suppressor T-Cell, Naturally-Occurring T-Cell, Naturally-Occurring Suppressor T-Cells, Naturally-Occurring Suppressor Tr1 Cells Tr1 Cells Cell, Tr1 Cells, Tr1 Tr1 Cell

Below are MeSH descriptors whose meaning is more general than "T-Lymphocytes, Regulatory".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Lymphocytes [A11.118.637.555.567]
Lymphocyte Subsets [A11.118.637.555.567.550]
T-Lymphocyte Subsets [A11.118.637.555.567.550.500]
T-Lymphocytes, Regulatory [A11.118.637.555.567.550.500.700]
T-Lymphocytes [A11.118.637.555.567.569]
CD4-Positive T-Lymphocytes [A11.118.637.555.567.569.200]
T-Lymphocytes, Regulatory [A11.118.637.555.567.569.200.700]
T-Lymphocyte Subsets [A11.118.637.555.567.569.500]
T-Lymphocytes, Regulatory [A11.118.637.555.567.569.500.700]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Lymphocytes [A15.145.229.637.555.567]
Lymphocyte Subsets [A15.145.229.637.555.567.550]
T-Lymphocyte Subsets [A15.145.229.637.555.567.550.500]
T-Lymphocytes, Regulatory [A15.145.229.637.555.567.550.500.700]
T-Lymphocytes [A15.145.229.637.555.567.569]
CD4-Positive T-Lymphocytes [A15.145.229.637.555.567.569.200]
T-Lymphocytes, Regulatory [A15.145.229.637.555.567.569.200.700]
T-Lymphocyte Subsets [A15.145.229.637.555.567.569.500]
T-Lymphocytes, Regulatory [A15.145.229.637.555.567.569.500.700]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Lymphocytes [A15.382.490.555.567]
Lymphocyte Subsets [A15.382.490.555.567.550]
T-Lymphocyte Subsets [A15.382.490.555.567.550.500]
T-Lymphocytes, Regulatory [A15.382.490.555.567.550.500.700]
T-Lymphocytes [A15.382.490.555.567.569]
CD4-Positive T-Lymphocytes [A15.382.490.555.567.569.200]
T-Lymphocytes, Regulatory [A15.382.490.555.567.569.200.700]
T-Lymphocyte Subsets [A15.382.490.555.567.569.500]
T-Lymphocytes, Regulatory [A15.382.490.555.567.569.500.700]

Below are MeSH descriptors whose meaning is related to "T-Lymphocytes, Regulatory".

Below are MeSH descriptors whose meaning is more specific than "T-Lymphocytes, Regulatory".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "T-Lymphocytes, Regulatory" by people in this website by year, and whether "T-Lymphocytes, Regulatory" was a major or minor topic of these publications.

Bar chart showing 151 publications over 24 distinct years, with a maximum of 11 publications in 2012 and 2017 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1998	0	2	2
2003	1	1	2
2004	3	0	3
2006	2	2	4
2007	6	1	7
2008	6	3	9
2009	6	2	8
2010	3	3	6
2011	4	6	10
2012	7	4	11
2013	7	2	9
2014	2	1	3
2015	5	3	8
2016	9	1	10
2017	9	2	11
2018	8	2	10
2019	3	5	8
2020	8	3	11
2021	1	0	1
2022	2	3	5
2023	1	3	4
2024	1	0	1
2025	2	4	6

Below are the most recent publications written about "T-Lymphocytes, Regulatory" by people in Profiles.

Racine JJ, Dwyer JR, Chapman HD, Bell A, Robledo RF, Serreze DV. Direct-in-NOD genetic ablation of Bcl3 leads to complete type 1 diabetes protection. J Immunol. 2025 Nov 01; 214(11):2847-2860.

View in: PubMed
Dostal J, Peters K, McDonald T, Lee DJ. Resolution of Autoimmune Uveitis Requires CCL20-Dependent Regulatory T Cells. Eur J Immunol. 2025 Jun; 55(6):e51854.

View in: PubMed
Ahn M, Dostal J, Hegde P, Lee DJ. CTLA-4 expression on tregs is needed for suppression of autoimmune uveitis. Sci Rep. 2025 May 22; 15(1):17745.

View in: PubMed
Castagnoli R, Pala F, Subramanian P, Oguz C, Schwarz B, Lim AI, Burns AS, Fontana E, Bosticardo M, Corsino C, Angelova A, Delmonte OM, Kenney H, Riley D, Smith G, Ott de Bruin L, Oikonomou V, Dos Santos Dias L, Fink D, Bohrnsen E, Kimzey CD, Marseglia GL, Alva-Lozada G, Bergerson JRE, Brett A, Brigatti KW, Dimitrova D, Dutmer CM, Freeman AF, Ale H, Holland SM, Licciardi F, Pasic S, Poskitt LE, Potts DE, Dasso JF, Sharapova SO, Strauss KA, Ward BR, Yilmaz M, Kuhns DB, Lionakis MS, Daley SR, Kong HH, Segre JA, Villa A, Pittaluga S, Walter JE, Vujkovic-Cvijin I, Belkaid Y, Notarangelo LD. Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency. J Exp Med. 2025 Aug 04; 222(8).

View in: PubMed
Allard-Chamard H, Hillier K, Ramseier ML, Bertocchi A, Kaneko N, Premo K, Yuen G, Karpel M, Mahajan VS, Tsekeri C, Hong JS, Vencic J, Crotty R, Sharda AV, Barmettler S, Westermann-Clark E, Walter JE, Ghebremichael M, Shalek AK, Farmer JR, Pillai S. Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans. Blood Adv. 2025 Feb 11; 9(3):520-532.

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Anwar IJ, DeLaura I, Ladowski JM, Schilir? D, Gao Q, Manook M, Yoon J, Belloni R, Park A, Schuster DJ, Song M, Lin L, Farris AB, Magnani D, Williams K, Kwun J, Knechtle SJ. CD154 blockade effectively controls antibody-mediated rejection in highly sensitized nonhuman primate kidney transplant recipients. Sci Transl Med. 2025 Jan; 17(779):eadn8130.

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Xie F, Shen B, Luo Y, Zhou H, Xie Z, Zhu S, Wei X, Chang Z, Zhu Z, Ding C, Jin K, Yang C, Batzu L, Chaudhuri KR, Chan LL, Tan EK, Wang Q. Repetitive transcranial magnetic stimulation alleviates motor impairment in Parkinson's disease: association with peripheral inflammatory regulatory T-cells and SYT6. Mol Neurodegener. 2024 Oct 25; 19(1):80.

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Hu P, Xiao H, Elmore S, Agosto-Burgos C, Hu Y, Hogan SL, Ciavatta DJ, Falk RJ, Jennette JC, Free ME. Regulatory T cells effectively downregulate the autoimmune anti-MPO response and ameliorate anti-MPO induced glomerulonephritis in mice. J Autoimmun. 2024 07; 147:103266.

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Peters K, McDonald T, Muhammad F, Walsh M, Drenen K, Montieth A, Stephen Foster C, Lee DJ. A2Ar-dependent PD-1+ and TIGIT+ Treg cells have distinct homing requirements to suppress autoimmune uveitis in mice. Mucosal Immunol. 2023 08; 16(4):422-431.

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Mohan D, Sherman HL, Mitra A, Lawlor R, Shanthalingam S, Ullom J, Pobezinskaya EL, Zhang G, Osborne BA, Pobezinsky LA, Tew GN, Minter LM. LKB1 isoform expression modulates T cell plasticity downstream of PKC? and IL-6. Mol Immunol. 2023 05; 157:129-141.

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